导师姓名： 陈晓翔 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属仁济医院 三级学科/
专业领域： 风湿病
导师类型： 硕士生导师 专业学位导师： 兼
联系方式：
邮编： 200001 邮箱地址： xiaoxiang0721@126.com

研究方向 (点击浏览详细信息)
自身免疫病的转化性研究
骨免疫和炎症自身免疫的发生

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** Fra2/AP-1通过OX40+细胞调节银屑病的免疫学机制 国家自然基金面上项目 2020-01~2023-12 55万元 课题负责人
** B细胞通过HIF1α/IL-10通路调控自身免疫和骨稳态的机制 国家自然基金 2018-01~2022-12 55万元 课题负责人
** HIF1a通过骨髓B细胞调节破骨细胞分化和关节炎的发生机制 上海市科委国际交流重点项目 2014-07~2017-06 30万元 课题负责人
** 狼疮致病靶分子 OAS1 新功能的研究：通过pre-miR-105 对自身抗体唾液酸化调节机制 国家自然基金 2013-01~2016-12 60万元 课题负责人
10ZR** miR-105对SLE患者IgG-Fc糖基化修饰及功能的影响 上海市科委 2010-04~2013-03 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Guo R, Zhang T, Meng X, Lin Z, Lin J, Gong Y, Liu X, Yu Y, Zhao G, Ding X, Chen X （通讯作者）, Lu L. Lymphocyte mass cytometry identifies a CD3-CD4+ cell subset with a potential role in psoriasis. JCI Insight. 2019 pii: 125306.
Lichong SHEN, Qingran YAN, Xiaoxiang CHEN （通讯作者） Efficacy of Combination Therapy With Pirfenidone and Low-Dose Cyclophosphamide for Refractory Interstitial Lung Disease Associated With Connective Tissue Disease: A Case-Series of Seven Patients Arch Rheumatol 2019 2020;35(x):i-ix
Ruru Guo, Yang Tu, Shan Cao, Zhen Lin, Yang Song, Suli Wang, Xiaoxiang Chen* （通讯作者）, Liangjing Lu*. Abnormal expression of receptor-interacting protein kinase-1 involves in neutrophil extracellular trap formation in patients with systemic lupus erythematosus. Cellular Physiology and Biochemistry 2018 45:2317-2328.
Deng J, Fan C, Gao X, Zeng Q, Guo R, Wei Y, Chen Z, Chen Y, Gong D, Feng J, Xia Y, Xiang S, Gong S, Yuan L, Shen W, Shen W, Lin L, Jiang T, He D, Lu L, Chen X （通讯作者）, Yu D. Signal Transducer and Activator of Transcription 3 Hyperactivation Associates With Follicular Helper T Cell Differentiation and Disease Activity in Rheumatoid Arthritis. Front Immunol. 2018 4;9:1226.
Wang J, Chen GL, Cao S, Zhao MC, Liu YQ, Chen XX, Qian C. Adipogenic niches for melanoma cell colonization and growth in bone marrow. Lab Invest 2017 97(6):737-745.
Chen GL, Luo Y, Eriksson D, Meng X, Qian C, B?uerle T, Chen XX, Schett G, Bozec A. High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6. Oncotarget. 2016 7(18):26653-69.
Chen XX, Li ZG, Wu HX, Zhao DB, Li XF, Xu JH, Tao Y, Yang NP, Hu SX, Huang AB, Jiang LD, Wang GC, Zhang X, Bao CD. A randomized, controlled trial of efficacy and safety of Anbainuo, a bio-similar etanercept, for moderate to severe rheumatoid arthritis inadequately responding to methotrexate. Clin Rheumatol 2016 35(9):2175-83.
Chen XX （通讯作者）, Chen YQ, Ye S. Measuring decreased serum IgG sialylation: a novel clinical biomarker of lupus. lupus 2015 24(9):948-54.
Chen XX, Baum W, Dwyer D, Stock M, Schwabe K, Ke HZ, Stolina M, Schett G, Bozec A. Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis. Ann Rheum Dis. 2013 72(10):1732-6.
Chen XX, Dai Q, Huang AB,et al A multicenter, randomized, double-blind clinical trial of combination therapy with Anbainuo, a novel recombinant human TNFRII:Fc fusion protein, plus methotrexate versus methotrexate alone or Anbainuo alone in Chinese patients with moderate to severe rheumatoid arthritis. Clin Rheumatol 2013 32(1):99-108
Lu XY, Chen XX （共同第一作者）, Huang LD, et al Anti-alpha-internexin autoantibody from neuropsychiatric lupus induce cognitive damage via inhibiting axonal elongation and promote neuron apoptosis. PLoS One 2010 15;5(6):e11124.
Chen XX, Gu YY, Li SJ, Qian J, Hwang KK, Chen PP, Chen SL, Yang CD. Some plasmin-induced antibodies bind to cardiolipin, display lupus anticoagulant activity and induce fetal loss in mice. J Immunol. 2007 26(10):1647-54.