导师姓名： 王宏林 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 附属第一人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市黄浦区重庆南路280号
邮编： 200025 邮箱地址： honglin.wang@sjtu.edu.cn

研究方向 (点击浏览详细信息)
免疫学；自身免疫性疾病

社会任职
中华医学会皮肤性病学分会实验学组副组长
上海优秀学术带头人
中国免疫学会会员；美国免疫学会会员；
中华中医药学会免疫学分会副主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** Pri-miR-31编码多肽调控银屑病角质形成细胞生物学功能的作用及机制 国家自然科学基金重点项目 2020-01~2024-12 297万元 课题负责人
** 银屑病免疫学机理及治疗新靶点 国家****科学基金 2018-01~2022-12 400万元 课题负责人
** 皮肤区域免疫特性及银屑病靶向治疗新策略 国家自然科学基金面上项目 2016-01~2019-12 72万元 课题负责人
** 治疗银屑病新型候选化合物的研究 上海市科学技术委员会 2015-07~2018-06 50万元 课题负责人
** iTreg的表观调控及其在自身免疫性疾病中的作用机制 国家自然科学基金重点项目 2014-01~2018-12 303万元 课题负责人
2014CB541905 狼疮靶器官受损相关炎症通路活化的细胞及分子调节机制研究 国家重点基础研究计划（973计划）项目 2014-01~2018-12 442万元 课题负责人
2012CB917100 恶性肿瘤免疫负调控分子网络的形成与干预 国家重点基础研究计划（973计划）项目 2012-01~2016-12 144万元 课题参与人
** 间充质干细胞参与非可控性炎症恶性转化的分子机制 国家自然科学基金重大研究计划 2011-01~2013-12 70万元 课题负责人
10PJ** 皮肤真皮间充质干细胞治疗银屑病可行性和安全性的研究 上海市科学技术委员会 2010-09~2012-09 25万元 课题负责人
抗银屑病纯天然新药的研究 上海市科学技术委员会 2010-04~2012-12 10万元 课题负责人
** 运用生物荧光GFP标记的CD4+CD25+调节性T细胞诊断早期胃癌的研究 国家自然科学基金面上项目 2010-01~2012-12 30万元 课题负责人
2010CB529700 炎症过程中细胞间相互作用的信号转导机制及其应用研究 国家重点基础研究计划（973计划）项目 2010-01~2014-12 54万元 课题参与人
构建FOXP3-GFP银屑病小鼠模型的研究 上海市科学技术委员会 2009-10~2011-09 20万元 课题负责人
构建Foxp3-GFP银屑病小鼠模型的研究 上海市科学技术委员会 2009-09~2011-09 20万元 课题负责人
** 诱导调节性T细胞治疗自身免疫性疾病的研究 上海市教育委员会 2009-01~2011-12 50万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Liman Niu, Fangzhou Lou, Yang Sun, Libo Sun, Xiaojie Cai, Zhaoyuan Liu, Hong Zhou, Hong Wang, Zhikai Wang, Jing Bai, Qianqian Yin, Junxun Zhang, Linjiao Chen, Danhong Peng, Zhenyao Xu, Yuanyuan Gao, Sibei Tang, Li Fan, Honglin Wang （通讯作者） A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation Science advances 2020 6(21)
FangzhouLou, YangSun, ZhenyaoXu, LimanNiu, ZhikaiWang,SiyuDeng, ZhaoyuanLiu, HongZhou, JingBai, Qianqian Yin, Xiaojie Cai, Libo Sun, Hong Wang, Qun Li, Zhouwei Wu, Xiang Chen, Jun Gu, Yu-Ling Shi, Wufan Tao, Florent Ginhoux, Honglin Wang （通讯作者） Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis Immunity 2020 53(1):204-216
Li X, Cai W, Xi W, Sun W, Shen W, Wei T, Chen X, Sun L, Zhou H, Sun Y, Chen W, Gao P, Wang H （通讯作者）, Li Q. MicroRNA-31 Regulates Immunosuppression in Ang II (Angiotensin II)-induced Hypertension by Targeting Ppp6C (Protein Phosphatase 6c). Hypertension 2019 73(5):e14-e24
Bai J, Gao Y, Chen L, Yin Q, Lou F, Wang Z, Xu Z, Zhou H, Li Q, Cai W, Sun Y, Niu L, Wang H, Wei Z, Lu S, Zhou A, Zhang J, Wang H. （通讯作者） Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes EBioMedicine 2019 39: 575–590
Wu R, Zeng J, Yuan J, Deng X, Huang Y, Chen L, Zhang P, Feng H, Liu Z, Wang Z, Gao X, Wu H, Wang H, Su Y, Zhao M, Lu Q MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation The Journal of Clinical Investigation 2018 2018;128(6):2551-2568.
Liu Z, Bai J, Zhang L, Lou F, Ke F, Cai W, Wang H （通讯作者） Conditional knockout of microRNA-31 promotes the development of colitis associated cancer Biochemical and Biophysical Research Communications 2017 490(1):62-68
Zhu H, Lou F, Yin Q, Gao Y, Sun Y, Bai J, Xu Z,Liu Z, Cai W, Ke F, Zhang L, Zhou H, Wang H, Wang G, Chen X, Zhang H, Wang Z, Florent Ginhoux, Lu C, Su B, Wang H （通讯作者） RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease EMBO Molecular Medicine 2017 May;9(5):589-604.
Ke F, Zhang L, Liu Z, Yan S, Xu Z, Bai J, Zhu H, Lou F, Cai W, Sun Y, Gao Y, Wang H, Wang H （通讯作者） sTNFR1 Released by Skin-Derived Mesenchymal Stem Cells is Critical for Inhibiting Th17 Cell Differentiation Stem Cells Translational Medicine 2016 5(3):301-13
Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, Liu Z, Liu J, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Su B, Li Q, Yang X, Yu J, Lai Y, Yu XZ, Zheng Y, Shen N, Chin YE, Wang H （通讯作者） NF-kB-Induced microRNA-31 Promotes Epidermal Hyperplasia by Repressing Protein Phosphatase 6 in Psoriasis Nature Communications 2015 6:7652
Bai J, Liu Z, Xu Z, Ke F, Zhang L, Zhu H, Lou F, Wang H, Fei Y, Shi YL, Wang H （通讯作者） Epigenetic downregulation of SFRP4 contributes to epidermal hyperplasia in psoriasis The Journal of Immunology 2015 194:4185-4198
Li H, Li C, Zhang H, Zhang L, Cheng R, Li M, Guo Y, Zhang Z, Lu Z, Zhuang Y, Yan M, Gu Y, Feng X, Liang J, Yu X, Wang H* （通讯作者）, Yao Z* Effects of lidocaine on regulatory T cells in atopic dermatitis Journal of Allergy and Clinical Immunology 2015 S0091-6749(15)
Zhang L, Ke F, Liu Z, Bai J, Liu J, Yan S, Xu Z, Lou F, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Li Q, Yu XZ, Qian Y, Hua Z, Deng J, Li QJ, Wang H （通讯作者） MicroRNA-31 Negatively Regulates Peripherally Derived Regulatory T Cell Generation by Repressing Retinoic Acid-Inducible Protein 3 Nature Communications 2015 6: 7639
Zhang QQ, Hu XW, Liu YL, Ye ZJ, Gui YH, Zhou DL, Qi CL, He XD, Wang H* （通讯作者）, Wang LJ* CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell recruitment Scientic Reports 2015 doi:10.1038/srep15948
Liu J, Ke F, Xu Z, Liu Z, Zhang L, Yan S, Wang Z, Wang H, Wang H （通讯作者） CCR6 is a Prognostic Marker for Overall Survival in Patients with Colorectal Cancer, and Its Overexpression Enhances Metastasis in vivo PLoS ONE 2014 Jun 30;9(6):e101137. doi: 10.1371
Ke F, Zhang L, Liu Z, Liu J, Yan S, Xu Z, Bai J, Zhu H, Lou F, Wang H, Shi Y, Jiang Y, Su B, Wang H （通讯作者） Autocrine IL-6 Drives Skin-Derived Mesenchymal Stem Cell Trafficking via Regulating Voltage-Gated Ca2+ Channels Stem Cells 2014 2014 Jun 6. doi: 10.1002
Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B The ubiquitin ligase stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor foxp3 Immunity 2013 39(2):272-85
Zhu S, Pan W, Song X, Liu Y, Shao X, Tang Y, Liang D, He D, Wang H, Liu W, Shi Y, Harley JB, Shen N, Qian Y The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α Nature Medicine 2012 18(7):1077-86.
Semple K, Nguyen A, Yu Y, Wang H, Anasetti C, Yu XZ Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling Blood 2011 117(11):3096-3103
Liu J, Zhang N, Li Q, Zhang W, Ke F, Leng Q, Wang H, Chen J, Wang H （通讯作者） Tumor-associated Macrophages Recruit CCR6+ Regulatory T cells and Promote the Development of Colorectal Cancer via Enhancing CCL20 Production in Mice PLoS ONE 2011 8(1):e19495
Li Q*, Ke F*, Zhang W, Shen X, Xu Q, Wang H, Yu XZ, Leng Q, Wang H （通讯作者） Plasmin Plays an Essential Role in Amplification of Psoriasiform Skin Inflammation in Mice PLoS ONE 2011 6(2):e16483
Wang H (第一作者), von Rohrscheidt J, Roehrbein J, Peters T, Sindrilaru A, Kess D, Preissner KT, Scharffetter-Kochanek K Extracellular adherence protein of Staphylococcus aureus suppresses disease by inhibiting T cell recruitment in a mouse model of psoriasis Journal of Investigative Dermatology 2010 130(3):743-754
Wang H（第一作者）, Syrovets T, Kess D, Büchele B, Hainzl H, Lunov O, Weiss JM, Scharffetter-Kochanek K, Simmet T Targeting NF-kappa B with a natural triterpenoid alleviates skin inflammation in a mouse model of psoriasis The Journal of Immunology 2009 183(7):4755-4763
Wang H（第一作者）, Peters T, Sindrilaru A, Scharffetter-Kochanek K Key role of macrophages in the pathogenesis of CD18 hypomorphic murine model of psoriasis Journal of Investigative Dermatology 2009 29 (5):1100-1114
Sindrilaru A, Peters T, Schymeinsky J, Oreshkova T, Wang H, Gompf A, Mannella F, Wlaschek M, Sunderk?tter C, Rudolph KL, Walzog B, Bustelo XR, Fischer KD, Scharffetter-Kochanek K Wound healing defect of Vav3-/- mice due to impaired beta2-integrin dependent macrophage phagocytosis of apoptotic neutrophils Blood 2009 113(21):5266-5276
Peters T, Weiss JM, Sindrilaru A, Wang H, Oreshkova T, Wlaschek M, Maity P, Reimann J, Scharffetter-Kochanek K Reactive oxygen intermediate-induced pathomechanisms contribute to immunosenescence, chronic inflammation and autoimmunity Mechanisms of Ageing and Development 2009 130(9):564-587
Wang H（第一作者）, Kess D, Lindqvist AK, Peters T, Sindrilaru A, Wlaschek M, Blakytny R, Holmdahl R, Scharffetter-Kochanek K A 9-cM region of chromosome 10 controls the T-cell dependent psoriasiform skin disease and arthritis in a murine psoriasis model The Journal of Immunology 2008 180(8):5520-5529
Wang H（第一作者）, Peters T, Sindrilaru A, Kess D, Oreshkova T, Yu XZ, Seier AM, Schreiber H, Wlaschek M, Blakytny R, R?hrbein J, Schulz G, Weiss JM, Scharffetter-Kochanek K TGF-alpha-dependent suppressive function of regulatory T-cells in a psoriasis murine model requires CD18 wild-type levels The Journal of Clinical Investigation 2008 118(7):2629-2639
Kess D, Lindqvist AK, Peters T, Wang H, Zamek J, Nischt R, Broman KW, Blakytny R, Krieg T, Holmdahl R, Scharffetter-Kochanek K Identification of susceptibility loci for skin disease in a murine psoriasis model The Journal of Immunology 2006 177(7):4612-9
Wang H*（共同第一作者）, Peters T*, Kess D, Sindrilaru A, Oreshkova T, Van Rooijen N, Stratis A, Renkl AC, Sunderk?tter C, Wlaschek M, Haase I, Scharffetter-Kochanek K Activated Macrophages are Essential in a Murine Model for T Cell-Mediated Chronic Psoriasiform Skin Inflammation The Journal of Clinical Investigation 2006 116(8):2105-2114
Peters T, Sindrilaru A, Wang H, Oreshkova T, Renkl AC, Kess D, Scharffetter-Kochanek K CD18 in Monogenic and Polygenic Inflammatory Processes of the Skin J Investig Dermatol Symp Proc 2006 126(Supl):7-15
Peters T, Sindrilaru A, Hinz B, Hinrichs R, Menke A, Al-Azzeh EA, Holzwarth K, Oreshkova T, Wang H, Kess D, Walzog B, Sulyok S, Sunderk?tter C, Friedrich W, Wlaschek M, Krieg T, Scharffetter-Kochanek K Wound-healing defect of CD18 (-/-) mice due to a decrease in TGF-beta1 and myofibroblast differentiation The EMBO Journal 2005 24:3400-3410