导师姓名： 沈骏 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属仁济医院 三级学科/
专业领域： 消化系病
导师类型： 硕士生导师 专业学位导师：
联系方式： shenjun@vip.163.com
邮编： 200127 邮箱地址： shenjun@vip.163.com

研究方向 (点击浏览详细信息)
肠黏膜免疫
炎症性肠病
肠道菌群

社会任职
《胃肠病学和肝病学杂志》编委
《中华炎症肠病杂志》青年学术组副组长
Journal of Digestive Diseases执行编辑
亚洲克罗恩和结肠炎组织（AOCC）委员
中国炎症性肠病青年****俱乐部（CYCCC）副组长
中国医学装备学会炎症性肠病学组（CAME-IBD）委员兼秘书
上海市炎症性肠病学组委员
北京市医学奖励基金会炎症性肠病专家委员会委员
金砖国家炎症性肠病联盟（BRICS-IBD）秘书兼转化医学委员会委员
《中华炎性肠病杂志》编委
中国医药生物技术协会组织生物样本库分会炎症性肠病学组委员兼秘书

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
PYI-17-003 基于纹理分析技术的炎症性肠病鉴别诊断和狭窄治疗中的多学科联合诊疗研究 上海交通大学医学院附属仁济医院 2018-01~2020-12 15万元 课题负责人
** 干预tRNA衍生片段tRF-35-P4R8YP9LON4VN1调控II型上皮-间质转化关键环路抑制克罗恩病肠壁纤维化的机制研究 国家自然科学基金委员会 2018-01~2021-12 56万元 课题负责人
160111 克罗恩病的炎症性狭窄和纤维性狭窄鉴别：肠道能谱CT和磁共振DWI特点与对比研究 上海交通大学医学院附属仁济医院 2016-01~2018-12 30万元 课题参与人
** 干预非编码转录超保守区uc.261重塑克罗恩病肠黏膜屏障紧密连接的策略研究 国家自然科学基金委员会 2015-01~2018-12 75万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Lai Li Jie, Shen Jun （通讯作者）, Ran Zhi Hua Natural killer T cells and ulcerative colitis Cellular Immunology 2019 2019; 335: 1-5
Xu Y, Shen J, Ran Z Emerging views of mitophagy in immunity and autoimmune diseases Autophagy 2019 5:1-15
Qiao YQ, Cai CW, Shen J, Zheng Q, Ran ZH Circular RNA expression alterations in colon tissues of Crohn's disease patients. Mol Med Rep 2019 19 (5):4500-4506
Zhang Y, Chen D, Wang F, Li X, Xue X, Jiang M, Xu B, Chu Y, Wang W, Wu K, Mao R, Shen J （通讯作者）, Yang S, Liang J. Comparison of the efficiency of different enemas on patients with distal ulcerative colitis. Cell Prolif 2019 52 (2):e12559
Jiang H, Shen J （通讯作者）, Ran Z Epithelial-mesenchymal transition in Crohn's disease Mucosal Immunol 2018 11 (2):294-303
Qian X, Wang T, Shen J （通讯作者）, Ran Z Low dose of azathioprine is effective to induce and maintain remission in active Crohn disease: A prospective observational study. Medicine (Baltimore) 2018 97(34):e11814
崔雨迪,沈骏 （通讯作者） 免疫调节剂对炎症性肠病手术的影响及围手术期撤减策略 中华炎性肠病杂志 2018 2(4): 267-269
Li Hanyang, Liu Xuanzhe, Chen Xuyang, Qiu Yujia, Fu Jiarong, Shen Jun （通讯作者）, Ran Zhihua Application of Zebrafish Models in inflammatory Bowel Disease Frontiers in Immunology 2017 3;8:501
Li X, Shen J （通讯作者）, Ran Z Crosstalk between the gut and the liver via susceptibility loci: Novel advances in inflammatory bowel disease and autoimmune liver disease. Clin Immunol 2017 175: 115-123
Zhen Jun Zhao, Jun Shen （通讯作者） Circular RNA participates in the carcinogenesis and the malignant behavior of cancer RNA Biology 2017 14(5): 514–521
Lu JT, Xu AT, Shen J, Ran ZH Crosstalk between intestinal epithelial cell and adaptive immune cell in intestinal mucosal immunity J Gastroenterol Hepatol 2017 32(5): 975-980
Jin S, Zhao D, Cai C, Song D, Shen J, Xu A, Qiao Y, Ran Z, Zheng Q Low-dose penicillin exposure in early life decreases Th17 and the susceptibility to DSS colitis in mice through gut microbiota modification Sci Rep 2017 8;7:43662
Zhao D, Cai C, Zheng Q, Jin S, Song D, Shen J, Ran Z Vancomycin pre-treatment impairs tissue healing in experimental colitis: Importance of innate lymphoid cells Biochem Biophys Res Commun 2017 483(1):237-244
Lu JT, Xu AT, Shen J, Ran ZH. Crosstalk between intestinal epithelial cell and adaptive immune cell in intestinal mucosal immunity. J Gastroenterol Hepatol 2017 32(5):975-980
周易,沈骏,冉志华 新型口服生物制剂治疗炎症性肠病的研究进展 胃肠病学 2017 22 (8): 498-501
Qian XX, Peng JC, Xu AT, Zhao D, Qiao YQ, Wang TR, Shen J （通讯作者）, Ran ZH Noncoding Transcribed Ultraconserved Region (T-UCR) uc.261 Participates in Intestinal Mucosa Barrier Damage in Crohn's Disease Inflamm Bowel Dis 2016 22: 2840-2852.
Qi F, Jun S （共同第一作者）, Qi QY, Chen PJ, Chuan GX, Jiong Z, Rong XJ. Utility of the diffusion-weighted imaging for activity evaluation in Crohn's disease patients underwent magnetic resonance enterography. BMC Gastroenterol 2015 15: 12
Shen J, Mao AP, Zhu MM, Zhao P, Xu JJ, Zuo Z. Ulcerative Colitis Database: An Integrated Database and Toolkit for Gene Function and Medication Involved in Ulcerative Colitis. Inflamm Bowel Dis 2015 21: 1872-82
Peng JC, Ran ZH, Shen J （通讯作者） Seasonal variation in onset and relapse of IBD and a model to predict the frequency of onset, relapse, and severity of IBD based on artificial neural network. Int J Colorectal Dis 2015 30: 1267-73
Mao AP, Shen J （共同第一作者）, Zuo Z. Expression and regulation of long noncoding RNAs in TLR4 signaling in mouse macrophages. BMC Genomics 2015 16:45
Zhao D, Xu A, Dai Z, Peng J, Zhu M, Shen J, Zheng Q, Ran Z WNT5A transforms intestinal CD8αα? IELs into an unconventional phenotype with pro-inflammatory features. BMC Gastroenterol. 2015 15: 173
Tong J, Zheng Q, Zhang C, Lo R, Shen J, Ran Z Incidence, prevalence, and temporal trends of microscopic colitis: a systematic review and meta-analysis Am J Gastroenterol 2015 110(2):265-76
Qiao YQ, Huang ML, Zheng Q, Wang TR, Xu AT, Cao Y, Zhao D, Ran ZH, Shen J （通讯作者） CNTNAP3 associated ATG16L1 expression and Crohn's disease. Mediators Inflamm 2015 2015: 404185
Mao AP, Shen J （共同第一作者）, Zuo Z Expression and regulation of long noncoding RNAs in TLR4 signaling in mouse macrophages. BMC Genomics 2015 16: 45
Cao Y, Zhao D, Xu AT, Shen J, Ran ZH. Effects of immunosuppressants on immune response to vaccine in inflammatory bowel disease. Chin Med J (Engl) 2015 128: 835-8.
Xu AT, Li Y, Zhao D, Shen J, Xu XT, Qiao YQ, Zhu MM, Wang TR, Cui Y, Ai LY, Ran ZH High suppressor of cytokine signaling-3 expression impairs STAT3-dependent protective effects of interleukin-22 in ulcerative colitis in remission. Inflamm Bowel Dis 2015 21: 241-50
Shen J, Zuo ZX, Mao AP. Effect of probiotics on inducing remission and maintaining therapy in ulcerative colitis, Crohn's disease, and pouchitis: meta-analysis of randomized controlled trials. Inflamm Bowel Dis 2014 20: 21-35
Xu J, Lin H, Feng X, Tang M, Shen J （通讯作者）, Ran Z Different therapeutic approaches on quality of life in patients with inflammatory bowel disease. BMC Gastroenterol 2014 14: 199
Wang TR, Peng JC, Qiao YQ, Zhu MM, Zhao D, Shen J （通讯作者）, Ran ZH Helicobacter pylori regulates TLR4 and TLR9 during gastric carcinogenesis. Int J Clin Exp Pathol 2014 7: 6950-5
Shen J, Qiao YQ, Ran ZH, Wang TR Different Activation of TRAF4 and TRAF6 in Inflammatory Bowel Disease. Mediators Inflamm 2013 2013: 647936
Qiao YQ, Huang ML, Xu AT, Zhao D, Ran ZH, Shen J （通讯作者） LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn's disease. J Biomed Sci 2013 1;20:87
Xu J, Tang M, Shen J （通讯作者） Trends and Factors Affecting Hospitalization Costs in Patients with Inflammatory Bowel Disease: A Two-Center Study over the Past Decade Gastroenterol Res Pract 2013 2013:267630
Tong JL, Feng Q, Shen J, Qiao YQ, Zheng Q, Gu Y, Chen XY, Li XB, Dai J, Hua J, Xu JR, Ran ZH Computed tomography enterography versus balloon-assisted enteroscopy for evaluation of small bowel lesions in Crohn's disease. J Gastroenterol Hepatol 2013 28: 1180-1186
Shen J, Qiao Y, Ran Z, Wang T, Xu J, Feng J. Intestinal protein expression profile identifies inflammatory bowel disease and predicts relapse. Int J Clin Exp Pathol 2013 6: 917-925
Shen J, Qiao YQ, Ran ZH, Wang TR. Up-regulation and Pre-activation of TRAF3 and TRAF5 in Inflammatory Bowel Disease. Int J Med Sci 2013 10: 156-163
Peng JC, Shen J, Ran ZH Transcribed ultraconserved region in human cancers. RNA Biol 2013 10: 1771-1777
Qiao YQ, Shen J, Gu Y, Tong JL, Xu XT, Huang ML, Ran ZH Gene expression of tumor necrosis factor receptor associated-factor (TRAF)-1 and TRAF-2 in inflammatory bowel disease. J Dig Dis 2013 14: 244-250
Huang ML, Xu XT, Shen J, Qiao YQ, Dai ZH, Ran ZH. Prevalence and factors related to hepatitis B and C infection in inflammatory bowel disease patients in China: A retrospective study. J Crohns Colitis 2013 pii: S1873-9946(13)00310-3
沈骏,乔宇琪,冉志华,童锦禄,朱明明,王天蓉,黄美兰 Obestatin与Ghrelin在炎症性肠病中的表达及临床价值。 胃肠病学和肝病学杂志 2012 21:1073-1076
沈骏,乔宇琪,冉志华,童锦禄,朱明明,王天蓉,黄美兰 血浆早老蛋白- 1对溃疡性结肠炎及克罗恩病的诊断价值研究。 医学临床研究杂志 2012 26：2054-2056
沈骏,乔宇琪,冉志华,童锦禄,朱明明,王天蓉,黄美兰 溃疡性结肠炎患者Wnt9b的高表达及临床价值。 现代消化及介入诊疗 2012 17：208-211
沈骏,乔宇琪,冉志华,童锦禄,朱明明,王天蓉,黄美兰 半胱氨酸天冬氨酸蛋白酶-3在炎症性肠病中的差异表达。 临床消化病杂志 2012 24：195-197
沈骏,冉志华,黄美兰,王天蓉,钱孝先,张凤,乔宇琪 炎症性肠病患者外周血TRAF-5表达与内镜下疾病活动性的相关性。 临床消化杂志 2011 2011；23：84-86
Shen Jun, Qian Xiaoxian, Ran Zhihua, Tong Jinlu, Qiao Yuqi and Huang Meilan. Activated expression of CD27-CD70 co-stimulatory molecules in inflamed and non-inflamed tissues of intestinal mucosa in patients with inflammatory bowel disease. Sci Res Essays 2011 6: 793–798
Huang ML, Ran ZH, Shen J, Li XB, Xu XT, Xiao SD Efficacy and safety of adalimumab in Crohn's disease: meta-analysis of placebo-controlled trials. J Dig Dis 2011 12: 165-172
沈骏,钱孝先,冉志华,童锦禄,徐锡涛,乔宇琪,黄美兰 炎症性肠病患者肠黏膜炎症和非炎症组织CD27的激活表达。 胃肠病学和肝病学杂志 2010 19：842-845
沈骏,冉志华,童锦禄,黄美兰,王天蓉 血浆TRAF-3表达在炎症性肠病中的意义。 现代消化及介入诊疗 2010 15：195-198
沈骏,冉志华,童锦禄,蔡青,黄美兰,王天蓉 血浆肿瘤坏死因子受体相关因子-2升高与炎症性肠病内镜下疾病活动性的相关性分析。 医学临床研究 2010 27：212-214
沈骏,冉志华,郑青,童锦禄,蔡青,朱明明,黄美兰,王天蓉 炎症性肠病患者CD40-CD154共刺激途径的激活及其与内镜下疾病活动程度的相关性研究。 中华消化内镜杂志 2010 27：80-84
沈骏,冉志华,童锦禄,蔡青,黄美兰,王天蓉,钱孝先,张凤 血浆肿瘤坏死因子受体相关因子-4升高对炎症性肠病的临床意义。 医学新知杂志 2010 20：12-15
Tong JL, Ran ZH, Shen J, Xiao SD Sequential therapy vs. standard triple therapies for Helicobacter pylori infection: a meta-analysis. J Clin Pharm Ther 2009 34: 41-53
Shen J, Ran ZH, Zhang Y, Cai Q, Yin HM, Zhou XT, Xiao SD Biomarkers of altered coagulation and fibrinolysis as measures of disease activity in active inflammatory bowel disease: A gender-stratified, cohort analysis. Thromb Res 2009 123: 604-611
Shen Jun, Ran Zhi Hua, Yin Hong Min, Zhou Xiao Tian, Xiao Shu Dong Meta-analysis: the effect and adverse events of Lactobacilli versus placebo in maintenance therapy for Crohn's disease. Intern Med J 2009 39: 103-109
Nie F, Shen J, Tong JL, Xu XT, Zhu MM, Ran ZH Meta-analysis: the efficacy and safety of monoclonal antibody targeted to epidermal growth factor receptor in the treatment of patients with metastatic colorectal cancer. J Dig Dis 2009 10: 247-257
沈骏,冉志华,聂芳,童锦禄,朱明明,蔡青,黄美兰,王天蓉 炎症性肠病患者血浆TRAF1的表达及其临床意义。 胃肠病学和肝病学杂志 2009 18：896-899
Shen Jun, Ran Zhi Hua, Tong Jin Lu, Chen Xiang, Xiao Shu Dong Are endoscopic grading and scoring systems in inflammatory bowel disease the same? Saudi Medical Journal 2008 29: 1432-1437
Tong JL, Ran ZH, Shen J, Fan GQ, Xiao SD Association between fecal bile acids and colorectal cancer: a meta-analysis of observational studies. Yonsei Med J 2008 49: 792-803
Shen J, Ran ZH, Tong JL, Xiao SD Meta-analysis: The utility and safety of heparin in the treatment of active ulcerative colitis. Aliment Pharmacol Ther 2007 26:653-663
Tong JL, Ran ZH, Shen J, Zhang CX, Xiao SD Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther 2007 25: 155-168