导师姓名： 张岩 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第一人民医院 三级学科/
专业领域： 血液病
导师类型： 博士生导师 专业学位导师：
联系方式： 电话：86-; 电子邮箱: yan.zhang19510@shgh.cn.
邮编： 201620 邮箱地址： yanzhangshandong@163.com

研究方向 (点击浏览详细信息)
血液系统恶性肿瘤发病机制；免疫细胞治疗；血液系统遗传病基因治疗

社会任职
中国免疫学会 会员
中国实验血液学会 会员
中国细胞生物学会 会员
中国生物化学与分子生物学会 会员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
19JC** 人造血干细胞经由人工胸腺类器官向T淋巴细胞分化途径的建立与新型CAR-T细胞的获得 上海市科委 2020-01~2022-12 80万元 课题负责人
2019YFA** 新型造血干细胞产品的制备及在血液系统疾病中的临床应用 “干细胞与转化研究”国家重点研发计划 2020-01~2023-12 150万元 课题参与人
** Trithorax家族成员MLL5蛋白参与调控天然免疫反应的功能与机制研究 国家自然科学基金委员会 2017-01~2020-12 60万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wan X., Liu L., Zhou P., Hui X., He Q., Yu F., Zhang W., Ding X., Yuan X., Zhang N.,Zhao Y., Zhu R., Liu Y., Hao P., Auwerx J,. Song X. Leng Q., and Zhang, Y*. （通讯作者） The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo Blood Adv 2019 3:644-657.
Liu L., Wan X., Zhou P., Zhou X., Zhang W., Hui X., Yuan X., Ding X., Zhu R., Meng G., Xiao H., Ma F., Huang H., Song X., Zhou B., Xiong S., and Zhang Y*. （通讯作者） The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis J Hematol Oncol 2018 11: 27.
Zhou P., Ding X., Wan X., Liu L., Yuan X., Zhang W., Hui X., Meng G., Xiao H., Li B., Zhong J., Hou F., Deng L., and Zhang Y*. （通讯作者） MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation Nat Commun 2018 9: 1243.
Ma S., Wan X., Deng Z., Shi L., Hao C., Zhou Z., Zhou C., Fang Y., Liu J., Yang J., Chen X., Li T., Zang A., Yin S., Li B., Plumas J., Chaperort L., Zhang X., Xu G., Jiang L., Shen N., Xiong S., Gao X., Zhang Yan., and Xiao H. Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med 2017 214: 1471-1491.
Xing Y., Yao X., Li H., Xue G., Guo Q., Yang G., An L., Zhang Y., and Meng G. Cutting Edge: TRAF6 Mediates TLR/IL-1R Signaling-Induced Nontranscriptional Priming of the NLRP3 Inflammasome. J Immunol 2017 199: 1561-1566.
Zhang X., Novera W., Zhang Y., and Deng L.W. MLL5 (KMT2E): structure, function, and clinical relevance. Cell Mol Life Sci 2017 74: 2333-2344.
Li Y., Lu Y., Wang S., Han Z., Zhu F., Ni Y., Liang R., Zhang Y., Leng Q., Wei G.,Shi G., Zhu R., Li D., Wang H., Zheng S., Xu H., Tsun A., and Li B. USP21 prevents the generation of T-helper-1-like Treg cells. Nat Commun 2016 7: 13559.
Ding X., Jiang W., Zhou P., Liu L., Wan X., Yuan X., Wang X., Chen M., Chen J., Yang J., Kong C., Li B., Peng C., Wong C. Hou F., Zhang, Y*. （通讯作者） Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7). PLoS One 2015 10: e**.
Wong J.C., Weinfurtner K.M., Alzamora Mdel P., Kogan S.C., Burgess M.R., Zhang Y., Nakitandwe J., Ma J., Cheng J., Chen S.C., Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis. Elife 2015 4
Wan X., Liu L., Ding X., Zhou P., Yuan X., Zhou Z., Hu P., Zhou H., Li Q., Zhang S., Xiong S., and Zhang Y*. （通讯作者） Mll2 controls cardiac lineage differentiation of mouse embryonic stem cells by promoting H3K4me3 deposition at cardiac-specific genes. Stem Cell Rev Rep 2014 10: 643-652.
Zhou P., Wang Z., Yuan X., Zhou C., Liu L., Wan X., Zhang F., Ding X., Wang C., Xiong S., Wang Z., Yuan J., Li Q., and Zhang Y*. （通讯作者） Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). J Biol Chem 2013 288: 17532-17543.
Hu C, Zhang S, Gao X, Gao X, Xu X, Lv Y, Zhang Y, Zhu Z, Zhang C, Li Q, Wong J, Cui Y, Zhang W, Ma L, and Wang C. Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response. J Biol Chem 2012 287:18937–18952.
Wong J, Zhang Y, Lieuw K, Tran M, Forgo E, Weinfurtner K, Alzamora P, Kogan S, Akagi K, Wolff L, Le Beau M, Killeen N, and Shannon K. Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. BLOOD 2010 115:4524-4532.
Zhang Y, Wong J, Klinger M, Tran M, Shannon K, and Killeen N Mll5 contributes to hematopoietic stem cell fitness and homeostasis. BLOOD 2009 113:1455-1463