导师姓名： 林晓曦 专业代码： 100210
性别： 男 专业名称： 外科学
培养单位： 附属第九人民医院 三级学科/
专业领域： 整形
导师类型： 博士生导师 专业学位导师： 兼
联系方式： linxiaoxi@126.com
邮编： 200011 邮箱地址： linxiaoxi@126.com

研究方向 (点击浏览详细信息)
血管瘤与脉管畸形
面部整形与面部年轻化
激光美容医学
体表肿瘤与胎记

社会任职
《中国美容整形外科杂志》副主编
《中华整形外科杂志》副主编
《组织工程与重建外科》常务编委
《中华医学美学与美容学杂志》执行主编
国家自然科学基金委 终审专家
中华医学会整形外科分会血管瘤和脉管畸形学组组长；面部年轻化学组（筹）副组长
中国整形美容协会微创与皮肤整形美容分会副会长 血管与脉管畸形分会 副会长
上海交通大学医学院教授（二级）
中国抗癌协会第一届肿瘤整形外科专业委员会常务委员
中华医学会医学美学与美容学分会常务委员；美容外科学组组长
中国整形美容协会激光美容分会会长
国际血管瘤与脉管畸形研究学会（ISSVA） active member
美国整形重建外科杂志PRS（Plastic and Reconstructive Surgery） Global Open Associate Editor
中国研究型医院学会整形外科学专业委员会 副主任委员
上海市医学会医学美学与美容学分会前任主任委员
中国康复医学会修复重建外科专业委员会委员
中国医师协会美容与整形医师分会微创抗衰老亚专业委员会执行委员
中国整形美容协会常务理事, 专家委员会 副主任委员
中华医学科技奖评审委员会 委员
中国医师协会微创硬化治疗技术推广委员会委员、介入微创外科学组副组长
World Society for Plastic Surgeons of Chinese Descent Board member
卫生部科技项目评审组 评审专家
《中华外科杂志》通讯编委
《Cosmetic Surgery World Report》专家委员
中华口腔医学会口腔颌面外科专业委员会脉管学组委员
中华医学会医疗鉴定专家库 鉴定专家

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 基于CD90+特异性间充质干细胞构建新型血管瘤动物模型 国自然面上项目 2020-01~2023-12 55万元 课题负责人
九院 复杂血管瘤和脉管畸形生物样本库项目 九院 2019-08~2021-12 150万元 课题负责人
- 2018年高水平地方高校创新团队项目 上海市教育委员会、上海市人力资源和社会保障局、上海市财政局 2018-12~2021-12 150万元 课题负责人
九院 疑难血管血管畸形治疗的关键性问题 研究型MDT课题资助（A档 每年50万元） 2018-01~2020-11 150万元 课题负责人
** FSH是间充质干细胞向血管瘤干细胞转化的关键因素。 国家自然科学基金项目面上科学基金项目 2018-01~2020-12 56万元 课题负责人
16CR1007A 选择性无创激光技术阻抑婴幼儿期静脉畸形的前瞻性、多中心、随机空白对照临床试验 上海市申康临床技能与临床创新三年行动计划 2017-01~2019-06 200万元 课题负责人
17XD** 间充质干细胞转化为血管瘤干细胞相关因素的研究 上海市优秀学术带头人 2017-01~2019-12 40万元 课题负责人
2016 颅外动静脉畸形博来霉素早期干预的前瞻性、多中心、单盲、随机对照临床试验 上海交通大学医学院多中心临床研究项目 2016-09~2020-08 150万元 课题负责人
2016 高选择性无创激光技术阻抑婴幼儿静脉畸形前瞻性、单中心、自身空白对照临床试验 上海交通大学医学院附属第九人民医院临床研究助推计划( 临+计划 ) 2016-09~2018-08 40万元 课题负责人
051 婴幼儿血管瘤普萘洛尔治疗后的复发机制与精准治疗研究 上海领军人才课题 上海市委组织部、人事局 2016-01~2019-12 50万元 课题负责人
** 婴幼儿血管瘤可能来源于间充质干细胞：实验依据及临床 意义 国家自然科学基金委 2016-01~2019-12 58万元 课题负责人
2013ZYJB0014 血管瘤和血管畸形的早期监控和治疗优化研究 上海市卫生系统重要疾病联合攻关项目上海市卫生计生委 2014-01~2017-01 50万元 课题负责人
** 婴幼儿血管瘤普萘洛尔治疗后的复发现象与相关机制研究 国家自然科学基金 2013-01~2016-12 70万元 课题负责人
** 利用同卵双生子模型研究婴幼儿血管瘤的发病机制 国家自然科学基金 2012-01~2015-12 60万元 课题负责人
** 婴幼儿血管瘤血清标志物的寻找、鉴定和临床应用研究 国家自然科学基金 2011-01~2013-12 32万元 课题负责人
[2008]704 全固态激光治疗血管瘤设备（全固态激光器及其应用技术） 国家高技术研究发展计划（863计划） 2009-04~2012-04 263万元 子课题负责人
[2009]7号 动静脉畸形的模型与临床血管内治疗研究 教育部新世纪优秀人才计划 2009-03~2012-03 50万元 课题负责人
血管瘤和血管畸形的早期监控和治疗优化研究 国家卫生公益性行业科研专项经费项目 2008-12~2011-12 198万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Hu L, Chen H, Yang X, Wang Y, Gu H, Liu M, Lin X. （通讯作者） Risk factors associated with pain in patients with venous malformations of the extremities. Vasc Med. 2019 24(1):56-62.
Yu W, Zhu J, Gu Y, Chen Y, Han Y, Shang Y, Chen H, Jin Y, Yang X, Chang L, Ma G, Lin X. （通讯作者） Port-wine stains on the neck respond better to a pulsed dye laser than lesions on the face: An intrapatient comparison study with histopathology J Am Acad Dermatol. 2019 80(3):779-781.
Cai R, Gu H, Liu F, Wang L, Zeng X, Yu W, Zhang X, Liu Y, Ma G, Lin X. （通讯作者） Novel GNAQ mutation(R183G) of Port-wine stains: first case in East Asia. Int J Dermatol. 2019 58(3):e75-e77
Gu Y, Yu W, Jin Y, Chen H, Ma G, Chang SJ, Lin X. （通讯作者） Safety and Efficacy of Cosmetic Augmentation of the Nasal Tip and Nasal Dorsum With Expanded Polytetrafluoroethylene: A Randomized Clinical Trial. JAMA Facial Plast Surg. 2018 1;20(4):277-283.
Ma G, Yu Z, Liu F, Wang L, Yu W, Zhu J, Gu H, Liu Y, Cai R, Lin X （通讯作者） Somatic GNAQ mutation in different structures of port-wine macrocheilia. Br J Dermatol. 2018 179(5):1109-1114.
Hu L, Chen H, Yang X, Liu M, Yan M, Lin X. （通讯作者） Joint dysfunction associated with venous malformations of the limbs: which patients are at high risk? Phlebology. 2018 33(2):89-96
Yu W, Zhu J, Chang SJ, Chen H, Jin Y, Yang X, Wang T, Chang L, Chen Y, Ma G, Lin X. （通讯作者） Shorter treatment intervals of east asians with port-wine stain with pulsed dye laser are safe and effective-a prospective side-by-side comparison. Photomed Laser Surg. 2018 36(1):37-43.
Jin Y, Zou Y, Hua C, Chen H, Yang X, Ma G, Chang L, Qiu Y, Lyu D, Wang T,Chang SJ, Qiao C, Luo C, Tremp M, Lin X. （通讯作者） Treatment of early-stage extracranial arteriovenous malformations with intralesional interstitial bleomycin injection: a Pilot Study. Radiology 2018 287(1):194-204.
Hua C, Wang L, Yang X, Jin Y, Lin X. （通讯作者） Intravascularly disseminated cutaneous angiosarcoma arising in a non-irradiated lymphatic-venous malformation mimicking intravascular lymphoma. Eur J Dermatol. 2018 1;28(4):557-558.
Cai R, Liu F, Cen Q, Yu W, Gong X, Liu Y, Hu X, Ma G, Lin X. （通讯作者） Capillary malformation in the midline of the face: Salmon patch or port-wine stain? J Dermatol. 2018 45(11):e317-e319.
Zou Y, Hu L, Tremp M, Jin Y, Chen H, Ma G, Lin X. （通讯作者） Surgical management of large periorbital cutaneous defects: aesthetic considerations and technique refinements. Ann Plast Surg. 2018 81(6S Suppl 1): S71-S75.
Cai R, Liu F, Hua C, Yu Z, Ramien M, Malic C, Yu W, Zhang X, Liu Y, Jin Y, HuX, Lin X. （通讯作者） A novel RASA1 mutation causing capillary malformation-arteriovenous malformation (CM-AVM): the first genetic clinical report in East Asia. Hereditas. 2018 16;155:24.
Wang T, Chen D, Yang J, Ma G, Yu W, Lin X. （通讯作者） Safety and efficacy of dual-wavelength laser (1064 + 595 nm) for treatment of non-treated port-wine stains. J Eur Acad Dermatol Venereol 2018 32(2): 260-264
Hua C, Jin Y, Yang X, Zou Y, Wang T, Gu H, Qiao C, Zhang Z, Lin X. （通讯作者） Midterm and long-term results of ethanol embolization of auricular arteriovenous malformations as first-line therapy. J Vasc Surg Venous Lymphat Disord. 2018 6(5):626-635.
Hu L, Zou Y, Chang SJ, Qiu Y, Chen H, Gang M, Jin Y, Lin X. （通讯作者） Effects of botulinum toxin on improving facial surgical scars: a prospective, split-scar, double-blinded randomized controlled trial. Plast Reconstr Surg. 2018 141(3):646-650.
Hua C, Yang X, Jin Y, Zou Y, Chen H, Ma G, Qiu Y, Hu X, Tremp M, Lin X. （通讯作者） Treatment of head and neck arteriovenous malformations (AVMs) involving the facial nerve: a tailored algorithm. Ann Plast Surg. 2018 81(6S Suppl 1): S44-S53.
Chang L, Lv D, Yu Z, Ma G, Ying H, Qiu Y, Gu Y, Jin Y, Chen H, Lin X. （通讯作者） Infantile hemangioma: factors causing recurrence after propranolol treatment. Pediatr Res. 2018 83(1-1):175-182.
Cai R, Liu F, Liu Y, Chen H, Lin X. （通讯作者） RASA-1 somatic "second hit" mutation in capillary malformation-arteriovenous malformation. J Dermatol 2018 45(12):1478-1480.
Yu W, Zhu J, Wang L, Qiu Y, Chen Y, Yang X, Chang L, Ma G, Lin X. （通讯作者） Double pass 595?nm pulsed dye laser does not enhance the efficacy of port wine stains compared with single pass: a randomized comparison with histological examination. Photomed Laser Surg. 2018 36(6):305-312.
Chang L, Chen H, Yang X, Jin Y, Ma G, Lin X. （通讯作者） Intralesional Bleomycin Injection for Propranolol-Resistant Hemangiomas. J Craniofac Surg. 2018 29(2):e128-e130.
Ying H, Qiao C, Yang X, Lin X. （通讯作者） A Case Report of 2 Sirolimus-Related Deaths Among Infants with Kaposiform Hemangioendotheliomas. Pediatrics. 2018 141(Suppl 5): S425-S429.
Hua C, Gu Y, Jin Y, Lin X. （通讯作者） An unexpected donor site complication after aesthetic rhinoplasty: arteriovenous fistula of the superficial temporal artery. Facial Plast Surg. 2018 34(2):235-236.
Hua C, Yang X, Jin Y, Zou Y, Chen H, Ma G, Qiu Y, Hu X, Tremp M, Lin X. （通讯作者） Treatment of Head and Neck Arteriovenous Malformations Involving the Facial Nerve: A Tailored Algorithm. Ann Plast Surg. 2018 81(6S Suppl 1):S44-S53.
Cai R, Yang X, Gu H, Chen H, Lin X. （通讯作者） Sirolimus for the treatment of"verrucous" venous malformation: are we missing the lymphatic malformationcomponent? J Am Acad Dermatol. 2018 18. pii: S0190-9622(18)32578-7.
Yu W, Zhu J, Ma G, Yang J, Qiu Y, Chen Y, Chen H, Jin Y, Yang X, Hu X, Wang T, Chang L, Lin X. （通讯作者） Randomized split-face, controlled comparison of treatment with 1565-nm nonablative fractional laser for enlarged facial pores. Br J Dermatol 2018 178(4):e271-e272
Zhu J, Yu W, Wang T, Chen Y, Lyu D, Chang L, Ma G, Lin X （通讯作者） Less is more: similar efficacy in three sessions and seven sessions of pulsed dye laser treatment in infantile port-wine stain patients. Lasers Med Sci. 2018 33(8):1707-1715.
Yu W, Wang T, Zhu J, Qiu Y, Chen H, Jin Y, Yang X, Hu X, Chang L, Chen Y, Ma G, Lin X. （通讯作者） EMLA cream does not influence efficacy and pain reduction during pulsed-dye laser treatment of port-wine stain: a prospective side-by-side comparison. Lasers Med Sci. 2018 33(3):573-579.
Yu W, Zhu J, Yu W, Lyu D, Lin X （通讯作者）, Zhang Z. A split-face, single-blinded, randomized controlled comparison of alexandrite 755-nm picosecond laser versus alexandrite 755-nm nanosecond laser in the treatment of acquired bilateral nevus of Ota-like macules. J Am Acad Dermatol. 2018 79(3):479-486.
Jin Y, Yang X, Hua C, Lin X （通讯作者）, Chen H, Ma G, Wang T, Yu W. Ethanol embolotherapy for the management of refractory chronic skin ulcers caused by arteriovenous malformations. J Vasc Interv Radiol. 2018 29(1):107-113.
Wu Y, Yu R, Chen D, Xu L, Zhu L, Li M, Guo C, Gu P, Lin X, Guo W. Early Trabeculotomy Ab Externo in Treatment of Sturge-Weber Syndrome. Am J Ophthalmol. 2017 182:141-146.
Lyu D, Zou Y, Jin Y, Chang L, Chen H, Ma G, Tremp M, Lin X. （通讯作者） tepwise, multi-incisional, and single-stage approach to reshape facial contour after large cutaneous lesion resection. J Craniofac Surg 2017 28(6):1498-1501.
Yu W, Jin Y, Lin X. （通讯作者） Optimizing Injection Technique to Minimize Ecchymosis in Blepharoplasty-Reply. JAMA Facial Plast Surg. 2017 1;19(4):339-340.
Ying H, Zou Y, Yu W, Qiu Y, Ma G, Chang L, Gu Y, Lyu D, Lin X. （通讯作者） Prospective, open-label, rater-blinded and self-controlled pilot study of the treatment of proliferating superficial infantile hemangiomas with 0.5% topical timolol cream versus 595-nm pulsed dye laser. J Dermatol 2017 44(6):660-665.
Lyu D, Jin Y, Chang L, Chen H, Ma G, Yu W, Tremp M, Lin X. （通讯作者） The modified Z-epicanthoplasty-a stepwise and individualized design. Ann Plast Surg. 2017 78(1):7-11.
Yu W, Jin Y, Yang J, Ma G, Qiu Y, Chen H, Yang X, Chang L, Lin X. （通讯作者） Occurrence of bruise, hematoma, and pain in upper blepharoplasty using blunt-needle vs sharp-needle anesthetic injection in upper blepharoplasty: a randomized clinical trial JAMA Facial Plast Surg 2017 1;19(2):128-132.
Jin Y, Lyu D, Chen H, Ma G, Qiu Y, Zou Y, Tremp M, Lin X. （通讯作者） Invisible scarmedial epicanthoplasty: A novel approach. J Plast Reconstr Aesthet Surg. 2017 70(7):952-958
Jin Y, Hua C, Hu X, Chen H, Ma G, Zou Y, Chen B, Lyu D, Tremp M, Lin X. （通讯作者） Microsurgical replantation of total avulsed scalp: extending the limits. J Craniofac Surg. 2017 28(3):670-674.
Hou Y, Jin Y, Lin X, Chai G, Zhang Y, Qi Z. Individualized Plastic Reconstruction Strategy for Patients with Ectodermal Dysplasia Syndrome. Ann Plast Surg. 2017 78(6):684-691.
Chang L, Gu Y, Yu Z, Ying H, Qiu Y, Ma G, Chen H, Jin Y, Lin X. （通讯作者） When to stop propranolol for infantile hemangioma. Sci Rep. 2017 22; 7:43292.
Hu L, Jin Y, Tremp M, Lin X. （通讯作者） Reconstruction of a large divided nevus of the eyelid. Dermatologic surgery 2017 43(12):1483-1486.
Yang X, Chen H, Lin X （通讯作者）, Jin Y, Ma G, Hu L, Wang Y, Yu W, Chang L, Qiu Y. Intralesional lidocaine anesthesia: a novel facilitated anesthesia technique for ethanol sclerotherapy of venous malformation. J Craniofac Surg. 2017 28(6):1405-1407
Yu W, Ying H, Chen Y, Qiu Y, Chen H, Jin Y, Yang X, Wang T, Ma G, Lin X. （通讯作者） In vivo investigation of the safety and efficacy of pulsed dye laser with two spot sizes in port-wine stain treatment: a prospective side-by-side comparison. Photomed Laser Surg. 2017 35(9):465-471.
Chang L, Lv D, Jin Y, Yu W, Yang X, Ma G, Chen H, Lin X. （通讯作者） High-frequency color doppler ultrasound as the first diagnostic and monitoring choice for early superficial high-flow vascular malformations. J Med Ultrason (2001) 2017 44(3):275-278.
Chen B, Pan W, Lin X （通讯作者）, Hu Z, Jin Y, Chen H, Ma G, Qiu Y, Chang L, Hua C, Zou Y, Gao Y, Ying H, Lv D. MicroRNA-346 functions as an oncogene in cutaneous squamous cell carcinoma. Tumour Biol. 2016 37(2):2765-71.
Zhao Y, Tu P, Zhou G, Zhou Z, Lin X, Yang H, Lu Z, Gao T, Tu Y, Xie H, Zheng Q, Gu Y, Tao J, Zhu X. Hemoporfin Photodynamic Therapy for Port-Wine Stain: A Randomized Controlled Trial. PLoS One 2016 26;11(5):e**.
Hu X, Bogari M, Tan A, Gao X, Gao Y, Chen H, Li W, Jin Y, Ma G, Lin X. （通讯作者） Initial exploration on temporal branch of facial nerve function preservation in plexiform neurofibroma resection. J Craniofac Surg. 2016 27(6):1589-92.
Lyu D, Ying H, Chang L, Ma G, Lin X. （通讯作者） Isolation, culture and characterizationof infantile hemangioma stem cell Zhonghua Zheng Xing Wai Ke Za Zhi. 2016 32(4):293-8
Chang L, Jin Y, Lv D, Ying H, Wang T, Qiu Y, Ma G, Chen H, Yu W, Yang X, Lin X. （通讯作者） Use of propranolol for parotid hemangioma. Head Neck. 2016 38 Suppl1:E1730-6.
Chang L, Ye X, Qiu Y, Ma G, Jin Y, Chen H, Lv D, Yu W, Yang X, Wang T, Lin X. （通讯作者） Is propranolol safe and effective for outpatient use for infantile hemangioma? a prospective study of 679 cases from one center in China. Ann Plast Surg. 2016 76(5):559-63.
Hu L, Zhou B, Huang H, Chang L, Qiu Y, Ma G, Chen H, Jin Y, Xu X, Lin X （通讯作者）, Li W. Effects of systemic propranolol treatment on physical growth of patients with infantile hemangiomas J Dermatol. 2016 43(10):1160-1166.
Yu W, Ma G, Qiu Y, Chen H, Jin Y, Yang X, Hu X, Wang T, Chang L, Zhou H, Li W, Lin X. （通讯作者） Why do port-wine stains (PWS) on the lateral face respond better to pulsed dye laser (PDL) than those located on the central face. J Am Acad Dermatol. 2016 74(3):527-35
Eighteen Cases of Soft Tissue Atrophy After Intralesional Bleomycin A5 Injections for the Treatment of Infantile Hemangiomas: A Long-Term Follow-Up. Pediatric Dermatology 2015 2015：1-4
18 Years Long-Term Results of Facial Port-Wine Stain(PWS) After Photodynamic Therapy(PDT)-A Case Report. Photodiagnosis and Photodynamic Therapy 2015 2015(12): 143—145
Prospective Comparison Treatment of 595 nm Pulsed Dye Lasers (PDL) for Virgin Port-Wine Stain (PWS). Br J Dermatol. 2015 172, pp684–691
Management of periorbital microcystic lymphatic malformation with blepharoptosis: Surgical treatment combined with intralesional bleomycin injection[J]. Journal of Pediatric Surgery 2015 50 (2015) 1393–1397
A prospective self-controlled study of topical timolol 0.5% cream for large super?cial infantile hemangiomas. Journal of Dermatology 2015 42: 1–4
Are Arteriovenous Malformations (AVM) a Causative factor for Hypertrophic and Nodular Port-wine Stains? J Am Acad Dermatol 2014 71(10):219-221
Fractional carbon dioxide laser-assisted drug delivery of topical timolol solution for the treatment of deep infantile hemangioma: a pilot study. Pediatr Dermatol. 2014 31(3):286-91.
Angioarchitecture of extracranial arteriovenous malformations: a vascular casting study. Ann Plast Surg. 2014 73(9) :S43-8.
Nd:YAG laser for "fractional" treatment of angiofibromas. Int J Dermatol. 2014 53(5):638-42.
Angiogenin A Potential Serum Marker of Infantile Hemangioma Revealed by cDNA Microarray Analysis. Plast. Reconstr. Surg. 2014 134(2): 231e-239e.
Recurrence of infantile hemangioma after termination of propranolol treatment. Ann Plast Surg. 2014 72(2):173-5.
Highly Selective Electrocoagulation Therapy: An Innovative Treatment for Lymphangioma Circumscriptum. Dermatologic Surgery 2014 40(8):899-905.
Treating Protruding Infantile Hemangiomas with Topical Imiquimod 5% Cream Caused Severe Local Reactions and Disfiguring Scars. Pediatr Dermatol 2013 30(3):342-7
Outcomes and complications of sclerotherapy for venous malformations Vasc Endovascular Surg 2013 47(6): 454-61.
Monozygotic Twins Discordant for Port Wine Stains Supports the Postzygotic Mutation Hypothesis. Clinical Genetics. 2013 83(4):397-8.
Serum Level Changes of Vascular Endothelial Growth Factor (VEGF) in Children with Infantile Hemangioma after Oral Propranolol Therapy. Pediatric Dermatology. 2013 30(5): 549-53.
Imiquimod 5% cream vs. timolol 0.5% ophthalmic solution for treating superficial proliferating study. Clin Exp Dermatol. 2013 38(8):845-50.
Maternal and perinatal risk factors for infantile hemangioma: a case-control study. Pediatr Dermatol. 2013 30(4):457-61
Two-Z-epicanthoplasty in a three-dimensional model of Asian eyelids. Aesthetic Plast Surg. 2012 36(4):784-794
Treatment of venous infraorbital dark circles using a long-pulsed 1,064-nm neodymium-doped yttrium aluminum garnet laser. Dermatol Surg. 2012 38(8):1277-82
A prospective self-controlled phase II study of imiquimod 5% cream in the treatment of infantile hemangioma. Pediatric Dermatology 2011 28(3): 259-266
Nodules Arising Within Port-wine Stains: A Clinicopathologic Study of 31 Cases Am J Dermatopathol 2011 33:144-51
Reconstruction of the Cheek after Large Port-Wine Stain Lesion Resection. Aesthetic Plast Surg. 2011 35(5): 795-801
Retrospective analysis of facial paralysis caused by ethanol sclerotherapy for facial venous malformation. Head Neck 2011 33(11): 1616-1621
Deep Infantile Hemangiomas and Early Venous Malformations: Differential Diagnosis by 3D-CT Angiography. Ann Plast Surg 2010 64:755-758
Auricular Arteriovenous Malformations: Potential Success of Superselective Ethanol Embolotherapy. J Vasc Interv Radiol. 2009 20:736-744
Intralesional Hemorrhage in Venous Malformation. Plast Reconstr Surg. 2009 123:60-64
Craniofacial Venous Malformations: Magnetic Resonance Imaging Features that Predict Treatment Outcome. J Oral Maxil Surg. 2009 67:2388-96.
Patients with Intralesional Hemorrhage in Venous Malformations: Diagnosis and Embolosclerotherapy. Journal of Vascular Surgery. 2009 49:429-433.
Sclerotherapy after embolization of draining vein :a safe treatment method for venous malformations. J Vasc Surg. 2008 47:1292-1299.