高山峨 讲师
硕士招生类型：学术型
硕士招生专业：生物医学工程
博士招生类型：无
博士招生专业：无
所在院系：医学院再生医学系
联系方式：gaoshan2009@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

干细胞/神经退行性疾病/再生医学
StemCells, Neuron Degenerative Diseases, Regeneration Medicine

2009/09-至今 同济大学医学院 讲师
2009/09-Now School of Medicine,Tongji University, Lecture
2016/09-至今 同济大学附属东方医院转化研究中心 副研究员
2016/09- Now, The TranslationalResearch Center of East Hospital affiliated to Tongji University, AssociateResearcher


研究领域：自体脂肪干细胞治疗损伤及退行性疾病。采用基因组整合或非整合并结合小分子诱导的方式重编程人源脂肪干细胞分化为各种组织器官的功能细胞或其前体细胞，并进行临床级治疗用中间体种子细胞的生产。利用各种动物疾病模型研究中间体种子细胞治疗的疗效和作用机制。包括以下几个方面：
（1）人源脂肪干细胞及其体外预分化的神经元前体细胞治疗神经损伤和退行性神经疾病，如帕金森，阿尔茨海默病，脑卒中，脊髓损伤，脊髓缺血，新生儿脑缺氧缺血性疾病，多发性硬化症，脑损伤等；
（2）人源脂肪干细胞及其体外预分化的组织靶向型的中间体细胞治疗脏器相关疾病，如心梗，心衰，肾衰，肝衰等；
（3）人源脂肪干细胞治疗骨骼类疾病如骨质疏松，关节炎，股骨头坏死，骨损伤等；
（4）人源脂肪干细胞治疗代谢性疾病如糖尿病，痛风；
（5）人源脂肪干细胞治疗免疫系统疾病如红斑狼疮，风湿性关节炎。
Research Interest
Adipose stem cells andtheir treatment of degenerative diseases as well as their in vivo functional integration.
1.Genetic reprogram of hADSCs into projenitor cells or adult functionalcells and explore their reprogramming mechanism;
2.Transdifferentiate of hADSCs into neural stem cells or neural projenitorcells with bioactive or chemical moleculars and study their differentiation regulationmechanism;
4.Producing clinical level seeding cells in GMP lab for clinical studiesof some degenerative diseases such as Parkinson Diseases, Alzheimer Diseases, Stroke,etc;
3.Modelling some degenerative or acute injury diseases with rodent ornon-primate animals to determine the therapeutic effects of hADSCs or their derivativeprojenitor cells;
4.Make full use of their positive immune modulation vitue, treat some immune diseases such as lupus erythematosusand further analyze the modulation mechanism;
5.Developing various seeding cells and their delivering methods to findout the most efficient treating degenerative diseases manner;
6.Developing efficient methods to determine in vivo cell tracing andcell functional integrating;
7.Building animal behavior analyzing platform such as Open Field, MorrisTest, Electrophysiology, RotaRod,MotorEvoked Potential (MEP),etc.
发表文章：
1. Shane Gao, Xuanxuan Guo, Simeng Zhao, Yinpeng Jin, Fei Zhou,Ping Yuan, Limei Cao, Jian Wang, Yue Qiu, Chenxi Sun, Zhanrong Kang, GuishengZhong#, Liming Cheng#, Hongwen Zhu^#, Zhengliang Gao^#, XuChen, Jun Xu^#, Differentiation of human adipose-derived stem cellsinto neuron/motoneuron-like cells for cell replacement therapy of spinal cordinjury, Cell Death & Disease, 2019,10(8): 597（IF=5.638）
2. Jin Y, Wang J, Li H, Gao S, Shi R, Yang D, WangX, Wang X, Zhu L, Wang X, Chen C, Ning K, Gao Z#, Xu J#, Fu Q#. ExtracellularVesicle Secreted by Human Adipose-Derived Stem cells (hASCs) Improve SurvivalRate of Rats with Acute Liver Failure by Releasing lncRNA H19. EBioMedicine,34:231-242(IF=6.183)
3. Tianfang Jiang, Gen Li, Jun Xu, Shane Gao*, XuChen*. The Challenge of the Pathogenesis of Parkinson