吴叶林 研究员-高研院
硕士招生类型：学术型
硕士招生专业：生物医学工程
博士招生类型：无
博士招生专业：无
所在院系：附属第十人民医院
联系方式：Sk_wuyelin@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

（1）生物医用功能材料在肿瘤和皮肤学领域的应用研究；（2）肿瘤免疫；（3）皮肤免疫
（1）Application of biomedical functional material in cancer and dermatology；（2）Cancer immunology；（3）Skin immunology
（1）《中华乳腺病杂志（电子版）》中青年编委；（2）上海东方美谷药妆研究院 特聘专家
（1）Young and middle-aged editorial committee member of《ZHONGHUA RUXIAN BING ZAZHI》；（2）Specialized Expert of The Pharmaceutical and Cosmetics Research Institute of DONGFANG MEIGU
其研究成果以第一作者或通讯作者发表在 Nature communication, Cancer research, Advanced Science, Angew. Chem. Int. Ed等国际知名杂志中。申请专利3项，授权1项。主持国家自然科学基金青年基金1项，上海市基础项目1项。参与国家及省部级基金项目多项。
He has published multiple papers in high profile journals such as Nature communication, Cancer research, Advanced Science, Angew. Chem. Int. Ed. et. al., applied 3 patents (authorized 1) and got grant supports from the National Natural Science Foundation of China and the Key Project of Shanghai Science and Technology Commission.
主要承担的科研项目（项目负责人）：
1.国自然院内培育面上A类1项，糖尿病创面炎症的功能和机制研究。项目号：04.03.19.104。2020.01-2022.12，资助金额10万，主持
2.上海市基础项目子课题1项，化学动力学疗法的分子生物学功能及机制研究。项目号：19JC**。2019.11.01-2022.10.31，资助金额150万，主持
3.国家自然科学基金青年项目1项，TLR2调节IL-33抵抗细菌感染的功能和机制研究。项目号：**。 2013.1-2015.12，资助金额23万，主持
4.华东师大创新基金青年项目1项，白介素33（IL-33）在皮肤细菌感染中的功能及机制研究。项目号：**。2012.1-2013.12，资助金额15万，主持
论文列表（Publication List）:
1.Yanli Li, Peiran Zhao, Teng Gong*, Han Wang, Xingwu Jiang, Hui Cheng, Yanyan Liu, Yelin Wu*, Wenbo Bu* Redox Dyshomeostasis Strategy for Hypoxic Tumor Therapy Based on DNAzyme‐Loaded Electrophilic ZIFs. 2020. Angew. Chem. Int. Ed. 2020, DOI: 10.1002/anie.(Corresponding author)
2.Weiwei Su, Han Wang, Tao Wang, Xiao Li, Zhongmin Tang, Shuai Zhao, Meng Zhang, Danni Li, Xingwu Jiang, Teng Gong, Wei Yang, Changjing Zuo,* Yelin Wu,* Wenbo Bu*. Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy. Advanced Science. 2020.7.** (Corresponding author)
3.Xianfu Meng, *Yelin Wu, and *Wenbo Bu. Functional CT Contrast Nanoagents for the Tumor Microenvironment. Advanced Healthcare Materials. 2020; **(Corresponding author).
4.Yelin Wu, Yanchun Quan, Yuanqi Liu, Keiwei Liu, Hongquan Li, Ziwei Jiang, Tian Zhang, Hu Lei, K atherine A. Radek, Dongqing Li, Zhenhua Wang, Jilong Lu, Wang Wang, Shizhao Ji, Zhaofan Xia, Yuping Lai. Hyperglycemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes. Nature Communications, 2016 Nov 10; 7:13393. doi: 10.1038/ncomms13393.
5.Li Qin, Ye-lin Wu, Michael J. Toneff, Dabing Li, Lan Liao, Xiuhua Gao, Jean C-Y. Tien, Yixiang Xu, Zhen Feng, Suoling Zhou, Yi Li, and Jianming Xu. NCOA1 directly targets M-CSF1 expression to promote breast cancer metastasis. Cancer Res. 2014 Jul 25;74(13):3477-88 (Co-first author)
6.Hu Lei, Yue Wang, Tian Zhang, Leilei Chang, *Yelin Wu, *Yuping Lai.TLR3 activation induces S100A7 to regulate keratinocyte differentiation after skin injury. SCIENCE CHINA Life Sciences. 2017 Feb; 60(2):158-167. doi: 10.1007/s11427-016-0027-2. (Corresponding author)
7.Quan Huang, Jian Liu, Tenghui Chen, Lei Li, Lu Wang, *Yelin Wu. Gene expression analysis identifies common and distinct signatures underlying the ductal and lobular breast cancers. The Journal of Reproductive Medicine. 2017; 62:271-283. (Corresponding author)
8.吴叶林，全艳春，赖玉平. 角质形成细胞与T细胞的crosstalk诱发银屑病的研究现状及展望 生命科学Chinese Bulletin of Life Sciences. 2016. Feb. 28(2) 258-267.
9.Wei Xu, Shuang Liu, *Yelin Wu. Association between XRCC1 Arg280His polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis. Gent. Mol. Res. 2015 Jun 14(2)7122-7129. (Corresponding author)
10.Ye-Lin Wu, Hongquan Li, Ziwei Jiang, *Lai Y. The interleukin-1 family: a key regulator in the pathogenesis of psoriasis. Austin Journal of Clinical Immunology. Austin Journal of Clinical Immunology. 2014 Nov 17. 1(5) :1-5.
11.Ye-Lin Wu, Jing Huang, Jian Liu, Ming-fei Jin, Mei Gu, Yiguo Hong, Zi-rong Wu. Protective effect of recombinant human glucagons-like peptie-1(rhGLP-1) pretreatment in Streptozotocin-induced diabetic mice. Journal of Peptide Science: 2011 (17) 499-504.
12.Ye-Lin Wu，Jing Huang，Jin Xu，Jian Liu，Zhen Feng，Yang Wang，Yuping Lai，Zi-Rong Wu. Addition of a cysteine to glucagon-like peptide-1 (GLP-1) conjugates GLP-1 toalbumin in serum and prolongs GLP-1 action in vivo. Regulatory Peptides: 2010 (164) 83–89.
13.Miao Xu, Huiping Lu, Young-Hee Lee, Yelin Wu, Kewei Liu, Yuling Shi, Haoran An, Jingren Zhang, Xiaohu Wang, Yeping Lai, Chen Dong. An An Interleukin-25-Mediated Autoregulatory Circuit in Keratinocytes Plays a Pivotal Role in Psoriatic Skin In?ammation. Immunity: 48(2018)1-12.
14.Lai Y? Li D? Li C? Muhleisen B? Radek KA? Park HJ? Jiang Z? Li Z? Lei H? Quan Y? Zhang T? Wu Y, Kotol P? Morizane S? Hata TR? Iwatsuki K? Tang C? Gallo RL. The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. Immunity: 37(2012)74-84.