导师姓名： 杨克 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 心血管病
导师类型： 硕士生导师 专业学位导师：
联系方式： 上海市黄埔区瑞金二路197号瑞金医院老门诊楼地下一层心内科实验室
邮编： 200025 邮箱地址： ykk_ykkk@126.com

研究方向 (点击浏览详细信息)
瓣膜钙化中相关分子调控机制
TLR4对于动脉粥样硬化发生及发展的调控作用

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** FSTL1促糖尿病动脉粥样硬化斑块发生及机制研究 国家自然科学基金 2014-01~2018-12 73万元 课题负责人
** 动脉粥样硬化进展中TLR4结合并激活Src调控巨噬细胞脂质累积和炎症反应的机制研究 国家自然科学基金 2012-01~2014-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Yang K, Liu X, Liu Y, Wang X, Cao L, Zhang X, Xu C, Shen W, Zhou T. DC-SIGN and Toll-like receptor 4 mediate oxidized low-density lipoprotein-induced inflammatory responses in macrophages. Sci Rep 2017 7(1):3296
Sun JT, Liu Y, Lu L, Liu HJ, Shen WF, Yang K （通讯作者）, Zhang RY. Diabetes-Invoked High-Density Lipoprotein and Its Association with Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus. Am J Cardiol 2016 118(11):1674-1679
Sun JT, Yang K （共同第一作者）, Lu L, Zhu ZB, Zhu JZ, Ni JW, et al. Increased carbamylation level of HDL in end-stage renal disease: carbamylated-HDL attenuated endothelial cell function. Am J Physiol Renal Physiol 2016 310(6): F511-7
Sun JT, Yang K （共同第一作者）, Mao JY, Shen WF, Lu L, Wu QH, Wang YP, Wu LP, Zhang RY. Cyanate-Impaired Angiogenesis: Association with Poor Coronary Collateral Growth in Patients with Stable Angina and Chronic Total Occlusion. J Am Heart Assoc 2016 5(12)
Yang K, Wang X, Liu Z, Lu L, Mao J, Meng H, et al. Oxidized low-density lipoprotein promotes macrophage lipid accumulation via the toll-like receptor 4-Src pathway. Circ J 2015 79(11):2509-16
Yang K, Zhang XJ, Cao LJ, Liu XH, Liu ZH, Wang XQ, et al. Toll-like receptor 4 mediates inflammatory cytokine secretion in smooth muscle cells induced by oxidized low-density lipoprotein. PLoS One 2014 9(4): e95935
Yang Y, Yang K （共同第一作者）, Li Y, Li X, Sun Q, Meng H, et al. Decursin inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2. Mol Cell Endocrinol 2013 378(1-2):46-52
Yang K, Lu L, Liu Y, Zhang Q, Pu LJ, Wang LJ, et al. Increase of ADAM10 level in coronary artery in-stent restenosis segments in diabetic minipigs: high ADAM10 expression promoting growth and migration in human vascular smooth muscle cells via Notch 1 and 3. PLoS One 2013 8(12): e83853
Zhu J, Yang K （共同第一作者）, Jing Y, Du R, Zhu Z, Lu L, et al. The effects of low-dose nepsilon-(carboxymethyl)lysine (CML) and nepsilon-(carboxyethyl)lysine (CEL), two main glycation free adducts considered as potential uremic toxins, on endothelial progenitor cell function. Cardiovasc Diabetol 2012 11:90
Yang K, He YS, Wang XQ, Lu L, Chen QJ, Liu J, et al. MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4. FEBS Lett 2011 585(6):854-60
Yang K, Wang XQ, He YS, Lu L, Chen QJ, Liu J, et al. Advanced glycation end products induce chemokine/cytokine production via activation of p38 pathway and inhibit proliferation and migration of bone marrow mesenchymal stem cells. Cardiovasc Diabetol 2010 9:66