李丽 教授
硕士招生类型：学术型
硕士招生专业：生物医学工程
博士招生类型：学术型
博士招生专业：基础医学
所在院系：医学院
联系方式：lilirz@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

表观遗传学与生物信息学/心肌细胞定向分化的调节机制
上海市医学会医学遗传学专科分会委员；中国优生科学协会青年工作委员会第二届委员
主要从事生物信息学与表观遗传学的研究。利用生物信息学策略和分子遗传学技术研究心肌细胞定向分化的表观遗传调节机制和心脏病相关基因的识别；基于生物大数据的复杂疾病的生物标志物识别、分子分型及网络构建。主持国家自然科学基金4项，上海市科委基础领域重点项目1项等。发表SCI论文50余篇。
科研项目：
1.项目来源：国家自然科学基金面上项目；项目名称：RNA结合蛋白SAMD4靶向FGF2/FGF18维系心肌细胞分化通路的研究；项目负责人。
2.项目来源：国家自然科学基金面上项目；项目名称：ERG1介导Integrinβ1维持大鼠心脏发育信号稳态的研究；项目负责人。
3.项目来源：上海市科委基础领域重点项目；项目名称：microRNA-26b核内调节机制；项目负责人。
4.项目来源：中央高校基本科研业务费重点学科交叉；项目名称：新的先天性致病基因CX45的识别功能研究及诊断芯片研制；项目负责人。
5.项目来源：国家自然科学基金面上项目；项目名称：microRNA-26b在心肌细胞分化中对GATA4和KCNJ2的同步调节机制；项目负责人。
6.项目来源：国家重点基础研究发展计划；项目名称：miRNA和蛋白质修饰在干细胞对称和不对称分裂过程中的作用及机理；项目骨干。
7.项目来源：国家自然科学基金青年项目；项目名称：离子通道药物靶点识别的生物信息融合方法研究；项目负责人。
近五年发表论文：
*通信作者
1.Li Z，Meng Y, Liu C, Liu H, Cao W, Tong C, Lu M, Li L*, Peng L*. Kcnh2 mediates FAK/AKT‐FOXO3A pathway to attenuate sepsis. Cell Proliferation.2020
2.Wang Y, Yi N, Hu Y, Zhou X, Jiang H, Lin Q, Chen R, Liu H, Gu Y, Tong C, Lu M, Zhang J, Zhang B, Peng L*, Li L*. Molecular Signatures and Networks of Cardiomyocyte Differentiation in Humans and Mice. Mol Ther Nucleic Acids. 2020Sep 4;21:696-711.
3.Li Z, Yi N, Chen R, Meng Y, Wang Y, Liu H, Cao W, Hu Y, Gu Y, Tong C, Lu M, Li L*, Peng L*. miR-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting FOXO3A. Cell Signal. 2020 Jul 21:109716.
4.Xie D, Geng L, Xiong K, Zhao T, Wang S, Xue J, Wang C, Wang G, Feng Z, Zhou H, Li Y, Li L, Liu Y, Xue Z, Yang J, Ma H, Liang D, Chen YH. Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase. Circ Res. 2020 Jun 5;126(12):1706-1720.
5.Chen R, He J, Wang Y, Guo Y, Zhang J, Peng L, Wang D, Lin Q, Zhang J, Guo Z*,Li L*. Qualitative transcriptional signatures for evaluating the maturity degree of pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther. 2019 Mar 29;10(1):113.
6.Li Z, Zhu H, Liu C, Wang Y, Wang D, Liu H, Cao W, Hu Y, Lin Q, Tong C, Lu M,Sachinidis A, Li L*, Peng L*. GSK-3β inhibition protects the rat heart from thelipopolysaccharide-induced inflammation injury via suppressing FOXO3A activity. J Cell Mol Med. 2019 Nov;23(11):7796-7809.
7.Zhen LX, Gu YY, Zhao Q, Zhu HF, Lv JH, Li SJ, Xu Z, Li L, Yu ZR. MiR-301a promotes embryonic stem cell differentiation to cardiomyocytes. World J Stem Cells. 2019 Dec 26;11(12):1130-1141.
8.Guan Y, Gao X, Tang Q, Huang L, Gao S, Yu S, Huang J, Li J, Zhou D, Zhang Y, Shi D, Liang D, Liu Y, Li L, Cui Y, Xu L, Chen YH. Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity. J Cell Mol Med. 2019 Feb;23(2):1448-1457.
9.Wang D, Wang Y, Liu H, Tong C, Ying Q, Sachinidis A, Li L*, Peng L*. Laminin promotes differentiation of rat embryonic stem cells into cardiomyocytes by activating the integrin/FAK/PI3K p85 pathway. J Cell Mol Med. 2019 May;23(5):3629-3640.
10.Geng L, Wang S, Zhang F, Xiong K, Huang J, Zhao T, Shi D, Lv F, Li L, Liang D, Cui Y, Liu Y, Xie D, Chen YH. SNX17 (Sorting Nexin 17) Mediates Atrial Fibrillation Onset Through Endocytic Trafficking of the Kv1.5 (Potassium Voltage-Gated Channel Subfamily A Member 5) Channel. Circ Arrhythm Electrophysiol. 2019 Apr;12(4):e007097.
11.Gao X, Gao S, Guan Y, Huang L, Huang J, Lin L, Liu Y, Zhao H, Huang B, Yuan T, Liu Y, Liang D, Zhang Y, Ma X, Li L, Li J, Zhou D, Shi D, Xu L, Chen YH. Toll-like receptor 3 controls QT interval on the electrocardiogram by targeting the degradation of Kv4.2/4.3 channels in the endoplasmic reticulum. FASEB J. 2019 May 1;33(5):6197-6208.
12.Yao L, Xie D, Geng L, Shi D, Huang J, Wu Y, Lv F, Liang D, Li L, Liu Y, Li J, Chen YH. REEP5 (Receptor Accessory Protein 5) Acts as a Sarcoplasmic Reticulum Membrane Sculptor to Modulate Cardiac Function. J Am Heart Assoc. 2018 Feb 3;7(3):e007205.
13.Wen-Jing Wang Yu-Wei Wang, Yi Hu, Lin Qin, Rou Chen, Huan Liu, Wen-Ze Cao, Hui-Fang Zhu, Chang Tong, Li Li* and Lu-Ying Peng*.,HDncRNA: a manually constructed database of relationship between heart disease and noncoding RNAs. Database. 2018 Jan 1; doi: 10.1093/database/bay067.
14.Wang W, Zhang P, Li L, Chen Z, Bai W, Liu G, Zhang L, Jia H, Li L*, Yu Y*, Liao M*. ATD: a comprehensive bioinformatics resource for deciphering the association of autophagy and diseases. 1. Database (Oxford). 2018 Jan 1; doi: 10.1093/database/bay093.
15.Yao L, Xie D, Geng L, Shi D, Huang J, Wu Y, Lv F, Liang D, Li L, Liu Y, Li J, Chen YH. REEP5 (Receptor Accessory Protein 5) Acts as a Sarcoplasmic Reticulum Membrane Sculptor to Modulate Cardiac Function. J Am Heart Assoc. 2018 Feb 3;7(3).
16.Li RG, Xu YJ, Wang J, Liu XY, Yuan F, Huang RT, Xue S, Li L, Liu H, Li YJ, Qu XK, Shi HY, Zhang M, Qiu XB, Yang YQ. GATA4 Loss-of-Function Mutation and the Congenitally Bicuspid Aortic Valve. Am J Cardiol. 2018 Feb 15;121(4):469-474.
17.Yuan T, Wang S, Hu C, Wu Y, Liang D, Li L, Liu Y, Li J, Chen YH. Low-density lipoprotein receptor-related protein 6 regulates alternative pre-mRNA splicing. J Cell Mol Med. 2018 Oct;22(10):4653-4663.
18.Wang D, Liu C, Wang Y, Wang W, Wang K, Wu X, Li Z, Zhao C, Li L*, Peng L*. Impact of miR-26b on cardiomyocyte differentiation in P19 cells through regulating canonical/non-canonical Wnt signalling. Cell Prolif. 2017 Dec;50(6).
19.Wang D, Liu C, Li Z, Wang Y, Wang W, Wu X, Wang K, Miao W, Li L*, Peng L*. Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells. J Cell Biochem. 2017 Dec;118(12):4460-4467. doi: 10.1002/jcb.26102. Epub 2017 May 31.
20.Liu JJ, Zhao CM, Li ZG, Wang YM, Miao W, Wu XJ, Wang WJ, Liu C, Wang D, Wang K, Li L*, Peng LY*. miR-218 Involvement in Cardiomyocyte Hypertrophy Is Likely through Targeting REST. Int J Mol Sci. 2016 May 31;17(6). (Corresponding Author)
21.Miao W, Wu X, Wang K, Wang W, Wang Y, Li Z, Liu J, Li L*, Peng L*. Sodium Butyrate Promotes Reassembly of Tight Junctions in Caco-2 Monolayers Involving Inhibition of MLCK/MLC2 Pathway and Phosphorylation of PKCβ2. Int J Mol Sci. 2016 Oct 10;17(10).