摘要/Abstract
摘要： 目的·探讨单光子发射计算机断层成像术/电子计算机断层扫描（single-photon emission computed tomography/computed tomography，SPECT/CT）定量显像测定毒性弥漫性甲状腺肿（toxic diffuse goiter，GD；又称Graves病）患者SUV摄取值及甲状腺体积的可行性。方法·选入64例Graves 病患者，其中男性患者21例，女性患者43例，年龄（44.1±14.1）岁。所有受试者均进行血清FT3、FT4水平检测，以及2 h、24 h摄131I率检查。所有患者在静脉注射（5.5±0.5）mCi [ （204.2±16.8） MBq] 99mTcO4-放射性显像剂后，进行颈部SPECT/CT断层及平面显像。通过40%阈值法测定Graves 病患者的甲状腺定量摄取均值SUVmean、最大值SUVmax及三维甲状腺体积Vol3D，对SUVmean、SUVmax与血清甲状腺激素水平及摄131I率的相关性进行分析。通过Xeleris工作站（GE Healthcare）以及传统公式分别测定三维甲状腺体积Vol3D和二维甲状腺体积Vol2D，对Vol3D和Vol2D进行分析比较。结果·Graves病患者的甲状腺定量摄取值SUVmean和SUVmax分别为（262.5±110.2） g/mL和（471.4±192.1） g/mL，与血清甲状腺激素水平FT3、FT4之间均无相关性（P>0.05），与2 h摄131I率和24 h摄131I率之间具有正相关性（均r >0且P=0.000）。此外，Vol3D与Vol2D之间呈正相关（r=0.853，P=0.000）。结论·99mTcO4- SPECT定量显像测定甲状腺三维体积及SUV定量摄取值方法临床简便可行，可为Graves病患者诊断及评估治疗剂量提供临床依据，具有重要的临床诊断意义。
关键词: 毒性弥漫性甲状腺肿, 单光子发射计算机断层成像术/电子计算机断层扫描, 发射型计算机, 单光子, 标准摄取值
Abstract:
Objective · To investigate the feasibility of single-photon emission computed tomography/computed tomography (SPECT/CT) quantitative imaging in the determination of SUV uptake and thyroid volume in patients with Graves' disease. Methods · Sixty-four Graves' disease patients were selected, including 21 males and 43 females, aged (44.1±14.1) years. All subjects were tested for serum FT3 and FT4 levels, as well as 131I rate at 2 h and 24 h. All patients underwent neck SPECT/CT and planar imaging after intravenous injection of (5.5±0.5)mCi [(204.2±16.8) MBq] 99mTcO4- radiograph. Thyroid quantitative SUVmean, SUVmax and three-dimensional thyroid volume (Vol3D) of Graves' disease patients were determined by 40% threshold method, and the correlation between SUVmean, SUVmax and serum thyroid hormone levels, 131I rate was analyzed. Vol3D and Vol2D thyroid volume were measured by Xeleris workstation (GE Healthcare) and conventional formulas, respectively, analyzed and compared. Results · The quantitative values of SUVmean and SUVmax in patients with Graves' disease were (262.5±110.2) g/mL and (471.4±192.1) g/mL, respectively. There was no significant correlation between serum thyroid hormone levels (FT3 and FT4), SUVmean and SUVmax (all P>0.05). There was week correlation between iodine uptake rate and SUVmean, SUVmax (all r >0 and all P=0.000). In addition, there was a positive correlation between thyroid Vol3D and Vol2D (r=0.853, P=0.000). Conclusion · Quantitative imaging of 99mTcO4- SPECT/CT for the determination of three-dimensional thyroid volume and quantitative uptake of SUV is simple and feasible, providing clinical basis for the diagnosis and treatment dose assessment of Graves' disease, which has important clinical diagnostic significance.
Key words: Graves&apos, disease, single-photon emission computed tomography/computed tomography (SPECT/CT), emission computer, single photon, standard uptake value (SUV)
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