摘要/Abstract

摘要： 肺癌细胞的干性及耐药性是重要的恶性指标。ATP结合盒蛋白G超家族成员2（ATP-binding cassette superfamily G member 2，ABCG2）是细胞表面的ATP结合盒蛋白家族的成员之一，依赖ATP可将药物排到细胞外。ABCG2定位于人多种肿瘤细胞的膜上，它的表达与肿瘤化学治疗多药耐药性紧密相关，目前被认为是肺癌干细胞鉴定的辅助群体标志物。此外，ABCG2的一些单核苷酸多态性与肺癌多药耐药性存在显著相关性。该文就最新ABCG2相关研究进展进行总结和归纳，重点介绍ABCG2基因的表达调控、ABCG2与肺癌干性的关系以及ABCG2的单核苷酸多态性与肺癌耐药性的相关性研究，以期为肺癌患者的临床治疗提供新的策略。
关键词: ATP结合盒蛋白G超家族成员2, 肺癌, 细胞干性, 耐药性
Abstract:
The stemness and drug resistance of lung cancer cells are important features of malignancy. ATP-binding cassette superfamily G member 2 (ABCG2), a member of the ATP-binding cassette transporter family, is localized in the membrane of a variety of human cancer cells and excludes drugs from cells in an ATP-dependent manner. Single nucleotide polymorphisms in ABCG2 gene are significantly associated with multidrug resistance in cancer chemotherapy. In addition, ABCG2 has been used as a supporting biomarker for the identification of lung cancer stem cells. This review summarizes recent research progress in ABCG2, focusing on the regulation of ABCG2 gene expression, the potential roles of ABCG2 on cancer cell stemness, and the correlation of single nucleotide polymorphisms in ABCG2 with drug resistance in lung cancer, in order to provide a new strategy for the clinical treatment of lung cancer patients.
Key words: ATP-binding cassette superfamily G member 2 (ABCG2), lung cancer, stemness, drug resistance


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