摘要/Abstract
摘要： 目的·采用文献计量法分析乳腺肿瘤干细胞（breast cancer stem cell，BCSC）领域的研究现状，反映相关国家在该领域的科研水平，揭示BCSC领域的研究热点及发展趋势。方法·以PubMed和Scopus数据库为检索对象，检索2014—2019年有关BCSC的文献，利用SciVal分析平台，通过归一化影响因子（field-weighted citation impact，FWCI）、CiteScore（CS）、关键词、主题显著性指数等指标，分析BCSC相关文献的发文量、发文国家/地区和机构、高影响力期刊发文比例、研究热点等方面的现状。结果·在SciVal中收集到有效数据4 700条；BCSC领域发文量总体呈增长状态，FWCI为1.73；美国以1 742篇位居首位，美国国立卫生研究院发文的总被引次数、篇均被引次数及FWCI均为全球第一，研究热点集中于非编码RNA（non-coding RNA， ncRNA）、间充质干细胞和肿瘤免疫治疗。结论·ncRNA调控乳腺癌的发生及发展，乳腺肿瘤微环境和免疫治疗是BCSC领域的研究热点和发展方向。
关键词: 乳腺肿瘤干细胞, 非编码RNA, 肿瘤微环境, 肿瘤免疫治疗, 热点分析
Abstract:
Objective · To give a retrospective bibliometric analysis of documents about the breast cancer stem cell (BCSC) and reveal the hotspots and trends of global output. Methods · Articles about the research of BCSC between 2014 and 2019 were retrieved in PubMed and Scopus databases, and SciVal was used to evaluate the global scholarly output and identify the most active factors, such as publications, countries, institutions, and top journal percentile, from the indicators of Field-Weighted Citation Impact (FWCI), CiteScore (CS), keywords and topic prominence percentile. Research hotspots and trends were discussed in detail. Results · A total of 4 700 publications on the research of BCSC from 2014 to 2019 were retrieved in this study with FWCI 1.73. The USA was the top country with a total of 1 742 publications and National Institutes of Health was the top institution both in total citation and FWCI. Non-coding RNA (ncRNA), mesenchymal stem cells, and immunotherapy were the most frequently used topics in BCSC. Conclusion · Researches on the correlation of BCSC and ncRNA, tumor microenvironment, and immunotherapy are the hotspots and trends in BCSC.
Key words: breast cancer stem cell, non-coding RNA, tumor microenvironment, immunotherapy, hotspot analysis
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