导师姓名： 孙晶 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 普外
导师类型： 硕士生导师 专业学位导师： 兼
联系方式： 上海市瑞金二路197号瑞金医院10号楼11楼胃肠外科一病区
邮编： 200025 邮箱地址： sj11788@rjh.com.cn

研究方向 (点击浏览详细信息)
胃肠道恶性肿瘤的临床及基础研究

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** NDRG1抑制表皮生长因子受体酪氨酸激酶信号通路增强结直肠癌对西妥昔单抗敏感性的分子机制研究 国家自然科学基金面上项目 2019-01~2022-12 60万元 课题负责人
** 人工智能技术在胃癌综合治疗辅助决策中的应用研究 上海市科学技术委员会生药重点项目 2018-06~2021-06 50万元 课题负责人
2017YQ062 NDRG1蛋白调控细胞间连接对结直肠癌侵袭迁移的影响及其机制研究 上海市卫生计生委系统优秀青年医学人才培养计划 2017-06~2020-06 30万元 课题负责人
** NDRG1调控结直肠癌转移相关膜蛋白内吞与转运的机制研究 国家自然科学基金面上项目 2016-01~2019-12 57万元 课题参与人
无 上海青年医师培养资助计划（第三批） 上海市卫生与计划生育委员会 2015-01~2018-07 10万元 课题负责人
无 上海市高校教师产学研践习计划 上海市教委 2015-01~2017-12 5万元 课题负责人
14YF** NDRG1蛋白调控结直肠癌细胞骨架重构的机制研究 上海市科学技术委员会上海市青年科技英才扬帆计划 2014-06~2017-06 10万元 课题负责人
** NDRG1 蛋白调控 actin 骨架重构对结直肠癌迁移侵袭的影响及其机制研究 国家自然科学基金青年项目 2014-01~2017-12 23万元 课题负责人
13JC** NDRG1对结直肠癌肿瘤干细胞的影响及临床意义 上海市科学技术委员会基础重点项目 2013-09~2016-08 40万元 课题参与人
2012AA021103 腹盆腔外科LESS及NOTES关键技术临床应用研究及推广 863计划 2012-01~2016-12 450万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Zhu CC, Chen C, Xu ZQ, Zhao JK, Ou BC, Sun J, Zheng MH, Zong YP, Lu AG. CCR6 promotes tumor angiogenesis via the AKT/NF-κB/VEGF pathway in colorectal cancer Biochim Biophys Acta 2018 1864(2):387-397
Sun J, Wang W, Li J, Yue F, Feng B, Wang J, Wang M Laparoscopic Experience for Recurrent Inguinal Hernia Repair in a Single Center for 14 Years Am Surg 2018 84(3):344-350
Zhao J, Ou B, Han D, Wang P, Zong Y, Zhu C, Liu D, Zheng M, Sun J, Feng H, Lu A. Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways Mol Cancer 2017 16(1):70
Mi L, Zhu F, Yang X, Lu J, Zheng Y, Zhao Q, Wen X, Lu A, Wang M, Zheng M, Ji J, Sun J （通讯作者） The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells Oncogene 2017 6(30):4323-4335
Zhang X, Feng B, Zhu F, Yu C, Lu J, Pan M, He Z, Wangpu X, Sun J （通讯作者）, Yang X N-myc downstream-regulated gene 1 promotes apoptosis in colorectal cancer via up-regulating death receptor 4 Oncotarget 2017 8(47):82593-82608
Feng B, Lu J, Zhang S, Yan X, Li J, Xue P, Wang M, Lu A, Ma J, Zang L, Dong F, He Z, Yue F, Sun J, Hong X, Zheng M. Laparoscopic abdominoperineal excision with trans-abdominal individualized levator transection: interim analysis of a randomized controlled trial Colorectal Dis 2017 19(7):O246-O252
Yang X, Zhu F, Yu C, Lu J, Zhang L, Lv Y, Sun J （通讯作者）, Zheng M N-myc downstream-regulated gene 1 promotes oxaliplatin-triggered apoptosis in colorectal cancer cells via enhancing the ubiquitination of Bcl-2 Oncotarget 2017 8(29):47709-47724
Zhao J, Ou B, Feng H, Wang P, Yin S, Zhu C, Wang S, Chen C, Zheng M, Zong Y, Sun J （通讯作者）, Lu A. Overexpression of CXCR2 predicts poor prognosis in patients with colorectal cancer Oncotarget 2017 8(17):28442-28454
Ou B, Zhao J, Guan S, Feng H, Wangpu X, Zhu C, Zong Y, Ma J, Sun J, Shen X, Zheng M, Lu A CCR4 promotes metastasis via ERK/NF-κB/MMP13 pathway and acts downstream of TNF-α in colorectal cancer Oncotarget 2016 7(30):47637-47649
Ou B, Zhao J, Guan S, Wangpu X, Zhu C, Zong Y, Ma J, Sun J, Zheng M, Feng H, Lu A. Plk2 promotes tumor growth and inhibits apoptosis by targeting Fbxw7/Cyclin E in colorectal cancer Cancer Lett 2016 380(2):457-66
Sun J, Chen X, Li J, Zhang Y, Dong F, Zheng M Implementation of the trans-abdominal partial extra-peritoneal (TAPE) technique in laparoscopic lumbar hernia repair BMC Surg 2015 15:118
Wang P, Zhao J, Yang X, Guan S, Feng H, Han D, Lu J, Ou B, Jin R, Sun J, Zong Y, Feng B, Ma J, Lu A, Zheng M PFDN1, an indicator for colorectal cancer prognosis, enhances tumor cell proliferation and motility through cytoskeletal reorganization Med Oncol 2015 32(12):264
Cai Z, Malbrain ML, Sun J, Pan R, Ma J, Feng B, Dong F, Zheng M Does elevated intra-abdominal pressure during laparoscopic colorectal surgery cause acute gastrointestinal injury? Wideochir Inne Tech Maloinwazyjne 2015 10(2):161-169
Wangpu X, Yang X, Zhao J, Lu J, Guan S, Lu J, Kovacevic Z, Liu W, Mi L, Jin R, Sun J, Yue F, Ma J, Lu A, Richardson DR, Wang L, Zheng M The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear β-catenin and CD44 Oncotarget 2015 6(32):33893-911
Feng B, Ling TL, Lu AG, Wang ML, Ma JJ, Li JW, Zang L, Sun J, Zheng MH Completely medial versus hybrid medial approach for laparoscopic complete mesocolic excision in right hemicolon cancer Surg Endosc 2014 28(2):477-83
Pu Y, Cen G, Sun J, Gong J, Zhang Y, Zhang M, Wu X, Zhang J, Qiu Z, Fang F Warming with an underbody warming system reduces intraoperative hypothermia in patients undergoing laparoscopic gastrointestinal surgery: a randomized controlled study. Int J Nurs Stud 2014 51(2):181-9
Zhao H, Dong T, Zhou H, Wang L, Huang A, Feng B, Quan Y, Jin R, Zhang W, Sun J, Zhang D, Zheng M miR-320a suppresses colorectal cancer progression by targeting Rac1. Carcinogenesis 2014 35(4):886-95
Mao Z, Sun J （共同第一作者）, Feng B, Ma J, Zang L, Dong F, Zhang D, Zheng M The metastasis suppressor, N-myc downregulated gene 1 (NDRG1), is a prognostic biomarker for human colorectal cancer Plos One 2014 8(7):e68206
Sun J, Zhang D, Bae DH, Sahni S, Jansson P, Zheng Y, Zhao Q, Yue F, Zheng M, Kovacevic Z, Richardson DR Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors Carcinogenesis 2013 34(9):1943-54
Sun J, Zhang D, Zheng Y, Zhao Q, Zheng M, Kovacevic Z, Richardson DR Targeting the metastasis suppressor, NDRG1, using novel iron chelators: regulation of stress fiber-mediated tumor cell migration via modulation of the ROCK1/pMLC2 signaling pathway Mol Pharmacol 2013 83(2):454-69
Feng B, Sun J （共同第一作者）, Ling TL, Lu AG, Wang ML, Chen XY, Ma JJ, Li JW, Zang L, Han DP, Zheng MH Laparoscopic complete mesocolic excision (CME) with medial access for right-hemi colon cancer: feasibility and technical strategies Surg Endosc 2012 26(12):3669-75
Qiu Z, Sun J （共同第一作者）, Pu Y, Jiang T, Cao J, Wu W Learning curve of transumbilical single incision laparoscopic cholecystectomy (SILS): a preliminary study of 80 selected patients with benign gallbladder diseases World J Surg 2011 35(9):2092-101
Sun J, Jiang T, Qiu Z, Cen G, Cao J, Huang K, Pu Y, Liang H, Huang R, Chen S Short-term and medium-term clinical outcomes of laparoscopic-assisted and open surgery for colorectal cancer: a single center retrospective case-control study BMC Gastroenterol 2011 11:85