唐伦先 主任医师，副教授
硕士招生类型：学术型；专业型
硕士招生专业：急诊医学
博士招生类型：学术型；专业型
博士招生专业：急诊医学
所在院系：附属东方医院
联系方式：456tlx@163.com
课题组链接：
研究方向
主要任职
科研业绩

急性呼吸窘迫综合征的分子发病机制与临床The potential molecular mechanism and clinical aspects of ARDS
脓毒症的免疫功能障碍The immunological dysfunction of sepsis
中国中西医结合学会灾难分会创伤学组常委Member of the standing committee of society of disaster and trauma of Chinese traditional Chinese Medicine
中国医学救援协会重症医学分会委员Committee member of society of Critical care branch of Chinese salvage medicine
上海市中西医结合学会急危重症、抗感染分会委员Committee member of society of Critical care and Emergency/ anti-inflammatory branch of Shanghai traditional Chinese Medicine
同济大学附属东方医院急诊内科南院主任Executive chief of Internal Emergency Medicine in south branch of East Hospital/Tongji University
美国布朗大学访问****，一直致力于急性肺损伤/急性呼吸窘迫综合征的基础和临床研究，第一作者发表论文30余篇，其中SCI论文10篇。先后完成科委，卫计委课题2项，新区优秀学科带头人1项，国际自然科学基金1项。目前主持国家自然科学基金面上项目1项、省部级自然基金重点项目1项、上海市科委医学创新研究专项1项和浦东新区领先人才计划1项，科研经费近200万元。培养硕士研究生9名，毕业5名。博士在读1名。
Visiting doctor of Brown University in USA. Research interests include projects looking at the potential molecular mechanism and clinical aspects of ARDS. More than 30 papersof 1st author had been published including 10 SCI papers. Two grants had been accomplished. Two grants from NSFC and key programs of provincial grants and Leading talents of Health Bureau of Pudong New District are now in progress.
附主要课题：(1) 国家自然科学基金面上项目，**，Circ-Rock1调控巨噬细胞极化在脓毒症致急性肺损伤中的作用及机制研究，2020.01-2023.12，55万元（直接费用），在研，主持。
(2)上海市科委 “科技创新行动计划”医学创新研究专项项目，肺源性脓毒症患者环状RNA表观遗传标记物的筛选及临床价值研究，2020.10-2023.09, 30万元，在研，主持。
(3)上海市浦东新区卫计委领先人次项目，PWRI2019-05，组蛋白甲基化转移酶EZH2调控CD4+T细胞免疫功能对脓毒症的预测作用研究，2019.09-2022.08，40万元，在研，主持。
(4)江西省自然科学基金重点项目，S2018ZRZDB0179, 组蛋白甲基转移酶EZH2调控巨噬细胞极化参与ARDS后肺纤维化的机制研究，2018.08-2020.08，50万元，在研，主持。
(5) 国家自然科学基金青年项目，**，Tim3+Treg通过调节巨噬细胞极化影响急性肺损伤修复的机制研究，2016.01-2018.12，18万元（直接费用），结题，主持。
主要论文：1. Zhao D,Li Z,Liu X,Liu N,Bao X,Sun H,Meng Q,Ren H,Bai J,Zhou X,Tang L*. Lymphocyte expression of EZH2 is associated with mortality and secondary infectious complications in sepsis.Int Immunopharmacol 2020;89(Pt B) :107042 [Epub ahead of print] (IF 3. 943)
2.Zhang Q, Sun H, Zhuang S, Liu N, Bao X, Liu X, Ren H, Lv D, Li Z, Bai J, Zhou X, Tang L*. Novel pharmacological inhibition of EZH2 attenuates septic shock by altering innate inflammatory responses to sepsis. Int Immunopharmacol. 2019 Sep 10;76:105899
3.Bao X, Zhang Q, Liu N, Zhuang S, Li Z, Meng Q, Sun H, Bai J, Zhou X, Tang L*. Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis-induced acute lung injury.J Cell Mol Med. 2019 Aug 14. doi: 10.1111/jcmm.14577. [Epub ahead of print] (IF 4.658)
4. Liu X, Jiang S, Zhang Q, Xu S, Bao X, Cao W, Bai J, Tang L*.Tim-3 Regulates Tregs' Ability to Resolve the Inflammation and Proliferation of Acute Lung Injury by Modulating Macrophages Polarization. Shock. 2017 Nov 30.[Epub ahead of print](IF 3.113)
5.Tang L, Zhang H, Wang C, Li H, Zhang Q, Bai J. M2a and M2c Macrophage subsets ameliorate inflammation and fibroproliferation in acute lung injury through interleukin 10 pathway. Shock. 2017; 48(1):119-12(IF 3.113)
6.Tang L, Bai J, Chung CS, Lomas-Neira J, Chen Y, Huang X,Ayala A. Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1.J Leukoc Biol. 2014; 96(5): 809-820. (IF 4. 304)
7.Tang L, Bai J, Chung CS, Lomas-Neira J, Chen Y, Huang X,Ayala A. PD-L1 regulates the Tregs' capacity to repress shock/sepsis induced indirect lung injury (iALI) by recruiting phosphatase SHP-1. Shock.2015; 43(1):47-54.(IF 3.113)
8.Bai J, Tang L#, Lomas-Neira J, Chen Y, McLeish KR, Uriarte SM, Chung CS, Ayala A. TAT-SNAP-23 treatment inhibits the priming of neutrophil functions contributing to shock and/or sepsis-induced extra-pulmonary acute lung injury. Innate Immun. 2015;21(1):42-54. (IF 2.83)
9.Tang L, Li Q, Bai J, Zhang H, Lu Y, Ma S. Severe pneumonia mortality in elderly patients is associated with downregulation of Toll-like receptors 2 and 4 on monocytes. Am J Med Sci. 2014;347(1):34-41. (IF 1.515)
10.Song H, Tang L#, Xu M, Li H, Xu S, Li G, Bao X, Sun B, Cheng T, Yang Q, Bai J. CD86 polymorphism affects pneumonia-induced sepsis by decreasing gene expression in monocytes.Inflammation.2015;38(2):879-885. (IF 2.618)
11. Zhou Y, Tang L#, Lin M, Xu S, Bai J*, Song H*.Expression of Cytotoxic T-Lymphocyte Antigen 4 on CD4+ and CD8+ T Cells Is Increased in Acute Lung Injury.DNA Cell Biol.2013,32(12): 722-726. (IF 2.574 )
12.包晓玮，孙宏，杨倩，刘显东，陈春香，白建文，唐伦先（通讯作者）*.共刺激分子程序性死亡配体-1在急性肺损伤中的作用及机制初探.中华危重病急救医学, 2016,28(6):498-503
13.孙宏，刘显东，吕迪宇，包晓玮，白建文，唐伦先（通讯作者）*.转化生长因子-β/Smad信号通路对急性肺损伤小鼠免疫平衡的影响.中华危重病急救医学, 2016,28(11):967-972
14.张倩倩，周晓慧，唐伦先（通讯作者）.组蛋白甲基转移酶抑制剂对脓毒症小鼠腹腔巨噬细胞极化的影响. 中华危重病急救医学, 2019,31(2):187-192
专利：1.唐伦先，孙宏，包晓玮，赵冬旸，刘娜，周如女，许明正，李珂; 组蛋白甲基转移酶EZH2在制备用于诊断脓毒症生物标记物中的用途, 2020-04-15, 中国, 2.0.
2. 唐伦先，任慧娟，杨倩，赵冬旸，刘显东，杨倩; 尿TIMP-2和IGFBP-7在制备用于诊断脓毒症急性肾损伤的生物标记物中的用途,2020-04-15, 中国, 5.0.