导师姓名： 陈立 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 传染病
导师类型： 硕士生导师 专业学位导师： 兼
联系方式： CLB1247@rjhn.com.cn
邮编： 201820 邮箱地址： CLB1247@rjhn.com.cn

研究方向 (点击浏览详细信息)
慢性肝病基础与临床

社会任职
中华医学会肝病学分会青年委员
中华医学会肝病学分会肝炎学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 乙型肝炎病毒全基因组表观遗传修饰在核苷类似物停药复发中的作用机制研究 国家自然科学基金 2018-01~2021-12 51万元 课题负责人
** GPC3嵌合 抗原受体基因修饰的T细胞靶向治疗肝细胞癌的研究 国家自然科学基金 2016-01~2019-12 72万元 课题参与人
** 肝内乙型肝炎病毒准种分布和cccDNA甲基化在核苷类似物停药复发中的作用研究 国家自然科学基金 2011-01~2013-12 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Leilei Gu,Bin Wang,Lu Liu,Qiaorong Gan,Xiaolong Liu,Lihong Chen,Li Chen （通讯作者） Hepatic fibrinogen storage disease and hypofibrinogenemia caused by fibrinogen Aguadilla mutation: a case report Journal of International Medical Research 2020 48(1) 1–7
Ying Zhang , Xiaocui Huang , Fang Luo , Yun Lei , Li Chen （通讯作者）, Zuquan Weng , Longhua Guo , Zhenyu Lin Highly sensitive electrochemical immunosensor for golgi protein 73 based on proximity ligation assay and enzyme-powered recycling amplification Analytica Chimica Acta 2018 1040:150-157
Chen L, Gan QR, Zhang DQ, Yao LF, Lin RS, Li Q, Lin MH, Yu DM, Zhang XX, Pan C. Increased intrahepatic quasispecies heterogeneity correlates with off-treatment sustained response to nucleos(t)ide analogues in e antigen-positive chronic hepatitis B patients. Clin Microbiol Infect 2016 22(2):201-7
Yang ZT, Huang SY, Chen L, Liu F, Cai XH, Guo YF, Wang MJ, Han Y, Yu DM, Jiang JH, Zhang DH, Gong QM, Zhang GQ, Zang GQ, Lu ZH, Huang LH, Zhang XX Characterization of Full-Length Genomes of Hepatitis B Virus Quasispecies in Sera of Patients at Different Phases of Infection J Clin Microbiol 2015 53(7):2203-14
Han Y, Gong L, Sheng J, Liu F, Li XH, Chen L, Yu DM, Gong QM, Hao P, Zhang XX Prediction of virological response by pretreatment hepatitis B virus reverse transcriptase quasispecies heterogeneity: the advantage of using next-generation sequencing Clin Microbiol Infect 2015 21(8):797.e1-8
Chen L, Li XH, Zheng ZY, Lu XJ, Lin MH, Pan C, Liu JF. A novel ATP7B gene mutation in a liver failure patient with normal ceruloplasmin and low serum alkaline phosphatase Gene 2014 538(1):204-6
Chen L, Zheng CX, Lin MH, Huang ZX, Li QG, Chen RH, Li Q, Pan C. Distinct quasispecies characteristics and positive selection within precore/core gene in HBV associated acute-on-chronic liver failure. Journal of Gastroenterology and Hepatology 2013 28(6):1040-6
Gong L, Han Y, Chen L, Liu F, Hao P, Sheng J, Li XH, Yu DM, Gong QM, Tian F, Guo XK, Zhang XX Comparison of next-generation sequencing and clone-based sequencing in analysis of hepatitis B virus reverse transcriptase quasispecies heterogeneity. J Clin Microbiol 2013 51(12):4087-94
Liu F, Chen L, Yu DM, Deng L, Chen R, Jiang Y, Chen L, Huang SY, Yu JL, Gong QM, Zhang XX Evolutionary patterns of hepatitis B virus quasispecies under different selective pressures: correlation with antiviral efficacy Gut 2011 60(9):1269-77
Chen L, Zhang Q, Yu DM, Wan MB and Zhang XX. Early changes of hepatitis B virus quasispecies during lamivudine treatment and the correlation with antiviral efficacy Journal of Hepatology 2009 50: 895-905