导师姓名： 那溶 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属瑞金医院 三级学科/
专业领域： 泌尿外
导师类型： 硕士生导师 专业学位导师：
联系方式： 上海市黄浦区瑞金二路197号
邮编： 200025 邮箱地址： nr12112@rjh.com.cn

研究方向 (点击浏览详细信息)
前列腺癌遗传学
转化医学和精准医学

社会任职
中国医师协会泌尿外科医师分会全国青年委员
中华医学会泌尿外科学分会全国青年委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 前列腺癌风险单核苷酸多态性rs**在三维构象上远程调控BMPR1B导致疾病发生发展的机制研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
** 新型前列腺癌肿瘤标志物（p2PSA、4K）及基因检测技术在前列腺癌早期发现及诊断中的作用 上海交通大学医学院高峰高原计划——“临床专职科研队伍” 2018-10~2021-09 100万元 课题负责人
18QA** MicroRNA及其作用靶点多态与前列腺癌发病风险及预后的研究 上海市青年科技启明星 2018-04~2021-03 40万元 课题负责人
** CHEK2基因种系遗传突变与前列腺癌发生发展的分子机制及其对靶向药物疗效的影响 国家自然科学基金面上项目 2018-01~2021-12 57万元 课题负责人
17CG09 中国人群特异性前列腺癌风险相关种系拷贝数变异GRM5扩增影响前列腺癌发生发展的机制研究 上海市“晨光计划” 2018-01~2019-12 6万元 课题负责人
2017YFC** 可疑前列腺癌病例队列研究 国家重点研发计划-精准医学研究专项 2017-07~2020-12 1500万元 课题参与人
** 非编码单核苷酸多态性（SNPs）与基因在染色体三维构象上的相互作用及其对前列腺癌发生发展的影响 国家自然科学基金青年项目 2015-01~2017-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Zhang N, Chen S, Jiang G, Wu Y, Shao J, Liu W, Wang X, Na R （通讯作者）, Xu J. The study on copy number alteration of clear cell renal cancer in Chinese population. J Cancer 2020 11(1): 16.
Huang D, Wu Y-S, Ye D-W, Qi J, Liu F, Helfand BT, Zheng SL, Ding Q, Xu D-F, Na R （通讯作者）, Xu J-F, Sun Y-H. Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer: results from a multicenter study in China. Asian J Androl 2020 22: 1-5.
Na R, Labbate C, Yu H, Shi Z, Fantus RJ, Wang C-H, Andriole GL, Isaacs WB, Zheng SL, Helfand BT, Xu J. Single-Nucleotide Polymorphism–Based Genetic Risk Score and Patient Age at Prostate Cancer Diagnosis. JAMA Netw Open 2019 2(12): e**-e.
Xu Y, Huang D, Wu Y, Ye D, Zhang N, Gao Y, Xu D, Na R （通讯作者）, Xu J. Family history is significantly associated with prostate cancer and its early onset in Chinese population. Prostate 2019 79(15): 1762-6.
Zhang N, Chen S, Wu L, Wu Y, Jiang G, Shao J, Chen L, Sun J, Na R （通讯作者）, Wang X, Xu J. Identification of Cancer-Specific Methylation of Gene Combination for the Diagnosis of Bladder Cancer. J Cancer 2019 10(26): 6761.
Zhang C, Huang D, Liu A, Xu Y, Na R （通讯作者）, Xu D. Genome‐wide screening and cohorts validation identifying novel lncRNAs as prognostic biomarkers for clear cell renal cell carcinoma. J Cell Biochem 2019 121(3): 2559-70.
Wu Y, Chen H, Jiang G, Mo Z, Ye D, Wang M, Qi J, Lin X, Zheng SL, Zhang N, Na R （通讯作者）, Ding Q, Xu J, Sun Y. Genome-wide association study (GWAS) of germline copy number variations (CNVs) reveal genetic risks of prostate cancer in chinese population. J Cancer 2018 9(5): 923.
Wu Y-S, Wu X-B, Zhang N, Jiang G-L, Yu Y, Tong S-J, Jiang H-W, Mao S-H, Na R （通讯作者）, Ding Q. Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population. Asian J Androl 2018 20(4): 324.
Jiang G, Hu Q, Wang H, Ding W, Zhang N, Wu Y, Zhou Q, Sun C, Xia G, Ding Q, Na R （通讯作者）, Xu K. A Cumulative Analysis of Current Evidence for Association between Expression of Epithelial-Mesenchymal Transition Markers and Clinicopathological Outcomes in Patients after Radical Prostatectomy. Ann Clin Lab Sci 2018 48(1): 18-28.
Na R, Wu Y, Jiang G, Yu H, Lin X, Wang M, Conran CA, Fantus RJ, Zhang N, Liu S, Helfand BT, Zheng SL, Isaacs WB, Ding Q, Shen Z, Xu J. Germline mutations in DNA repair genes are associated with bladder cancer risk and unfavourable prognosis. BJU Int 2018 122(5): 808-13.
Na R, Zheng SL, Han M, Yu H, Jiang D, Shah S, Ewing CM, Zhang L, Novakovic K, Petkewicz J, Gulukota K, Helseth DL, Quinn M, Humphries E, Wiley KE, Isaacs SD, Wu Y, Liu X, Zhang N, Wang C-H, Khandekar J, Hulick PJ, Shevrin DH, Cooney KA, Shen Z, Partin AW, Carter HB, Carducci MA, Eisenberger MA, Denmeade SR, McGuire M, Walsh PC, Helfand BT, Brendler CB, Ding Q, Xu J, Isaacs WB. Germline mutations in ATM and BRCA1/2 distinguish risk for lethal and indolent prostate cancer and are associated with early age at death. Eur Urol 2017 71(5): 740-7.
Na R, Ye D, Qi J, Liu F, Helfand BT, Brendler CB, Conran CA, Packiam V, Gong J, Wu Y, Zheng SL, Mo Z, Ding Q, Sun Y, Xu J. Prostate health index significantly reduced unnecessary prostate biopsies in patients with PSA 2‐10 ng/mL and PSA> 10 ng/mL: Results from a Multicenter Study in China. Prostate 2017 77(11): 1221-9.
Chen H, Na R （共同第一作者）, Packiam VT, Conran CA, Jiang D, Tao S, Yu H, Lin X, Meng W, Zheng SL, Brendler CB, Helfand BT, Xu J. Reclassification of prostate cancer risk using sequentially identified SNPs: results from the REDUCE trial. Prostate 2017 77(11): 1179-86.
Na R, Helfand BT, Chen H, Conran CA, Crawford SE, Hayward SW, Tammela TLJ, Hoffman‐Bolton J, Zheng SL, Walsh PC, Schleutker J, Platz EA, Isaacs WB, Xu J. A genetic variant near GATA3 implicated in inherited susceptibility and etiology of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Prostate 2017 77(11): 1213-20.
Zhang N, Jiang G, Liu X, Na R （通讯作者）, Wang X, Xu J. Prediction of bacillus Calmette-Guerin response in patients with bladder cancer after transurethral resection of bladder tumor by using genetic variation based on genomic studies. BioMed Res Int 2016 **
Na R, Wu Y, Ding Q, Xu J. Clinically available RNA profiling tests of prostate tumors: utility and comparison. Asian J Androl 2016 18(4): 575.
Na R, Xu J, Isaacs WB. DNA-Repair Gene Mutations in Metastatic Prostate Cancer. N Engl J Med 2016 375(18): 1802-3.
Zhang N, Jiang G, Liu X, Na R （通讯作者）, Wang X, Xu J. Prediction of bacillus Calmette-Guerin response in patients with bladder cancer after transurethral resection of bladder tumor by using genetic variation based on genomic studies. BioMed Res Int 2016 **
Na R, Ye D, Qi J, Liu F, Lin X, Helfand BT, Brendler CB, Conran C, Gong J, Wu Y, Gao X, Chen Y, Zheng SL, Mo Z, Ding Q, Sun Y, Xu J. Race-specific genetic risk score is more accurate than nonrace-specific genetic risk score for predicting prostate cancer and high-grade diseases. Asian J Androl 2016 18(4): 525.
Wu Y-S, Zhang N, Liu S-H, Xu J-F, Tong S-J, Cai Y-H, Zhang L-M, Bai P-D, Hu M-B, Jiang H-W, Na R （通讯作者）, Ding Q, Sun Y-H. The Huashan risk calculators performed better in prediction of prostate cancer in Chinese population: a training study followed by a validation study. Asian J Androl 2016 18(6): 925.
Conran CA, Na R （通讯作者）, Chen H, Jiang D, Lin X, Zheng SL, Brendler CB, Xu J. Population-standardized genetic risk score: the SNP-based method of choice for inherited risk assessment of prostate cancer. Asian J Androl 2016 18(4): 520.
Yu G-P, Na R （共同第一作者）, Ye D-W, Qi J, Liu F, Chen H-T, Wu Y-S, Zhang G-M, Sun J-L, Zhu Y, Huang L-Q, Ren S-C, Jiang D-K, Zheng SL, JIang H-W, Sun Y-H, Ding Q, Xu J. Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography. Asian J Androl 2016 18(4): 633.
Zhang N, Wu Y, Wang J, Xu J, Na R （通讯作者）, Wang X. The effect of discrepancy between radiologic size and pathologic tumor size in renal cell cancer. SpringerPlus 2016 5(1): 899.
Liu S, Hou J, Zhang H, Wu Y, Hu M, Zhang L, Xu J, Na R （通讯作者）, Jiang H, Ding Q. The evaluation of the risk factors for non-muscle invasive bladder cancer (NMIBC) recurrence after transurethral resection (TURBt) in Chinese population. PloS one 2015 10(4): e**.
Na R, Ye D, Liu F, Chen H, Qi J, Wu Y, Zhang G, Wang M, Wang W, Sun J, Yu G, Zhu Y, Ren S, Zheng SL, Jiang H, Sun Y, Ding Q, Xu J. Performance of serum prostate-specific antigen isoform [-2]proPSA (p2PSA) and the prostate health index (PHI) in a Chinese hospital-based biopsy population. Prostate 2014 74(15): 1569-75.
Wu YS, Na R （共同第一作者）, Xu JF, Bai PD, Jiang HW, Ding Q. The influence of prostate volume on cancer detection in the Chinese population. Asian J Androl 2014 16(3): 482-6.
Gu X, Na R （共同第一作者）, Huang T, Wang L, Tao S, Tian L, Chen Z, Jiao Y, Kang J, Zheng S, Xu J, Sun J, Qi J. SRD5A1 and SRD5A2 are associated with treatment for benign prostatic hyperplasia with the combination of 5alpha-reductase inhibitors and alpha-adrenergic receptor antagonists. J Urol 2013 190(2): 615-9.
Na R, Wu Y, Xu J, Jiang H, Ding Q. Age-specific prostate specific antigen cutoffs for guiding biopsy decision in Chinese population. PloS one 2013 8(6): e67585.
Na R, Liu F, Zhang P, Ye D, Xu C, Shao Q, Qi J, Wang X, Chen Z, Wang M, He D, Wang Z, Zhou F, Yuan J, Gao X, Wei Q, Yang J, Jiao Y, Ou-Yang J, Zhu Y, Wu Q, Chen H, Lu D, Shi R, Lin X, Jiang H, Wang Z, Jiang D, Sun J, Zheng SL, Ding Q, Mo Z, Sun Y, Xu J. Evaluation of reported prostate cancer risk-associated SNPs from genome-wide association studies of various racial populations in Chinese men. Prostate 2013 73(15): 1623-35.
Sun J, Na R （共同第一作者）, Hsu FC, Zheng SL, Wiklund F, Condreay LD, Trent JM, Xu J. Genetic score is an objective and better measurement of inherited risk of prostate cancer than family history. Eur Urol 2013 63(3): 585-7.
Na R, Jiang H, Kim ST, Wu Y, Tong S, Zhang L, Xu J, Sun Y, Ding Q. Outcomes and trends of prostate biopsy for prostate cancer in Chinese men from 2003 to 2011. PloS one 2012 7(11): e49914.