导师姓名： 胡国勇 专业代码： 100201
性别： 男 专业名称： 内科学
培养单位： 附属第一人民医院 三级学科/
专业领域： 消化系病
导师类型： 硕士生导师 专业学位导师： 兼
联系方式： huguoyongsh@163.com;huguoyongsh@yahoo.com
邮编： 200080 邮箱地址： huguoyongyz@yahoo.com.cn

研究方向 (点击浏览详细信息)
胰腺疾病的基础与临床

社会任职
中华医学会消化病分会胰腺病学组委员
上海市消化病学会青年委员
上海市肠内肠外营养学会青年委员
中华医学会消化病分会青年委员
中国医师协会胰腺病分会急性胰腺炎学组委员
上海市消化病学会胰腺病学组副组长
中华医学会消化病分会营养协作组委员
中国研究性医院学会胰腺病专业委员会急性胰腺炎学组委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 慢性高甘油三酯血症诱导的srebp1c/miR-153信号通路失调在急性胰腺炎中的作用及其机制研究 国家自然科学基金 2020-01~2023-12 55万元 课题负责人
18PJD041 多巴胺D2受体信号通路调控急性胰腺炎中巨噬细胞的极化状态及其分子机制研究 上海市浦江人才计划 2018-09~2020-08 20万元 课题负责人
** 胰腺内源性多巴胺系统调控急性胰腺炎诱导的炎症反应及 其分子机制研究 国家自然科学基金 2017-01~2020-12 58万元 课题负责人
** JAM-C调控中性粒细胞转内皮迁移在急性胰腺炎的作用及其机制研究 国家自然科学基金 2014-01~2017-12 70万元 课题负责人
** RIP1/RIP3激酶依赖的程序性坏死促进急性胰腺炎重症演变及其调控机理研究 国家自然科学基金 2012-01~2014-12 23万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Huang L, Chen C, Yang L, Wan R, Hu G （通讯作者） Neutrophil-to-lymphocyte ratio can specifically predict the severity of hypertriglyceridemia-induced acute pancreatitis compared with white blood cell J Clin Lab Anal 2019 33(4):e22839
Zhang R, Shi J, Zhang R, Ni J, Habtezion A, Wang X, Hu G （通讯作者）, Xue J. Expanded CD14(hi)CD16(-) Immunosuppressive Monocytes Predict Disease Severity in Patients with Acute Pancreatitis J Immunol 2019 202(9):2578-2584
Li B, Han X, Ye X, Ni J, Wu J, Dai J, Wu Z, Chen C, Wan R, Wang X, Hu G. （通讯作者） Substance P-regulated leukotriene B4 production promotes acute pancreatitis-associated lung injury through neutrophil reverse migration. Int Immunopharmacol 2018 57:147-156
Wu J, Zhang R, Hu G, Zhu HH, Gao WQ, Xue J. Carbon Monoxide Impairs CD11b(+)Ly-6C(hi) Monocyte Migration from the Blood to Inflamed Pancreas via Inhibition of the CCL2/CCR2 Axis J Immunol 2018 200(6):2104-2114
Chen C, Xiao W, Huang L, Yu G, Ni J, Yang L, Wan R, Hu G. （通讯作者） Shikonin induces apoptosis and necroptosis in pancreatic cancer via regulating the expression of RIP1/RIP3 and synergizes the activity of gemcitabine. Am J Transl Res 2017 9(12):5507-5517
Chen C, Yu G, Xiao W, Xing M, Ni J, Wan R, Hu G. （通讯作者） Thalidomide inhibits proliferation and epithelial-mesenchymal transition by modulating CD133 expression in pancreatic cancer cells Oncol Lett 2017 14(6):8206-8212
Wu J, Mulatibieke T, Ni J, Han X, Li B, Zeng Y, Wan R, Wang X, Hu G. （通讯作者） Dichotomy between Receptor-Interacting Protein 1- and Receptor-Interacting Protein 3-Mediated Necroptosis in Experimental Pancreatitis Am J Pathol 2017 187(5):1035-1048
Han X, Li B, Ye X, Mulatibieke T, Wu J, Dai J, Wu D, Ni J, Zhang R, Xue J, Wan R, Wang X （通讯作者）, Hu G Dopamine D(2) receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway. Br J Pharmacol 2017 174(24):4751-4770
Wu D, Zeng Y, Fan Y, Wu J, Mulatibieke T, Ni J, Yu G, Wan R, Wang X, Hu G. （通讯作者） Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury Sci Rep 2016 6:20545
Hu B, Zhang K, Li S, Li H, Yan Z, Huang L, Wu J, Han X, Jiang W, Mulatibieke T, Zheng L, Wan R, Wang X, Hu G. （通讯作者） HIC1 attenuates invasion and metastasis by inhibiting the IL-6/STAT3 signalling pathway in human pancreatic cancer Cancer Lett 2016 376(2):387-98
Huang L, Hu B, Ni J, Wu J, Jiang W, Chen C, Yang L, Zeng Y, Wan R, Hu G （通讯作者）, Wang X. Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis J Exp Clin Cancer Res 2016 35:27
Yin G, Hu G （共同第一作者）, Wan R, Yu G, Cang X, Ni J, Xiong J, Hu Y, Xing M, Fan Y, Xiao W, Qiu L, Wang S, Wang X. Role of bone marrow mesenchymal stem cells in L-arg-induced acute pancreatitis: effects and possible mechanisms Int J Clin Exp Pathol 2015 8(5):4457-68
Fan YT, Yin GJ, Xiao WQ, Qiu L, Yu G, Hu YL, Xing M, Wu DQ, Cang XF, Wan R,Wang XP, Hu GY （通讯作者） Rosmarinic Acid Attenuates Sodium Taurocholate-Induced Acute Pancreatitis in Rats by Inhibiting Nuclear Factor-κB Activation Am J Chin Med 2015 43(6):1117-35
Xing M, Ni J, Wan R, Tang M, Hu Y, Yu G, Yin G, Chen C, Fan Y, Xiao W, Zhao Y, Wang X, Hu G （通讯作者） The tetraspanin CD9 is involved in pancreatic damage during caerulein-induced acute pancreatitis in mice J Dig Dis 2015 16(1):43-51
Yu G, Li S, Wan R, Wang X, Hu G. （通讯作者） Nafamostat Mesilate for Prevention of Post-ERCP Pancreatitis: A Meta-analysis of Prospective, Randomized, Controlled Trials. Pancreas 2015 44(4):561-9
Yu G, Wan R, Yin G, Xiong J, Hu Y, Xing M, Cang X, Fan Y, Xiao W, Qiu L, Wang X, Hu G （通讯作者） Diosmetin ameliorates the severity of cerulein-induced acute pancreatitis in mice by inhibiting the activation of the nuclear factor-κB Int J Clin Exp Pathol 2014 7(5):2133-42
Hu Y, Wan R, Yu G, Shen J, Ni J, Yin G, Xing M, Chen C, Fan Y, Xiao W, Xu G, Wang X, Hu G. （通讯作者） Imbalance of Wnt/Dkk negative feedback promotes persistent activation of pancreatic stellate cells in chronic pancreatitis. PLoS One 2014 9(4):e95145
Yu G, Wan R, Hu Y, Ni J, Yin G, Xing M, Shen J, Tang M, Chen C, Fan Y, Xiao W, Zhao Y, Wang X, Hu G. （通讯作者） Pancreatic acinar cells-derived cyclophilin A promotes pancreatic damage by activating NF-κB pathway in Biochem Biophys Res Commun. 2014 444(1):75-80
Ni J, Hu G （共同第一作者）, Xiong J, Shen J, Shen J, Yang L, Tang M, Zhao Y, Ying G, Yu G, Hu Y, Xing M, Wan R, Wang X. Involvement of interleukin-17A in pancreatic damage in rat experimental acute necrotizing pancreatitis. Inflammation 2013 36(1):53-65
Hu G, Zhao Y, Tang Y, Wang Y, Shen J, Liu L, Li H, Liu Y, Cui X, Yu Y, Guo C, Wang X, Liu G. Development of a novel model of hypertriglyceridemic acute pancreatitis in hamsters: protective effects of probucol. Pancreas 2012 41(6):845-8
Hu G, Shen J, Cheng L, Guo C, Xu X, Wang F, Huang L, Yang L, He M, Xiang D, Zhu S, Wu M, Yu Y, Han W, Wang X. Reg4 protects against acinar cell necrosis in experimental pancreatitis Gut 2011 60(6):820-8
Hu G, Shen J, Cheng L, Xiang D, Zhang Z, He M, Lu H, Zhu S, Wu M, Yu Y, Wang X, Han W. Purification of a bioactive recombinant human Reg IV expressed in Escherichia coli Protein Expr Purif 2010 69(2):186-90