摘要/Abstract

摘要： 尽管组蛋白修饰的表观遗传学调控作用受到越来越多的关注，但其具体调控机制尚未明确。该文主要介绍组蛋白H3K23 乙酰化修饰在胶质瘤发生发展中的作用，并进一步阐明H3K23 乙酰化调控胶质瘤发生发展的新机制。该机制的揭示有望为胶质瘤治疗提供新思路。
关键词: 组蛋白修饰, 胶质瘤, 乙酰化
Abstract:
Although epigenetic regulation of histone modification has attracted more and more attention, the underlying mechanisms are still unclear. The
present review introduces the role of acetylated H3 lysine 23 (H3K23ac) in glioma tumorigenesis, and demonstrates a new mechanism by which H3K23ac
regulates gliomagenesis, which may provide novel approaches to glioma treatment.
Key words: histone modification, glioma, acetylation


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