摘要/Abstract
摘要： 目的·测定亚甲基丁二酸（itaconic acid，ITA）在小鼠体内的半衰期和半数致死量，为评价ITA在体内的代谢速率和毒性提供直观的数据。方法·采用尾静脉注射将ITA注入小鼠体内，在不同的时间点通过眼底静脉丛采血测得ITA的浓度；同时，给药后连续观察14 d，记录受试小鼠的存活情况。结果·ITA在雄性C57BL/6J小鼠体内的半衰期为29.13 min，半数致死量为258.263 mg/kg。结论·ITA在小鼠体内的代谢速率较快，半衰期较短，属于超快速消除类药物；其在小鼠体内的半数致死量显示毒性较低。
关键词: 亚甲基丁二酸, 小鼠, 半数致死量, 半衰期
Abstract:
Objective · To determine the half-life and half-lethal dose of itaconic acid in mice, and provide intuitive data for the metabolic rate and toxicity of itaconic acid in mice. Methods · Itaconic acid was injected into mice through caudal vein. The concentration of itaconic acid was measured by blood collection under fundus venous plexus at different time. At the same time, the survival of the mice was recorded after injection for 14 d. Results · Under the conditions of this experiment, the half-life of itaconic acid in male C57BL/6J mice was 29.13 min, and the half-lethal dose of is 258.263 mg/kg. Conclusion · Itaconic acid has a fast metabolic rate and a short half-life in mice. Itaconic acid is less toxic, based on its half-lethal dose in mice.
Key words: itaconic acid, mouse, half-life, half-lethal dose
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