摘要/Abstract

摘要： 嗜酸性粒细胞性胃肠炎（eosinophilic gastroenteritis，EGE）是一种少见的慢性消化系统疾病，以胃肠道嗜酸性粒细胞浸润、胃肠壁水肿增厚为特点，目前病因和发病机制不明。临床表现与病变部位、累及的范围和深度有关，可伴有外周血嗜酸性粒细胞升高、血清免疫球蛋白E升高。影像学可见胃肠壁水肿增厚或结节样改变、肠腔狭窄、腹腔积液等；内镜下可见黏膜红斑、充血水肿、糜烂、溃疡等表现。病理活检有助于诊断，但由于患者的临床表现、实验室检查、影像学及内镜表现缺乏特异性，病理诊断缺乏统一的计数标准，目前临床上EGE的诊断仍较困难。该文主要就EGE的诊断和治疗进展作一综述，以期帮助临床医师提高对EGE的认识。
关键词: 嗜酸性粒细胞性胃肠炎, 病因, 发病机制, 临床表现, 诊断, 治疗
Abstract:
Eosinophilic gastroenteritis (EGE) is a rare chronic disease of digestive system, characterized by the eosinophil in?ltration of the gastrointestinal tract and the thickening of the gastrointestinal wall. At present, the etiology and pathogenesis of EGE are still unclear. Accompanied with eosinophilia and elevation of serum immunoglobulin E, the clinical manifestations of EGE are dependent on the location of lesions and the extent or depth of eosinophil in?ltration in the gastrointestinal tract. The thickening or edema of the gastrointestinal wall, nodular-like changes, intestinal stenosis and ascites can be regarded as common radiological findings of EGE, while erythema, hyperemia or edema, erosion and ulcer of mucosal are the endoscopic features of EGE. Tissue biopsy is helpful for the diagnosis of EGE. However, with unspecific clinical manifestations, laboratory tests, radiological and endoscopic findings and unidentified cut-off count of pathological diagnostic criteria, EGE is very difficult to be diagnosed. Therefore, this paper mainly reviews the research progress in the diagnosis and treatment of EGE, attempting to improve the clinicians' understanding of EGE.
Key words: eosinophilic gastroenteritis (EGE), etiology, pathogenesis, clinical manifestation, diagnosis, therapy


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