摘要/Abstract

摘要： 延髓头端腹内侧区是疼痛下行易化和抑制调节系统中的核心结构，向上接受下丘脑、中脑导水管周围灰质、臂旁核等的投射，向下通过脊髓背外侧束和脊髓腹外侧束对疼痛发挥易化或抑制性调节的作用，是中枢疼痛调控通路的最后一道闸门。此区域的神经元根据其对疼痛刺激所引起的放电活动的反应，可分为 On细胞、 Off细胞和 Neutral细胞，其与疼痛调节以及阿片类药物发挥镇痛作用有密切的关系。该文就 On细胞和 Off细胞结构和功能的研究进行综述，以期为进一步探究延髓头端腹内侧区的 On细胞和 Off细胞在疼痛调节中的作用机制提供方向。
关键词: 延髓头端腹内侧区, On细胞, Off细胞, 阿片类受体, 疼痛
Abstract:
The rostral ventromedial medulla is one of the key structures in descending pain modulation system. It receives inputs the thalamus, the periaqueductal gray, and parabrachial nucleus, and sends descending projections through the dorsolateral funiculus and ventrolateral funiculus to the spinal dorsal horns. The rostral ventromedial medulla is thought to be the final relay in descending modulation of pain. The neurons in this region can be classified into On-cells, Off-cells and Neutral cells according to the changes in the firing activity before tail flick. This review mainly focuses on pain modulation functions and potential analgesia mechanisms of On-cells and Off-cells.
Key words: rostral ventromedial medulla, On-cell, Off-cell, opioid receptor, pain


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