导师姓名： 王兴鹏 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第一人民医院 三级学科/
专业领域： 消化系病
导师类型： 博士生导师 专业学位导师： 兼
联系方式： richardwangxp@163.com
邮编： 200080 邮箱地址： wangxp1965@yahoo.com.cn

研究方向 (点击浏览详细信息)
胰腺疾病的基础与临床；肠道微生态与消化系疾病

社会任职
亚太地区胰腺病学会委员
中华消化病学会常务委员
中华消化病学会胰腺病学组组长
上海市医院管理协会常务理事
上海市医师学会消化病学分会会长
上海市消化病学会主任委员
中国医师学会消化病学分会常务委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
ZY（2018-2020）-FWTX-1004 重症急性胰腺炎 上海市中西医临床协作试点建设项目 2018-01~2020-12 210万元 课题负责人
** Reg4在急性胰腺炎后胰腺再生中的作用及分子机制研究 国家自然科学基金 2016-01~2019-12 68.4万元 课题负责人
** Hedgehog-Gli1-DNMTs 轴调控胰腺炎癌转化的表观遗传机 国家自然科学基金 2014-01~2017-12 70万元 课题负责人
重症急性胰腺炎早期诊治的多中心临床研究 市科委重点项目 2012-12~2015-12 100万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Han X, Ni J, Wu Z, Wu J, Li B, Ye X, Dai J, Chen C, Xue J, Wan R, Wen L, Wang X （通讯作者）, Hu G. Myeloid-specific dopamine D2 receptor signalling controls inflammation in acute pancreatitis via inhibiting M1 macrophage. Br J Pharmacol. 2020 177(13):2991-3008.
Shen S, Li B, Dai J, Wu Z, He Y, Wen L, Wang X （通讯作者）, Hu G. BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux. Front Pharmacol. 2020 11:618.
Ren YC, Zhao Q, He Y, Li B, Wu Z, Dai J, Wen L, Wang X （通讯作者）, Hu G. Legumain promotes fibrogenesis in chronic pancreatitis via activation of transforming growth factor β1 J Mol Med (Berl). 2020 98(6):863-874.
Mei Q, Zeng Y, Huang C, Zheng J, Guo Y, Fan J, Fu X, Wang X （通讯作者）, Lu Y. Rapamycin Alleviates Hypertriglyceridemia-Related Acute Pancreatitis via Restoring Autophagy Flux and Inhibiting Endoplasmic Reticulum Stress Inflammation. 2020 43(4):1510-1523.
Wang J, Lang T, Shen J, Dai J, Tian L, Wang X. （通讯作者） Core Gut Bacteria Analysis of Healthy Mice. Front Microbiol 2019 10:887
Cheng L, Zhao Y, Tang M, Luo Z, Wang X. （通讯作者） Knockdown of ISOC1 suppresses cell proliferation in pancreatic cancer in vitro. Oncol Lett 2019 17(5):4263-4270
Zheng J, Fan J, Huang C, Lu Y, Huang Z, Wang X （通讯作者）, Zeng Y. Dynamic Detection of Monocyte Subsets in Peripheral Blood of Patients with Acute Hypertriglyceridemic Pancreatitis. Gastroenterol Res Pract 2019 2019:**
Liu L, Guo Y, Zheng J, Lu Y, Shen Y, Huang C, Zeng Y, Wang X. （通讯作者） Paneth cell ablation increases the small intestinal injury during acute necrotizing pancreatitis in rats. Mol Med Rep 2019 20(1):473-484
Zhang R, Shi J, Zhang R, Ni J, Habtezion A, Wang X （通讯作者）, Hu G, Xue J. Expanded CD14hiCD16- Immunosuppressive Monocytes Predict Disease Severity in Patients with Acute Pancreatitis. J Immunol. 2019 202(9):2578-2584.
Zheng J, Lou L, Fan J, Huang C, Mei Q, Wu J, Guo Y, Lu Y, Wang X （通讯作者）, Zeng Y. Commensal Escherichia coli Aggravates Acute Necrotizing Pancreatitis through Targeting of Intestinal Epithelial Cells. Appl Environ Microbiol 2019 85(12)
Xiong J, Wang K, Yuan C, Xing R, Ni J, Hu G, Chen F, Wang X （通讯作者） Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects Int J Mol Med 2017 39(1): 113-125
Wu J, Mulatibieke T, Ni J, Han X, Li B, Zeng Y, Wan R, Wang X （通讯作者）, Hu G Dichotomy between Receptor-Interacting Protein 1- and Receptor-Interacting Protein 3-Mediated Necroptosis in Experimental Pancreatitis. Am J Pathol 2017 187(5):1035-1048
Han X, Li B, Ye X, Mulatibieke T, Wu J, Dai J, Wu D, Ni J, Zhang R, Xue J, Wan R, Wang X （通讯作者）, Hu G. Dopamine D2 receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-kappaB signalling pathway Br J Pharmacol 2017 174(24): 4751-4770
Huang L, Hu B, Ni J, Wu J, Jiang W, Chen C, Yang L, Zeng Y, Wan R, Hu G, Wang X. （通讯作者） Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis J Exp Clin Cancer Res 2016 35:27
Wu D, Zeng Y, Fan Y, Wu J, Mulatibieke T, Ni J, Yu G, Wan R, Wang X （通讯作者）, Hu G. Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury Sci Rep 2016 6:20545
Hu B, Zhang K, Li S, Li H, Yan Z, Huang L, Wu J, Han X, Jiang W, Mulatibieke T, Zheng L, Wan R, Wang X （通讯作者）, Hu G. HIC1 attenuates invasion and metastasis by inhibiting the IL-6/STAT3 signalling pathway in human pancreatic cancer Cancer Lett 2016 376(2):387-98
Lu Y, Chen J, Zheng J, Hu G, Wang J, Huang C, Lou L, Wang X （通讯作者）, Zeng Y. Mucosal adherent bacterial dysbiosis in patients with colorectal adenomas Sci Rep 2016 6:26337
Yin G, Hu G, Wan R, Yu G, Cang X, Ni J, Xiong J, Hu Y, Xing M, Fan Y, Xiao W, Qiu L, Wang S, Wang X （通讯作者） Role of bone marrow mesenchymal stem cells in L-arg-induced acute pancreatitis: effects and possible mechanisms Int J Clin Exp Pathol 2015 8(5):4457-68
Xing, Miao,Ni, Jianbo,Wan, Rong,Tang, Maochun,Hu, Yanling,Yu, Ge （通讯作者）,Yin, Guojian,Chen, Congying,Fan, Yuting,Xiao, Wenqing,Zhao, Yan,Wang, Xingpeng,Hu, Guoyong The tetraspanin CD9 is involved in pancreatic damage during caerulein-induced acute pancreatitis in mice. J Dig Dis 2015 16（1）：43-45
Yin G, Cang X, Yu G, Hu G, Ni J, Xiong J, Hu Y, Xing M, Chen C, Huang Y, Tang M, Zhao Y, Cheng G, Wan R, Wang S, Wang X （通讯作者） Different Clinical Presentations of Hyperlipidemic Acute Pancreatitis: A Retrospective Study Pancreas 2015 44(7):1105-10
Yu, Ge,Wan, Rong,Yin, Guojian,Xiong, Jie,Hu, Yanling,Xing （通讯作者）, Miao,Cang, Xiaofeng,Fan, Yuting,Xiao, Wenqin,Qiu, Lei,Wang, Xingpeng,Hu, Guoyong Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-kB International Journal of Clinical and Experimental Pathology 2014 7（5）：2133-2142。
Xiao, Wen Qin,Yin, Guo Jian,Fan, Yu Ting,Qiu, Lei,Cang, Xiao Feng （通讯作者）,Yu, Ge,Hu, Yan Ling,Xing, Miao,Wu, De Qing,Wang, Xing Peng,Hu, Guo Yong,Wan, Rong Catalpol Ameliorates Sodium Taurocholate-Induced Acute Pancreatitis in Rats via Inhibiting Activation of Nuclear Factor Kappa B International Journal of Molecular Sciences 2014 15（7）：11957-11972
Yu, Ge,Wan, Rong,Hu, Yanling,Ni, Jianbo,Yin, Guojian,Xing, Miao,Shen （通讯作者）, Jie,Tang, Maochun,Chen, Congying,Fan, Yuting,Xiao, Wenqin,Zhao, Yan,Wang, Xingpeng,Hu, Guoyong Pancreatic acinar cells-derived cyclophilin A promotes pancreatic damage by activating NF-kappa B pathway in experimental pancreatitis Biochemical and Biophysical Research Communications 2014 444（1）：75-80
Hu, Yanling,Wan, Rong,Yu, Ge,Shen, Jie,Ni, Jianbo,Yin, Guojian （通讯作者）,Xing, Miao,Chen, Congying,Fan, Yuting,Xiao, Wenqin,Xu, Gang,Wang, Xingpeng,Hu, Guoyong Imbalance of Wnt/Dkk Negative Feedback Promotes Persistent Activation of Pancreatic Stellate Cells in Chronic Pancreatitis PLos One 2014 9（4）：e95145
Ni, Jianbo,Hu, Guoyong,Xiong, Jie,Shen, Jie,Shen, Jiaqing,Yang, Lijuan,Tang, Maochun （通讯作者）,Zhao, Yan,Ying, Guojian,Yu, Ge,Hu, Yanling,Xing, Miao,Wan, Rong,Wang, Xingpeng Involvement of Interleukin-17A in Pancreatic Damage in Rat Experimental Acute Necrotizing Pancreatitis Inflammation 2013 36（1）：53-65
Shen, Jiaqing,Gao, Jing,Chen, Congying,Lu, Huili,Hu, Guoyong,Shen, Jie,Zhu, Shunying （通讯作者）,Wu, MingYuan,Wang, Xia,Qian, Lan,Yu, Yan,Han, Wei,Wan, Rong,Wang, Xingpeng Antifibrotic role of chemokine CXCL9 in experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats Cytokine 2013 64（1）：382-39
Yin, Guojian,Hu, Guoyong,Cang, Xiaofeng,Yu, Ge,Hu, Yanling,Xing, Miao,Chen （通讯作者）, Congying,Huang, Yinshi,Tang, Maochun,Zhao, Yan,Cheng, Guilian,Wan, Rong,Wang, Xingpeng C-reactive protein: rethinking its role in evaluating the severity of hyperlipidemic acute pancreatitis Pancreas 2013 43（8）：1323-1328
Xiong, Jie,Ni, Jianbo,Hu, Guoyong,Shen, Jie,Zhao, Yan,Yang, Lijuan,Shen, Jiaqing （通讯作者）,Yin, Guojian,Chen, Congying,Yu, Ge,Hu, Yanling,Xing, Miao,Wan, Rong,Wang, Xingpeng Shikonin ameliorates cerulein-induced acute pancreatitis in mice Journal of Ethnopharmacology 2013 145（2）：573-580
Li B, Wan X, Zhu Q, Li L, Zeng Y, Hu D, Qian Y, Lu L, Wang X （通讯作者）, Meng X. Net expression inhibits the growth of pancreatic ductal adenocarcinoma cell PL45 in vitro and in vivo. PLoS One. 2013 8(2):e57818
Xu, Yaping,Wu, Deqing （通讯作者）,Zeng, Yue,Wang, Xingpeng Pancreatic Exocrine Function and Morphology Following an Episode of Acute Pancreatitis Pancreas 2012 41（6）：922-927
Yan Zhao,Wei Jia,Mingming Su,Yunping Qiu,Xingpeng Wang （通讯作者） Novel biomarkers of hyperlipidemic acute pancreatitis:metabolomic identification Asian Biomedicine 2012 6（5）：765-769
Shen, Jie,Wan, Rong,Hu, Guoyong,Yang, Lijuan,Xiong, Jie,Wang, Feng （通讯作者）,Shen, Jiaqing,He, Shanshan,Guo, Xiaoyan,Ni, Jianbo,Guo, Chuanyong,Wang, Xingpeng miR-15b and miR-16 induce the apoptosis of rat activated pancreatic stellate cells by targeting Bcl-2 in vitro Pancreatology 2012 12（2）：91-99
Xu, Xuanfu,Guo, Chuanyong,Zhou, Yingqun,Xie, Chuangao,Wei, Shu-mei,Gan, Huizhong （通讯作者）,He, Shengli,Wang, Fan,Xu, Ling,Lu, Jie,Dai, Weiqi,He, Lei,Chen, Ping,Wang, Xingpeng Genome-Wide Screening Reveals an EMT Molecular Network Mediated by Sonic Hedgehog-Gli1 Signaling in Pancreatic Cancer Cells PLos One 2012 7（8）：e43119。
Yang, LiJuan,Shen, JiaQing,He, ShanShan,Hu, GuoYong,Shen, Jie,Wang, Feng,Xu （通讯作者）, Ling,Dai, WeiQi,Xiong, Jie,Ni, JianBo,Guo, ChuanYong,Wan, Rong,Wang, XingPeng L-Cysteine Administration Attenuates Pancreatic Fibrosis Induced by TNBS in Rats by Inhibiting the Activation of Pancreatic Stellate Cell PLos One 2012 7（2）：e31807
Zhang, Wei,Zhao, Yun,Zeng, Yue,Yu, Xiaofeng,Yao, Jianfeng,Zhao, Shangmin,Bao, Zhijun,Chen, Jie,Wang, Xingpeng Hyperlipidemic Versus Normal-Lipid Acute Necrotic Pancreatitis Proteomic Analysis Using an Animal Model Pancreas 2012 41（2）：317-322
Shen, Jiaqing,Wan, Rong,Shen, Zhenyu,Gao, Jing,Wang （通讯作者）, Xia,Qian, Lan,Lu, Huili,Han, Wei,Wang, Xingpeng Chemokine receptor CXCR3 is involved in the acute pancreatitis-associated lung injury Biomedicine & Pharmacotherapy 2012 66（5）：390-396
Shen, Jiaqing,Gao, Jing,Zhang, Jing,Xiang, Di,Wang, Xia,Qian, Lan （通讯作者）,Shen, Jie,Yang, Lijuan,Zhu, Shunying,Wu, Mingyuan,Yu, Yan,Han, Wei,Wang, Xingpeng Recombinant human interleukin-1 receptor antagonist (rhIL-1Ra) attenuates caerulein-induced chronic pancreatitis in mice Biomedicine & Pharmacotherapy 2012 66（2）：83-88
Hu, Guoyong,Zhao, Yan,Tang, Yin,Wang, Yuhui,Shen, Jie,Liu, Lu,Li, Haibo,Liu, Yahan,Cui, Xin,Yu, Yongchun,Guo, Chuanyong,Wang, Xingpeng,Liu, George Development of a Novel Model of Hypertriglyceridemic Acute Pancreatitis in Hamsters Protective Effects of Probucol Pancreas 2012 41（6）：845-848
Shen, Jia Qing,Shen （通讯作者）, Jie,Wang, Xing Peng Expression of insulin-like growth factor binding protein-4 (IGFBP-4) in acute pancreatitis induced by L-arginine in mice Acta Histochemica 2012 114（4）：379-385
Wu, Deqing,Xu, Yaping （通讯作者）,Zeng, Yue,Wang, Xingpeng Endocrine Pancreatic Function Changes After Acute Pancreatitis Pancreas 2011 40（7）：1006-1011
He, ShanShan,Wang, Feng,Yang, LiJuan,Guo, ChuanYong,Wan, Rong,Ke （通讯作者）, AiWu,Xu, Ling,Hu, GuoYong,Xu, XuanFu,Shen, Jie,Wang, XingPeng Expression of DNMT1 and DNMT3a Are Regulated by GLI1 in Human Pancreatic Cancer PLos One 2011 6（11）：e27684
Hu, Guoyong,Shen, Jiaqing,Cheng, Li,Guo, Chuanyong,Xu, Xuanfu,Wang, Feng,Huang, Li,Yang （通讯作者）, Lijuan,He, Miao,Xiang, Di,Zhu, Shunying,Wu, Mingyuan,Yu, Yan,Han, Wei,Wang, Xingpeng Reg4 protects against acinar cell necrosis in experimental pancreatitis Gut 2011 60（6）：820-828
Wang, Feng,Xu, Ling,Guo, Chuanyong,Ke, Aiwu,Hu, Guoyong,Xu （通讯作者）, Xuanfu,Mo, Wenhui,Yang, Lijuan,Huang, Yinshi,He, Shanshan,Wang, Xingpeng Identification of RegIV as a Novel GLI1 Target Gene in Human Pancreatic Cancer PLos One 2011 6（4）：e18434
Gao, Zhenjun （通讯作者）,Wang, Xingpeng,Wu, Kai,Zhao, Yan,Hu, Guoyong Pancreatic Stellate Cells Increase the Invasion of Human Pancreatic Cancer Cells through the Stromal Cell-Derived Factor-1/CXCR4 Axis Pancreatology 2010 10（2-3）：186-193
Wei Zhang,Wang XP （通讯作者）,Yu ZW,Wang LS,Zhu Y,Yu XF,Wu K,Zeng Y,Xu MY Hyperlipidemic versus healthy pancreases: a protepmic analysis using an animal model IUBMB Life 2010 62（10）：781-789
Hu, Guoyong,Shen, Jiaqin,Cheng, Li,Xiang, Di,Zhang, Zhonghui,He （通讯作者）, Miao,Lu, Huili,Zhu, Shunying,Wu, Mingyuan,Yu, Yan,Wang, Xingpeng,Han, Wei Purification of a bioactive recombinant human Reg IV expressed in Escherichia coli Protein Expression and Purification 2010 69（2）：186-190