导师姓名： 吕祁峰 专业代码： 100211
性别： 男 专业名称： 妇产科学
培养单位： 附属第九人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： Lyuqifeng@126.com
邮编： 200011 邮箱地址： lyuqifeng@126.com

研究方向 (点击浏览详细信息)
女性卵子成熟及其受精与胚胎发育

社会任职
《生殖与避孕》杂志编委
中国辅助生殖技术管理专家库成员
上海中西医结合学会生殖医学分会胚胎实验学组副组长
中国康复医学会生殖健康专委会常委
中国性学会女性生殖医学分会胚胎实验学组副组长
上海市医学会生殖医学专科分会第三届副主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 受精钙振荡调控端粒影响胚胎染色体稳定性的机制研究 国家自然科学基金面上项目 2019-01~2022-12 68万元 课题负责人
2018YFC** 核质置换人类供-受体卵匹配标准与处理技术的临床前优化研究 科技部重点研发计划项目课题 2018-07~2021-07 600万元 课题负责人
** 辅助激活受精对含DNA损伤精子遗传风险的影响及其机制研究 国家自然科学基金面上项目 2016-01~2019-12 57万元 课题负责人
15ZR** 高孕激素状态下超促排卵不发生自发性LH峰的机制研究 上海市科研计划项目 2015-04~2018-03 10万元 课题负责人
** 影响囊胚内细胞团正常凝聚的内外因素及其相关的同卵孪生发生机制研究 国家自然科学基金面上项目 2011-01~2013-12 32万元 课题负责人
** 囊胚异常孵化相关的同卵孪生发生机制研究 国家自然科学基金面上项目 2009-01~2009-12 8万元 课题负责人
大鼠显微受精（ICSI）新技术的建立 上海市科委实验动物专项自然基金 2008-09~2011-09 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wu L, Chen H, Li D, Song D, Chen B, Yan Z, Lyu Q, Wang L, Kuang Y, Li B, Sang Q. Novel mutations in PATL2: expanding the mutational spectrum and corresponding phenotypic variability associated with female infertility J Hum Genet 2019 64(5):379-385
Chen B, Wang W, Peng X, Jiang H, Zhang S, Li D, Li B, Fu J, Kuang Y, Sun X, Wang X, Zhang Z, Wu L, Zhou Z, Lyu Q, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Sang Q, Wang L. The comprehensive mutational and phenotypic spectrum of TUBB8 in female infertility Eur J Hum Genet 2019 27(2):300-307
Lu X, Yan Z, Cai R, Khor S, Wu L, Sun L, Wang Y, Xu Y, Tian H, Chen Q, Qiao J, Li B, Chen B, Cao Y, Lyu Q, Wang L, Kuang Y. Pregnancy and live birth in women with pathogenic LHCGR variants using their own oocytes J Clin Endocrinol Metab 2019 pii: jc.2019-01276
Si J, Zhu X, Lyu Q, Kuang Y. Obstetrical and neonatal outcomes after transfer of cleavage-stage and blastocyst-stage embryos derived from monopronuclear zygotes: a retrospective cohort study Fertil Steril 2019 pii: S0015-0282(19)30424-8
Qing Sang, Zhihua Zhang, Juanzi Shi, Xiaoxi Sun, Bin Li, Zheng Yan, Songguo Xue, Ai Ai, Qifeng Lyu, Wei Li, Jilin Zhang, Ling Wu, Xiaoyan Mao, Biaobang Chen, Jian Mu, Qiaoli Li, Jing Du, Qiang Sun, Li Jin, Lin He, Shujia Zhu, Yanping Kuang, Lei Wang A pannexin 1 channelopathy causes human oocyte death Science Translational Medicine 2019 11(485)
Yang Q, Li R, Lyu Q （共同第一作者）, Hou L, Liu Z, Sun Q, Liu M, Shi H, Xu B, Yin M, Yan Z, Huang Y, Liu M, Li Y, Wu L. Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes Nat Commun 2019 10(1):3389
Zhu J, Zhu Q, Wang Y, Wang B, Lyu Q, Kuang Y. Comparative study on risk for birth defects among infants after in vitro fertilization and intracytoplasmic sperm injection Syst Biol Reprod Med 2019 65(1):54-60
Zhao X, Wang Y, Ma M, Zhang W, Si J, Wang W, Lin Z, Han G, Chen CD, Tong M, Kuang Y, Lyu Q. （通讯作者） A new panel containing specific spermatogenesis markers to identify spermatogenic cells in nonobstructive azoospermia patients Acta Biochim Biophys Sin (Shanghai) 2019 51(6):656-659
Zhu Q, Zhu J, Wang Y, Wang B, Wang N, Yin M, Zhang S, Lyu Q, Kuang Y. Live birth rate and neonatal outcome following cleavage-stage embryo transfer versus blastocyst transfer using the freeze-all strategy Reprod Biomed Online 2019 38(6):892-900
Xiaowei Wen, Yanping Kuang, Lixia Zhou, Baofeng Yu, Qiuju Chen, Yonglun Fu, Zheng Yan, Haiyan Guo, Qifeng Lyu, Jun Xie, Weiran Chai Lipidomic Components Alterations of Human Follicular Fluid Reveal the Relevance of Improving Clinical Outcomes in Women Using Progestin-Primed Ovarian Stimulation Compared to Short-Term Protocol Med Sci Monit 2018 24: 3357–3365
Du T, Wang Y, Fan Y, Zhang S, Yan Z, Yu W, Xi Q, Chen Q, Mol BW, Lyu Q （通讯作者）, Kuang Y. Fertility and neonatal outcomes of embryos achieving blastulation on Day 7: are they of clinical value? Hum Reprod 2018 33(6):1038-1051
Hongjuan Ye, Hui Tian, Wen He, Qifeng Lyu, Yanping Kuang, Qiuju Chen, Lihua Sun. Progestin-primed milder stimulation with clomiphene citrate yields fewer oocytes and suboptimal pregnancy outcomes compared with the standard progestin-primed ovarian stimulation in infertile women with polycystic ovarian syndrome Reprod Biol Endocrinol 2018 16（1）: 53
Qing Sang, Bin Li, Yanping Kuang, Xueqian Wang, Zhihua Zhang, Biaobang Chen, Ling Wu, Qifeng Lyu, Yonglun Fu, Zheng Yan, Xiaoyan Mao, Yao Xu, Jian Mu, Qiaoli Li, Li Jin, Lin He, Lei Wang Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility Am J Hum Genet 2018 102(4): 649–657
Long H, Wang Y, Wang L, Lu Y, Nie Y, Cai Y, Liu Z, Jia M, Lyu Q （通讯作者）, Kuang Y, Sun Q. Age-related nomograms of serum anti-Mullerian hormone levels in female monkeys: Comparison of rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) monkeys Gen Comp Endocrinol 2018 269:171-176
Xiaowei Wen, Jun Xie, Lixia Zhou, Yong Fan, Baofeng Yu, Qiuju Chen, Yonglun Fu, Zheng Yan, Haiyan Guo, Qifeng Lyu, Yanping Kuang, Weiran Chai The role of combining medroxyprogesterone 17-acetate with human menopausal gonadotropin in mouse ovarian follicular development. Sci Rep 2018 8（1）: 4439
Suo L, Zhou YX, Jia LL, Wu HB, Zheng J, Lyu QF, Sun LH, Sun H, Kuang YP. Transcriptome profiling of human oocytes experiencing recurrent total fertilization failure Sci Rep 2018 8(1):17890
Liu Y, Chen Q, Yu S, Wang Y, He W, Chang HY, Wang B, Gao H, Long H, Wang L, Lyu Q, Ai A, Kuang Y. Progestin-primed ovarian stimulation with or without clomiphene citrate supplementation in normal ovulatory women undergoing in vitro fertilization/intracytoplasmic sperm injection: A prospective randomized controlled trial Progestin-primed ovarian stimulation with or without clomiphene citrate supplementation in normal ovulatory women undergoing in vitro fertilization/intracytoplasmic sperm injection: A prospective randomized controlled trial Clin Endocrinol (Oxf) 2018 88(3):442-452
Zhu Q, Chen Q, Wang L, Lu X, Lyu Q, Wang Y, Kuang Y. Live birth rates in the first complete IVF cycle among 20 687 women using a freeze-all strategy Hum Reprod 2018 33(5):924-929
Sun L, Ye J, Wang Y, Chen Q, Cai R, Fu Y, Tian H, Lyu Q, Lu X, Kuang Y. Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles Sci Rep 2018 8(1):13835
Long H, Nie Y, Wang L, Lu Y, Wang Y, Cai Y, Liu Z, Jia M, Lyu Q （通讯作者）, kuang Y, Sun Q. Serum anti-Mullerian hormone predicts ovarian response in (Macaca fascicularis) monkeys Endocr Connect 2018 7(9):983-989
Yu S, Long H, Chang HY, Liu Y, Gao H, Zhu J, Quan X, Lyu Q, Kuang Y, Ai A. New application of dydrogesterone as a part of a progestin-primed ovarian stimulation protocol for IVF: a randomized controlled trial including 516 first IVF/ICSI cycles Hum Reprod 2018 33(2):229-237
Lihua Sun, Jing Ye, Yun Wang, Qiuju Chen, Renfei Cai, Yonglun Fu, Hui Tian, Qifeng Lyu, Xuefeng Lu, Yanping Kuang. Elevated basal luteinizing hormone does not impair the outcome of human menopausal gonadotropin and medroxyprogesterone acetate treatment cycles Sci Rep 2018 8（1）: 13835
Lu X, Khor S, Zhu Q, Sun L, Wang Y, Chen Q, Wu L, Fu Y, Tian H, Lyu Q, Cai R, Kuang Y. Decrease in preovulatory serum estradiol is a valuable marker for predicting premature ovulation in natural/unstimulated in vitro fertilization cycle J Ovarian Res 2018 11(1):96
He W, Li X, Adekunbi D, Liu Y, Long H, Wang L, Lyu Q, Kuang Y, O'Byrne KT. Hypothalamic effects of progesterone on regulation of the pulsatile and surge release of luteinising hormone in female rats Sci Rep 2017 7(1):8096
Guo H, Wang Y, Chen Q, Chai W, Sun L, Ai A, Fu Y, Lyu Q, Kuang Y. Use of medroxyprogesterone acetate in women with ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization Sci Rep 2017 7(1):11927
Liang HX, Lu SS, Yan Z, Kuang YP, Zhu XX, Yan ZG, Du T, Chai WR, Long H, Lyu QF. （通讯作者） Andrographolide disrupts meiotic maturation by blocking cytoskeletal reorganisation and decreases the fertilisation potential of mouse oocytes Reprod Fertil Dev 2017 doi: 10.1071/RD16343
Dong J, Wang Y, Chai WR, Hong QQ, Wang NL, Sun LH, Long H, Wang L, Tian H, Lyu QF, Lu XF, Chen QJ, Kuang YP. The pregnancy outcome of progesterone-primed ovarian stimulation using medroxyprogesterone acetate4mg versus 10mg daily in infertile women undergoing in vitro fertilization: a randomized controlled trial BJOG 2017 124(7):1048-1055
Zhu X, Ye J, Fu Y, Ai A, Cai R, Wang Y, Hong Q, Hui T, Lyu Q, Chen Q, Kuang Y. The effect of human chorionic gonadotrophin contained in human menopausal gonadotropin on the clinical outcomes during progestin-primed ovarian stimulation Oncotarget 2017 8(50):87340-87352
Du T, Chen H, Fu R, Chen Q, Wang Y, Mol BW, Kuang Y, Lyu Q. （通讯作者） Comparison of ectopic pregnancy risk among transfers of embryos vitrified on day 3, day 5, and day 6 Fertil Steril 2017 108(1):108-116
Kong P, Yin M, Chen D, Li S, Li Y, Xing F, Jiang M, Fang Z, Lyu Q （通讯作者）, Chen X. Effects of the histone deacetylase inhibitor 'Scriptaid' on the developmental competence of mouse embryos generated through round spermatid injection Hum Reprod 2017 32(1):76-87
Liu W, Han B, Zhu W, Cheng T, Fan M, Wu J, Yang Y, Zhu H, Si J, Lyu Q, Chai W, Zhao S, Song H, Kuang Y, Qiao J. Polymorphism in the Alternative Donor Site of the Cryptic Exon of LHCGR: Functional Consequences and Associations with Testosterone Level Sci Rep 2017 7:45699. doi: 10.1038/srep45699
Chen Q, Wang Y, Sun L, Zhang S, Chai W, Hong Q, Long H, Wang L, Lyu Q, Kuang Y. Controlled ovulation of the dominant follicle using progestin in minimal stimulation in poor responders Reprod Biol Endocrinol 2017 15(1):71
Liu S, Kuang Y, Wu Y, Feng Y, Lyu Q, Wang L, Sun Y, Sun X. High oestradiol concentration after ovarian stimulation is associated with lower maternal serum beta-HCG concentration and neonatal birth weight Reprod Biomed Online 2017 35(2):189-196
Wang L, Yin M, Liu Y, Chen Q, Wang Y, Ai A, Fu Y, Yan Z, Jin W, Long H, Lyu Q （通讯作者）, Kuang Y. Effect of Frozen Embryo Transfer and Progestin-primed Ovary Stimulation on IVF outcomes in women with high body mass index Sci Rep 2017 7(1):7447.
Qin N, Chen Q, Hong Q, Cai R, Gao H, Wang Y, Sun L, Zhang S, Guo H, Fu Y, Ai A, Tian H, Lyu Q, Daya S, Kuang Y. Flexibility in starting ovarian stimulation at different phases of the menstrual cycle for treatment of infertile women with the use of in vitro fertilization or intracytoplasmic sperm injection Fertil Steril 2016 106(2):334-341
Wang N, Wang Y, Chen Q, Dong J, Tian H, Fu Y, Ai A, Lyu Q, Kuang Y. Luteal-phase ovarian stimulation versus conventional ovarian stimulation in patients with normal ovarian reserve treated for IVF: a large retrospective cohort study. Clin Endocrinol (Oxf). 2016 84(5):720-8
Lu X, Chen Q, Fu Y, Ai A, Lyu Q, Kuang YP. Elevated progesterone on the trigger day does not impair the outcome of Human Menotrophins Gonadotrophin and Medroxyprogesterone acetate treatment cycles Sci Rep 2016 6:31112. doi: 10.1038/srep31112.
Lu X, Hong Q, Sun L, Chen Q, Fu Y, Ai A, Lyu Q, Kuang Y. Dual trigger for final oocyte maturation improves the oocyte retrieval rate of suboptimal responders to gonadotropin-releasing hormone agonist Fertil Steril 2016 106(6):1356-1362
Zheng Yan, Hongxing Liang, Li Deng, Hui Long, Hong Chen, Weiran Chai, Lun Suo, Chen Xu, Yanping Kuang, Lingqian Wu, Shengsheng Lu, Qifeng Lyu （通讯作者） Eight-shaped Hatching Increases the Risk of Inner Cell Mass Splitting in Extended Mouse Embryo Culture Plos One 2015 10(12):e**
Yun Wang*, Hong Chen, NingLing Wang, HaiYan Guo, Yonglun Fu, Songguo Xue, Ai Ai, Qifeng Lyu, Yanping Kuang*. Combined 17β-Estradiol with TCDD Promotes M2 Polarization of Macrophages in the Endometriotic Milieu with Aid of the Interaction between Endometrial Stromal Cells and Macrophages. Plos one 2015 10(5): e**
Hong Chen, Yun Wang, Qifeng Lyu, Ai Ai, Yonglun Fu, Hui Tian, Renfei Cai, Qingqing Hong, Qiuju Chen, Zeev Shoham, and Yanping Kuang. Comparison of live-birth defects after luteal-phase ovarian stimulation vs. conventional ovarian stimulation for in vitro fertilization and vitrified embryo transfer cycles. Fertility and Sterility. 2015 103(5):1194-1201
Yanping Kuang, Qiuju Chen,Yonglun Fu,Yun Wang,Qingqing Hong,Qifeng Lyu, Ai Ai,Zeev Shoham. Medroxyprogesterone acetate is an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in vitro fertilization. Fertility and Sterility. 2015 104(1):62–70
Kuang Y., Chen Q., Hong Q., Lyu Q., Ai A., Fu Y., Shoham Z. Double stimulations during the follicular and luteal phases of poor responders in IVF/ICSI programmes (Shanghai protocol). Reprod. Biomed. Online 2014 29：684–691
Sha Yu , Hui Long, Qi-feng Lyu （共同第一作者）, Qin-hua Zhang, Zhi-guang Yan, Hong-xing Liang, Wei-ran Chai, Zheng Yan, Yan-ping Kuang, Cong Qi. Protective Effect of Quercetin on the Development of Preimplantation Mouse Embryos against Hydrogen Peroxide-induced Oxidative Injury PloS One 2014 9（2）:e89520
Yun Wang, Hong Chen, Yonglun Fu, Ai Ai, Songguo Xue, Qifeng Lyu （通讯作者）, Yanping Kuang The M2 polarization of macrophage induced by Fractalkine in the endometriotic milieu enhances invasiveness of endometrial stromal cells Int J Clin Exp Pathol 2014 7(1):194-203
Kuang Y, Hong Q, Chen Q, Lyu Q, Ai A, Fu Y, Shoham Z Luteal-phase ovarian stimulation is feasible for producing competent oocytes in women undergoing in vitro fertilization/intracytoplasmic sperm injection treatment, with optimal pregnancy outcomes in frozen-thawed embryo transfer cycles Fertility and Sterility 2013 101(1):105-111
Hui Long, Sheng-Sheng Lu, Yan-Ping Kuang, Zhi-Guang Yan, Hong-Xing Liang, Sha Yu , Wei-Ran Chai, Zheng Yan, Qi-Feng Lyu （通讯作者） Incubation of sperm heads impairs fertilization and early embryo development following intracytoplasmic sperm injection (ICSI) by decreasing oocyte activation in mice Biotechnol Lett 2013 35(11):1823-1829
Yun Wang, Hong Chen, Yonglun Fu, Ai Ai, Songguo Xue, Qifeng Lyu （通讯作者）, Yanping Kuang MiR-195 inhibits proliferation and growth and induces apoptosis of endometrial stromal cells by targeting FKN Int J Clin Exp Pathol 2013 6(12):2824-2834
Wang Y, Fu YL, Cao SF, Chen QJ, Xue SG, Lyu QF （通讯作者）, Kuang YP Reducing the trigger dose of human chorionic gonadotrophin does not affect final oocyte maturation and subsequently pregnancy outcome of frozen-thawed embryo transfer J Reprod Contracep 2013 24(3):151-158
QP Peng, SF Cao, QF Lyu, SG Xue, W Jin, XY Liu, WJ Zhang, HI Nielsen, YP Kuang. A novel method for cryopreservation of individual human spermatozoa In Vitro Cellular & Developmental Biology-Animal 2011 47(8):565-572
QF Lyu, L Deng, SG Xue, SF Cao, XY Liu, W Jin, LQ Wu, YP Kuang. New technique for mouse oocyte injection via a modified holding pipette Reproductive biomedicine online 2010 21(5):663-666
Y Dai, L Wang, H Wang, Y Liu, N Li, QF Lyu, DL Keefe, DF Albertini, L Liu Fate of centrosomes following somatic cell nuclear transfer (SCNT) in bovine oocytes Reproduction 2006 131(6):1051-1061
QF Lyu, LQ Wu, YP Li, Q Pan, DE Liu, K Xia, DS Liang, F Cai, ZG Long, HP Dai, JH Xia. An improved mechanical technique for assisted hatching Human Reproduction 2005 20(6):1619-1623