导师姓名： 印彤 专业代码： 100201
性别： 女 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 血液病
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： yintong0101@163.com

研究方向 (点击浏览详细信息)
白血病发病机制的多组学研究
造血干细胞和微环境的相互作用

社会任职
上海市科委专家库

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 上海交通大学医学院“双百人”计划 上海市教委 2020-07~2023-06 100万元 课题负责人
** 急性淋巴细胞白血病的代谢组学研究 医学基因组学国家重点实验室 2019-01~2021-12 20万元 课题负责人
** C/EBPε缺失在骨髓增生异常/骨髓增殖性肿瘤发病中的作用及机制研 究 国家自然科学基金面上项目 2018-01~2021-12 55万元 课题负责人
16PJ** 上海市浦江人才计划 上海市科委 2016-07~2018-06 20万元 课题负责人
** 硫化砷联合格列卫治疗慢性粒细胞白血病的分子机制研究 国家自然科学基金面上项目 2006-01~2008-12 25万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xiangyun Chen*, Xingming Zhang*, Haiyan Cai, Wupeng Yang, Hu Lei, Hanzhang Xu, Weiwei Wang, Qi Zhu, Jingwu Kang, Tong Yin# （通讯作者）, Wenli Gu#, Ying-Li Wu# Targeting USP9x/SOX2 axis contributes to the anti-osteosarcoma effect of neogambogic acid Cancer Letters 2020 469:277–286
Xin-Jie Chen*, Wei-Na Zhang*, Bing Chen*#, Wen-Da Xi, Ying Lu, Jin-Yan Huang, Yue-Ying Wang, Jun Long, Song-Fang Wu, Yun-Xiang Zhang, Shu Wang, Si-Xing Li, Tong Yin, Min Lu, Xiao-Dong Xi, Jun-Min Li, Kan-Kan Wang, Zhu Chen#, and Sai-Juan Chen# Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor PNAS 2019 116(6):2220-5
Yuewang Song*, Mengmeng Zhao*, Yuan Xie*, Tingfang Zhu, Wenbin Liang, Baiming Sun, Weixin Liu, Liqun Wu, Guoping Lu, Tao-Sheng Li#, Tong Yin# （通讯作者）, Yucai Xie Bmi-1 high-expressing cells enrich cardiac stem/ progenitor cells and respond to heart injury Journal of Cellular and Molecular Medicine 2019 23(1):104-111
Xiang Zhang, Xinlei Chen, Jing Liu, Xin Xu, Yuanliang Zhang, Zheng Ruan, Yinyin Xie, Qiuhua Huang#, Tong Yin# （通讯作者）, Zhu Chen & Saijuan Chen# Palladin is a novel microtubule associated protein responsible for spindle orientation Scientific Reports 2017 7(1):11806.doi:10.1038/ s41598-017-12051-w
Hyung C. Suh*, Touati Benoukraf*, Pavithra Shyamsunder*, Tong Yin* （共同第一作者）, Qi Cao, Jonathan Said, Stephen Lee, Ricky Lim, Henry Yang, Jacqueline Salotti, Peter F. Johnson, Vikas Madan, H. Phillip Koeffler LPS independent activation of the pro-inflammatory receptor Trem1 by C/EBPε in granulocytes Scientific Reports 2017 7:46440. doi: 10.1038/srep46440
Tong Yin, Yucai Xie, Winfried Wiegraebe, Xi C. He, Linheng Li Tracking stem cell’s home through live imaging Science 2016 Special issue: 61-64 (http://www.sciencemag.org/collections/pushing-boundaries-scientific-research-120-years-addressing-global-issues)
Dechen Lin, Tong Yin, Maya Koren-Michowitz, Lingwen Ding, Saskia Gueller, Sigal Gery, Takayuki Tabayashi, Ulla Bergholz, Julhash U. Kazi, Lars R?nnstrand, Carol Stocking, and H. Phillip Koeffler Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3 Blood 2012 120:3310-7
He N, Xiao Z, Yin T, Stubbs J, Li L, Quarles LD Inducible expression of Runx2 results in multiorgan abnormalities in mice J Cell Biochem. 2011 112: 653-65
Tong Yin and Linheng Li Fountain of Youth: aged blood-forming stem cells could be rejuvenated by young microenvironment Cell Research 2010 20: 504-505
Kentaro Hosokawa, Fumio Arai, Hiroki Yoshihara, Hiroko Iwasaki, Mark Hembree, Tong Yin, Yuka Nakamura, Yumiko Gomei, Keiyo Takubo, Haruko Shiama, Sahoko Matsuoka, Linheng Li, and Toshio Suda Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow Cell Stem Cell 2010 6: 194-198
Tong Yin, Yucai Xie and Linheng Li Visualize eHPCs in different zones Blood 2009 114: 230-231
Xie Y*, Yin T* （共同第一作者）, Wiegraebe W, He XC, Miller D, Stark D, Perko K, Alexander R, Schwartz J, Grindley JC, Park J, Haug JS, Wunderlich JP, Li H, Zhang S, Johnson T, Feldman RA, Li L Detection of functional haematopoietic stem cell niche using real-time imaging Nature 2009 457: 97-101
He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L PTEN-deficient intestinal stem cells initiate intestinal polyposis Nature Genetics 2007 39: 189-98
Tong Yin and Linheng Li The stem cell niches in bone Journal of Clinical Investigation 2006 116: 1195–1201
Jiwang Zhang, Justin C. Grindley, Tong Yin, Sachintha Jayasinghe, Xi C. He, Jason T. Ross, Jeffrey S. Haug, Dawn Rupp, Kimberly S. Porter-Westpfahl, Leanne M. Wiedemann, Hong Wu and Linheng Li PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention Nature 2006 441: 518-522
Xuetao Bai, Baiwei Gu, Tong Yin, Chao Niu, Xiaodong Xi, Ji Zhang, Zhu Chen, and Saijuan Chen Trans-Repressive Effect of NUP98-PMX1 on PMX1-Regulated c-FOS Gene through Recruitment of Histone Deacetylase 1 by FG Repeats Cancer Res 2006 66: 4584-4590
Yueying Wang*, Guangbiao Zhou*, Tong Yin* （共同第一作者）, Bing Chen, Jingyi Shi, Wenxue Liang, Xiaolong Jin, Jianhua You, Guang Yang, Zhixiang Shen, Jue Chen, Shumin Xiong, Guoqing Chen, Feng Xu, Yiwei Liu, Zhu Chen, Saijuan Chen AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: Implication in stepwise leukemogenesis and response to Gleevec PNAS 2005 102: 1104-1109
Tong Yin （共同第一作者）, Yingli Wu, Huiping Sun, Guanlin Sun, Yanzhi Du, Kankan Wang, Ji Zhang, Guoqiang Chen, Saijuan Chen, Zhu Chen. Combined effects of As4S4 and Imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein Blood 2004 104: 4219-4225