许可 研究员
硕士招生类型：学术型
硕士招生专业：生物医学工程
博士招生类型：学术型
博士招生专业：临床医学（生物医学方向）
所在院系：高等研究院
联系方式：kx2129@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

疾病相关重要蛋白质的结构与功能研究，包括重要的酶类、转运蛋白及受体。
Structural andfunctional studies of disease-related proteins including important enzymes,transporters and receptors.


2015．11 至 2019.12 在美国纽约哥伦比亚大学著名结构生物学家童亮教授实验室进行博士后的研究。
From 2015.11to 2019.12, I worked as a postdoctoral research associate in Liang Tong’s lab,who is a very famous structural biologist in Columbia University, located inthe city of New York in USA.




在博士工作期间，主要进行能量耦合因子型ABC转运蛋白的结构生物学研究,解析了第一个能量耦合因子型转运蛋白的结构并提出其独特的底物转运及能量偶联的机制。在博士后工作期间，主要从事组蛋白表观修饰、RNA修饰及剪切相关的 结构与功能研究。在国际顶尖学术期刊Nature、eLife、PNAS、CellResearch 等 发表文章多篇。曾获得获得中科院最高荣誉奖励：中国科学院三好学生标兵，中国科学院院长特别奖；及优秀博士生国家奖学金。入选第64届德国林岛诺贝尔奖得主大会中国博士代表团（30人），赴德国进行学术交流。
DuringPh.D. period, I focused on the structural and functional studies ofEnergy-Coupling-Factor (ECF) type ABC transporters. I solved the firststructure of ECF transporters and proposed its unique substrate transport andenergy coupling mechanism. As for my postdoctoral period, I worked on manyprojects which are related to histone epigenetics modification, RNAmodification and splicing. I have published many papers in the top scientificjournals including Nature, eLife, PNAS, Cell Research and so on. Due to myoutstanding contribution, I was awarded highest level honors of Chinese Academyof Science (CAS) (Pacemaker to Merit Student of CAS and The Special Prize ofPresident Scholarship of CAS) and The National Scholarship for PostgraduateStudents of P. R. China. Besides that, I was also elected as one member of ChinesePh.D. delegation (30 members) of 64^th German Lindau Nobel PrizeLaureate, participating in academic exchange in Germany.
文章列表Publications：
1. Ke Xu*, Minhua Zhang*, Qin Zhao*,Fang Yu*, Hui Guo, Chengyuan Wang, Fangyuan He, Jianping Ding, Peng Zhang. (2013)Crystal structure of a folate energy-coupling factor transporter from Lactobacillusbrevis. Nature. 497(7448):268-271.
2. Chun-Min Shan*,Jiyong Wang*, Ke Xu*, Huijie Chen, Jia-Xing Yue, Stuart Andrews, James JMoresco, John R Yates III, Peter L Nagy,Liang Tong, Songtao Jia.(2016) Ahistone H3K9M mutation traps histone methyltransferase Clr4 to preventheterochromatin spreading. eLife. 5:e17903.
3. Minhua Zhang*, Zhihao Bao*, QinZhao, Hui Guo, Ke Xu, Chengcheng Wang, Peng Zhang. (2014) Structure of apantothenate transporter and implications for ECF module sharing and energycoupling of group II ECF transporters. Proc. Natl. Acad. Sci. USA.111(52):18560-565.
4. Zhihao Bao*, Xiaofeng Qi*, SenHong, Ke Xu, Fangyuan He, Minhua Zhang, Jiugeng Chen, Daiyin Chao, WeiZhao, Dianfan Li, Jiawei Wang, Peng Zhang. (2017) Structure and mechanism of agroup-I cobalt energy coupling factor transporter. Cell Res.27:675–687.
5. Shukun Luo, KeXu, Shaoyun Xiang, Jie Chen, Chunyun Chen, Chuangxin Guo, Youzhi Tong andLiang Tong. (2018) High-resolution structures of inhibitor complexes of humanindoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Crystallogr. F.74 (11).
*Theseauthors contribute to the paper equally.