王旭
职称：长聘教轨副教授，博士生导师，独立P，上海浦江人才计划（2019）
所属学科：园艺学，细胞生物学
电子信箱：xu.wang@sjtu.edu.cn
办公室地址：创新楼513
实验室地址：创新楼B508a
电话：


教育经历：
2007 - 2013 清华大学 生命科学学院 生物学 博士(师从辛世文教授，中国工程院院士)
2004 - 2007 吉林大学 生命科学学院 生物化学与分子生物学 硕士(师从郝东云教授)
2000 - 2004 吉林大学 生命科学学院 生物技术 本科
研究经历：
2013 - 2018 瑞士洛桑联邦理工学院 生命科学学院 博士后（师从Johan Auwerx教授，欧洲分子生物学会EMBO院士）
2008 - 2013 香港中文大学 生命科学学院 研究助理（博士联合培养，导师何军贤教授）
主要研究领域：
运用分子生物学、多组学、系统生物学等方法，解析与环境具有密切相互作用的复杂表型，特别是与线粒体密切相关的抗逆、衰老和发育等相关表型。前期研究工作第一次揭示了线粒体未折叠蛋白反应 (mitochondrial unfolded protein response, UPR^mt) 调节植物细胞适应线粒体逆境的过程及调节机制。
目前实验室综合应用系统生物学、细胞生物学、遗传学等手段研究线粒体与细胞核及其他细胞器互作机制，重点关注以下几个主要方向：
(1)植物发育及逆境中的细胞器互作与线粒体逆向信号
(2)线粒体来源信号调节细胞与个体衰老的机制
(3)系统生物学在植物线粒体研究中的应用
主要论文：
# 共同第一作者，*共同通讯作者
2020
1. Sleiman MB, Jha P, Houtkooper R, Williams R, Wang X*, Auwerx J*. The gene regulatory footprint of aging highlights conserved central regulators. Cell Reports. 2020 In Press. (IF= 8.109)
2. Liu M^#, Sun W^#, Ma Z, Yu G, Li J, Wang Y, Wang Xu. Comprehensive multiomics analysis reveals key roles of NACs in plant growth and development and its environmental adaption mechanism by regulating metabolite pathways. Genomics. 2020; 112: 4897-4911. (IF= 6.205)
3. Oppi S, Nusser-Stein S, Blyszczuk P, Wang X, Jomard A, Marzolla V, Yang K, Velagapudi S, Ward LJ, Yuan XM, Geiger MA, Guillaumon AT, Othman A, Hornemann T, Rancic Z, Ryu D, Oosterveer MH, Osto E, Lüscher TF, Stein S. Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPARγ signature. Eur Heart J. 2020; 41: 995-1005. (IF=22.673)
4. Houzelle A, Dahlmans D, Nascimento EBM, Schaart G, Jörgensen JA, Moonen-Kornips E, Kersten S, Wang X, Hoeks J. MicroRNA-204-5p modulates mitochondrial biogenesis in C2C12 myotubes and associates with oxidative capacity in humans. J Cell Physiol. 2020: 1-13. (IF=5.546)
2019
5. Dahlmans D, Houzelle A, Andreux P, Wang X, Jorgensen JA, Moullan N, Daemen S, Kersten S, Auwerx J, Hoeks J. MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells. J Cell Physiol2019; 234: 6601-6610. (IF=5.546)
2018
6. Li H^#, Wang X^#, Rukina D, Huang Q, Lin T, Sorrentino V, Zhang H, Sleiman MB, Arends D, McDaid A, Luan P, Ziari N, Velázquez-Villegas LA, Gariani K, Kutalik Z, Schoonjans K, Radcliffe RA, Prins P, Morgenthaler S, Williams RW, Auwerx J. An integrated systems genetics and omics toolkit to probe gene function. Cell Systems2018; 6: 90-102. (IF=8.673)
2017
7. Wang X& Auwerx J. Systems phytohormone responses to mitochondrial proteotoxic stress. Molecular Cell2017; 68: 540-51. (IF=15.584)
8. Stein S^#, Lemos V^#, Xu P, Demagny H, Wang X, Ryu D, Jimenez V, Bosch F, Lüscher TF, Oosterveer MH, Schoonjans K. Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. J Clin Invest. 2017; 127(2):583-592. (IF=11.864)
9. Greggio C^#, Jha P^#, Kulkarni SS^#, Lagarrigue S, Broskey NT, Boutant M, Wang X, Conde Alonso S, Ofori E, Auwerx J*, Cantó C*, Amati F*. Enhanced respiratory chain supercomplex formation in response to exercise in human skeletal muscle. Cell Metabolism. 2017; 25(2):301-311. (IF=21.567)
10. Dahlmans D, Houzelle A, Andreux P, Jörgensen J A., Wang X, de Windt L J., Schrauwen P, Auwerx J, Hoeks J. An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism. Molecular Metabolism. 2017; 6(11):1429-1442. (IF=6.448)
11. Luo J, Wang X, Feng L, Li Y, He JX. The mitogen-activated protein kinase kinase 9 (MKK9) modulates nitrogen acquisition and anthocyanin accumulation under nitrogen-limiting condition in Arabidopsis. Biochem Biophys Res Commun. 2017; 487(3):539-544. (IF=2.985)
2016
12. Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D'Amico D, Ropelle ER, Lutolf MP, Aebersold R, Schoonjans K, Menzies KJ*, Auwerx J*. NAD?repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016; 352(6292):1436-43. (IF=41.845)
13. Ryu D^#, Zhang H^#, Ropelle ER^#, Sorrentino V, Mázala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Cantó C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ*, Auwerx J*. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med. 2016; 8(361):361ra139. (IF=16.304)
14. Gariani K^#, Menzies KJ^#, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J. Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology. 2016; 63(4):1190-204. (IF=14.679)
15. Xu P, Oosterveer MH, Stein S, Demagny H, Ryu D, Moullan N, Wang X, Can E, Zamboni N, Comment A, Auwerx J, Schoonjans K. LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer. Genes & Development. 2016; 30(11):1255-60. (IF=9.527)
16. Jha P, Wang X, Auwerx J. Analysis of Mitochondrial Respiratory Chain Supercomplexes Using Blue Native Polyacrylamide Gel Electrophoresis (BN-PAGE). Curr Protoc Mouse Biol. 2016 Mar 1;6(1):1-14.
2015
17. Wang X^#, Ryu D^#, Houtkooper RH*, Auwerx J*. Antibiotic use and abuse: a threat to mitochondria and chloroplasts with impact on research, health, and environment. BioEssays2015; 37:1045-53. (IF=4.627)
18. Moullan N^#, Mouchiroud L^#, Wang X, Ryu D, Williams EG, Mottis A, Jovaisaite V, Frochaux MV, Quiros PM, Deplancke B, Houtkooper RH*, Auwerx J*. Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research. Cell Reports. 2015; 10(10): 1681–91. (IF=8.109)
19. Jo YS^#, Ryu D^#, Maida A, Wang X, Evans RM, Schoonjans K, Auwerx J. Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. Hepatology. 2015; 62(5):1606-18. (IF=14.679)
2014
20. Stein S, Oosterveer MH, Mataki C, Xu P, Lemos V, Havinga R, Dittner C, Ryu D, Menzies KJ, Wang X, Perino A, Houten SM, Melchior F, Schoonjans K. SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport. Cell Metabolism. 2014; 20(4):603-13. (IF=21.567)
21. Andreux PA, Mouchiroud L, Wang X, Jovaisaite V, Mottis A, Bichet S, Moullan N, Houtkooper RH, Auwerx J. A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans. Scientific Reports. 2014; 4:5285. (IF=3.998)
2013
22. Wang YD^#, Wang X^#, Wong YS.Generation of selenium-enriched rice with enhanced grain yield, selenium content and bioavailability through fertilization with selenite. Food Chemistry2013; 141:2385-93. (IF=6.306)
23. Wang YD^#, Wang X^#, Ngai SM, Wong YS.Comparative proteomics analysis of selenium responses in selenium-enriched rice grains. Journal ofProteome Research2013;12:808-20. (IF=4.074)
24. Wang X^#, Bian Y^#, Cheng K, Gu LF, Ye M, Zou H, Sun SSM, He JX. A Large-scale protein phosphorylation analysis reveals novel phosphorylation motifs and phosphoregulatory networks in Arabidopsis. Journal ofProteomics2013; 78:486-98. (IF=3.509)
2012
25. Wang X^#, Bian Y, Cheng K, Zou H, Sun SSM, He JX. A comprehensive differential proteomic study of nitrate deprivation in Arabidopsisreveals complex regulatory networks of plant nitrogen responses. Journal ofProteome Research2012; 11:2301-15. (IF=4.074)
26. Wang YD^#, Wang X^#, Wong YS. Proteomics analysis reveals multiple regulatory mechanisms in response to selenium in rice. Journal ofProteomics2012; 75:1849-1866. (IF=3.509)
Before 2012
27. Zhang JH, Sun LW, Liu LL, Lian J, An SL, Wang X, Zhang J, Jin JL, Li SY, Xi JH. Proteomic analysis of interactions between the generalist herbivore Spodoptera exigua (Lepidoptera: Noctuidae) and Arabidopsis thaliana. Plant Mol Biol Rep. 2010; 28(2):324-333. (IF=1.336)
28. Li SY, Fan J, Xi JH, Zhang HY, Du HW, Zhou X, Wang X, Ning B, Liu LY, Hao DY. Spleen lymphocyte proteome analysis in bronchial asthma of Wistar rats. Chem J Chinese U. 2007; 28(9):1696-1700. (IF=0.576)
29. Xi J, Wang X, Li S, Zhou X, Yue L, Fan J, Hao D.Polyethylene glycol fractionation improved detection of low-abundant proteins in two-dimensional electrophoresis analysis of plant proteome. Phytochemistry2006, 67:2341-2348. (IF=3.044)

完整论文列表：
https://www.ncbi.nlm.nih.gov/sites/myncbi/1bszwXerzLSQC/bibliography/**/public/?sort=date&direction=descending
招生招聘：
实验室欢迎国内外有志于生命科学的硕博士研究生、博士后和专职科研人员加盟！
招生要求：
(1) 具有生物学、生物信息学、统计学或计算机科学等相关学习或研究背景；
(2) 生物学背景需要具有一定的生物化学及分子生物学实验基础；
(3) 已取得一定的研究成果，在本学科重要学术刊物上发表过SCI论文者优先；
(4) 热爱研究工作、踏实严谨、善于沟通、有良好的团队协作精神；
(5) 英语熟练，有独立撰写学术论文的能力。
联系方式：
请将详细个人简历发送至电子邮箱（xu.wang@sjtu.edu.cn），主题请注明“硕士/博士研究生申请”。热忱欢迎优秀毕业生加盟！