姓 名：朱融融
学 位：博士
导师情况： 硕导/博导
研究领域：纳米生物医药
研究方向：
1、纳米材料促进脊髓损伤修复和神经再生及其机制研究
2、纳米材料维持干细胞干性和诱导定向分化的作用机制
3、纳米材料搭载小分子在神经退行性疾病治疗上的应用
4、纳米载药体系应用于免疫调控
E-mail：rrzhu@tongji.edu.cn
联系电话：暂无
通讯地址：同济大学（沪北校区）
个人简介：
朱融融教授，博士生导师，现任同济大学生命科学与技术学院、附属同济医院、脊柱脊髓损伤再生修复教育部重点实验室教授，并担任中国研究型医院学会神经再生与修复专业委员会神经保护学组委员、上海生物化学与分子生物学学会理事。2002年毕业于同济大学环境科学与技术学院，2007年获得同济大学生命科学与技术学院博士学位，2009年赴美国石溪大学作访问****。已主持或参与国家、省部级项目10余项，作为负责人承担国家自然基金项目5项并参与国家重点研发计划1项，共发表SCI收录文章70余篇，被引频次1100余次，授权中国发明专利7项、国际专利1项。荣获2008年上海市晨光****，2009年同济大学优秀青年教师，2017年国际神经修复学会Raisman青年论坛二等奖，2018年中华医学会骨科学术会基础青年研究二等奖，2019年获国家自然科学基金委员会优秀青年科学基金项目支持，2019年上海医学科技奖成果推广奖第六完成人、华夏医学科技奖一等奖等荣誉。


研究领域（具体内容）：
针对“再生修复与纳米材料”领域研究，重点聚焦在纳米生物材料设计、优化、合成，用以调控干细胞命运和免疫微环境促进脊髓损伤修复和治疗神经退行性疾病等再生修复领域的相关研究，解析纳米材料对干细胞的命运调控的性能和机制，基于生物材料和干细胞技术构建靶向损伤器官、靶细胞及特定膜受体的多维复杂纳米材料体系，揭示其促进组织再生的关键作用靶点，并获得了一系列原创性成果。
专业业绩（承担项目、发表论文、教学成果）：
负责承担科研项目：
1. 国家自然科学基金委员会，优秀青年科学基金项目，**，再生修复与纳米材料，2020/01-2022/12，120万元，主持；
2. 国家自然科学基金面上项目，**，LDH-NT3@外泌体激活内源性神经干细胞修复脊髓损伤及其机制研究，2019/01-2022/12，57万元，主持；
3. 上海市科委基础研究项目，类脊髓微器官构建及其修复脊髓损伤机制研究，19JC**，2019-2022，100万元，主持；
4. 国家自然科学基金面上项目，**，大麻素受体CB2作为帕金森病治疗新靶点的作用及其分子机制研究，2017/01-2020/12，52万元，主持；
5. 国家重大科研仪器研制项目（**）（子课题）高分辨自由流电泳-在线检测仪器装备技术的研制，88万元，主持，2013/01-2015/12；
6. 国家重点研发计划——课题三子课题，2016YFA**，基于动员内源性神经干细胞修复脊髓损伤的机制与转化研究，2016/07-2021/07，100万，主持；
7. 中央高校基本科研业务费学科交叉类（面上）项目，超声刺激内源性神经干细胞修复脊髓损伤机理研究，2017/01-2018/12，20万元，主持；
8. 国家自然科学青年基金，**, 基于大麻素受体CB1的固体脂质纳米粒治疗抑郁症研究，2013/01-2016/12，23万，主持；
9. 中央高校基本科研业务费学科交叉类（面上）项目，Avastin介导的LDH@SiO₂-DOX纳米复合药物载体抗肺癌机制研究，2015-2016，20万，主持；
10.国家博士点基金，纳米TiO2对亚单位疫苗的佐剂效应，019，2010/01-2012/12，6万元，主持；
11.中央高校基本科研业务费基础研究人才培养计划，SLN-姜黄素治疗哮喘及其信号通路研究，2011-2012，主持；
12.上海市教委晨光计划，蛋白酶分子水平多尺度纳米TiO2生物效应研究，2008CG26，2007/12-2010/12，主持；
13. 09年度校优青资助，羟基化金红石型纳米TiO2作为免疫佐剂的研究，，2009/12-2011/12，主持；
14. 973项目，心脏中内源性H2S生成调控及其传递，2010CB912604，项目骨干；
发表文章列表（近5年）：
近五年代表性论文（* 通讯作者）
1.Wang Zhaojie; Xu Ziping; Jing Guoxin; Wang Qingxiu; Yang Li; He Xiaolie; Lin Lijuan; Niu Jintong; Yang Linnan; Li Kun; Liu Zhongmin; Qian Yechang*; Wang Shilong*; Zhu Rongrong*; Layered double hydroxide eliminate embryotoxicity of chemotherapeutic drug through BMP-SMAD signaling pathway, Biomaterials, 2020, 230: 119602.
2.Zhu Yanjing; Huang Ruiqi; Zhu Rui; Xu Wei;Zhu Rongrong*; Cheng Liming*; DeepScreen: An Accurate, Rapid, and Anti‐Interference Screening Approach for Nanoformulated Medication by Deep Learning, Advanced Science, 2018, 5(9): **.
3.Jing Guoxin; Wang Zhaojie; Zhuang Xizhen; He Xiaolie; Wu Huijun; Wang Qingxiu; Cheng Liming; Liu Zhongmin; Wang Shilong*; Zhu Rongrong*; Suspended graphene oxide nanosheets maintain the self-renewal of mouse embryonic stem cells via down-regulating the expression of Vinculin, Biomaterials, 2018, 171: 1-11.
4.Zhang B#, Yan W#, Zhu Y, Yang W, Le W, Chen B*, Zhu R*, Cheng L*. Nanomaterials in Neural-Stem-Cell-Mediated Regenerative Medicine: Imaging and Treatment of Neurological Diseases. Adv Mater. 2018 Mar 15:e**.
5.Zhu Yanjing#;Zhu Rongrong#*; Wang Mei; Wu Bin; He Xiaolie; Qian Yechang*; Shilong Wang*; Anti-Metastatic and Anti-Angiogenic Activities of Core-Shell SiO2@LDH Loaded with Etoposide in Non-Small Cell Lung Cancer, Advanced Science, 2016, 3(11): **（封面文章，ESI高被引）.
6.Wang Zhaojie; Liang Peng; He Xiaolie; Wu Bin; Liu Qiang; Xu Ziping; Wu Huijun; Liu Zhongmin; Qian Yechang*; Wang Shilong*;Zhu Rongrong*;Etoposide loaded layered double hydroxide nanoparticles reversing chemoresistance and eradicating human glioma stem cells in vitro and in vivo, Nanoscale, 2018, 10(27): 13106-13121.
近五年其他论文：
1.Zhu Rongrong#*; Hu Xiao#; Xu Wei#; Wu Zhourui; Zhu Yanjing; Ren Yilong; Cheng Liming*; LncRNA MALAT1 inhibits hypoxia/reoxygenation-induced human umbilical vein endothelial cell injury via targeting the microRNA-320a/RAC1 axis, Biological Chemistry. 2020, 401(3):349-360.
2.Xu Wei#; Hu Xiao#; Qi Xi; Zhu Rui; Li Chen; Zhu Yanjing; Yin Shuai; Cheng Liming*; Zhu Rongrong*; Vitamin D Ameliorates Angiotensin II-Induced Human Endothelial Progenitor Cell Injury via the PPAR-γ/HO-1 Pathway. Journal of vascular research, 2019, 56(1): 17-27.
3.Yang Linnan#; Sun Jing#; Liu Qiang;Zhu Rongrong; Yang Qiannan; Hua Jiahui; Zheng Longpo; Li Kun; Wang Shilong*; Li Ang*; Synergetic functional nanocomposites enhance immunotherapy in solid tumors by remodeling the immunoenvironment. Advanced Science, 2019, 6(8):**.
4.Liu Qiang; Wang Jiao; Yang Linnan; Xia Xiaofei; Wang Mei; Chen Shengguang; Zhu Rongrong; Wang Qingxiu; Wu Xianzheng; Wang Shilong*; Facile synthesis by a covalent binding reaction for pH-responsive drug release of carboxylated chitosan coated hollow mesoporous silica nanoparticles, IET Nanobiotechnology, 2018, 12(4): 446-452.
5.Zhang Bingbo#; Yan Wei#; Zhu Yanjing; Yang Weitao; Le Wenjun; Chen Bingdi*; Zhu Rongrong*; Cheng Liming*; Nanomaterials in Neural-Stem-Cell- Mediated Regenerative Medicine: Imaging and Treatment of Neurological Diseases, Advanced Materials, 2018, 30(17): e**.
6.Wang Jiao#; Liu Qiang#; Yang Linnan; Xia Xiaofei; Zhu Rongrong; Chen Shengguang; Wang Mei; Cheng Liming; Wu Xianzheng*; Wang Shilong*; Curcumin-Loaded TPGS/F127/P123 Mixed Polymeric Micelles for Cervical Cancer Therapy: Formulation, Characterization, and In Vitro and In Vivo Evaluation, Journal of Biomedical Nanotechnology, 2017, 13(12): 1631-1646.
7.Jiang Shan; Zhu Rongrong; He Xiaolie; Wang Jiao; Wang Mei; Qian Yechang*; Wang Shilong*; Enhanced photocytotoxicity of curcumin delivered by solid lipid nanoparticles, International Journal of Nanomedicine, 2017, 12: 167-178
8.Wu Bin; Zhu Rongrong; Wang Mei; Liang Peng; Qian Yechang*; Wang Shilong*; Fluorescent carbon dots from antineoplastic drug etoposide for bioimaging in vitro and in vivo, Journal of Materials Chemistry B, 2017, 5(38):7796-7800
9.Dong Fangyuan; Zheng Tingting;Zhu Rongrong; Wang Shilong; Tian Yang*; An engineered thermo-sensitive nanohybrid particle for accurate temperature sensing at the single-cell level and biologically controlled thermal therapy, Journal of Materials Chemistry B, 2016, 4(47): 7681-7688.
10.Zhu Rongrong#; Wang Zhaoqi #; Liang Peng; He Xiaolie; Zhuang Xizhen; Huang Ruiqi; Wang Mei; Wang Qigang; Qian Yechang*; Wang Shilong*; Efficient VEGF targeting delivery of DOX using Bevacizumab conjugated SiO2@LDH for anti-neuroblastoma therapy, Acta Biomaterialia, 2017, 63:163-180.
11.He Xiaolie#; Zhu Yanjing#; Wang Mei; Jing Guoxin; Zhu Rongrong*; Wang Shilong*; Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression, International journal of nanomedicine, 2016, 11: 4975-4990.
12.Zhu Rongrong; Wang Qingxiu; Zhu Yanjing; Wang Zhaoqi; Zhang Haixia; Wu Bin; Wu Xianzheng*; Wang Shilong*; pH sensitive nano layered double hydroxides reduce the hematotoxicity and enhance the anticancer efficacy of etoposide on non-small cell lung cancer, Acta Biomaterialia, 2016, 29: 320-332.
13. Zhang Haixia; Zhu Yanjing; Sun Xiaoyu; He Xiaolie; Wang Mei; Wang Zhaoqi; Wang Qingxiu;Zhu Rongrong*; Wang Shilong*; Curcumin-Loaded Layered Double Hydroxide Nanoparticles-Induced Autophagy for Reducing Glioma Cell Migration and Invasion, Journal of Biomedical Nanotechnology, 2016, 12(11): 2051-2062.
14. Wang Jiao; Wang Yue; Liu Qiang; Yang Linnan; Zhu Rongrong; Yu Chengzhong*; Wang Shilong*; Rational Design of Multifunctional Dendritic Mesoporous Silica Nanoparticles to Load Curcumin and Enhance Efficacy for Breast Cancer Therapy, ACS Applied Materials & Interfaces, 2016, 8(40): 26511-26523.
15. Qian Tingting; Wang Mei; Wang Jiao; He Xiaolie;Zhu Rongrong; Sun Xiaoyu; Sun Dongmei; Wang Qingxiu*; Wang Shilong*; Transient spectra study on photo-dynamics of curcumin, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2016, 166: 38-43.
16.Qiao Li; Wang Xia*; Gao Yawei; Wei Qingcong; Hu Wen; Wu Lei; Li Pei; Zhu Rongrong; Wang Qigang*; Laccase-mediated formation of mesoporous silica nanoparticle based redox stimuli-responsive hybrid nanogels as a multifunctional nanotheranostic agent, Nanoscale, 2016, 8(39): 17241-17249
17. Wu Qing; Wang Zhaoqi; Zhang Haixia; Zhu Rongrong; Wang Shilong*; Wang Qigang*; Fe3O4@nanogel via UOx/HRP initiated surface polymerization for pH sensitive drug delivery, RSC Advances, 2016, 6(58): 53170-53174.
18.Zhu Yanjing; Wu Youjun; Zhang Haixia; Wang Zhaoqi; Wang Shilong*; Qian Yechang*;Zhu Rongrong*; Enhanced Anti-Metastatic Activity of Etoposide Using Layered Double Hydroxide Nano Particles, Journal of Biomedical Nanotechnology, 2015, 11(12): 2158-2168.
19.Wang Jiao#; Wang Haoyue#; Zhu Rongrong; Liu Qiang; Fei Jian*; Wang Shilong*; Anti-inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1beta transgenic mice subjected to the lipopolysaccharide-induced sepsis, Biomaterials, 2015, 53: 475-483.
20.Wu Youjun; Zhu Rongrong; Ge Xin; Sun Xiaoyu; Wang Zhaoqi; Wang Wenrui; Wang Mei; Liu Hui*; Wang Shilong*; Size-dependent effects of layered double hydroxide nanoparticles on cellular functions of mouse embryonic stem cells, Nanomedicine (Lond), 2015, 10(23): 3469-3482.
21.Zhang Chenchen; Jiang Shan; Li Kun; Wang Mei;Zhu Rongrong; Sun Xiaoyu; Wang Qingxiu*; Wang ShiLong*; The triplet state of tanshinone I and its synergic effect on the phototherapy of cancer cells with curcumin, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015, 150: 181-186.
22.Wang Jiao; Zhu Rongrong; Sun Dongmei; Sun Xiaoyu; Geng Zhengsong; Liu Hui*; Wang Shilong*; Intracellular Uptake of Curcumin-Loaded Solid Lipid Nanoparticles Exhibit Anti-Inflammatory Activities Superior to Those of Curcumin Through the NF-κB Signaling Pathway, Journal of Biomedical Nanotechnology, 2015, 11(3): 403-415.

授权专利：
1.RIGAS Basil; MACKENZIE Gerardo; YU Sun; HUANG Liqun; ZHU Rongrong; NIE Ting；COMBINATION TREATMENTS AND FORMULATIONS FOR CANCER, 2011.10.20，美国，WO；
2.汪世龙；朱融融；静国欣，纳米氧化石墨烯在促进小鼠胚胎干细胞培养和自我更新中的应用，2019.12.27，中国；
3.汪世龙；朱融融；王兆琪，一种具有主动靶向肿瘤的纳米药物载体-贝伐单抗介导的SiO2@LDH、制备方法及应用，2019.10.18，中国，ZL5.8；
4.成昱；朱融融。纳米金包覆层状双氢氧化物复合材料及其制备和应用，2018.2.9，中国，ZL0.4；
5.汪世龙；孙晓宇；吴又君；朱融融。无机纳米材料层状双氢氧化物在小鼠胚胎干细胞培养中的应用，2017.2.1，中国，ZL9.9；6.程黎明；汪世龙；朱融融，一种促进神经再生修复脊髓损伤的纳米层状双氢氧化物-多因子综合体系，2019.5.7，中国，ZL6.X；
7.朱融融；靳令经，一种化合物在制备治疗帕金森病的药物中的应用，2019.4.9，中国，ZL3.0；
8.靳令经；朱融融，帕金森病动物模型的制备方法及其用途，2019.4.9，中国，ZL.6