导师姓名： 武健 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： wujian@shsmu.edu.cn
邮编： 200125 邮箱地址： wujian@shsmu.edu.cn

研究方向 (点击浏览详细信息)
lncRNA复合物结构与功能

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
19XD** 少汗性外胚层发育不良相关蛋白质的结构与功能 上海市科委优秀学术带头人计划 2019-05~2022-04 40万元 课题负责人
** CST复合物在维持端粒稳定性中的结构与功能研究 上海市人社局人才发展资金项目 2019-01~2021-12 30万元 课题负责人
** lncRNA-蛋白质复合物的结构与功能 上海交通大学医学院“临床专职科研队伍”人才项目 2018-10~2021-09 100万元 课题负责人
U** CST复合物在维持端粒稳定性中的结构与功能研究 国家自然科学基金委大科学装置联合基金培育项目 2018-01~2020-12 68万元 课题负责人
U** 端粒蛋白质复合体在哺乳动物减数分裂前期的结构和功能研究 国家自然科学基金委联合基金重点支持项目 2017-01~2020-12 285万元 课题参与人
** POT1-TPP1保护端粒单链DNA的 分子机制 国家自然科学基金委青年科学基金项目 2016-01~2018-12 25.2万元 课题负责人
- 端粒单链DNA区域高级结构的分子基础 中国科学院青年创新促进会人才项目 2016-01~2017-12 30万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wang Y#, Chen Y#, Chen J, Wang L, Nie L, Long J, Chang H, Wu J, Huang C*, and Lei M* The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope Nature Communication 2019 10(1): 564
Wan F#, Wang Q#, Tan J#, Tan M, Chen J, Shi S, Lan P*, Wu J* （通讯作者）, and Lei M* Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme Nature Communication 2019 10(1): 2617
Chen H#, Xue J#, Churikov D, Hass EP, Shi S, Lemon LD, Luciano P, Bertuch AA, Zappulla DC, Geli V, Wu J* （通讯作者）, and Lei M* Structural insights into yeast telomerase recruitment to telomeres Cell 2018 172(1-2): 331-343
Wu J#, Niu S#, Tan M#, Huang C, Li M, Song Y, Chen J, Shi S, Lan P*, and Lei M* Cryo-EM structure of the human Ribonuclease P holoenzyme Cell 2018 175(5), 1393-1404
Lan P#, Tan M#, Zhang Y#, Niu S, Qiu S, Chen J, Shi S, Qiu S, Wang X, Peng X, Cai G, Cheng H, Wu J* （通讯作者）, Li G*, and Lei M* Structural insight into precursor tRNA processing by yeast ribonuclease P Science 2018 362(6415), pii: eaat6678
Liu X#, Wei W, Liu Y, Yang X, Wu J, Zhang Y, Zhang Q, Shi T, Du J, Zhao Y, Lei M, Zhou J, Li J, and Wong J* MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300 Cell Discovery 2017 3:17016
Xue J#, Chen H#, Wu J, Takeuchi M, Inoue H, Liu Y, Sun H, Chen Y*, Kanoh J*, and Lei M* Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex Cell Research 2017 27(12): 1503-1520
Long J#, Huang C#, Chen Y, Zhang Y, Shi S, Wu L, Liu Y, Liu C, Wu J* （通讯作者）, and Lei M* Telomeric TERB1-TRF1 interaction is crucial for male meiosis Nature Structural & Molecular Biology 2017 24(12): 1073-1080
Tan R#, Nakajima S, Wang Q, Sun H, Xue J, Wu J, Hellwig S, Zeng X, Yates NA, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B*, and Lan L* Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1 Molecular Cell 2017 65(5): 818-831
Chen C#, Gu P#, Wu J, Chen X, Niu S, Sun H, Wu L, Li N, Peng J, Shi S, Fan C, Huang M, Wong CCL, Gong Q, Kumar-Sinha C, Zhang R, Pusztai L, Rai R, Chang S*, and Lei M* Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer Nature Communication 2017 8:14929
Li Y, Han J, Zhang Y, Cao F, Liu Z, Li S, Wu J, Hu C, Wang Y, Shuai J, Chen J, Cao L, Li D, Shi P, Tian C, Zhang J, Dou Y, Li G*, Chen Y*, and Lei M* Structural basis for activity regulation of MLL family methyltransferases Nature 2016 530(7591): 447-452
Yin J#, Wan B#, Sarkar J#, Horvath K, Wu J, Chen Y, Cheng G, Wan K, Chin P, Lei M*, and Liu Y* Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex Nucleic Acids Research 2016 44(10): 4871-4880
Wan B#, Tang T#, Upton H, Shuai J, Zhou Y, Li S, Chen J, Brunzelle J, Zeng Z, Collins K, Wu J* （通讯作者）, and Lei M* The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex Nature Structural & Molecular Biology 2015 22(12): 1023-1026
Deng W#, Wu J# （共同第一作者）, Wang F#, Kanoh J, Dehe P. Inoue H, Chen J, and Lei M* Fission yeast telomere-binding protein Taz1 is a functional but not a structural counterpart of human TRF1 and TRF2 Cell Research 2015 25(7): 881-884
Zhang Z, Wu J, Lin W, Wang J, Yan H, Zhao W, Ma J, Ding J*, Zhang P*, and Zhao G* Subdomain II of α-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition The Journal of Biological Chemistry 2014 289(40): 27966-27978
Huang J, Brown A, Wu J, Xue J, Bley C, Rand D, Wu L, Zhang R, Chen J*, and Lei M* Structural Basis for Protein-RNA Recognition in Telomerase Nature Structural & Molecular Biology 2014 21(16): 507-512
Wan B#, Yin J#, Horvath K#, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Liu Y*, and Lei M* SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres Cell Reports 2013 4(5): 861-869
Xu S, Wu J, Sun B, Zhong C, and Ding J* Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding Nucleic Acids Research 2011 39(10): 4438-4449
Chang Y, Wu J, Tong XJ, Zhou JQ, and Ding J* Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism Biochemical Journal 2011 433(2): 295-302
Du J, Wu J, Zhang H, Zhang Y, Qiu B, Wu F, Chen Y, Li J, Nan F* , Ding J* , and Li J* Isoquinoline-1,3,4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species The Journal of Biological Chemistry 2008 283(44): 30205-30215
Zhang L, Kong Y, Wu D, Zhang H, Wu J, Chen J, Ding J, Hu L, Jiang H, and Shen X* Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay Protein Science 2008 17(11): 1971-1978
Wu J, Tao Y, Zhang M, Howard M, Gutteridge S*, and Ding J* Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region The Journal of Biological Chemistry 2007 282(30): 22185-22194