导师姓名： 陈源文 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属新华医院 三级学科/
专业领域： 消化系病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市杨浦区控江路1665号新华医院消化内科shsmus@263.net
邮编： 200092 邮箱地址： shsmus@263.net

研究方向 (点击浏览详细信息)
代谢相关脂肪性肝病及肝纤维化的发病机制与防治

社会任职
中华医学会肝病学分会青年委员会委员
《实用肝脏病杂志》编委
上海市医学会肝病专科分会委员兼秘书
《胃肠病学和肝病学杂志》编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 甘丙肽调控脂肪组织CD11c+巨噬细胞促炎功能改善小鼠肝内细胞免疫失衡和NASH的作用及机制研究 国家自然科学基金面上项目 2020-01~2023-12 53万元 课题负责人
** 脯氨酰内肽酶介导肝细胞脂肪变及中性粒细胞诱导的肝内炎症微环境在小鼠NASH发病中的作用 国家自然科学基金面上项目 2018-01~2021-12 56万元 课题负责人
-10 甘丙肽及其受体调控肝星状细胞生物学行为研究 新疆维吾尔自治区自然科学基金 2012-01~2014-12 10万元 课题负责人
XYQ** 脯氨酰寡肽酶调控肝损伤修复功能研究 上海市卫生局，新优秀青年医学人才计划 2012-01~2014-12 60万元 课题负责人
** 脯氨酰寡肽酶对慢性肝损伤时局部微环境的调节和双重与协同调控损伤修复的作用研究 国家自然科学基金面上项目 2012-01~2015-12 60万元 课题负责人
10PJ** 肝内源性AcSDKP的调控及其肝内生理功能研究 上海市科委，浦江人才计划 2010-07~2013-09 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jiang DX, Zhang JB, Li MT, Lin SZ, Wang YQ, Chen YW （通讯作者）,Fan JG Prolyl endopeptidase gene disruption attenuates high fat diet-induced nonalcoholic fatty liver disease in mice by improving hepatic steatosis and inflammation . Annals of translational medicine 2020 8(5):218
Zhang J, Lin S, Jiang D, Li M, Chen Y （通讯作者）, Li J, Fan J Chronic hepatitis B and non-alcoholic fatty liver disease: Conspirators or competitors? Liver Int 2020 40(3):496-508
Zhou D, Chen YW （共同第一作者）, Zhao ZH, Yang RX, Xin FZ, Liu XL, Pan Q, Zhou H, Fan JG Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression Exp Mol Med 2018 50(12): 157
Li BH, He FP, Yang X, Chen YW （通讯作者）, Fan JG Steatosis induced CCL5 contributes to early-stage liver fibrosis in nonalcoholic fatty liver disease progress Transl Res 2017 180:103-117
Huang YH, Ye TT, Liu CX, Wang L, Chen YW, Dong Y Maternal high-fat diet impairs glucose metabolism, β-cell function and proliferation in the second generation of offspring rats Nutr Metab (Lond) 2017 2;14:67
Zhou D, Pan Q, Shen F, Cao HX, Ding WJ, Chen YW （通讯作者）, Fan JG Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota Sci Rep 2017 7(1):1529
Zhou D, Wang J, Li BH, He LN, Ding YN, Chen YW （通讯作者）, Fan JG Prolyl oligopeptidase attenuates hepatic stellate cell activation through induction of Smad7 and PPAR?γ Exp Ther Med 2017 13(2):780-786
Zhou D, Pan Q, Xin FZ, Zhang RN, He CX, Chen GY, Liu C, Chen YW, Fan JG Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier World J Gastroenterol 2017 23(1):60-75
Zhou D, Pan Q, Liu XL, Yang RX, Chen YW, Liu C, Fan JG Clostridium butyricum B1 alleviates high-fat diet-induced steatohepatitis in mice via enterohepatic immunoregulation J Gastroenterol Hepatol 2017 32(9):1640-1648
He LN, Li ZH, Zhou D, Ding YN, Xu LM, Chen YW （通讯作者）, Fan JG Galanin receptor 2 mediates antifibrogenic effects of galanin on hepatic stellate cells Exp Ther Med 2016 12(5):3375-3380
Zhou D, Li BH, Wang J, Ding YN, Dong Y, Chen YW （通讯作者）, Fan JG Prolyl Oligopeptidase Inhibition Attenuates Steatosis in the L02 Human Liver Cell Line PLoS One 2016 11(10):e**
Ulasova E, Gladden JD, Chen Y, Zheng J, Pat B, Bradley W, Powell P, Zmijewski JW, Zelickson BR, Ballinger SW, Darley-Usmar V, Dell'italia LJ Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overload J Mol Cell Cardiol 2011 50(1):147-156
Chen YW, Pat B, Gladden JD, Zheng J, Powell P, Wei CC, Cui X, Husain A, Dell'italia LJ Dynamic molecular and histopathological changes in the extracellular matrix and inflammation in the transition to heart failure in isolated volume overload Am J Physiol Heart Circ Physiol 2011 300(6):H2251-60
Pat B, Chen Y, Killingsworth C, Gladden JD, Shi K, Zheng J, Powell PC, Walcott G, Ahmed MI, Gupta H, Desai R, Wei CC, Hase N, Kobayashi T, Sabri A, Granzier H, Denney T, Tillson M, Dillon AR, Husain A, Dell'italia LJ Chymase inhibition prevents fibronectin and myofibrillar loss and improves cardiomyocyte function and LV torsion angle in dogs with isolated mitral regurgitation Circulation 2010 122(15):1488-1495
Chen Y, Pat B, Zheng J, Cain L, Powell P, Shi K, Sabri A, Husain A, Dell'italia LJ Tumor necrosis factor-alpha produced in cardiomyocytes mediates a predominant myocardial inflammatory response to stretch in early volume overload J Mol Cell Cardiol 2010 49(1):70-78
Pat B, Killingsworth C, Chen Y, Gladden JD, Walcott G, Powell PC, Denney T, Gupta H, Desai R, Tillson M, Dillon AR, Dell'italia LJ Mast cell stabilization decreases cardiomyocyte and LV function in dogs with isolated mitral regurgitation J Card Fail 2010 16(9):769-776
Chen YW, Liu BW, Zhang YJ, Chen YW, Dong GF, Ding XD, Xu LM, Fan JG, Li DG Preservation of basal AcSDKP attenuates carbon tetrachloride-induced fibrosis in the rat liver J Hepatol 2010 53(3):528-536
Zheng J, Chen Y, Pat B, Dell'italia LA, Tillson M, Dillon AR, Powell PC, Shi K, Shah N, Denney T, Husain A, Dell'Italia LJ Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog Circulation 2009 119(15):2086-2095