导师姓名： 谭蔚泓 专业代码： 100214
性别： 男 专业名称： 肿瘤学
培养单位： 附属仁济医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市浦东新区浦建路160号10号楼
邮编： 200127 邮箱地址： tan@hnu.edu.cn

研究方向 (点击浏览详细信息)
影像诊断、靶向治疗、核酸纳米技术

社会任职
国家自然科学基金委化学部咨询委员会委员
湖南省科协副主席
SCIENCE CHINA Chemistry 副主编
美国化学会JACS杂志副主编
教育部科技委员会委员
湖南省院士联谊会会长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
YGJCQT200002 家庭简易式新型冠状病毒感染自查技术与试剂盒 校级/上海交通大学各类基金 2020-02~2021-01 100万元 课题负责人
2020YFC** 新型冠状病毒（2019-nCov）核酸现场快速检测设备及试剂的研发 科技部国家重点研发计划 2020-02~2020-04 100万元 课题负责人
** 功能核酸单轮筛选科学装置 国家自然科学基金委 2019-01~2023-12 865.6万元 课题负责人
** 化学生物传感的分析化学基础研究 国家自然科学基金创新研究群体项目 2016-01~2018-12 600万元 课题负责人
** 多波长荧光互相关光谱仪（FCCS）研制 国家自然科学基金仪器专项 2014-01~2017-12 350万元 课题负责人
** 化学生物传感的分析化学基础研究 国家自然科学基金创新研究群体项目 2013-01~2015-12 600万元 课题负责人
2011YQ** PERS仪器在细胞及生物体系检测中的应用 科技部国家重大科学仪器设备开发专项 2011-10~2015-09 287.43万元 子课题负责人
2011CB911000 基于核酸适配体的蛋白质研究新技术和新方法 科技部重大科学研究计划 2011-01~2015-08 2627万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Da Zhang , Youshi Zheng , Ziguo Lin , Xiaolong Liu , Juan Li , Huanghao Yang , Weihong Tan （通讯作者） Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking Aptamers for Enhanced Adoptive Immunotherapy in Solid Tumors Angewandte Chemie, International Edition 2020 59(29):12022-12028
Jiaxuan He , Tianhuan Peng , Yongbo Peng , Lili Ai , Zhengyu Deng , Xue-Qiang Wang , Weihong Tan （通讯作者） Molecularly Engineering Triptolide with Aptamers for High Specificity and Cytotoxicity for Triple-Negative Breast Cancer Journal of the American Chemical Society 2020 142(6):2699-2703
Lei He , Fengming Chen , Dailiang Zhang , Sitao Xie , Shujuan Xu , Zhimin Wang , Lili Zhang , Cheng Cui , Yanlan Liu , Weihong Tan （通讯作者） Transducing Complex Biomolecular Interactions by Temperature-Output Artificial DNA Signaling Networks Journal of the American Chemical Society 2020 142(33):14234-14239
Xu Chang, Chao Zhang, Cheng Lv, Yang Sun, Mingzhi Zhang,Yumeng Zhao, Linlin Yang,Da Han, and Weihong Tan （通讯作者） Construction of a Multiple-Aptamer-Based DNA Logic Device on Live Cell Membranes via Associative Toehold Activation for Accurate Cancer Cell Identification Journal of the American Chemical Society 2019 141:12738?12743
Da Han,Juan Li,Weihong Tan （通讯作者） CRISPR propels a smart hydrogel The DNA hydrogel displays an enhanced response to target nucleic acid sequences SCIENCE 2019 365 (6455):754-755
Lei He, Danqing Lu, Hao Liang, Sitao Xie, Xiaobing Zhang, Qiaoling Liu, Quan Yuan*, Weihong Tan* （通讯作者） A mRNA-initiated, three-dimensional DNA amplifier able to function inside living cells Journal of the American Chemical Society 2018 140: 258-263
Yuan Wu, Liqin Zhang, Cheng Cui, Sena Cansiz, Hao Liang, Cuichen Wu, I-Ting Teng, Weijun Chen, Yuan Liu, Weijia Hou, Xiaobing Zhang*, Weihong Tan* （通讯作者） Enhanced targeted gene transduction: AAV2 vectors conjugated to multiple aptamers via reducible disulfide linkages Journal of the American Chemical Society 2018 140: 2-5
Mingxu You*, Yifan Lvy, Da Han, Liping Qiu, Qiaoling Liu, Tao Chen, Cuichen Wu, Lu Peng, Liqin Zhang, Gang Bao, and Weihong Tan* （通讯作者） DNA probe for monitoring dynamic and transient molecular encounters on live cell membranes Nature Nanotechnology 2018 12: 453-459
Ruowen Wang*, Cheng Jin, Xiaoyan Zhu, Liyi Zhou, Wenjing Xuan, Yuan Liu, Qiaoling Liu and Weihong Tan* Artificial base zT as functional "element" for constructing photoresponsive DNA nanomolecules Journal of the American Chemical Society 2017 139: 9104-9107
Liqin Zhang, Shuo Wan, Ying Jiang, Yanyue Wang, Ting Fu, Qiaoling Liu, Zhijuan Cao, Liping Qiu,Weihong Tan* （通讯作者） Molecular elucidation of disease biomarkers at the interface of chemistry and biology Journal of the American Chemical Society 2017 139: 2532-2540
Huanhuan Fan, Zilong Zhao, Guobei Yan, Xiaobing Zhang, Chao Yang, Hongmin Meng, Hui Liu, Weihong Tan* （通讯作者） A smart DNAzyme-MnO2 nanosystem for efficient gene silencing Angewandte Chemie International Edition 2016 55: 5477-5482
Liqin Zhang, Zunyi Yang,Thu Le Trinh, I-Ting Teng, Sai Wang, Kevin M Bradley, Shuichi Hoshika, Qunfeng Wu, Sena Cansiz, Diane J Rowold, Christopher McLendon, Myong-Sang Kim, Yuan Wu, Cheng Cui, Yuan Liu, Weijia Hou, Kimberly Stewart, Chen Liu*, Steven A. Benner*, Weihong Tan* （通讯作者） Combining Genetic Systems from Synthetic Biology with Cell Engineering and Laboratory Evolution. Aptamers against Glypican 3 Angewandte Chemie, International Edition 2016 55: 12372-12375
Mingxu You, Guizhi Zhu, Tao Chen, Michael J. Donovan and Weihong Tan* Programmable and Multiparameter DNA-based Logic Platform For Cancer Recognition and Targeted Therapy Journal of the American Chemical Society 2015 137: 667-674
Da Han, Cuichen Wu, Mingxu You, Tao Zhang, Shuo Wan, Tao Chen, Liping Qiu, Zheng Zheng, Hao Liang, Weihong Tan* （通讯作者） A cascade reaction network mimicking the basic functional steps of adaptive immune response Nature Chemistry 2015 7: 836-842
Cuichen Wu, Sena Cansiz, Liqin Zhang, I-Ting Teng, Liping Qiu, Juan Li, Yuan Liu, Cuisong Zhou, Rong Hu, Tao Zhang, Cheng Cui, Liang Cui, Weihong Tan* （通讯作者） A Non-enzymatic Hairpin DNA Cascade Reaction Provides High Signal Gain of mRNA Imaging inside Live Cells Journal of the American Chemical Society 2015 137: 4900-4903
Ruowen Wang, Guizhi Zhu, Lei Mei, Yan Xie, Haibin Ma, Mao Ye, Fengling Qing, Weihong Tan* （通讯作者） Automated modular synthesis of aptamer-drug conjugates for targeted drug delivery Journal of the American Chemical Society 2014 136: 2731-2734
Liyi Zhou, Qianqian Wang, Xiaobing Zhang, Yifan Lv, Guojiang Mao, Aili Luo, Yongxiang Wu, Yuan Wu, Jing Zhang, Weihong Tan* （通讯作者） Molecular engineering of a TBET-based two-photon fluorescent probe for ratiometric imaging of living cells and tissues Journal of the American Chemical Society 2014 136: 9838-9841
Guizhi Zhu, Jing Zheng, Erqun Song, Michael Donovan, Kejing Zhang, Chen Liu, Weihong Tan* （通讯作者） Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics Proceedings of the National Academy of Sciences of the United States of America 2013 110: 7998-8003
Dihua Shangguan, Ying Li, Zhiwen Tang, Zehui Charles Cao, Hui William Chen, Prabodhika Mallikaratchy, Kwame Sefah, Chaoyong James Yang, Weihong Tan* （通讯作者） Aptamers evolved from live cells as effective molecular probes for cancer study Proceedings of the National Academy of Sciences of the United States of America 2006 103: 11838-11843
Weihong Tan, Zhongyou Shi, Steve Smith, Duane Birnbaum, Raoul Kopelman* Submicrometer intracellular chemical optical fiber sensors Science 1992 258(5083): 778-781