导师姓名： 汪希鹏 专业代码： 100211
性别： 男 专业名称： 妇产科学
培养单位： 附属新华医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： wangxipeng@xinhuamed.com.cn
邮编： wangxipeng@xinhuamed.com.cn 邮箱地址： xipengwang@hotmail.com

研究方向 (点击浏览详细信息)
女性生殖系统损伤修复
妇科肿瘤与免疫问题研究
女性肿瘤患者的保留生育功能研究
液态活检用于产前诊断和肿瘤早期筛查的研究

社会任职
《中国实用妇科与产科杂志》编委
美国临床肿瘤学会（American Society of Clinical Oncology, ASCO）正式会员
上海市医学会妇科肿瘤学专科分会第三届委员会 副主任委员
中华妇科肿瘤学会青年委员会副主任委员
《中华妇产科杂志》编委
《现代妇产科进展》编委
国际妇科肿瘤协会（International Society of Gynecologic Cancer, ISGC）正式会员
《 Journal of Gynecologic Oncology》编委
上海市疾控中心妇科肿瘤防治委员会副主任委员
《国外医学－妇幼保健分册》特约编委
《中国妇产科临床杂志》青年编委
《国际妇产科学杂志》编委
《International Journal of Gynecologic Cancer》特约审稿
中国国际医疗保健促进会青年委员会副主任委员
上海市抗癌协会妇科肿瘤分会会员
《Gynecologic Oncology》特约审稿

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2020YFC** 增龄相关主要器官健康状况的调控和临床干预策略，子课题三： 结合非人灵长类动物模型建立促进组织再生及延缓器官衰老新技术 国家重点研发计划“主动健康和老龄化科技应对”专项 2020-07~2023-06 298万元 子课题负责人
** 特异性外泌体的功能机制及其作为新型肿瘤标志物在卵巢癌精准检验中 的应用研究 国家自然科学基金重点项目 2020-01~2024-12 295万元 课题负责人
** TEMs调控上皮性卵巢癌lnc-CTSLP8-PKM2通路异常激活促进腹膜转移的机制研究 国家自然科学基金面上项目 2019-01~2022-12 57万元 课题负责人
** 基于尿液外泌体分子差异用于上皮性卵巢癌病情监测和预后评估的临床应用研究 市科委医学引导类科技支持项目 2017-05~2020-06 20万元 课题负责人
2016CR4028A 探索剖宫产后子宫切口憩室适宜诊断方法和有效手术治疗的研究 常见疾病适宜技术研发与推广应用项目 2016-12~2018-11 15万元 课题负责人
** 一种治疗剖宫产后子宫切口憩室的新型手术及其规范化推广研究 上海市科委医学引导类 2015-07~2018-09 30万元 课题负责人
** 血小板微粒通过诱导巨噬细胞分化和极化参与形成上皮性卵巢癌腹膜免疫缺陷的研究细胞分化和极化参与形成上皮性卵巢癌腹膜免疫缺陷的研究 上海市卫计委重点 2014-01~2016-12 10万元 课题负责人
** 血小板微粒通过诱导巨噬细胞分化和极化参与形成上皮性卵巢癌腹膜免疫缺陷的研究 国家自然科学基金面上项目 2013-01~2017-12 80万元 课题负责人
XBR** 凝血酶通过诱导EMT促进上皮性卵巢癌腹膜转移的研究上皮性卵巢癌腹膜转移的 上海市卫生系统新**** 2011-11~2014-10 50万元 课题负责人
** Tie2+单核细胞通过作用于内皮细胞调控上皮性卵巢癌腹膜转移灶血管生成机制研究内皮细胞调控上皮性卵巢癌腹膜转移灶血管生成机制研究 国家自然科学基金面上项目 2011-01~2013-12 32万元 课题负责人
PW2010D-5 复发性卵巢癌靶向治疗的信息芯片制备初探信息芯片制备初探 上海市浦东新区重点合作课题 2010-08~2013-08 15万元 课题负责人
0 指导卵巢癌个体靶向治疗的分子标志体系建立的分子标志体系建立 上海市科委课题 2010-01~2013-03 10万元 课题负责人
09ZZ113 肿瘤相关巨噬细胞－内皮细胞相互作用对卵巢癌腹膜转移的生物学行为研究 上海市教委 2009-01~2011-12 15万元 课题负责人
** 激活的凝血因子－肿瘤相关巨噬细胞对卵巢癌腹膜转移生物学行为影响研究 国家自然基金委,面上项目 2007-01~2009-12 22万元 课题负责人
06qh14010 激活的凝血因子-肿瘤相关巨噬细胞对卵巢癌腹膜转移生物学行为的研究 上海市科委,启明星 2006-10~2009-09 15万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Xiaoduan Li , Meiling Tang , Qinyi Zhu , Xinjing Wang , Yingying Lin , Xipeng Wang （通讯作者） The exosomal integrin α5β1/AEP complex derived from epithelial ovarian cancer cells promotes peritoneal metastasis through regulating mesothelial cell proliferation and migration Cellular Oncology 2020 2020 Apr;43(2):263-277
Huizhen Sun , Husheng Wang , Xue Wang , Yoichi Aoki , Xinjing Wang , Yufei Yang , Xi Cheng , Ziliang Wang , Xipeng Wang （通讯作者） Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells Theranostics 2020 2020 May 25;10(15):6928-6945
Xiaocui Zheng , Xiaoduan Li , Xipeng Wang （通讯作者） Extracellular vesicle-based liquid biopsy holds great promise for the management of ovarian cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2020 2020 Jul 19;1874(1):188395
Rong Sheng , Xiaoduan Li , Ziliang Wang , Xipeng Wang （通讯作者） Circular RNAs and their emerging roles as diagnostic and prognostic biomarkers in ovarian cancer Cancer Letters 2020 2020 Mar 31;473:139-147
Xin Chen , Xiaoduan Li , Xinjing Wang , Qinyi Zhu , Xiaoli Wu , Xipeng Wang （通讯作者） MUC16 impacts tumor proliferation and migration through cytoplasmic translocation of P120-catenin in epithelial ovarian cancer cells: an original research BMC Cancer 2019 2019 Feb 22;19(1):171.
Yizhi Wang , Qinyi Zhu , Feikai Lin , Li Xie , Jiarui Li , Xipeng Wang （通讯作者） Development and internal validation of a Nomogram for preoperative prediction of surgical treatment effect on cesarean section diverticulum BMC Womens Health 2019 2019 Nov 11;19(1):136
Zhou Jieru , Li Xiaoduan , Wu Xiaoli , Zhang Ting, Zhu Qinyi, WangXinjing, Wang Husheng, Wang Kai, Lin Yingying , Wang Xipeng （通讯作者） Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer Cancer Immunology Research 2018 2018.12, 6(12): 1578~1592
Jiang Li , Fang Xuhong, Wang Hong, Li Diyou, Wang Xipeng （通讯作者） Ovarian Cancer-Intrinsic Fatty Acid Synthase Prevents Anti-tumor Immunity by Disrupting Tumor-Infiltrating Dendritic Cells Frontiers in Immunology 2018 2018.12.14, 9:0~2927
Chen Xin , Zhou Jieru ,Li Xiaoduan ,Wang Xinjing,Lin Yingying ,Wang Xipeng （通讯作者） Exosomes derived from hypoxic epithelial ovarian cancer cells deliver microRNAs to macrophages and elicit a tumor-promoted phenotype Cancer Letters 2018 2018, 435: 80~91
Zhou X, Yao M, Zhou J, Tan W, Wang H, Wang X （通讯作者） Defect width: the prognostic index for vaginal repair of cesarean section diverticula Archives of Gynecology and Obstetrics 2017 295(3):623-630
Yao M, Wang W, Zhou J, Sun M, Zhu J, Chen P, Wang X （通讯作者） Cesarean section scar diverticulum evaluation by saline contrast-enhanced magnetic resonance imaging: The relationship between variable parameters and longer menstrual bleeding Journal of obstetrics and gynaecology research 2017 43(4):696-704
Chen X, Ying X, Wang X, Wu X, Zhu Q, Wang X （通讯作者） Exosomes derived from hypoxic epithelial ovarian cancer deliver microRNA-940 to induce macrophage M2 polarization Oncology reports 2017 38(1):522-528
Chen H,Zhou J,Wang H,Tan W,Yao M,Wang X （通讯作者） The Treatment of Cesarean Scar Pregnancy with Uterine Artery Embolization and Curettage as Compared to Transvaginal Hysterotomy Eur J Obstet Gynecol Reprod Biol 2017 20;44-49
Qinyi Zhu, Xiaoli Wu, Xiang Ying, Xipeng Wang （通讯作者） The differential distribution of tumor associated macrophages and Treg/Th17 cells in the progression of epithelial malignant and benign ovarian tumor Oncology Letters 2017 13(1):159-166
Quanfeng Wu#, Xiaoli Wu#, Xiang Ying, Qinyi Zhu, Xinjing Wang, Lu Jiang, Xin Chen, Yueqian Wu ,Xipeng Wang （通讯作者） Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA Cancer Cell International 2017 6;17:62
Xiaoduan Li, Xipeng Wang （通讯作者） The emerging roles and therapeutic potential of exosomes in epithelial ovarian cancer Molecular cancer 2017 5;16(1):92
Qinyi Zhu, Xiaoli Wu, Xiang Ying, Xipeng Wang （通讯作者） The expression of Duffy antigen receptor for chemokines by epithelial ovarian cancer attenuates growth potential Oncology letters 2017 13(6):4302-4306
Wang Xinjing , Zhu Qinyi , Lin Yingying , Wu Li, Wu Xiaoli, Wang Kai, He Qizhi, Xu Congjian, Wan Xiaoping, Wang Xipeng （通讯作者） Crosstalk between TEMs and endothelial cells modulates angiogenesis and metastasis via IGF1-IGF1R signalling in epithelial ovarian cancer British Journal of Cancer 2017 2017.10, 117(9): 1371~1382
Qinyi Zhu#, Meiling Tang#, Xipeng Wang （通讯作者） The expression of asparaginyl endopeptidase promotes growth potential in epithelial ovarian cancer cancer biology & therapy 2017 18(4):222-228
Ying X, Wu Q, Wu X, Zhu Q, Wang X, Jiang L, Chen X, Wang X （通讯作者） Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages Oncotarget 2016 7(28):43076-43087
Zhu Qinyi#, Wu Xiaoli#, Wu Yueqian, Xipeng Wang （通讯作者） Interaction between Treg cells and tumor-associated macrophages in the tumor microenvironment of epithelial ovarian cancer Oncology Reports 2016 36(6):3472-3478
XinjingWang, Zhiyuan Dai, Xiaoli Wu, Kai Wang, XipengWang （通讯作者） Distinct RNA transcriptome patterns are potentially associated with angiogenesis in Tie2-expressing monocytes Gene 2016 2016; 580: 1-7
Zhou X, Wang H, Wang X （通讯作者） Preoperative CA125 and fibrinogen in patients with endometrial cancer: a risk model for predicting lymphovascular space invasion Journal of Gynecologic oncology 2016 28(2):e11
Pu Xiaowen,Gu Zhuowei,Wang Xipeng Polymorphisms of the interleukin 6 gene and additional gene-gene interaction contribute to cervical cancer susceptibility in Eastern Chinese women Archives of Gynecology and Obstetrics 2016 294（6）：1305~1310
Zhou J, Yao M, Wang H, Tan W, Chen P, Wang X （通讯作者） Vaginal Repair of Cesarean Section Scar Diverticula that Resulted in Improved Postoperative Menstruation J Minim Invasive Gynecol 2016 23(6):969-78
Yueqian Wu, Huiting Zhu, Jing Sun, Xipeng Wang （通讯作者） Accuracy of frozen section in management and prediction of lymph node metastasis in endometrial GYNECOLOGY AND MINIMALLY INVASIVE THERAPY 2015 4(4),126–131
Wu Yueqian,Dai Zhiyuan, Wang （通讯作者）, Xipeng Hand-assisted laparoscopic surgery and its applications in gynecology GYNECOLOGY AND MINIMALLY INVASIVE THERAPY 2015 2015 5: 12-15
Zhou Lina,Meng Zhenni,Wu Yueqian,Zhu Huiting,Wang Xipeng （通讯作者） Prediction of endometrial carcinogenesis probability while diagnosedas atypical endometrial hyperplasia: A new risk model based on age,ca199 and ca125 assay European Journal of Obstetrics & Gynecology and Reproductive Biology 2014 2014:5-9
Hu J, Liu Z, Wang X （通讯作者） Does tp53 mutation promote ovarian cancer metastasis to omentum by regulating lipid metabolism? Medical hypotheses 2013 81:515-520
Xipeng Wang, Xiaobo Zhao, Kai Wang, et al Interaction of monocytes?macrophages with ovarian cancer cells promotes angiogenesis in vitro Cancer Science 2013 104:516-523
Ma Z, Zhang T, Wang R, Cheng Z, Xu H, Li W, Wang Y, Wang X （通讯作者） Tissue factor-factor viia complex induces epithelial ovarian cancer cell invasion and metastasis through a monocytes-dependent mechanism international journal of gynecological cancer 2011 21:616-624
Wang R, Zhang T, Ma Z, Wang Y, Cheng Z, Xu H, Li W, Wang X （通讯作者） The interaction of coagulation factor xii and monocyte/macrophages mediating peritoneal metastasis of epithelial ovarian cancer Gynecologic oncology 2010 117:460-466
Zhang T, Ma Z, Wang R, Wang Y, Wang S, Cheng Z, Xu H, Jin X, Li W, Wang X （通讯作者） Thrombin facilitates invasion of ovarian cancer along peritoneum by inducing monocyte differentiation toward tumor-associated macrophage-like cells Cancer Immunol Immunother 2010 59:1097-1108
Wang, Xipeng(#),Zhang, Hui,Di, Wen,Li, Weiping Clinical factors affecting the diagnostic accuracy of assessing dilation and curettage vs frozen section specimens for histologic grade and depth of myometrial invasion in endometrial carcinoma Am J Obstet Gynecol 2009 201（2）：194.e1~194.e10
Wang X, Deavers M, Patenia R, Bassett RL Jr, Mueller P, Ma Q, Wang E, Freedman RS Monocyte/macrophage and T-cell infiltrates in peritoneum of patients with ovarian cancer or benign pelvic disease journal of translational medicine 2006 2006;4:30
Xipeng Wang, Ralph S Freedman, Jinsong Liu, Kavanagh. JJ Immunobiology of gestional trophoblastic disease Int J Gynaecol Cancer 2006 2006;16:1-16
Wang X, Fu S, Freedman RS Venous thromboembolism syndrome in gynecological cancer Int J Gynecol Cancer 2006 2006;16 Suppl 1:458-471
WANG X, TANGJITGAMOL S, LIU J, KAVANAGH JJ Response of recurrent uterine high-grade malignant mixed mullerian tumor to letrozole International Journal of Gynecological Cancer 2005 15:1243-1248
Wang X, Wang E, Kavanagh JJ, Freedman RS Ovarian cancer, the coagulation pathway, and inflammation J Transl Med 2005 2005;3:25
Wang X, Huang Z, Di W, Lin Q Comparison of d&c and hysterectomy pathologic findings in endometrial cancer patients Arch Gynecol Obstet 2005 2005;272:136-141