导师姓名： 王黎 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 血液病
导师类型： 硕士生导师 专业学位导师： 兼
联系方式： wangli_rj@126.com
邮编： 200025 邮箱地址： dr_wangli@126.com

研究方向 (点击浏览详细信息)
淋巴瘤靶向治疗的临床和科研

社会任职
上海血液质控中心秘书
中国老年学学会淋巴血液肿瘤分委青年委员
上海市抗癌协会血液肿瘤委员会委员
中华医学会血液学分会青年委员
中国抗癌协会淋巴瘤委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
研究型医师 上海交通大学高原高峰计划 后续支持 2019-01~2021-12 100万元 课题负责人
无 恶性淋巴瘤表观遗传学基因突变与耐药的机制和靶向治疗的研究 上海人才发展基金 2017-10~2020-12 20万元 课题负责人
** LncRNA ST20-AS1 激活NOTCH通路促进T细胞淋巴瘤进展的机制和靶向干预研究 国家自然科学基金 面上 2017-01~2020-12 60万元 课题负责人
研究型医师 上海交通大学高原高峰计划 2015-10~2018-10 100万元 课题负责人
** 人源性淋巴瘤小鼠模型的建立 上海市科委 2014-07~2016-10 20万元 课题负责人
** 纳米新药靶向淋巴瘤治疗新技术 上海市科委 2014-07~2017-09 30万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jiang T, Wang L （共同第一作者）, Zhao WL Use of Complete Blood Count for Prognostic Evaluation of Peripheral T-Cell Lymphoma. Acta Haematol 2019 1-3
Cao Y, Liu Z, Wu W, Qian Y, Shi Q, Shen R, Ouyang B, Xu P, Cheng S, Ye J, Lu Y, Wang C, Yang C, Wang L （通讯作者）, Zhao WL Presence of multiple abnormal immunologic markers is an independent prognosticfactor of diffuse large B-cell lymphoma Front Med 2019 13(1):94-103
Fang Y, Wang H, Dou HJ, Fan X, Fei XC, Wang L, Cheng S, Janin A, Wang L （通讯作者）, ZhaoWL. Doxorubicin-loaded dextran-based nano-carriers for highly efficient inhibition of lymphoma cell growth and cynchronous reduction of cardiac toxicity nt J Nanomedicine 2018 13: 5673-5683
Fan X, Zhong HJ, Zhao BB, Ou Yang BS, Zhao Y, Ye J, Lu YM, Wang CF, Xiong H, Chen SJ, Janin A, Wang L （通讯作者）, Zhao WL Metformin prolonged the survival of diffuse large B-cell lymphoma and grade 3b follicular lymphoma patients responding to first-line treatment with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone: A prospective Phase II clinical trial Trans Cancer Res 2018 7(4):1044-1053
Xu PP, Sun YF, Fang Y, Song Q, Yan ZX, Chen Y, Jiang XF, Fei XC, Zhao Y, Leboeuf C, Li B, Wang CF, Janin A, Wang L （通讯作者）, ZhaoWL. JAM-A overexpression is related to disease progression in diffuse large B-cell lymphoma and downregulated by lenalidomide Scientific Report 2017 7(1):7433
Zheng Z, Xu PP, Wang L （共同第一作者）, Zhao HJ, Weng XQ, Zhong HJ, Qu B, Xiong J, Zhao Y, Wang XF, Janin A, Zhao WL MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells. J Exp Clin Cancer Res 2017 36(1):82
Xiong J, Wang L （共同第一作者）, Fei XC, Jiang XF, Zheng Z, Zhao Y, Wang CF, Li B, Chen SJ, Janin A, Gale RP, Zhao WL MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma Blood Cancer J 2017 7(7):e0
Shi Q, Shen R, Wang CF, Fan X, Qian Y, Ou-Yang BS, Zhao Y, Leboeuf C, Janin A, Cheng S, Wang L （通讯作者）, Zhao WL Pretreatment Liver Injury Predicts Poor Prognosis of DLBCL Patients Mediators Inflamm 2017 2017(11):1-9
Xue W, Sheng Y, Weng X, Zhu Y, Zhao Y, Xu P, Fei X, Chen X, Wang L （通讯作者）, Zhao W Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies: a single-institution study of 225 cases Front Med 2015 9(4):468-77
Yan ZX, Zheng Z, Xue W, Zhao MZ, Fei XC, Wu LL, Huang LM, Leboeuf C, Janin A, Wang L （通讯作者）, Zhao WL MicroRNA181a is overexpressed in T-cell leukemia/lymphoma and related to chemoresistance BioMed Res Int 2015 2015: 197241
Wang Li, Zhao Wei-Li Inhibition of mTOR Pathway and Induction of Autophagy Block Lymphoma Cell Growth: Role of AMPK Activation AUTOPHAGY, CANCER, OTHER PATHOLOGIES, INFLAMMATION, IMMUNITY, INFECTION AND AGING, VOLUME 3: MITOPHAGY 2014 xxx
Yan ZX, Wu LL, Xue K, Zhang QL, Guo Y, Romero M, Leboeuf C, Janin A, Chen SJ, Wang L （通讯作者）, Zhao WL MicroRNA187 overexpression is related to tumor progression and determines sensitivity to bortezomib in peripheral T-cell lymphoma Leukemia 2014 28(4):880-7
Dong LH, Cheng S, Zheng Z, Wang L （共同第一作者）, Shen Y, Shen ZX, Chen SJ, Zhao WL Histone deacetylase inhibitor potentiated the ability of mTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphoma J Hematol Oncol 2013 6:53
Wang L, Romero M, Ratajczak P, Leboeuf C, Belhadj S, Peffault de Latour R, Zhao L, Socie G and Janin A Increased apoptosis is linked to severe acute GVHD in patients with Fanconi anemia Bone marrow transplantation 2013 48(6): 849-853
Shi WY, Wang L （共同第一作者）, Xiao D, Yao Y, Yang F, Jiang XX, Leboeuf C, Janin A, Chen SJ, Zhao WL Proteasome inhibitor bortezomib targeted tumor – endothelial cell interaction in T-cell leukemia/lymphoma Ann Hematol 2011 90 (1): 53-56
Wang L, Shi WY, Yang F, Tang W, Gapihan G, Varna M, Shen ZX, Chen SJ, Leboeuf C, Janin A, Zhao WL Bevacizumab potentiates chemotherapeutic effect on T-leukemia/lymphoma cells by direct action on tumor endothelial cells Haematologica 2011 96(6):927-31
Wang L, Shi WY, Wu ZY, Varna M, Wang AH, Zhou L, Chen L, Shen ZX, Lu H, Zhao WL, Janin A Cytostatic and anti-angiogenic effects of temsirolimus in refractory mantle cell lymphoma J Hematol Oncol 2010 3:30
Zhang QL, Wang L （共同第一作者）, Zhang YW, Jiang XX, Yang F, Wu WL, Janin A, Chen Z, Shen ZX, Chen SJ, Zhao WL The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis Leukemia 2009 23 (8) :1507-14
Zhao WL, Liu YY, Zhang QL, Wang L （共同第一作者）, Leboeuf C, Zhang YW, Ma J, Garcia JF, Song YP, Li JM, Shen ZX, Chen Z, Janin A, Chen SJ PRDM1 is involved in chemoresistance of T-cell lymphoma and down-regulated by the proteasome inhibitor Blood 2008 111(7):3867-71