导师姓名： 申锷 专业代码： 100207
性别： 女 专业名称： 影像医学与核医学
培养单位： 附属第六人民医院 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师： 兼
联系方式： shene2008@163.com
邮编： 200233 邮箱地址： shene2008@163.com

研究方向 (点击浏览详细信息)
1、糖尿病心肌病的临床与基础研究；2、血管代谢超声的临床与基础研究；

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** LncRNA Gm38235介导糖尿病心肌细胞肥大的机制研究 上海市卫生和计划生育委员会 2019-01~2021-12 20万元 课题负责人
YG2017ZD12 超声联合纳米级荷载rAAV9-FGF21微泡靶向糖尿病心肌细胞肥大的实验研究 上海交通大学医工交叉项目（重点） 2018-01~2020-12 75万元 课题负责人
** MicroRNA 靶向Rac1 与糖尿病心肌病心肌肥大的关系 国家自然科学基金面上项目 2013-01~2016-12 70万元 主要责任人
09PJ** Rac1-NADPH氧化酶在高糖致心肌细胞凋亡中的作用及其机制研究 上海市科委（浦江人才计划，人才资助项目） 2009-08~2011-07 20万元 主要责任人

学术论文 作者论文标题期刊名出版年卷期页码
Wang YZ, Zhu DY, Xie XM, Ding M, Wang YL, Sun LL, Zhang N, Shen E （通讯作者）, Wang XX. EA15, MIR22, LINC00472 as diagnostic markers for diabetic kidney disease Journal of Cellular Physiology 2019 234(6):8797-8803
Meng Z, Chen C, Cao H, Wang J, Shen E. （通讯作者） Whole transcriptome sequencing reveals biologically significant RNA markers and related regulating biological pathways in cardiomyocyte hypertrophy induced by high glucose Journal of Cellular Biochemistry 2019 120(1):1018-1027
Chen C, Meng Z, Zheng Y, Hu B, Shen E. （通讯作者） Fibroblast growth factor 21 inhibition aggravates cardiac dysfunction in diabetic cardiomyopathy by improving lipid accumulation Experimental and Therapeutic Medicine 2018 15(1):75-84
孟哲颖,胡兵,陈翠,曹洪丽,王静怡,申锷 （通讯作者） 1型糖尿病小鼠心肌组织miR-142-3p的lncRNA和circRNA靶标分析 国际心血管病杂志 2018 45(4)
陈翠,孟哲颖,郑元义,胡兵,申锷 （通讯作者） FGF21改善STZ诱导的1型糖尿病小鼠心肌纤维化的实验研究 实验动物科学 2017 34(2)
陈翠,孟哲颖,郑元义,胡兵,申锷 （通讯作者） 心肌线粒体改变对1型糖尿病小鼠心脏结构与功能的影响 医学研究杂志 2017 46(3)
张淑玲,孟哲颖,陈翠,胡兵,申锷 （通讯作者） 速度向量成像技术评估蒽环类药物所致心肌损害的临床价值 中国医学前沿杂志 2017 9(5)
Wang YU, Chen YN, Zhang W, Yang YU, Bai WK, Shen E, Hu B. Upregulation of ULK1 expression in PC-3 cells following tumor protein P53 transfection by sonoporation Oncology Letters 2016 11(1):699-704
Sun D, Wei C, Shen E, Ying T, Hu B. Quantitative Study of Elasticity of Rabbit VX2 Liver Tumor with Alternated Cooling and Heating Treatment based on ARFI Ultrasound Imaging Technique Scientific Reports 2016 6:29303
孟哲颖,王玉,林艳端,南淑良,徐卫平,胡兵,申锷 （通讯作者） 微小RNA–182通过靶基因Rac1调控高糖诱导的心肌细胞肥大 中华心血管病杂志 2015 43(7):619-24
Meng Z, Chen C, Zhu Y, Zhang S, Wei C, Hu B, Yu L, Hu B, Shen E. （通讯作者） Diagnostic performance of the automated breast volume scanner: a systematic review of inter-rater reliability/agreement and meta-analysis of diagnostic accuracy for differentiating benign and malignant breast lesions European radiology 2015 25(12):3638-47
Wang YU, Chen YN, Zhang W, Yang YU, Shen E, Hu B. Upregulation of Beclin-1 expression in DU-145 cells following low-frequency ultrasound irradiation combined with microbubbles Oncology Letters 2015 10(4):2487-2490
Wang YU, Chen YN, Zhang W, Yang YU, Bai WK, Shen E, Hu B. Upregulation of ULK1 expression in PC-3 cells following tumor protein P53 transfection by sonoporation Oncology Letters 2015 11(1):699-704
Yi XL, Chen J, Li J, Feng L, Wang Y, Zhu JA, Shen E, Hu B. Risk factors associated with PICC‐related upper extremity venous thrombosis in cancer patients Journal of Clinical Nursing 2014 23(5-6):837-43
Yi X, Zhu J, Wei M, Li J, Chen J, Wang Y, Shen E, Hu B. Risk factors of venous thrombosis in patients with ankle fractures International Angiology 2014 33(4):324-8
Shen ZY, Shen E, Zhang JZ, Bai WK, Wang Y, Yang SL, Nan SL, Lin YD, Li Y, Hu B Effects of low-frequency ultrasound and microbubbles on angiogenesis-associated proteins in subcutaneous tumors of nude mice Oncology Reports 2013 30(2):842-50
Yang SL, Mu YM, Tang KQ, Jiang XK, Bai WK, Shen E, Hu B. Enhancement of recombinant adeno-associated virus mediated transgene expression by targeted echo-contrast agent Genetics and Molecular Research 2013 12(2):1318-26
Wang Y, Bai WK, Shen E, Hu B. Sonoporation by low-frequency and low-power ultrasound enhances chemotherapeutic efficacy in prostate cancer cells in vitro Oncology Letters 2013 6(2):495-498
Bai WK, Shen E, Hu B. The induction of the apoptosis of cancer cell by sonodynamic therapy: a review Chinese Journal of Cancer Research 2012 24(4):368-373
Wen-Κun Bai,Zuo-Ηui Wu,E Shen,Ji-Ζhen Zhang,Bing Hu The improvement of liposome-mediated transfectionof pEGFP DNA into human prostate cancer cellsby combining low-frequency and low-energy ultrasound with microbubbles Oncology Reports 2012 27(2): 475-480
1.Shen E （共同第一作者）, Diao X, Wang X, Chen R, Hu B. MicroRNAs involved in the mitogen-activated protein kinase cascades pathway during glucose-induced cardiomyocyte hypertrophy Am J Pathol 2011 179(2):639-50
2.Diao X, Shen E （共同第一作者）, Wang X, Hu B Differentially expressed microRNAs and their target genes in the hearts of streptozotocin-induced diabetic mice Mol Med Report 2011 4(4):633-40
3.Li J, Zhu H, Shen E （共同第一作者）, et al. Differentially expressed microRNAs and their target genes in the hearts of streptozotocin-induced diabetic mice Deficiency of Rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress and reduces myocardial remodeling in type-I diabetic mice 2010 59(8):2033-42
4.Shen E （共同第一作者）,Diao Xuehong,Wei Cong,et al MicroRNAs target gene and signaling pathway by bioinformatics analysis in the cardiac hypertrophy Biochem Biophys Res Commun 2010 397(3):380-5
5.Shen E （共同第一作者）, Li Yanwen, Li Ying, et al Rac1 Is Required for Cardiomyocyte Apoptosis During Hyperglycemia. Diabetes 2009 58 (12):2386-2395
6.Shen E （共同第一作者）, Fan Jue, Peng T Glycogen synthase kinase-3beta suppresses tumor necrosis factor- alpha expression in cardiomyocytes during lipopolysaccharide stimulation. J Cell Biochem 2008 104(1):329-328
7.Shen E （共同第一作者）, Fan Jue, Peng T. Phospholipase Cgamma1 signalling regulates lipopolysaccharide -induced cyclooxygenase-2 expression in cardiomyocytes J Mol Cell Cardiol 2007 43(3):308-318