任天斌 教授
硕士招生类型：学术型
硕士招生专业：药学
博士招生类型：学术型
博士招生专业：临床医学（生物医学方向）
所在院系：医学院
联系方式：rtb002@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

1、肿瘤及感染免疫治疗
2、靶向和敏感释放生物材料
3、复杂药物和材料体系的分析方法
4、功能性粘接和涂层
1、Immunotherapyfor Tumors and Infections
2、Biomaterialsfor Targeted and Sensitive Release System
3、AnalysisMethod for Complex Drugs and Material Systems
4、Functional Adhesives and Coatings

同济大学医学院教授，博导，同济大学材料学院双聘教授，上海市科协委员，杨浦区科协委员，上海市粘接技术协会理事长，上海生物医学工程学会医用材料专委会委员，中国胶粘剂、胶体与聚合物等专业杂志编委，教育部首批优秀创新创业导师，多家高科技公司创始人。
Professorof School of Medicine and School of Materials Science and Engineer, TongjiUniversity, Member of Shanghai Association of Science, Member of YangpuDistrict Association of Science, President of Shanghai Association of Adhesive Technology,Member of Medical Materials Committee of Shanghai Society of BiomedicalEngineering, Editorial Board of Chinese Journals of Adhesives, Colloids andPolymers, etc. Founders of several high-tech companies.

作为项目负责人及主要承担者完成了包括国家自然科学基金、科技部世博科技专项、上海市科技攻关重点项目、上海市重大科技基础研究项目、国家863科技专项、上海市基础研究重点项目、上海市纳米专项重点项目及企业横向项目等科研项目40余项。发表各类学术论文100篇余篇，其中SCI收录论文60余篇，获得上海市科技进步二等奖一项，授权发明专利50余项，多项科研成果实现了产业化。
当前在研纵向项目：
1. 国家自然基金面上项目 “黑”细胞靶向调控肿瘤氧化应激微环境及促光热抗肿瘤效应负责人 2020.1-2023.12
2. 国家自然基金面上项目 应用纳米自组装技术克服治疗性疫苗载体免疫反应负责人 2016.1-2019.12
3. 国家自然基金面上项目 分域隔离纳米疫苗抗泛耐药肺炎克雷伯菌的作用机制研究第二负责人 承担一半科研经费 2017-2020
4. 中央高校基本科研经费学科交叉重点项目“纳米环巴胺协同PD-L1序贯高效杀伤耐药三阴性乳腺癌作用机制的实验研究 第二负责人 经费各半2017-2019
部分发表论文：
1) Wang K, WenSM, He LH, Li A, Li Y, Dong HQ, Li W, Ren TB, ShiDL, Li YY. “Minimalist” Nanovaccine Constituted from Near Whole Antigen forCancer Immunotherapy ACS Nano, 2018, 12 (7), 6398–6409
2) Li Y, He LH, DongHQ, Liu YQ, Wang K, Li A, Ren TB, Shi DL, Li YY.Fever‐Inspired Immunotherapy Based on Photothermal CpG Nanotherapeutics: TheCritical Role of Mild Heat in Regulating Tumor Microenvironment. AdvancedScience2018,5,6:** ( 2018-03-25)
3) Luo S, Fan L,Yang K, Zhong Z, Wu XJ and Ren TB. In situ and controllable synthesis ofAg NPs in tannic acid-based hyperbranched waterborne polyurethanes to prepareantibacterial polyurethanes/Ag NPs composites. RSC Adv., 2018,8,36571-36578
4) Luo S, Yang K,Zhong Z, Wu XJ and Ren TB.. Facile preparation of degradablemulti-arm-star-branched waterborne polyurethane with bio-based tannic acid. RSCAdv., 2018,8, 37765-37773
5) Zhong Z, LuoS, Yang K, Wu XJ, Ren TB. High-performance anionicwaterborne polyurethane/Ag nanocomposites with excellent antibacterial propertyvia in situ synthesis of Ag nanoparticles.RSC Adv. 2017,7, 67: 42296-42304
6) Tang M, DongHQ, Li YY, Ren TB. Harnessing the PEG-cleavable strategy tobalance cytotoxicity, intracellular release and the therapeutic effect ofdendrigraft poly-L-lysine for cancer gene therapy. Journal of MaterialsChemistry B. 2016,4,7 1284-1295
7) Zhou JS, Li Y,Dong HQ, Yuan H, Ren TB, Li YY. Effect of monomer sequence ofpoly(histidine/ lysine) catiomers on gene packing capacity and deliveryefficiency. RSC Advances . 2015,5(19): 14138-14146
8) Dong HQ, DongHY, Xia WJ, Li YY , Ren TB. Self-assembled, Redox-sensitive,H-shaped Pegylated Methotrexate Conjugates with High Drug-carryingCapability for Intracellular Drug Delivery. MedChemComm, 2014,5, 147-152
9) Li YY, Lei X,Dong HQ, Ren TB.Sheddable, degradable, cationic micelles enabling drugand gene delivery. RSC Advances, 2014,4, 8165-8176
10) Zhu HY,DongCY,Dong HQ, Ren TB,Wen XJ, Su JS, Li YY. Cleavable PEGylation andHydrophobic Histidylation of Polylysine for siRNA Delivery and Tumor GeneTherapy. ACS Appl. Mater. Interfaces, 2014,6(13), 10393–10407
11) Dong HQ, DongCY, Ren TB, Li YY, Shi DL.Surface-Engineered Graphene-BasedNanomaterials for Drug Delivery. Journal of Biomedical Nanotechnology. 2014,10(9), 2086-2106
12) Ren TB,Wu W, Jia MH, Dong HQ, Li YY, Ou ZL. Reduction-Cleavable Polymeric Vesicleswith Efficient Glutathione-Mediated Drug Release Behavior for Reversing DrugResistance. ACS Appl. Mater. Interfaces 2013, 5 (21), 10721–10730
13) Li YY, Li Lan,Dong HQ, Cai XJ, Ren TB. Pluronic F127 nanomicelles engineered withnuclear localized functionality for targeted drug delivery. Materials Scienceand Engineering: C, 2013, 33(5): 2698–2707
14) Chu M, DongCY, Zhu HY, Cai XJ , Dong HQ, Ren TB,et al. Biocompatible polyethylenimine-graft-dextrancatiomer for highly efficient gene delivery assisted by a nuclear targetingligand. Polymer Chemisty, 2013,4, 2528-2539
15) Ren TB,Li L, Cai XJ et al. Engineered polyethylenimine/graphene oxide nanocompositefor nuclear localized gene delivery. Polymer chemistry，2012,9:1759-9954.
16) Ren TB,Liu QM, Lu H et al. Multifunctional Polymer Vesicles for UltrasensitiveMagnetic Resonance Imaging and Drug Delivery, Journal of materials chemistry 2012,22, 12329-12338.
17) Lu H, Fan L,Liu QM, Wei JR, Ren TB et al. Preparation of water-dispersiblesilver-decorated polymer vesicles and micelles with excellent antibacterialefficacy. Polymer chemistry 2012,3(8): 2217-2227.
18) Ren TB,Feng Y, Zhang ZH, et al. Shell-sheddable micelles based on star-shapedpoly(epsilon-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellulardrug release. Soft matter. 2011, 7(6): 2329-2331.
19) Ren TB,Wang A, Yuan WZ, et al. Synthesis, Self-Assembly, Fluorescence, andThermosensitive Properties of Star-Shaped Amphiphilic Copolymers with PorphyrinCore. Journal of polymer science part a-polymer chemistry.2011,49(10):2303-2313.
20) Ren TB;Xia WJ; Dong HQ. Sheddable micelles based on disulfide-linked hybridPEG-polypeptide copolymer for intracellular drug delivery. Polymer.2011,20(52): 3580-3586.
21) Ren TB,Xu N, Cao CH, et al. Preparation and Therapeutic Efficacy ofPolysorbate-80-Coated Amphotericin B/PLA-b-PEG Nanoparticles. Journal ofbiomaterials science- polymer edition. 2009, 20(10): 1369-1380.
22) Ren TB,Weigel T, Groth T et al. Microwave plasma surface modification of siliconeelastomer with Allylamine for improvement of biocompatibility. Journal ofbiomedical materials research part A. 2008,86A(1): 209-219.

。发表100篇余篇，其中SCI收录

As the project leader and mainparticipant, More than 40 research projects have been completed, including theNational Natural Science Foundation of China, the Expo Science and TechnologyProject of the Ministry of Science and Technology, the key projects of scienceand technology in Shanghai, the major basic research projects of science andtechnology in Shanghai, the 863 national science and technology project, thekey projects of basic research in Shanghai, the key projects of nanotechnologyin Shanghai and enterprise entrusted projects. More than 100 academicpapers have been published, of which more than 60 papers have been indexedin SCI.
Currently research projects including:
1. National Natural Science FoundationProject (**): Black cell target-regulating tumor oxidative stressmicroenvironment for improved photothermal therapy (2020.1-2023.12)
2. National Natural Science FoundationProject (**) Suppression of Immune Response of Therapeutic Vaccine Carrierby Nano-engineering Technology (2016.1-2019.12)
3. National Natural Science FoundationProject (8167 1944) Study on the Mechanism of Subarea Isolation of Nanovaccineagainst Pan-resistant Klebsiella pneumoniae (2017.1-2020.12)
4. Key projects of fundamentalscientific research funds in universities “Experimental study on the mechanismof sequential and highly effective killing of drug-resistant triple-negativebreast cancer by nanocyclopatamine combined with PD-L1” (2017-2019)

Selective Publications：
1) Wang K, WenSM, He LH, Li A, Li Y, Dong HQ, Li W, Ren TB, ShiDL, Li YY. “Minimalist” Nanovaccine Constituted from Near Whole Antigen forCancer Immunotherapy ACS Nano, 2018, 12 (7), 6398–6409
2) Li Y, He LH, DongHQ, Liu YQ, Wang K, Li A, Ren TB, Shi DL, Li YY.Fever‐Inspired Immunotherapy Based on Photothermal CpG Nanotherapeutics: TheCritical Role of Mild Heat in Regulating Tumor Microenvironment. AdvancedScience2018,5,6:** ( 2018-03-25)
3) Luo S, Fan L,Yang K, Zhong Z, Wu XJ and Ren TB. In situ and controllable synthesis ofAg NPs in tannic acid-based hyperbranched waterborne polyurethanes to prepareantibacterial polyurethanes/Ag NPs composites. RSC Adv., 2018,8,36571-36578
4) Luo S, Yang K,Zhong Z, Wu XJ and Ren TB.. Facile preparation of degradablemulti-arm-star-branched waterborne polyurethane with bio-based tannic acid. RSCAdv., 2018,8, 37765-37773
5) Zhong Z, LuoS, Yang K, Wu XJ, Ren TB. High-performance anionicwaterborne polyurethane/Ag nanocomposites with excellent antibacterial propertyvia in situ synthesis of Ag nanoparticles.RSC Adv. 2017,7, 67: 42296-42304
6) Tang M, DongHQ, Li YY, Ren TB. Harnessing the PEG-cleavable strategy tobalance cytotoxicity, intracellular release and the therapeutic effect of dendrigraftpoly-L-lysine for cancer gene therapy. Journal of Materials Chemistry B.2016,4,7 1284-1295
7) Zhou JS, Li Y,Dong HQ, Yuan H, Ren TB, Li YY. Effect of monomer sequence ofpoly(histidine/ lysine) catiomers on gene packing capacity and deliveryefficiency. RSC Advances . 2015,5(19): 14138-14146
8) Dong HQ, DongHY, Xia WJ, Li YY , Ren TB. Self-assembled, Redox-sensitive,H-shaped Pegylated Methotrexate Conjugates with High Drug-carryingCapability for Intracellular Drug Delivery. MedChemComm, 2014,5, 147-152
9) Li YY, Lei X,Dong HQ, Ren TB.Sheddable, degradable, cationic micelles enabling drugand gene delivery. RSC Advances, 2014,4, 8165-8176
10) Zhu HY,DongCY,Dong HQ, Ren TB,Wen XJ, Su JS, Li YY. Cleavable PEGylation andHydrophobic Histidylation of Polylysine for siRNA Delivery and Tumor GeneTherapy. ACS Appl. Mater. Interfaces, 2014,6(13), 10393–10407
11) Dong HQ, DongCY, Ren TB, Li YY, Shi DL.Surface-Engineered Graphene-BasedNanomaterials for Drug Delivery. Journal of Biomedical Nanotechnology. 2014,10(9), 2086-2106
12) Ren TB,Wu W, Jia MH, Dong HQ, Li YY, Ou ZL. Reduction-Cleavable Polymeric Vesicleswith Efficient Glutathione-Mediated Drug Release Behavior for Reversing DrugResistance. ACS Appl. Mater. Interfaces 2013, 5 (21), 10721–10730
13) Li YY, Li Lan,Dong HQ, Cai XJ, Ren TB. Pluronic F127 nanomicelles engineered withnuclear localized functionality for targeted drug delivery. Materials Scienceand Engineering: C, 2013, 33(5): 2698–2707
14) Chu M, DongCY, Zhu HY, Cai XJ , Dong HQ, Ren TB,et al. Biocompatiblepolyethylenimine-graft-dextran catiomer for highly efficient gene deliveryassisted by a nuclear targeting ligand. Polymer Chemisty, 2013,4, 2528-2539
15) Ren TB,Li L, Cai XJ et al. Engineered polyethylenimine/graphene oxide nanocompositefor nuclear localized gene delivery. Polymer chemistry，2012,9:1759-9954.
16) Ren TB,Liu QM, Lu H et al. Multifunctional Polymer Vesicles for UltrasensitiveMagnetic Resonance Imaging and Drug Delivery, Journal of materials chemistry 2012,22, 12329-12338.
17) Lu H, Fan L,Liu QM, Wei JR, Ren TB et al. Preparation of water-dispersiblesilver-decorated polymer vesicles and micelles with excellent antibacterialefficacy. Polymer chemistry 2012,3(8): 2217-2227.
18) Ren TB,Feng Y, Zhang ZH, et al. Shell-sheddable micelles based on star-shapedpoly(epsilon-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellulardrug release. Soft matter. 2011, 7(6): 2329-2331.
19) Ren TB,Wang A, Yuan WZ, et al. Synthesis, Self-Assembly, Fluorescence, andThermosensitive Properties of Star-Shaped Amphiphilic Copolymers with PorphyrinCore. Journal of polymer science part a-polymer chemistry.2011,49(10):2303-2313.
20) Ren TB;Xia WJ; Dong HQ. Sheddable micelles based on disulfide-linked hybrid PEG-polypeptidecopolymer for intracellular drug delivery. Polymer. 2011,20(52): 3580-3586.
21) Ren TB,Xu N, Cao CH, et al. Preparation and Therapeutic Efficacy ofPolysorbate-80-Coated Amphotericin B/PLA-b-PEG Nanoparticles. Journal ofbiomaterials science- polymer edition. 2009, 20(10): 1369-1380.
22) Ren TB,Weigel T, Groth T et al. Microwave plasma surface modification of siliconeelastomer with Allylamine for improvement of biocompatibility. Journal ofbiomedical materials research part A. 2008,86A(1): 209-219.