导师姓名： 郑元义 专业代码： 100207
性别： 男 专业名称： 影像医学与核医学
培养单位： 附属第六人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市徐汇区宜山路600号科研综合楼704
邮编： 200233 邮箱地址： zhengyuanyi@163.com

研究方向 (点击浏览详细信息)
临床研究方向：肌骨超声诊断与介入治疗、超声人工智能诊断
基础研究方向：脑科学超声新技术、影像监控下的磁调控、超声造影剂研发

社会任职
中国生物医学工程学会青年工作委员会　副主任委员
中国超声医师协会肌骨委员会副主任委员
卫计委超声医学专科能力建设项目专家委员会委员
中华医学会超声分会　委员
中国超声医学工程学会超声分子影像专委会 副主任委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2018SHZDZX05 全脑神经联接图谱与克隆猴模型计划 上海市科委上海市市级科技重大专项 2018-11~2023-12 442万元 课题负责人
人工工程肿瘤生物磁体高效聚集相转变型纳米粒用于肿瘤治疗与超声 国家基金委：重点国际(地区)合作研究项目 2018-01~2022-12 232万元 课题负责人
2018YFC** 影像监控下的磁调控系统用于肿瘤物理治疗的关键技术研究 国家科技部 2018-01~2021-06 968万元 课题负责人
** 磁致相变型微纳米材料多模显像与诊疗一体化研究 上海交通大学双**** 2016-12~2019-12 100万元 课题负责人
1 科研启动经费 上海交通大学附属第六人民医院 2016-07~2019-12 600万元 课题负责人
** 超声分子显像 国家****科学基金 2015-01~2019-12 400万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Weiwei Ying, Yang Zhang, Wei Gao, Xiaojun Cai, Gang Wang, Xiafang Wu, Lei Chen*, Zheying Meng, Yuanyi Zheng*, Bing Hu* （通讯作者）, and Xianfang Lin*. Hollow Magnetic Nanocatalysts Drive Starvation–Chemodynamic–Hyperthermia Synergistic Therapy for Tumor. ACS Nano 2020 doi:10.1021/acsnano.0c00910.
Li Yao,a Liangzhu Feng, *b Danlei Tao,b Huiquan Tao,b Xiaoyan Zhong, b Chao Liang,b Yujie Zhu,b Bing Hu,a Zhuang Liu *b and Yuanyi Zheng *a. Perfluorocarbon nanodroplets stabilized with cisplatin-prodrug-constructed lipids enable efficient tumor oxygenation and chemo-radiotherapy of cancer?. Nanoscale 2020 DOI:https://doi.org/10.1039/D0NR01476A
Bing Lianga, Deyu Zuo, Kexiao Yub,, Xiaojun Caic,??, Bin Qiaoa, Rui Dengd, Junsong Yange, Lei Chud （通讯作者）, Zhongliang Dengd, Yuanyi Zheng,??, Guoqing Zuoa,? . Multifunctional bonecementfor synergistic magnetic hyperthermia ablation and chemotherapy of osteosarcoma. Materials Science & Engineering C. 2020 108, 110460-66.
Kai Zhang, Mengjiao Tu, Wei Gao, Xiaojun Cai*, Fahuan Song, Zheng Chen, Qian Zhang, Jing Wang, Chentao Jin, Jingjing Shi, Xiang Yang, Yuankai Zhu, Weizhong Gu, Bing Hu, Yuanyi Zheng* （通讯作者）, Hong Zhang*, and Mei Tian* Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis Nano Lett 2019 19(5): 2812-2823
Kexiao Yu, Bing Liang, Yuanyi Zheng* （通讯作者）, Agata Exner, Michael Kolios, Tiantian Xu, Dajing Guo, Xiaojun Cai, Zhigang Wang, Haitao Ran, Lei Chu*, and Zhongliang Deng* PMMA-Fe3O4 for internal mechanical support and magnetic thermal ablation of bone tumors Theranostics 2019 9(14):4192-4207
Jiulong Zhao, Wei Gao, Xiaojun Cai*, Jiajia Xu, Duowu Zou*, Zhaoshen Li, Bing Hu*, Yuanyi Zheng* （通讯作者） Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease Theranostics 2019 9(10):2843-2855
Chengwei Ye, Jia Liu, Xinyu Wu, Ben Wang, Li Zhang,Yuanyi Zheng, and Tiantian Xu Hydrophobicity Influence on Swimming Performance of Magnetically Driven Miniature Helical Swimmers Micromachines (Basel) 2019 10(3): 175-178
Bing Liang, Kexiao Yu, Yi Ling, Micheal Kolios, Agata Exner, Zhigang Wang, Bing Hu, Guoqing Zuo,* Yu Chen* and Yuanyi Zheng* An artificially engineered “tumor bio-magnet” for collecting blood-circulating nanoparticles and magnetic hyperthermia Biomaterials Science 2019 published on 11 Jun 2019
Xiuzhen Tang, Yanjun Xu, Jie Chen, Tao Ying, Longchen Wang, Lixin Jiang, Yan Wang, Zhenhai Wang, Yi Ling, Fengjuan Wang, Li Yao, Haitao Ran, Zhigang Wang, Bing Hu* and Yuanyi Zheng* Intermittent time-set technique controlling the temperature of magnetic-hyperthermia-ablation for tumor therapy RSC advances 2018 8(30):16410-16418
Hailin Tang, Yuanyi Zheng* （通讯作者）, Yu Chen* Material Chemistry of Nanoultrasonic Biomedicine Advanced Materials 2017 20(10)
Yi Ling,a Xiuzhen Tang,a Fengjuan Wang,a Xiaohan Zhou,a Ronghui Wang,a Liming Deng,a Tingting Shang, Bing Liang, Pan Li, Haitao Ran, Zhigang Wang, Bing Hu, Chunhong Li,* Guoqing Zuo* and Yuanyi Zheng* Highly efficient magnetic hyperthermia ablation of tumors using injectable polymethylmethacrylate–Fe3O4 RSC advances 2017 5
Zhaogang Teng, Ronghui Wang, Yang Zhou, Michael Kolios, Yanjie Wang, Nan Zhang, Zhigang Wang, Yuanyi Zheng* （通讯作者）, Guangming Lu* A magnetic droplet vaporization approach using perfluorohexane-encapsulated magnetic mesoporous particles for ultrasound imaging and tumor ablation Biomaterials 2017 134 :43
Fengjuan Wang, Yang Yang, Yi Ling, Jianxin Liu, Xiaojun Cai, Xiaohan Zhou, Xiuzhen Tang, Bing Liang, Yini Chen, Hangrong Chen, Dengming Chen, Chunhong Li, Zhigang Wang, Bing Hu, Yuanyi Zheng* （通讯作者） Injectable and thermally contractible hydroxypropyl methyl cellulose/Fe3O4 for magnetic hyperthermia ablation of tumors Biomaterials 2017 128 :84
Ronghui Wang; Yang Zhou; Ping Zhang; Yu Chen; Wei Gao; Jinshun Xu; Hangrong Chen;Xiaojun Cai; Kun Zhang; Pan Li; Zhigang Wang; Bing Hu*; Tao Ying*; Yuanyi Zheng* Phase-transitional Fe3O4/perfluorohexane Microspheres for Magnetic Droplet Vaporization Theranostics 2017 7(4):846-854
Xiaoqin Qian, Yuanyi Zheng* （通讯作者）, Yu Chen*. Micro/Nano particles Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation Advanced Materials 2016 2016 Jul 6
Nan Zhang, Xiaojun Cai, Wei Gao, Ronghui Wang, Chunyan Xu, Bing Liang, Lan Hao, Hangrong Chen*, Yuanyi Zheng* （通讯作者）, Zhigang Wang*. A multifunctional theranosticnanoagent based-on hollow mesoporous Prussian blue nanoparticle: synergistic effect between diagnosis and therapy. Theranostics 2016 2016; 6(3): 404-417. doi:10.7150/thno.13478.
Wei Gao, Yuanyi Zheng* （通讯作者）, Ronghui Wang, Hangrong Chen, Xiaojun Cai, Guangming Lu, Lei Chu, Chunyan Xu, Nan Zhang, Zhigang Wang, Haitao Ran, Pan Li, Chunjiang Yang, Zhechuan Mei*, Jinlin Song*. A smart, phase transitional and injectable DOX/PLGA-Fe implant for magnetic-hyperthermia-induced synergistic tumor eradication. ACTA Biomaterialia 2016 2016 Jan;29:298-306.
Yi Ling, Xiuzhen Tang, Fengjuan Wang, Xiaohan Zhou, Ronghui Wang, Liming Deng, Tingting Shang, Bing Liang, Pan Li, Haitao Ran, Zhigang Wang, Bing Hu, Chunhong Li*, Guoqing Zuo*, Yuanyi Zheng* （通讯作者） Highly efficient magnetic hyperthermia ablation of tumors using injectable Polymethylmethacrylate-Fe3O4 RSC Advances 2016 7（5），2913-2918?
Jinshun Xu, Yu Chen, Liming Deng, Jianxin Liu, Yang Cao, Pan Li, Haitao Ran, Yuanyi Zheng* （通讯作者）, Zhigang Wang* Microwave-activated nanodroplet vaporization for highly efficient tumor ablation with real-time monitoring performance Biomaterials 2016 106:264-75
Yang Zhou, Ronghui Wang, Zhaogang Teng, Zhigang Wang, Bing Hu, Michael Kolios, Hangrong Chen, Nan Zhang, Yanjie Wang, Pan Li, Xing Wu, Guangming Lu,* Yu Chen,* Yuanyi Zheng* （通讯作者） Magnetic Nanoparticle-Promoted Droplet Vaporization for In Vivo Stimuli-Responsive Cancer Theranostics NPG Asia Materials 2016 8, e313
Di Zhou, Chuanfei Li, Minyu He, Ming Ma, Pan Li, Yuping Gong, Haitao Ran, Zhibiao Wang, Zhigang Wang*, Yuanyi Zheng* and Yang Sun* （通讯作者） Folate-targeted perfluorohexane nanoparticles carrying bismuth sulfide for use in US/CT dual-mode imaging and synergistic high-intensity focused ultrasound ablation of cervical cancer J. Mater. Chem. B 2016 Accepted 04 May 2016
Yajing Zhao, Weixiang Song, Dong Wang, Haitao Ran, Ronghui Wang, Yuanzhi Yao, Zhigang Wang, Yuanyi Zheng* （通讯作者）, Pan Li*. Phase-shifted PFH/Fe3O4@PLGAFe3O4/PFH@PLGA Nanocapsules for MRI/US Imaging and Photothermal Therapy with Near-infrared Irradiation. ACS Applied Materials & Interfaces 2015 2015 Jul 8;7(26):14231-42
Chunyan Xu, Yuanyi Zheng* （通讯作者）, Wei Gao, Jinshun Xu, Guoqing Zuo, Yu Chen, Minzhu Zhao, Jianbo Li, Jinlin Song, Nan Zhang, Zhigang Wang, Hongyun Zhao, Zhechuan Mei*. Magnetic Hyperthermia Ablation of Tumor using Injectable Fe3O4/Calcium Phosphate Cement. ACS Applied Materials & Interfaces. 2015 2015 Jul 1;7(25):13866-75
Kun Zhang., Huixiong Xu., Xiaoqing Jia, Shuguang Zheng., Xiaojun Cai, Ronghui Wang, Juan Mou, Yuanyi Zheng* （通讯作者）, Jianlin Shi*. CO2 bubbling-based 'Nanobomb' System for Targetedly Suppressing Panc-1 Pancreatic Tumor via Low Intensity Ultrasound-activated Inertial Cavitation. Theranostics. 2015 2015; 5(11): 1291-1302.
Xuemei Zhang, Yuanyi Zheng* （通讯作者）, Zhigang Wang, Shuai Huang, Yu Chen, Wei Jiang, Hua Zhang, Mingxia Ding, Qingshu Li, Xiaoqiu Xiao, Xin Luo, Zhibiao Wang, Hongbo Qi*. Methotrexate-loaded plga nanobubbles for ultrasound imaging and synergistic targeted therapy of residual tumor during hifu ablation Biomaterials. 2014 2014;35:5148-5161
Yu Chen, Ling Jiang, Ronghui Wang, Ming Lu, Qunxia Zhang, Yang Zhou, Zhigang Wang, Guangming Lu,* Ping Liang, Haitao Ran, Hangrong Chen*, Yuanyi Zheng*. （通讯作者） Injectable Smart Phase-Transformation Implants for Highly Efficient In Vivo Magnetic-Hyperthermia Regression of Tumor Advanced Materials 2014 2014;26(44):7532-7538
Yang Sun, Yuanyi Zheng* （通讯作者）, Pan Li, Dong Wang, Chengcheng Niu, Yuping Gong, Rongzhong Huang, Zhibiao Wang, Zhigang Wang and Haitao Ran*. Evaluation of superparamagnetic iron oxide-polymer composite microcapsules for magnetic resonance-guided high-intensity focused ultrasound cancer surgery. BMC Cancer. 2014 2014;14:800
Yang Zhou, Zhigang Wang, Yu Chen, Hongxia Shen, Zhenchun Luo, Ao Li, Qi Wang, Haitao Ran, Pan Li, Zhu Yang, Hangrong Chen, Huaidong Hu, Zhibiao Wang, Guangmin Lu, Yuanyi Zheng*. （通讯作者） Microbubbles from Gas-Generating Perfluorohexane Nanoemulsions for Targeted Temperature-Sensitive Ultrasonography and Synergistic HIFU Ablation of Tumors. Adv Mater. 2013 2013 Aug 14;25(30):4123-30.
Chengcheng Niu, Zhigang Wang, Guangming Lu, Tianyi M. Krupka, Yang Sun, Yufang You, Weixiang Song, Haitao Ran , Pan Li, Yuanyi Zheng*. （通讯作者） Doxorubicin Loaded Superparamagnetic PLGA-Iron Oxide Multifunctional Microbubbles for Dual-Mode US/MR Imaging and Therapy of Metastasis in Lymph Nodes. Biomaterials. 2013 2013;34(9):2307-2317.
Wenjie Dong, Yongsheng Li*, Dechao Niu, Zhi Ma, Xiaohang Liu, Jinlou Gu, Wenru Zhao, Changsheng Liu, Yuanyi Zheng* （通讯作者）, Jianlin Shi*. A Simple Route to Prepare Monodisperse Au NPs-Decorated and dye-doped, Superparamagnetic Nanocomposites for Optical, MR and CT Trimodal Imagings. Small. 2013 2013 Aug 12;9(15):2500-8