导师姓名： 吴云成 专业代码： 100204
性别： 男 专业名称： 神经病学
培养单位： 附属第一人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市虹口区武进路86号，上海交通大学附属第一人民医院神经内科
邮编： 200080 邮箱地址： drwu2006@hotmail.com

研究方向 (点击浏览详细信息)
神经变性疾病和脑血管病的临床和基础研究

社会任职
中国研究型医院学会脑血管病学专委会青年委员会副主任委员
中国卒中学会重症脑血管病分会&脑小血管病分会委员
国际神经病学联盟帕金森病及相关疾病科学委员会委员及亚太工作组委员
国家卫计委脑卒中防治专家委员会出血性卒中内科专委会常务委员
上海市中西医结合学会神经内分泌专业委员会副主任委员
上海市中西医结合学会眩晕病专业委员会副主任委员
中国医师协会神经内科分会全国委员
Editor, Clinical Parkinsonism and Related Disorders
Associate Editor, BMC Neurology
中国卒中学会青年理事会常务理事
上海市医师协会神经内科医师分会委员
中华医学会神经内科分会帕金森病和运动障碍疾病学组全国委员
中国神经科学学会神经病学基础与临床分会、神经退行性疾病分会委员
上海医学会神经内科分会委员、帕金森病和运动障碍疾病学组成员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** TET2在帕金森病多巴胺能神经元损伤中的作用机制及调控研究 国家自然科学基金面上项目 2020-01~2023-12 55万元 课题负责人
CTCCR-** 醒后卒中登记研究 上海市第一人民医院临床研究创新团队建设项目 2018-06~2020-05 60万元 课题负责人
2017YFC** 基于医院的脑血管病临床研究大数据仓库及生物样本和影像平台建设 十三五国家重点研发计划 2018-01~2020-12 15万元 课题参与人
** HIF-1α-ATP13A2信号通路对帕金森病多巴胺能神经元损伤的保护作用和机制研究 国家自然科学基金面上项目 2017-01~2020-12 57万元 课题负责人
YG2014MS31 白藜芦醇调控SIRT1-P53通路对多巴胺能神经元损伤的保护作用及机制研究 上海交通大学医工交叉研究基金 2015-01~2017-12 15万元 课题负责人
WCPAfund2014-1 不安腿综合征患者焦虑障碍的临床研究 西部精神协会基金 2014-07~2015-06 8万元 课题负责人
** SIRT1-HIF-1α信号通路对帕金森病多巴胺能神经元损伤的保护作用及其机制研究 国家自然科学基金面上项目 2014-01~2017-12 70万元 课题负责人
** Resveratrol调控AMPK-SIRT1途径对多巴胺能神经元线粒体损伤的保护作用及机制研究 国家自然科学基金面上项目 2012-01~2015-12 60万元 课题负责人
11PJD019 白藜芦醇调控AMPK-SIRT1途径对多巴胺能神经元线粒体损伤的保护作用及机制研究 上海市浦江人才计划 2011-10~2013-09 20万元 课题负责人
** 白藜芦醇对帕金森病的保护作用及其机制研究 上海市卫生局科研课题面上项目 2011-01~2012-12 6万元 课题负责人
2011CB707506 视神经炎及相关神经变性病的线粒体损伤机制及其神经保护治疗研究 国家重点基础研究项目(973项目)二级子课题 2011-01~2015-12 30万元 子课题负责人
07DJ14005 老年痴呆症早期诊治的基础研究 上海市科委重大基础研究项目 2008-01~2009-09 40万元 课题参与人
06JC14043 缺血缺氧性神经元损伤ER应激机制的基础研究 上海市科委基础研究重点项目 2006-08~2008-08 20万元 课题参与人
** 脑深部电刺激治疗帕金森病作用机制研究 国家自然科学基金面上项目 2003-01~2005-12 21万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Zhu XY, Wu TT, Wang HM, Li X, Ni LY, Chen TJ, Qiu MY, Shen J, Liu T, Ondo WG, Wu YC. （通讯作者） Correlates of nonanemiac iron deficiency in Restless Legs Syndrome. Front Neurol. 2020 11:298.
Wu TT, Liu T, Li X, Chen YJ, Chen TJ, Zhu XY, Chen JL, Li Q, Liu Y, Feng Y, Wu YC. （通讯作者） TET2-mediated Cdkn2A DNA hydroxymethylation in midbrain dopaminergic neuron injury of Parkinson’s disease. Hum Mol Genet. 2020 29(8):1239-1252.
Zhang YL, Zhang JF, Wang XX, Wang Y, Anderson CS, Wu YC. （通讯作者） Wake-up stroke: imaging-based diagnosis and recanalization therapy. J Neurol. 2020 doi: 10.1007/s00415-020-10055-7.
Mao Q, Wang XP, Fan L, Zhang Y, Wu YC, Ji J, Xu J, Zhang H, Zheng C, Wang K, Li CSR, Luo X. KTN1 variants underlying putamen gray matter volumes and Parkinson’s disease. Front Neurosci. 2020 14:651
Li X, Feng Y, Wang XX, Truong D, Wu YC. （通讯作者） The Critical Role of SIRT1 in Parkinson’s Disease: Mechanism and Therapeutic Considerations. Aging Dis. 2020 11(6): 10.14336/AD.2020.0216
Zhu XY, Wu YC （通讯作者） Impulse control disorders in very elderly patients with restless legs syndrome Clinical Parkinsonism & Related Disorders 2019 1:4-65.
Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H. Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation. J Clin Invest. 2019 129(1):252-267
Zhang XJ, Xu ZY, Wu YC, Tan EK. Paroxysmal movement disorders: Recent advances and proposal of a classification system. Parkinsonism Relat Disord. 2019 59:131-139.
Lin XW, Zhang JF, Qiu MY, Ni LY, Yu HL, Kuo SH, Ondo WG, Yu Q, Wu YC. （通讯作者） Restless legs syndrome in end stage renal disease patients undergoing hemodialysis. BMC Neurol. 2019 19(1):47
Zhang JF, Qiu MY, Zhang YL, Wang XX, Wang GP, Geng Y, Zhang KZ, Fang K, Wu YC. （通讯作者） Neurology practice and stroke services across East China: a multi-site, county-level hospital-based survey. BMC Neurol. 2019 19(1):293.
Chen Y, Wu T, Li H, Li X, Li Q, Zhu X, Yu M, Kuo SH, Huang F, Wu YC. （通讯作者） Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation. Front Aging Neurosci. 2019 11:44.
Zhu XY, Wu TT, Wang HM, Ni LY, Li X, Liu Y, Zhang XJ, Chen YJ, Cui XX, Ondo WG, Wu YC. （通讯作者） Clinical features and subtypes of restless legs syndrome in Chinese population: a study of 359 patients. Sleep Med. 2019 59:15-23.
Zhang JF, Zhang YL, Wu YC. （通讯作者） The Role of Sirt1 in Ischemic Stroke: Pathogenesis and Therapeutic Strategies. Front Neurosci. 2018 12:833.
Zhang L, Xu J, Gao J, Wu Y, Yin M, Zhao W CD200-, CX3CL1-, and TREM2-mediated neuron-microglia interactions and their involvements in Alzheimer's disease Rev Neurosci 2018 29(8):837-848.
Yang HR, Ma L, Jiang YF, Wu YC, Lai EC, Zhu YH。 Process and Results of Implementing Disease Management Program in Patients with First-time Ischemic Stroke. Iran J Public Health 2018 47(7):1007-1016
Lin Y, Li B, Tang H, Xu Q, Wu Y, Cheng Q, Li C, Xiao S, Shen L, Tang W, Yu H, He N, Lin H, Yan F, Cao W, Yang S, Liu Y, Zhao W, Lu D, Jiao B, Xiao X, Zhou L, Chen S Shanghai cognitive intervention of mild cognitive impairment for delaying progress with longitudinal evaluation-a prospective, randomized controlled study (SIMPLE): rationale, design, and methodology BMC Neurol 2018 18(1):103
Li X, Cui XX, Chen YJ, Wu TT, Xu HX, Yin HY, Wu YC （通讯作者） Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function Front Aging Neurosci 2018 10:121.
Cui XX, Li X, Dong SY, Guo YJ, Liu T, Wu YC （通讯作者） SIRT3 deacetylated and increased citrate synthase activity in PD model Biochem Biophys Res Commun 2017 484(4):767-773.
Liu Y, Zhu XY, Zhang XJ, Kuo SH, Ondo WG, Wu YC （通讯作者） Clinical features of Parkinson's disease with and without rapid eye movement sleep behavior disorder Transl Neurodegener 2017 6:35.
Zhuo Y, Wu Y, Xu Y, Lu L, Li T, Wang X, Li K. Combined resting state functional magnetic resonance imaging and diffusion tensor imaging study in patients with idiopathic restless legs syndrome Sleep Med 2017 38:96-103.
Tang JJ, Zhao YB, Lu YY, Wang GD, Zhang Q, Zhou XL, Shen X, Song XY, Lu HY, Wang QS, Wu YC （通讯作者） Clinical characteristics of internal carotid artery aplasia Int J Clin Exp Med 2017 10(10):14503-14510.
Li J, Ren M, Dong A, Wu Y, Han N, Deng B, Bi X. A retrospective study of 23 cases with subacute combined degeneration Int J Neurosci 2016 126(10):872-7.
Dong SY, Guo YJ, Feng Y, Cui XX, Kuo SH, Liu T, Wu YC （通讯作者） The epigenetic regulation of HIF-1α by SIRT1 in MPP(+) treated SH-SY5Y cells Biochem Biophys Res Commun 2016 470(2):453-9
Lu H, Song X, Wang F, Wang G, Wu Y, Wang Q, Wang Y, Yang GY, Zhang Z Hyperexpressed Netrin-1 Promoted Neural Stem Cells Migration in Mice after Focal Cerebral Ischemia Front Cell Neurosci 2016 10:223
Fang K, Liu P, Dong S, Guo Y, Cui X, Zhu X, Li X, Jiang L, Liu T, Wu Y （通讯作者） Magnetofection based on superparamagnetic iron oxide nanoparticle-mediated low lncRNA HOTAIR expression decreases the proliferation and invasion of glioma stem cells Int J Oncol 2016 49(2):509-18.
Guo YJ, Dong SY, Cui XX, Feng Y, Liu T, Yin M, Kuo SH, Tan EK, Zhao WJ, Wu YC （通讯作者） Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3 Mol Nutr Food Res 2016 60(10):1-15
Pan W, Liu J, Chen X, Wang Q, Wu Y, Bai Y, Liu Y, Li W, Li W, Yuan C, Hou W, Bi X, Zhuang J, Dong Q, Cai D. A Practical Consensus Guideline for the Integrative Treatment of Parkinson's Disease in Shanghai, China Integr Med Int 2015 2:56-62
Zhu XY, Liu Y, Zhang XJ, Yang WH, Feng Y, Ondo WG, Tan EK, Wu YC （通讯作者） Clinical characteristics of leg restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome J Neurol Sci 2015 357(1-2):109-114.
Feng Y, Liu T, Wu YC （通讯作者） microRNA 182 inhibits the proliferation and migration of glioma cells through the induction of neuritin expression Oncol Lett 2015 10(2):1197-1203
Feng Y, Jankovic J, Wu YC （通讯作者） Epigenetic mechanisms in Parkinson’s disease J Neurol Sci 2015 349(1):3-9.
Zhu YP, Feng Y, Liu T, Wu YC （通讯作者） The epigenetic modification and its role in Alzheimer’s disease Integr Med Int 2015 2:63-72.
Feng Y, Liu T, Dong SY, Guo YJ, Jankovic J, Xu H, Wu YC （通讯作者） Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells J Neurochem 2015 134(4):668-76
Zhu XY, Pan TH, Ondo WG, Jimenez-Shahed J, Wu YC （通讯作者） Effects of deep brain stimulation in relatively young-onset multiple system atrophy Parkinsonism J Neurol Sci 2014 342(1-2):42-4
Feng Y, Liu T, Li XQ, Liu Y, Zhu XY, Jankovic J, Pan TH, Wu YC （通讯作者） Neuroprotection by Orexin-A via HIF-1α induction in a cellular model of Parkinson's disease Neurosci Lett 2014 579:35-40
Zhu XY, Kuo SH, Wan LP, Liu Y, Wu Y （通讯作者） Isolated peripheral neuropathy as an unusual presentation for an extramedullary relapse of acute leukemia Neurol Asia 2014 19(2):203-206
Yin H, Zhu Y, Zhu M, Hou S, Li Z, Zhong H, Lu J, Meng T, Wang J, Xia L, Xu Y, Wu Y （通讯作者） Role of mitochondria in programmed cell death mediated by arachidonic acid-derived eicosanoids Mitochondrion 2013 13(3):209-24
Ran LM, Luo KJ, Wu YC, Yao L, Feng YM An analysis of China's physician salary payment system J Huazhong Univ Sci Technolog Med Sci 2013 33(2):309-14
Liu Y, Zhang-Nunes S, Zhu X, Xu X, Sun X, Wu Y （通讯作者） Late adult onset of optic pathway astrocytoma J Clin Neurosci 2013 20(11):1610-2
Wu Y, Le W, Jankovic J Preclinical biomarkers of Parkinson’s disease Arch Neurol 2011 68(1):22-30
Wu Y, Li X, Zhu JX, Xie W, Le W, Fan Z, Jankovic J, Pan T Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson's Disease Neurosignals 2011 19(3):163-174.
Zhao S, Guo C, Wang M, Chen W, Wu Y, Tang W, Zhao Y. A clinical memory battery for screening for amnestic mild cognitive impairment in an elderly chinese population. J Clin Neurosci 2011 18(6):774-9.
Wu Y, Li X, Xie W, Jankovic J, Le W, Pan T. Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1alpha and induction of autophagy in SH-SY5Y cells Neurochem Int 2010 57(3):198-205.
Wu Y, Davidson AL, Pan T, Jankovic J. Asian Over-Representation Among Patients with Hemifacial Spasm J Neurol Sci 2010 298(1-2):61-3.
Pan T, Rawal P, Wu Y, Xie W, Jankovic J, Le W. Rapamycin protects against rotenone-induced apoptosis through autophagy induction Neuroscience 2009 164(2):541-51.
Wu YC （通讯作者）, Zhao YB, Tang MG, Zhang-Nunes SX, McArthur JC AIDS dementia complex in China J Clin Neurosci 2007 14(1):8-11.
Xu Y, Cai Y, Gong N, Chen C, Wu Y, Zhang-Nunes S, Wang Z, Xu T, Fei J Homeostatic plasticity of GABAergic synaptic transmission in mice lacking GAT1 Biochem Biophys Res Commun 2007 361(2):499-504.
Wu YC （通讯作者）, Zhao YB, Lu CZ, Qiao J, Tan YJ Correlation between serum level of neuron-specific enolase and long-term functional outcome after acute cerebral infarction: prospective study Hong Kong Med J 2004 10(4):251-4