摘要/Abstract

摘要： 蛋白质翻译后修饰在细胞有丝分裂和基因组稳定性中的作用机制一直是生物学研究的热点。该文主要介绍蛋白去SUMO化修饰酶SENP3在细胞有丝分裂期姐妹染色体分离中的作用，以及蛋白SUMO化修饰和磷酸化修饰的相互调控作用在维持细胞基因组稳定性中新的分子机制。
关键词: SUMO化, 磷酸化, SENP3
Abstract:
The mechanism of protein post-translational modifications in regulation of cell mitosis and genomic stability is always a hot issue in biological researches. The present review introduced the functional activity of de-SUMOylase SENP3 in sister chromatin dissociation at mitosis, and demonstrated a new molecular mechanism of cross-talk regulation between protein SUMOylation and phosphorylation in maintaining genomic stability.
Key words: SUMOylation, phosphorylation, SENP3


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