导师姓名： 高丰厚 专业代码： 100208
性别： 男 专业名称： 临床检验诊断学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： 上海宝山漠河路280号樟岭大楼312室
邮编： 201900 邮箱地址： fenghougao@163.com

研究方向 (点击浏览详细信息)
肿瘤分子生物学、小分子化合物与肿瘤靶标分子

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 异土木香内酯降解Bcr-Abl蛋白治疗CML的成药性研究 上海市科学技术委员会项目“科技创新行动计划”生物医药领域科技支撑项目 2014-01~2017-12 40万元 课题负责人
13ZZ089 冬凌草甲素靶向TrxR诱导肿瘤细胞凋亡和衰老 上海市教育委员会重点项目 2013-01~2015-12 16万元 课题负责人
** SUMO修饰hnRNP K蛋白在胃癌发生发展中的作用与分子机制 国家自然科学基金面上项目（医学部） 2012-01~2015-12 56万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Liu SL, Gao FH. （通讯作者） SUMO1/sentrin/SMT3 specific peptidase 2 modulates target molecules and its corresponding functions. Biochimie 2018 152:6-13
Liu SL, Liu Z, Zhang LD, Zhu HQ, Guo JH, Zhao M, Wu YL, Liu F, Gao FH. （通讯作者） GSK3β-dependent cyclin D1 and cyclin E1 degradation is indispensable for NVP-BEZ235 induced G0/G1 arrest in neuroblastoma cells. Cell Cycle 2017 6(24):2386-2395
Zhu HQ, Gao FH. （通讯作者） The Molecular Mechanisms of Regulation on USP2's Alternative Splicing and the Significance of Its Products. Int J Biol Sci. 2017 13(12):1489-1496
Lu J, Gao FH （通讯作者） The Molecular Mechanisms and the Role of hnRNP K Protein Post- Translational Modification in DNA Damage Repair Curr Med Chem. 2017 24(6):614-621
Zhang C, Lu J, Zhang QW, Zhao W, Guo JH, Liu SL, Wu YL, Jiang B, Gao FH （通讯作者） USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cells Int J Biochem Cell Biol. 2016 79:209-221
Lu J, Gao FH. （通讯作者） Role and molecular mechanism of heterogeneous nuclear ribonucleoprotein K in tumor development and progression. Biomed Rep. 2016 4(6):657-663
Zhang LD, Liu Z, Liu H, Ran DM, Guo JH, Jiang B, Wu YL, Gao FH. （通讯作者） Oridonin enhances the anticancer activity of NVP-BEZ235 against neuroblastoma cells in vitro and in vivo through autophagy. Int J Oncol 2016 49(2):657-65
Qin D, Wang W, Lei H, Luo H, Cai H, Tang C, Wu Y, Wang Y, Jin J, Xiao W, Wang T, Ma C, Xu H, Zhang J, Gao F （通讯作者）, Wu YL CDDO-Me reveals USP7 as a novel target in ovarian cancer cells Oncotarget. 2016 7(47):77096-77109
Lu J, Guo JH, Tu XL, Zhang C, Zhao M, Zhang QW, Gao FH. （通讯作者） Tiron Inhibits UVB-Induced AP-1 Binding Sites Transcriptional Activation on MMP-1 and MMP-3 Promoters by MAPK Signaling Pathway in Human Dermal Fibroblasts. PLoS One. 2016 11(8):e**
Wei W, Ma C, Cao Y, Yang L, Huang Z, Qin D, Chen Y, Liu C, Xia L, Wang T, Lei H, Yu Y, Huang M, Tong Y, Xu H, Gao F, Zhang J, Wu YL. Identification of H7 as a novel peroxiredoxin I inhibitor to induce differentiation of leukemia cells. Oncotarget. 2016 3873-83
Liu H, Xu XF, Zhao Y, Tang MC, Zhou YQ, Gao FH. （通讯作者） NS-398 promotes pancreatic cancer cell invasion by CD147 and MMP-2 via the activation of P38. Mol Med Rep. 2016 13(3):2208-14.
Zhao W, Tian B, Wu C, Peng Y, Wang H, Gu WL, Gao FH. （通讯作者） DOG1, cyclin D1, CK7, CD117 and vimentin are useful immunohistochemical markers in distinguishing chromophobe renal cell carcinoma from clear cell renal cell carcinoma and renal oncocytoma. Pathol Res Pract. 2015 211(4):303-7.
Qin DJ, Tang CX, Yang L, Lei H, Wei W, Wang YY, Ma CM, Gao FH, Xu HZ, Wu YL. Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells. PLoS One. 2015 10(7):e**.
Yang GL, Tao HR, Wang HW, Sun Y, Zhang LD, Zhang C, He W, Xu MH, Zhao JM, Gao FH. （通讯作者） Ara-C increases gastric cancer cell invasion by upregulating CD-147-MMP-2/MMP?9 via the ERK signaling pathway. Oncol Rep. 2015 33(4):2045-51.
Liu H, Xu XF, Zhao Y, Tang MC, Zhou YQ, Lu J, Gao FH. （通讯作者） MicroRNA-191 promotes pancreatic cancer progression by targeting USP10. Tumour Biol. 2014 35(12):12157-63
Guo YH, Zhang C, Shi J, Xu MH, Liu F, Yuan HH, Wang JY, Jiang B, Gao FH. （通讯作者） Abnormal activation of the EGFR signaling pathway mediates the downregulation of miR?145 through the ERK1/2 in non-small cell lung cancer. Oncol Rep. 2014 31(4):1940-6
He LC #, Gao FH # （共同第一作者）, Xu HZ, Zhao S, Ma CM, Li J, Zhang S, Wu YL. Ikaros inhibits proliferation and, through upregulation of Slug, increases metastatic ability of ovarian serous adenocarcinoma cells. Oncol Rep. 2012 28(4):1399-405
Fang Y, Hu XH, Jia ZG, Xu MH, Guo ZY, Gao FH*. （通讯作者） Tiron protects against UVB-induced senescence-like characteristics in human dermal fibroblasts by the inhibition of superoxide anion production and glutathione depletion. Australas J Dermatol. 2012 53(3):172-80.
郭跃辉,刘立宾,徐芒华,郭竹英,姜斌,李伟,高丰厚. （通讯作者） 生物素标记探 针-液相杂交-非变性PAGE检测非编码小RNA方法的建立和优化 国际检验医学杂志 2012 33(6):645-7.
Feng-Hou Gao, Feng Liu, Wei Wei, Li-Bin Liu, Mang-Hua Xu, Zhu-Ying Guo, Wei Li Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells. Int J Mol Med. 2012 29(4):649-55
Zhao M #, Gao FH # （共同第一作者）, Wang JY, Liu F, Yuan HH, Zhang WY, Jiang B. JAK2/STAT3 signaling pathway activation mediates tumor angiogenesis by upregulation of VEGF and bFGF in non-small-cell lung cancer. Lung Cancer. 2011 73(3):366-74
Zhao M, Jiang B, Gao FH *. （通讯作者） Small Molecule Inhibitors of STAT3 for Cancer Therapy. Curr Med Chem 2011 18(26):4012-8
高丰厚,郭竹英,徐芒华,王世婷. 冬凌草甲素诱导结直肠癌细胞SW- 1116凋亡与衰老的体内外实验研究 上海交通大学学报（医学版） 2010 30(6): 683-8.
Gao F, Tang Q, Yang P, Fang Y, Li W, Wu Y Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells. Int J Lab Hematol. 2010 32(1 Pt 1):e114-22
Gao FH, Hu XH, Li W, Liu H, Zhang YJ, Guo ZY, Xu MH, Wang ST, Jiang B, Liu F, Zhao YZ, Fang Y, Chen FY, Wu YL. Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc. BMC Cancer. 2010 10(1):610
杨鹏高,方勇,郭竹英,徐芒华,王仕婷,高丰厚. （通讯作者） 冬凌草甲素诱导 结肠癌细胞凋亡的机制研究 肿瘤 2009 29(9):842-6.
Gao FH, Wu YL, Zhao M, Liu CX, Wang LS, Chen GQ. Protein Kinase C-δ mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. Exp Cell Res. 2009 315(19):3250-8