导师姓名： 李晓东 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 心血管病
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： flylxd@163.com

研究方向 (点击浏览详细信息)

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 转录因子KLF15调控内皮细胞VASN-Notch1通路抑制血管新生的作用及机制 国家自然科学基金面上项目 2021-01~2024-12 55万元 课题负责人
0 肾远曲小管特异性NPR-C基因敲入诱发自发性高血压小鼠模型的建立及运用 上海市科委实验动物研究领域项目 2020-06~2023-06 20万元 课题负责人
** 盐诱导激酶2调控巨噬细胞活化在高盐诱导高血压中的作用机制研究 国家自然科学基金面上项目 2018-01~2021-12 55万元 课题负责人
** 血管外周神经肽Y调控血管炎症的机制研究 国家自然科学基金青年项目 2014-01~2016-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Li XD （通讯作者）, Hong MN, Chen J, Lu YY, Ye MQ, Ma Y, Zhu DL, Gao PJ. Adventitial fibroblast-derived vascular endothelial growth factor promotes vasa vasorum-associated neointima formation and macrophage recruitment Cardiovasc Res 2020 116(3):708-720
Lu YY, Li XD （通讯作者）, Zhou HD, Shao S, He S, Hong MN, Liu JC, Xu YL, Wu YJ, Zhu DL, Wang JG, Gao PJ. Transactivation domain of Krüppel-like factor 15 negatively regulates angiotensin II-induced adventitial inflammation and fibrosis FASEB J 2019 33(5):6254-6268
Zuo C, Li X （通讯作者）, Huang J, Chen D, Ji K, Yang Y, Xu T, Zhu D, Yan C, Gao P. Osteoglycin attenuates cardiac fibrosis by suppressing cardiac myofibroblast proliferation and migration through antagonizing lysophosphatidic acid 3/matrix metalloproteinase 2/epidermal growth factor receptor signalling Cardiovasc Res 2018 114(5):703-712
Lin JR, Zheng YJ, Zhang ZB, Shen WL, Li XD, Wei T, Ruan CC, Chen XH, Zhu DL, Gao PJ. Suppression of Endothelial-to-Mesenchymal Transition by SIRT (Sirtuin) 3 Alleviated the Development of Hypertensive Renal Injury Hypertension 2018 72(2):350-360
He RQ, Tang XF, Zhang BL, Li XD, Hong MN, Chen QZ, Han WQ, Gao PJ. Protease-activated receptor 1 and 2 contribute to angiotensin II-induced activation of adventitial fibroblasts from rat aorta Biochem Biophys Res Commun 2016 473(2):517-23
Hong MN, Li XD （通讯作者）, Chen DR, Ruan CC, Xu JZ, Chen J, Wu YJ, Ma Y, Zhu DL, Gao PJ. Renal denervation attenuates aldosterone expression and associated cardiovascular pathophysiology in angiotensin II-induced hypertension Oncotarget 2016 7(42):67828-67840
Zhang G, Li X （通讯作者）, Sheng C, Chen X, Chen Y, Zhu D, Gao P. Macrophages activate iNOS signaling in adventitial fibroblasts and contribute to adventitia fibrosis Nitric Oxide 2016 61:20-28
Ruan CC, Ge Q, Li Y, Li XD, Chen DR, Ji KD, Wu YJ, Sheng LJ, Yan C, Zhu DL, Gao PJ. Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice Arterioscler Thromb Vasc Biol 2015 35(3):598-606
Li XD, Chen J, Ruan CC, Zhu DL, Gao PJ. Vascular endothelial growth factor-induced osteopontin expression mediates vascular inflammation and neointima formation via Flt-1 in adventitial fibroblasts Arterioscler Thromb Vasc Biol 2012 32(9):2250-8
Jin X, Fu GX, Li XD, Zhu DL, Gao PJ. Expression and function of osteopontin in vascular adventitial fibroblasts and pathological vascular remodeling PLoS One 2011 6(9):e23558
Ruan CC, Zhu DL, Chen QZ, Chen J, Guo SJ, Li XD, Gao PJ. Perivascular adipose tissue-derived complement 3 is required for adventitial fibroblast functions and adventitial remodeling in deoxycorticosterone acetate-salt hypertensive rats Arterioscler Thromb Vasc Biol 2010 30(12):2568-74