导师姓名： 陆劲松 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属仁济医院 三级学科/
专业领域： 普外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海浦东浦建路160号仁济医院东院乳腺外科
邮编： 200127 邮箱地址： lujjss@163.com

研究方向 (点击浏览详细信息)
非编码RNA在乳腺癌发生发展中作用
乳腺癌术后复发转移机制及其应对策略
局部晚期乳腺癌新辅助治疗的探索及其机制研究

社会任职
中国临床肿瘤学会（CSCO）乳腺癌专业委员会常委
中国医学装备协会数字医疗技术分会乳腺疾病数字化诊疗专业委员会 委员
中国抗癌协会家族遗传性肿瘤专业委员会常务委员
中国医师协会外科分会MDT委员会委员（第一届）
中国抗癌协会乳腺癌专业委员会委员（第七届）
中国临床肿瘤学会（CSCO）理事
中国医师协会外科分会乳腺外科专业委员会委员（第一届）
中国医药教育协会乳腺疾病专业委员会副主任委员
中国抗癌协会肿瘤标志专业委员会乳腺癌标志物协作组副组长
中国初级卫生保健基金会智慧与健康产业发展公益基金专家委员会-乳腺疾病分会乳腺疾病专家委员会副主任委员
中华医学会心血管病学分会第十一届委员会肿瘤心脏病学学组 委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2018 年度上海市临床重点专科建设项目-女性肿瘤 上海市卫生和计划生育委员会，临床重点 2019-10~2022-12 30万元 子课题负责人
TM201908 前哨淋巴结新型显影技术与机器研发 上海交通大学医学院转化医学协同创新中心合作研究项目 2019-10~2021-09 8万元 课题负责人
ncRNAs作为新辅助化疗药物敏感性生物标志物的研究 上海市卫计委 2017-01~2019-12 15万元 课题负责人
SHDC** 局部晚期乳腺癌术前及术后优化化疗方案的多中心临床系列研究 上海申康医院发展中心 2016-11~2019-11 10万元 课题负责人
PYMDT-002 MDT综合指导下全程管理乳腺癌综合诊断治疗随访新模式的平台建设及该平台上核心疑难课题的前瞻性临床试验研究 仁济医院临床科研培育基金 2016-06~2022-05 55万元 课题负责人
15JC** PDGF在免疫应答改变Luminal型乳腺癌化疗敏感性及EMT过程中的作用机制研究 上海市科学技术委员会 2015-07~2018-09 50万元 课题负责人
** Luminal型高危乳腺癌患者个体化新辅助化疗的研究 上海市科学技术委员会 2014-07~2017-09 75万元 子课题负责人
**/ H1622 雌激素相关miRNA的基因扩增及多态在乳腺癌易感性的研究 国家自然基金 2012-01~2015-12 54万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Sheng X, Wang Y, Yang F, Lin Y, Xu S, Yin W, Zhou L, Lu J （通讯作者） Ultrasound-Guided Breast Biopsy: Improved Accuracy of 10-G Cable-Free Elite Compared With 14-G CCNB J Surg Res 2020 2020 Mar;247:172-179. doi: 10.1016/j.jss.2019.10.025. Epub 2019 Nov 21.
Jing Peng, Chenwei Yuan, Ziping Wu, Yan Wang, Wenjin Yin, Yanping Lin, Liheng Zhou, Jinsong Lu （通讯作者） Upregulation of microRNA1 Inhibits Proliferation and Metastasis of Breast Cancer Mol Med Rep 2020 2020 Jul;22(1):454-464. doi: 10.3892/mmr.2020.11111. Epub 2020 May 4.
Shan Zhang, Yaohui Wang, Yan Wang, Jing Peng, Chenwei Yuan, Liheng Zhou, Shuguang Xu, Yanping Lin, Yueyao Du, Fan Yang, Jie Zhang, Huijuan Dai, Wenjin Yin,Jinsong Lu （通讯作者） Serum miR-222-3p as a Double-Edged Sword in Predicting Efficacy and Trastuzumab-Induced Cardiotoxicity for HER2-Positive Breast Cancer Patients Receiving Neoadjuvant Target Therapy. Front. Oncol. 2020 10:631. doi: 10.3389/fonc.2020.00631
Zhang L, Du Y, Xu S, Jiang Y, Yuan C, Zhou L, Ma X, Bai Y, Lu J （通讯作者）, Ma J. DEPDC1, negatively regulated by miR-26b, facilitates cell proliferation via the up-regulation of FOXM1 expression in TNBC. Cancer Letters. 2019 2019;442:242–51.
Wang Y, Yin W, Lin Y, Zhou L, Du Y, Yin K, Lu J （通讯作者） Early breast cancer patients benefit more from longer course chemotherapy: a matched-pair analysis Future Oncol 2019 2019; 15: 1781-89.
Yaohui Wang, Wenjin Yin, Yanping Lin, Kai Yin, Liheng Zhou, Yueyao Du, Tingting Yan,Jinsong Lu （通讯作者） Downregulated circulating microRNAs aftersurgery: potential noninvasive biomarkersfor diagnosis and prognosis of early breastcancer Cell Death Discovery 2019 5, 116 (2019). https://doi.org/10.1038/s41420-019-0186-2
Liu Y, Sun J, Wu T, Lu X, Du Y, Duan H, Yu W, Su D, Lu J （通讯作者）, Tian J. Effects of serum from breast cancer surgery patients receiving perioperative dexmedetomidine on breast cancer cell malignancy: A prospective randomized controlled trial Cancer Med. 2019 2019 Dec;8(18):7603-7612. doi: 10.1002/cam4.2654. Epub 2019 Oct 30.
Wu Ziping,Zhang Lei,Peng Jing,Xu Shuguang,Zhou Liheng,Lin Yanpin,Wang Yan,Lu Jinglu,Yin Wenjin,Lu Jinsong （通讯作者） Predictive and prognostic value of PDL1 protein expression in breast cancer patients in neoadjuvant setting. Cancer Biol Ther 2019 2019, 20(6):941-947.
Wu Ziping,Zhang Lei,Xu Shuguang,Lin Yanping,Yin Wenjin,Lu Jinglu,Sha Rui,Sheng Xiaonan,Zhou Liheng,Lu Jinsong （通讯作者） Predictive and prognostic value of ZEB1 protein expression in breast cancer patients with neoadjuvant chemotherapy. Cancer Cell Int 2019 2019, 19:78.
Yaohui Wang, Haofeng Wang, Wenjin Yin, Yanping Lin, Liheng Zhou, Xiaonan Sheng, Yaqian Xu, Rui Sha, Jinsong Lu （通讯作者） Novel lymphocyte to red blood cell ratio (LRR), neutrophil to red blood cell ratio (NRR), monocyte to red blood cell ratio (MRR) as predictive and prognostic biomarkers for locally advanced breast cancer Gland Surg. 2019 2019 Dec; 8(6): 627–635. doi: 10.21037/gs.2019.10.10
Wang X, Peng J, Yang Z, Zhou PJ, An N, Wei L, Zhu HH, Lu J （通讯作者）, Fang YX, Gao WQ. Elevated expression of Gab1 promotes breast cancer metastasis by dissociating the PAR complex. J Exp Clin Cancer Res. 2019 2019 Jan 21;38(1):27. doi: 10.1186/s13046-019-1025-2.
Du Y, Lin Y, Yin K, Zhou L, Jiang Y, Yin W, Lu J. （通讯作者） Single nucleotide polymorphisms of let-7-related genes increase susceptibility to breast cancer. Am J Transl Res. 2019 2019;11:1748–59.
Battseren Bayarmaa, Ziping Wu, Jing Peng, Yan Wang, Shuguang Xu, Tingting Yan, Wenjin Yin, Jinsong Lu （通讯作者）, Liheng Zhou Association of LncRNA MEG3 Polymorphisms With Efficacy of Neoadjuvant Chemotherapy in Breast Cancer BMC Cancer 2019 2019 Sep 5;19(1):877. doi: 10.1186/s12885-019-6077-3.
Yaohui Wang, Bayarmaa Battseren, Wenjin Yin, Yanping Lin, Liheng Zhou, Fan Yang, Yan Wang, Lu Sun, and Jinsong Lu （通讯作者） Predictive and prognostic value of prognostic nutritional index for locally advanced breast cancer Gland Surg. 2019 2019 Dec; 8(6): 618–626. doi: 10.21037/gs.2019.10.08
Du Y, Zhou L, Lin Y, Yin K, Yin W, Lu J: （通讯作者） Polymorphisms in microRNA let-7 binding sites of the HIF1AN and CLDN12 genes can predict pathologic complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer. Ann Transl Med 2019 2019, 7(7):138.
Yuan C, Zhou L, Zhang L, Yin K, Peng J, Sha R, Zhang S, Xu Y, Sheng X, Wang Y, Lin Y, Xu S, Yin W, Lu J. （通讯作者） Identification and integrated analysis of key differentially expressed circular RNAs in ER-positive subtype breast cancer. Epigenomics. 2019 2019;11:297–321.
Zhang D, Zhang Q, Suo S, Zhuang Z, Li L, Lu J （通讯作者）, Hua J. Apparent diffusion coefficient measurement in luminal breast cancer: will tumour shrinkage patterns affect its efficacy of evaluating the pathological response? Clin Radiol. 2018 2018 Oct;73(10):909.e7-909.e14. doi: 10.1016/j.crad.2018.05.026. Epub 2018 Jun 30.
Wang Y, Weng X, Wang L, Hao M, Li Y, Hou L, Liang Y, Wu T, Yao M, Lin G, Jiang Y, Fu G, Hou Z, Meng X, Lu J （通讯作者）, Wang J. HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk. J. Clin. Invest. 2018 2018;128:5235–50.
Wu Z, Xu S, Zhou L, Yin W, Lin Y, Du Y, Wang Y, Jiang Y, Yin K, Zhang J, Lu J （通讯作者） Clinical significance of quantitative HER2 gene amplification as related to its predictive value in breast cancer patients in neoadjuvant setting. OncoTargets and Therapy 2018 2018;11:801–8.
Sun J, Hu Q, Peng H, Peng C, Zhou L, Lu J （通讯作者）, Huang C. The ubiquitin-specific protease USP8 deubiquitinates and stabilizes Cx43. J Bio Chem. 2018 2018;293:8275–84.
Zhou L, Xu S, Yin W, Lin Y, Du Y, Jiang Y, Wang Y, Zhang J, Wu Z, Lu J （通讯作者） Weekly paclitaxel and cisplatin as neoadjuvant chemotherapy with locally advanced breast cancer: a prospective, single arm, phase II study Oncotarget 2017 2017 May 17. doi: 10.18632/oncotarget.17954. [Epub ahead of print]
Yin K, Yin W, Wang Y, Zhou L, Liu Y, Yang G, Wang J, Lu J （通讯作者） MiR-206 suppresses epithelial mesenchymal transition by targeting TGF-beta signaling in estrogen receptor positive breast cancer cells Oncotarget 2016 7:24537-48
Zhou Q, Jiang Y, Yin W, Wang Y, Lu J （通讯作者） Single-nucleotide polymorphism in microRNA-binding site of SULF1 target gene as a protective factor against the susceptibility to breast cancer: a case-control study OncoTargets and therapy 2016 9:2749-57.
Zhou Q, Yin W, Du Y, Shen Z, Lu J. （通讯作者） Prognostic impact of chemotherapy-induced amenorrhea on premenopausal breast cancer: a meta-analysis of the literature. Menopause. 2015 2015;22(10):1091-7.
Yin K, Zhou L, Shao Z, Yin W, Lu J. （通讯作者） Clinical significance of locoregional and systemic treatment in operable high-risk breast cancer patients with more than four positive axillary lymph nodes. OncoTargets and therapy. 2015 2015;8:2665-73.
Liu Y, Wang Y, Zhou L, Yin K, Yin W, Lu J. （通讯作者） Prognostic effect of menstrual cycle on timing of surgery in premenopausal breast cancer patients. Am J Surg. 2015 2015;210(3):506-11.
Zhou Q, Yin W, Du Y, Lu J* （通讯作者） For or against adjuvant trastuzumab for pT1a-bN0M0 breast cancer patients with HER2-positive tumors: a meta-analysis of published literatures PLoS One 2014 9(1):e83646
Du Y, Zhou L, Wang Y, Yan T, Jiang Y, Shao Z, Yin W,Lu J. （通讯作者） Association of alpha2a and beta2 adrenoceptor expression with clinical outcome in breast cancer. Curr Med Res Opin. 2014 30(7):1337-44.
Wang Y, Liu Y, Du Y, Yin W*, Lu J* （通讯作者） The predictive role of phosphatase and tensin homolog (PTEN) loss, phosphoinositol-3 (PI3) kinase (PIK3CA) mutation, and PI3K pathway activation in sensitivity to trastuzumab in HER2-positive breast cancer: a meta-analysis Curr Med Res Opin 2013 29(6):633-642
Liu Y, Yin W, Yan T, Du Y, Shao Z, Lu J* （通讯作者） The clinical significance of Ki-67 as a marker of prognostic value and chemosensitivity prediction in hormone-receptor-positive breast cancer: a meta-analysis of the published literature Curr Med Res Opin 2013 29:1453-61
Yan T, Yin W, Zhou Q, Zhou L, Jiang Y, Du Y, Shao Z, Lu J* （通讯作者） The efficacy of zoledronic acid in breast cancer adjuvant therapy: a meta-analysis of randomised controlled trials Eur J Cancer 2012 48(2):187-195
Jiang Y, Yin W, Zhou L, Yan T, Zhou Q, Du Y, Shen Z, Shao Z, Lu J* （通讯作者） First efficacy results of capecitabine with anthracycline- and taxane-based adjuvant therapy in high-risk early breast cancer: a meta-analysis PloS one 2012 7(3):e32474
Lin YP, Yin WJ, Yan TT, Zhou LH, Di GH, Wu J, Shen ZZ, Shao ZM, Lu JS* （通讯作者） Risk factors for postoperative seromas in Chinese breast cancer patients Chin Med J (Engl) 2011 124(9):1300-1304
Du Y, Zhou Q, Yin W, Zhou L, Di G, Shen Z, Shao Z, Lu J* （通讯作者） The role of topoisomerase IIalpha in predicting sensitivity to anthracyclines in breast cancer patients: a meta-analysis of published literatures Breast Cancer Res Treat 2011 129(3):839-848
Yin W, Jiang Y, Shen Z, Shao Z, Lu J* （通讯作者） Trastuzumab in the adjuvant treatment of HER2-positive early breast cancer patients: a meta-analysis of published randomized controlled trials PloS one 2011 6(6):e21030
Zhou L, Yan T, Jiang Y, Di G, Shen Z, Shao Z, Lu J* （通讯作者） Prognostic and predictive value of TFF1 for adjuvant endocrine therapy in Chinese women with early ER positive breast cancer: comparing aromatase inhibitors with tamoxifen Breast (Edinburgh, Scotland) 2011 20(1):15-20
Yan T, Yin W, Zhou L, Jiang Y, Shen Z, Shao Z, Lu J. （通讯作者） Postoperative fever: the potential relationship with prognosis in node negative breast cancer patients. PLoS One. 2010 5(12):e15903.
Yin WJ, Lu JS （共同第一作者）, Di GH, Lin YP, Zhou LH, Liu GY,Wu, J.Shen, K. W.Han, Q. X.Shen, Z. Z. Shao, Z. M. Clinicopathological features of the triple-negative tumors in Chinese breast cancer patients. Breast Cancer Res Treat. 2009 115(2):325-33.
Yin W, Di G, Zhou L, Lu J （通讯作者）, Liu G, Wu J, Shen K,Han Q,ShenZ, Shao Z. Time-varying pattern of recurrence risk for Chinese breast cancer patients. Breast Cancer Res Treat. 2009 114(3):527-35.
Lin Y, Yin W, Yan T, Zhou L, Di G, Wu J, Shen Z,Shao Z, Lu J. （通讯作者） Site-specific relapse pattern of the triple negative tumors in Chinese breast cancer patients. BMC Cancer. 2009 9:342.