导师姓名： 伍均 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 附属第一人民医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式：
邮编： 邮箱地址： jun.wu@shsmu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤分子病理诊断和肿瘤表观遗传调控机制的研究

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 组蛋白乙酰基转移酶PCAF通过乙酰化CDK4抑制胃癌增殖的研究 国家自然科学基金青年项目 2015-01~2017-12 25万元 课题负责人
2014BAI09B03 基于分子标志物的胃癌早期诊断、分子分型及靶向治疗药物（成药）的研发 国家“973”计划子课题 2014-01~2017-12 80万元 子课题负责人
14YF** 组蛋白乙酰基转移酶PCAF通过正性转录调控p16及乙酰化p16丝氨酸/苏氨酸残基抑制胃癌增殖的研究 上海市科委 2014-01~2016-12 10万元 课题负责人
ZXZY603003 microRNA-24在胃癌异常表达分子调控机制的研究 教育部学术新人基金 2010-01~2012-12 3万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Cui Y#, Li SB#, Peng XC, Wu J* （通讯作者）, Fu GH* Trastuzumab Inhibits Growth of HER2-Negative Gastric Cancer Cells Through Gastrin-Initialized CCKBR Signaling. Dig Dis Sci. 2015 60(12):3631-41
Wen H#, Li Y#, Xi Y#, Jiang S, Stratton S, Peng D, Tanaka K, Ren Y, Xia Z, Wu J, Li B, Barton MC, Li W, Li H, Shi X* ZMYND11 links histone H3.3 K36 trimethylation to transcription elongation and tumor suppression Nature 2014 10-1038
Wei ZH#, Guo WH#, Wu J, Suo WH, Fu GH A nonsense mutation in the Xeroderma pigmentosum complementation group F (XPF) gene is associated with gastric carcinogenesis GENE 2014 S0378-1119(14)00003-1
Chul-Hwan Lee, Jun Wu, Bing Li* Chromatin remodelers fine-tune H3K36me -directed deacetylation of neighbor nucleosomes by Rpd3S Molecular Cell 2013 52(2):255-63
Huh JW#, Wu J# （共同第一作者）, Lee CH, Yun M, Gilada D, Brautigam CA, Li B Multivalent di-nucleosome recognition enables the Rpd3S histone deacetylase complex to tolerate decreased H3K36 methylation levels EMBO J 2012 31(17):3564-74
Yao Y#, Fan Y#, Wu J, Wan H, Wang J, Lam S, Lam WL, Girard L, Gazdar AF, Wu Z*, Zhou Q* Potential application of non-small cell lung cancer-associated autoantibodies to early cancer diagnosis. Biochem Biophys Res Commun 2012 21(4):564-78
Miyong Yun, Jun Wu, Jerry L Workman, Bing Li Readers of histone modifications. Cell Research 2011 21(4):564-78
Wu J, Zhang YC, Suo WH, Liu XB, Shen WW, Tian H, Fu GH Induction of anion exchanger-1 translation and its opposite roles in the carcinogenesis of gastric cancer cells and differentiation of K562 cells. Oncogene 2010 29(13):1987-96
Tian H, Zhang N, Suo WH, Wang T, Song LJ, Wu J, Liu Q, Shen WW, Fu GH Gastrin suppresses the interdependent expression of p16 and anion exchanger 1 favoring growth inhibition of gastric cancer cells Int J Cancer 2010 127(6):1462-74
Yang Y#, Wu PP#, Wu J, Shen WW, Wu YL, Fu AF, Zheng L, Jin XL, Fu GH Expression of anion exchanger 2 in human gastric cancer Exp Oncol 2008 30(1):81-7
Shen WW, Wu J, Cai L, Liu BY, Gao Y, Chen GQ, Fu GH Expression of anion exchanger 1 sequestrates p16 in the cytoplasm in gastric and colonic adenocarcinoma. Neoplasia 2007 9(10):812-9