摘要/Abstract

摘要： 目的·研究Ⅰ A期肺腺癌发生气道播散（spread through air space，STAS）的临床及病理危险因素。方法·回顾性收集2018年1月—2019年10月于上海交通大学附属胸科医院接受肺部手术且经术后病理诊断为Ⅰ A期肺腺癌患者的临床资料。根据是否存在STAS将其分为有STAS组和无STAS组。采用单因素分析及二分类Logistic回归分析对Ⅰ A期肺腺癌发生STAS的危险因素进行研究。结果·共计纳入Ⅰ A期肺腺癌患者1 365例，其中无STAS组患者1 312例，有STAS组患者53例。单因素分析显示，2组患者在性别、肺腺癌主要亚型上差异具有统计学意义（均P=0.000），而T分期的差异则无统计学意义。二分类Logistic回归分析显示，男性及非伏壁型为主的腺癌亚型是独立危险因素。结论·对于Ⅰ A期肺腺癌的治疗，尤其包含微乳头亚型，临床医师应注意STAS发生的可能。
关键词: 肺腺癌, 微乳头, 气道播散
Abstract:
Objective · To investigate the clinicopathological risk factors of spread through air space (STAS) in stage Ⅰ A lung adenocarcinoma. Methods · The clinical data of patients with stage Ⅰ A lung adenocarcinoma who underwent lung surgery in Shanghai Chest Hospital, Shanghai Jiao Tong University from Jan. 2018 to Oct. 2019 were retrospectively collected. According to whether STAS happened, the patients were divided into STAS group and non-STAS group. Univariate analysis and binary Logistic regression analysis were used to analyze the risk factors of STAS in stage Ⅰ A lung adenocarcinoma between the two groups. Results · A total of 1 365 patients with stage Ⅰ A lung adenocarcinoma were included, including 1 312 patients without STAS and 53 patients with STAS. Univariate analysis showed that there were significant differences in gender and major subtypes of lung adenocarcinoma between the two groups (both P=0.000), but there was no significant difference in T stage between the two groups. Binary Logistic regression analysis showed that male and non-lepidic subtypes were independent risk factors. Conclusion · For the treatment of stage Ⅰ A lung adenocarcinoma, especially those with micropapillary subtype, the clinicians should pay attention to the possibility of STAS.
Key words: lung adenocarcinoma, micropapillary, spread through air space (STAS)


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