导师姓名： 翟博 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属仁济医院 三级学科/
专业领域： 普外
导师类型： 博士生导师 专业学位导师： 兼
联系方式： zhaiboshi@sina.com
邮编： 200127 邮箱地址： zhaiboshi@sina.com

研究方向 (点击浏览详细信息)
肝脏等实质性脏器良恶性肿瘤介入性微创治疗基础与临床

社会任职
上海市抗癌协会消融治疗专业委员会副主任委员（候任主委）
中国医师协会肿瘤消融技术培训专家组副组长
上海抗癌协会常务理事
上海抗癌协会肿瘤微创治疗专业委员会主任委员
中国研究型医院学会介入医学专业委员会副主任委员
中华医学会放射学会介入分会委员兼肝肿瘤学组副主任委员
中国医师协会介入医师分会肿瘤消融治疗专业委员会副主任委员
中国抗癌协会肿瘤微创治疗专业委员会副主任委员
上海抗癌协会实体肿瘤聚焦诊疗专业委员会副主任委员
世界华人肿瘤医师协会微创与介入专业委员会副主任委员
国际肝胆胰协会中国分会微创介入治疗委员会副主任委员
中国医师协会微无创专业委员会肿瘤学分会副主任委员
亚太影像导引下肿瘤微创治疗协会常务理事
中国研究型医院学会肿瘤介入专业委员会常务委员
中国肿瘤临床学会（CSCO）消融治疗专业委员会副主任委员
中国抗癌协会肿瘤介入学专业委员会肝癌专家委员会常务委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 人肝细胞来源的肝前体样细 胞(HepLPC)通过外泌体传 递 miRNA 调控肝脏再生的 作用及其机制研究 国家自然科学基金 面上项目 2021-01~2024-12 54万元 课题负责人
2020yfc** 数字诊疗装备研发专项：康博刀治疗肝肿瘤的免疫环境重塑及免疫响应临床研究 国家科技部 2020-10~2023-09 183万元 子课题负责人
** 重大专项：新型同位素纳米粒子局部注射治疗原发性肝细胞癌的单臂、开放、前瞻性临床研究 上海市科学技术委员会 2019-09~2022-06 30万元 子课题负责人
18JC** 结肠癌靶向EpCAM1通用型CART细胞治疗研究 上海科学技术委员会 2018-07~2021-07 50万元 课题负责人
2017ZX002 CARgpc3T 细胞与射频及微波消融联合治疗原发性肝癌研究（艾滋病和病毒肝炎等重大传染病防治 国家科技部 2017-01~2020-12 83.29万元 子课题负责人
** 冷循环射频消融系统 上海市科学技术委员会 2016-07~2019-06 200万元 课题负责人
2015BAI21H00 自适应多功能肿瘤微创消融系统研发及产业化 国家科技部 2015-01~2017-07 275万元 子课题负责人
** Toll样受体4信号通路对肝细胞癌射频消融后局部复发和肝内新生的影响及机制研究 国家自然科学基金委员会面上项目 2015-01~2018-12 68万元 课题负责人
14ZZ112 MR设备兼容的无磁射频消融电极的研发和产业化 上海科学技术委员会 2015-01~2017-12 120万元 课题负责人
14ZZ112 TRL4信号通路对肝细胞癌射频消融后局部复发和肝内新生的影响及机制研究 上海市教育委员会 2013-01~2015-12 16万元 课题负责人
** 射频消融激活树突状细胞疫苗治疗兔VX2肝种植瘤的研究 国家自然科学基金委员会面上项目 2011-01~2013-12 28万元 课题负责人
10ZR** 射频消融联合树突状细胞疫苗治疗兔VX2肝种植瘤的研究 上海科学技术委员会 2011-01~2013-12 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Tang Xiaoyin, Li Ping, Lu Bingwei, Ding Min, Lin Yan, Zhai Bo （通讯作者） Double-Needle Lavage for Effective Treatment of Difficult-Aspiration Thyroid Cystic Nodules: A Single-Center Controlled Trial J Vasc Interv Radiol . 2020 S1051-0443
Zhang Y, Huang WJ, Yang QR, Zhang HD, Zhu XJ, Zeng M, Zhou X, Wang ZY, Li WJ, Jing HS, Zhang XB, Shi YP, Hu H, Yan HX, Li ZH, Zhai B （通讯作者） Cryopreserved biopsy tissues of rectal cancer liver metastasis for assessment of anticancer drug response in vitro and in vivo. Oncol Rep. 2020 43(2):405-414
Shi D, Shi Y, Kaseb AO, Qi X, Zhang Y, Chi J, Lu Q, Gao H, Jiang H, Wang H, Yuan D, Ma H, Wang H, Li Z, Zhai B. （通讯作者） Chimeric Antigen Receptor-Glypican-3 T-Cell Therapy for Advanced Hepatocellular Carcinoma: Results of Phase 1 Trials. Clin Cancer Res 2020 26(15):3979-3989
Shen Y, Cheng CS, Wang P, Zhu X, Lei G, Fang Y, Li H, Fan W, Pan H, Tang Z, Ma K, Li X, Lin Z, Zhuang Y, Ye X, Zhai B, Han Y, Huang J, Xu H, Zheng R, Chen R, Yu J, Xu D, Wang Z, Meng Z. CSCO Ablation Expert Workshop Report: Recommendations for the Management of Tumor Ablation During the Coronavirus Disease 2019 Epidemic J Cancer Res Ther 2020 16(2):350-355
Hao Hu, Bo Zhai （通讯作者）, Rong Liu, Jia Chang Chi Microwave Ablation Versus Wedge Resection for Stage I Non-small Cell Lung Cancer Adjacent to the Pericardium: Propensity Score Analyses of Long-term Outcomes Cardiovasc Intervent Radiol . 2020 Online ahead of print.
Wang X, Xie W, Gan S, Wang T, Chen X, Su D, Sun J, Lin J, Wu F, Xu P, Miao C, Yan M, Zhu S, Zhai B, Sun Y, Yu W, Tian J. Effects of general anesthesia versus local anesthesia in primary hepatocellular carcinoma patients presenting for thermal ablation surgery: a multiple center retrospective cohort study with propensity score matching. Ann Transl Med. 2020 8(6):277
Shi Y, Wang Z, Chi J, Shi D, Wang T, Cui D, Lin Y, Zhai B. （通讯作者） Long-term results of percutaneous microwave ablation for colorectal liver metastases HPB (Oxford) 2020 16:S1365-182X(20)30131-3.
Lin Y, Li P, Shi YP, Tang XY, Ding M, He Y, Zhai B （通讯作者） Sequential treatment by polidocanol and radiofrequency ablation of large benign partially cystic thyroid nodules with solid components: Efficacy and safety Diagn Interv Imaging. 2020 101(6):365-372
Li WJ, Zhu XJ, Yuan TJ, Wang ZY, Bian ZQ, Jing HS, Shi X, Chen CY, Fu GB, Huang WJ, Shi YP, Liu Q, Zeng M, Zhang HD, Wu HP, Yu WF, Zhai B （通讯作者）, Yan HX. An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs Sci Transl Med 2020 12(551):eaba5146
Yaoping Shi, Jingjing Song, Min Ding, Xiaoyin Tang, Zhi Wang, Jiachang Chi, Tao Wang, Jiansong Ji, Bo Zhai （通讯作者） Microwave ablation versus transcatheter arterial embolization for large hepatic hemangiomas: clinical outcomes Int J Hyperthermia 2020 37(1):938-943
Ding M, Zhao X, Zhao M, Shi Y, Wang T, Cui D, Shi D, Zhai B （通讯作者） Prognostic Nomogram for Patients with Hepatocellular Carcinoma After Thermal Ablation. Cardiovasc Intervent Radiol. 2020 Online ahead of print.
Wang H, Cao C, Wei X, Shen K, Shu Y, Wan X, Sun J, Ren X, Dong Y, Liu Y, Zhai B （通讯作者） A Comparison Between Drug-Eluting Bead-Transarterial Chemoembolization and Conventional Transarterial Chemoembolization in Patients With Hepatocellular Carcinoma: A Meta-Analysis of Six Randomized Controlled Trials J Cancer Res Ther 2020 16(2):243-249
Wang YG, Wang T, Ding M, Xiang SH, Shi M, Zhai B （通讯作者） hsa_circ_** acts as a ceRNA to suppress hepatocellular cancer progression by sponging hsa-miR-1307 Cancer Lett. 2019 28;460:128-138
Guangxin Jin,Yaying Li,Feng Zhang,Peicheng Li,Liangcai Zhao,Yiming Zhou,Hongxiu Ji,Sean Pietrini,Bo Zhai （通讯作者）, and Xiaoming Yang Epithelial ovarian cancer: feasibility of image-guided intratumoral radiofrequency hyperthermia-enhanced direct gene therapy Am J Cancer Res. 2019 9(2): 378–389
Wang H, Liu Y, Shen K, Dong Y, Sun J, Shu Y, Wan X, Ren X, Wei X, Zhai B （通讯作者） A comparison between radiofrequency ablation combined with transarterial chemoembolization and surgical resection in hepatic carcinoma: A meta-analysis. J Cancer Res Ther. 2019 15(7):1617-1623
Shi Y, Chi J, Wang T, Cui D, Tang X, Ding M, Li P, Zhai B （通讯作者） Mid-term outcome of percutaneous thermal ablation for intrahepatic recurrent hepatocellular carcinoma after liver transplantation Clin Radiol. 2019 74(9):735.e1-735.e7
Fu GB, Huang WJ, Zeng M, Zhou X, Wu HP, Liu CC, Wu H, Weng J, Zhang HD, Cai YC, Ashton C, Ding M, Tang D, Zhang BH, Gao Y, Yu WF, Zhai B （通讯作者）, He ZY, Wang HY, Yan HX Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens. Cell Res. 2019 29(1):8-22.
Ding M, Tang X, Cui D, Chi J, Shi Y, Wang T, Zhai B （通讯作者）, Li P Clinical outcomes of ultrasound-guided radiofrequency ablation for the treatment of primary papillary thyroid microcarcinoma Clin Radiol 2019 74(9):712-717
Zhen-Yu Wang, Wei-Jian Li, Qi-Gen Li, Hong-Shu Jing, Tian-Jie Yuan, Gong-Bo Fu, Dan Tang, Hong-Dan Zhang, He-Xin Yan, Bo Zhai （通讯作者） A DMSO-free hepatocyte maturation medium accelerates hepatic T differentiation of HepaRG cells in vitro Biomedicine & Pharmacotherapy 2019 116:109010
Wang YG, Wang T, Shi M, Zhai B （通讯作者） Long noncoding RNA EPB41L4A-AS2 inhibits hepatocellular carcinoma development by sponging miR-301a-5p and targeting FOXL1Wang J Exp Clin Cancer Res. 2019 10;38(1):153
Cui D, Ding M, Tang X, Chi J, Shi Y, Wang T, Zhai B （通讯作者）, Li P Efficacy and safety of a combination of hydrodissection and radiofrequency ablation therapy for benign thyroid nodules larger than 2 cm: A retrospective study J Cancer Res Ther. 2019 15(2):386-393
Wang T, Zhang XY, Lu X, Zhai B （通讯作者） Laparoscopic Microwave Ablation of Hepatocellular Carcinoma at Liver Surface: Technique Effectiveness and Long-Term Outcomes Technol Cancer Res Treat 2019 1;18:
Wang Z, Li W, Jing H, Ding M, Fu G, Yuan T, Huang W, Dai M, Tang D, Zeng M, Chen Y, Zhang H, Zhu X, Peng Y, Li Q, Yu WF, Yan HX, Zhai B （通讯作者） Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening. Theranostics 2019 18;9(22):6690-6705
Ding M, Ma S, Tang X, Wang T, Qi X, Chi J, Wang Z, Cui D, Shi Y, Zhang Y, Li P, Zhai B （通讯作者） Oliguric acute kidney injury after microwave ablation of large liver tumors: incidence and preventive measures Int J Hyperthermia. 2019 35(1):141-149
Zhang Y, Ding M, Chi JC, Wang T, Shi YP, Zhai B （通讯作者） The early evaluation of ultrasound-guided iodine-125 interstitial implants for high-risk hepatocellular carcinoma. Brachytherapy 2019 18(5):733-739
Tang X, Ding M, Lu B, Chi J, Wang T, Shi Y, Wang Z, Cui D, Li P, Zhai B （通讯作者） Outcomes of ultrasound-guided percutaneous microwave ablation versus surgical resection for symptomatic large hepatic hemangiomas Int J Hyperthermia 2019 36(1):632-639
Xiaoyin T, Ping L, Dan C, Min D, Jiachang C, Tao W, Yaoping S, Zhi W, Bo Z. （通讯作者） Risk Assessment and Hydrodissection Technique for Radiofrequency Ablation of Thyroid Benign Nodules. J Cancer. 2018 9(17):3058-3066
Hu H, Chen GF, Yuan W, Wang JH, Zhai B （通讯作者） Microwave ablation with chemoembolization for large hepatocellular carcinoma in patients with cirrhosis. Int J Hyperthermia 2018 34(8):1351-1358
Chi J, Ding M, Shi Y, Wang T, Cui D, Tang X, Li P, Zhai B. （通讯作者） Comparison study of computed tomography-guided radiofrequency and microwave ablation for pulmonary tumors: A retrospective, case-controlled observational study. Thorac Cancer 2018 9(10):1241-1248
Shen X, Ma S, Tang X, Wang T, Qi X, Chi J, Wang Z, Cui D, Zhang Y, Li P, Zhai B （通讯作者） Clinical outcome in elderly Chinese patients with primary hepatocellular carcinoma treated with percutaneous microwave coagulation therapy (PMCT): A Strobe-compliant observational study. Medicine (Baltimore) 2018 97(35):e11618
Xiaoyin T, Ping L, Dan C, Min D, Jiachang C, Tao W, Yaoping S, Zhi W, Bo Z （通讯作者） Risk Assessment and Hydrodissection Technique for Radiofrequency Ablation of Thyroid Benign Nodules J Cancer 2018 9(17):3058-3066
Wang Z, Tang X, Qi X, Shi Y, Chi J, Li P, Zhai B （通讯作者） Feasibility, safety, and efficacy of ultrasound-guided percutaneous microwave ablation for giant hepatic hemangioma Int J Hyperthermia 2018 2018;35(1):246-252
Gao J, Fan RF, Yang JY, Cui Y, Ji JS, Ma KS, Li XL, Zhang L, Xu CL, Kong XL, Ke S, Ding XM, Wang SH, Yang MM, Song JJ, Zhai B, Nin CM, Guo SG, Xin ZH, Lu J, Dong YH, Zhu HQ, Sun WB Radiofrequency ablation for hepatic hemangiomas: A consensus from a Chinese panel of experts. World J Gastroenterol. 2017 23(39):7077-7086
Zeng M, Yang QR, Fu GB, Zhang Y, Zhou X, Huang WJ, Zhang HD, Li WJ, Wang ZY, Yan HX, Zhai B. （通讯作者） Maintaining viability and characteristics of cholangiocarcinoma tissue by vitrification-based cryopreservation. Cryobiology 2017 21;12(9):e**
Wang T, Ma S, Qi X, Tang X, Cui D, Wang Z, Chi J, Li P, Zhai B （通讯作者） Knockdown of the differentially expressed gene TNFRSF12A inhibits hepatocellular carcinoma cell proliferation and migration in vitro. Mol Med Rep. 2017 15(3):1172-1178
Xiaoyin Tang, Dan Cui, Jiachang Chi, Zhi Wang, Tao Wang, Bo Zhai （通讯作者）, Ping Li. Evaluation of the safety and efficacy of radiofrequency ablation for treating benign thyroid nodules Journal of Cancer 2017 8(5):754-760
Dan Cui, Zhi Wang, Tao Wang, Xiaoyin Tang, Bo Zhai （通讯作者） Low expression level of Dickkopf 4 in hepatocellular carcinoma and its clinical significance Int J Clin Exp Pathol 2017 10(1):760-769
Shi Y, Wang J, Bai Z, Li Y, Qiu L, Zhai B, Zhang F, Yang X. Radiofrequency hyperthermia-enhanced herpes simplex virus-thymidine kinase/ganciclovir direct intratumoral gene therapy of esophageal squamous cancers Am J Cancer Res. 2016 6(9): 2054–2063.
Ding M, Wang Y, Chi J, Wang T, Tang X, Cui D, Qian Q, Zhai B （通讯作者） Is Adjuvant Cellular Immunotherapy Essential after TACE-Predominant Minimally-Invasive Treatment for Hepatocellular Carcinoma? A Systematic Meta-Analysis of Studies Including 1774 Patients. PLoS One. 2016 11(12):e**.
Wang T, Ma S, Qi X, Tang X, Cui D, Wang Z, Chi J, Li P, Zhai B. （通讯作者） Long noncoding RNA ZNFX1-AS1 suppresses growth of hepatocellular carcinoma cells by regulating the methylation of miR-9. Onco Targets Ther 2016 12(9):5005-14
Wang T, Xia L, Ma S, Qi X, Li Q, Xia Y, Tang X, Cui D, Wang Z, Chi J, Li P, Feng YX, Xia Q, Zhai B. （通讯作者） Hepatocellular carcinoma: thyroid hormone promotes tumorigenicity through inducing cancer stem-like cell self-renewal Sci Rep. 2016 2016 ;6:25183
Ma S, Ding M, Li J, Wang T, Qi X, Shi Y, Ming Y, Chi J, Wang Z, Tang X, Cui D, Zhang Y, Zhai B. （通讯作者） Ultrasound-guided percutaneous microwave ablation for hepatocellular carcinoma: clinical outcomes and prognostic factors. J Cancer Res Clin Oncol. 2016 2017;143(1):131-142
Shi Y, Zhai B （通讯作者） A Recent Advance in Image-Guided Locoregional Therapy for Hepatocellular Carcinoma. Gastrointest Tumors. 2016 3(2):90-102
Wang T, Lu XJ, Chi JC, Ding M, Zhang Y, Tang XY, Li P, Zhang L, Zhang XY, Zhai B （通讯作者） Microwave ablation of hepatocellular carcinoma as first-line treatment: long term outcomes and prognostic factors in 221 patients. Sci Rep. 2016 13(6):32728
Li P, Xiao-Yin T, Cui D, Chi JC, Wang Z, Wang T, Qi XX, Zhai B. （通讯作者） Evaluation of the safety and efficacy of percutaneous radiofrequency ablation for treating multiple breast fibroadenoma. J Cancer Res Ther 2016 12:138-142.
Dai H, Cui D, Li D, Zhai BO （通讯作者）, Zhang J Hepatic abscess with hepatobronchial fistula following percutaneous radiofrequency ablation for hepatocellular carcinoma: A case report. Oncol Lett. 2015 9(5):2289-2292
Ye X,Fan W,Chen JH,Feng WJ,Gu SZ,Han Y,Huang GH,Lei GY,Li XG,Li YL,Li ZJ,Lin ZY,Liu BD,Liu Y,Peng ZM,Wang H,Yang WW,Yang X,Zhai B ,Zhang J. Chinese expert consensus workshop report: Guidelines for thermal ablation of primary and metastatic lung tumors Thorac Cancer. 2015 6(1):112-21
Shi D, Zhai B （通讯作者）, Zheng Y, Ren R, Han M, Wang X Transcatheter arterial infusion chemotherapy increases expression level of miR-142-5p in stage III colorectal cancer Indian J Cancer 2015 52(Suppl2):e47-55.
Du J, Li HL, Zhai B （通讯作者）, Chang S, Li FH Radiofrequency Ablation for Hepatocellular Carcinoma: Utility of Conventional Ultrasound and Contrast-enhanced Ultrasound in Guiding and Assessing Early Therapeutic Response and Short-term Follow-up Results. Ultrasound Med Bio 2015 41(9):2400-11
Tang XY, Wang Z, Wang T, Cui D, Zhai B. （通讯作者） Efficacy, safety and feasibility of ultrasound-guided percutaneous microwave ablation for large hepatic hemangioma. J Dig Dis 2014 16(9):525-30
Long XD, Yao JG, Zeng Z, Ma Y, Huang XY, Wei ZH, Liu M, Zhang JJ, Xue F, Zhai B, Xia Q. Polymorphisms in the coding region of X-ray repair complementing group 4 and aflatoxin B1-related hepatocellular carcinoma. Hepatology. 2013 58(1):171-181
Long XD, Zhao D, Wang C, Huang XY, Yao JG, Ma Y, Wei ZH, Liu M, Zeng LX, Mo XQ, Zhang JJ, Xue F, Zhai B, Xia Q. Genetic polymorphisms in DNA repair genes XRCC4 and XRCC5 and aflatoxin B1-related hepatocellular carcinoma. Epidemiology 2013 24(5):671-681
Zhang HL, Yu LX, Yang W, Tang L, Lin Y, Wu H, Zhai B, Tan YX, Shan L, Liu Q, Chen HY, Dai RY, Qiu BJ, He YQ, Wang C, Zheng LY, Li YQ, Wu FQ, Li Z, Yan HX, Wang HY. Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats. J Hepatol. 2012 57(4):803-812
Guo WX, Zhai B （共同第一作者）, Lai EC, Li N, Shi J, Lau WY, Wu MC, Cheng SQ Percutaneous radiofrequency ablation versus partial hepatectomy for multicentric small hepatocellular carcinomas: a nonrandomized comparative study. World J Surg. 2010 34(11):2671-2676.
Liu Q, Zhai B （共同第一作者）, Yang W, Yu LX, Dong W, He YQ, Chen L, Tang L, Lin Y, Huang DD, Wu HP, Wu MC, Yan HX, Wang HY Abrogation of local cancer recurrence after radiofrequency ablation by dendritic cell-based hyperthermic tumor vaccine. Mol Ther. 2009 17(12):2049-2057
Zhai B, Yan HX, Liu SQ, Chen L, Wu MC, Wang HY. Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters. World J Gastroenterol. 2008 14(23):3739-3744
Zhai B, Yan HX, Liu SQ, Chen L, Wu MC, Wang HY. Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas. World J Gastroenterol. 2008 14(37):5665-5673
Chen L, Yan HX, Chen J, Yang W, Liu Q, Zhai B, Cao HF, Liu SQ, Wu MC, Wang HY. Negative regulation of c-Myc transcription by pancreas duodenum homeobox-1 Endocrinology 2007 148(5):2168-2180
Yan HX, Yang W, Zhang R, Chen L, Tang L, Zhai B, Liu SQ, Cao HF, Man XB, Wu HP, Wu MC, Wang HY. Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion. J Biol Chem 2006 281(22):15423-15433