导师姓名： 郭澄 专业代码： 100700
性别： 男 专业名称： 药学
培养单位： 附属第六人民医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： gboss@126.com
邮编： 200233 邮箱地址： gboss@126.com

研究方向 (点击浏览详细信息)
1.抗肿瘤药理学2.中药免疫药理学

社会任职
《中国药业》杂志执行主编
中国药学会医院药学专委会委员
《中国药房》杂志副主编
上海市医院协会药事管理专委会副主任委员
中国医院协会临床药事管理专业委员会委员
上海市药学会医院药学专委会副主任委员
中国药学会药学服务专委会副主任委员
《中国临床药学杂志》等6家杂志编委

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 欧前胡素特异性抑制STAT3介导蛋白降解改善肿瘤恶病质骨骼肌萎缩的作用机 国家自然科学基金 2021-01~2024-12 55万元 课题负责人
** 苦参碱通过BDK/BCKDC通路改善肿瘤恶病质骨骼肌萎缩的作用及机制 国家自然科学基金面上项目 2019-01~2022-12 57万元 课题负责人
2016ZB0302-01 上海市卫生计生系统重要薄弱学科建设 上海市卫生与计划生育委员会 2017-01~2019-12 26万元 课题负责人
16DZ** 注射用苯磺顺阿曲库胺（库泰）在骨科手术中的应用性研究 上海市科学技术委员会 2016-09~2019-09 20万元 课题负责人
AB007 上海市临床药学重点专科建设基金 上海市卫计委 2016-08~2018-08 100万元 课题负责人
** 基于核糖体蛋白S5的木犀草素抗肝纤维化新靶点及机制研究 国家自然科学基金青年项目 2016-01~2018-12 17.9万元 课题参与人
** β2-AR激动剂福莫特罗调控BCKDC改善恶病质骨骼肌萎缩的作用机制研究 国家自然科学基金青年项目 2016-01~2018-12 17.9万元 课题参与人
20154Y0191 CerK 调节脊髓星形胶质细胞炎性因子表达及其在炎性疼痛中的作用 上海市卫计委 2016-01~2018-12 2万元 课题参与人
YG2014MS21 天然Nur77激动剂金丝桃苷及其结构类似物抑制血管平滑肌细胞增生作用机制研究 上海交大“科技创新专项资金” 2015-01~2017-12 15万元 课题参与人
YG2014QN08 基于一种S1P/S1PR1新型通路治疗骨癌痛的研究 上海交大“科技创新专项资金” 2015-01~2017-12 8万元 课题参与人
ZY3-RCPY-3-1036 中医药（中药临床药学）专门人才计划 上海市卫生局 2014-09~2016-08 10万元 课题参与人
14ZR** 金丝桃苷调控Nur77表达抑制血管平滑肌细胞增殖机制研究 上海市科委 2014-07~2017-06 10万元 课题参与人
2013BAI06B04Y023026 紫杉醇、卡培他滨的综合评价研究 国家科技部科技支撑计划子课题 2013-01~2013-12 54万元 子课题负责人
** 多奈哌齐立体选择性代谢和转运机制及相关候选基因研究 国家自然科学基金 2013-01~2015-12 23万元 课题参与人
2010Y008A 中药威灵仙微乳制剂的临床前研究 上海市卫生局 2011-01~2012-12 3万元 课题负责人
** ERK5/MAPK信号通路在肝纤维化中的作用及木犀草素抗肝纤维化作用机制的研究 国家自然科学基金 2011-01~2013-12 32万元 课题负责人
10dz** 美哒灵、优哒灵临床用药评价及药物经济学研究 上海市科委 2010-08~2013-12 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Lu J, Wang X, Wan L, Fu J, Huo Y, Zhao Y, and Guo C. （通讯作者） Gene Polymorphisms Affecting the Pharmacokinetics and Pharmacodynamics of Donepezil Efficacy Front Pharmacol 2020 934
Zhang H, Chen L, Sun X, Yang Q, Wan L, and Guo C （通讯作者） Matrine: A Promising Natural Product With Various Pharmacological Activities Front Pharmacol 2020 588
Chen L, Xu W, Yang Q, Zhang H, Wan L, Xin B, Zhang J, and Guo C （通讯作者） Imperatorin alleviates cancer cachexia and prevents muscle wasting via directly inhibiting STAT3 Pharmacological Research 2020 104871
Chen L, Yang Q, Zhang H, Wan L, Xin B, Cao Y, Zhang J, and Guo C. （通讯作者） Cryptotanshinone prevents muscle wasting in CT26-induced cancer cachexia through inhibiting STAT3 signaling pathway J Ethnopharmacol 2020 113066
Li Chen, Linlin Chen, Lili Wan, Yan Huo, Jinlu Huang, Jie Li, Jin Lu, Bo Xin, Quanjun Yang,Cheng Guo （通讯作者） Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mTOR/FoxO3alpha signaling pathway in C2C12 myotubes and mice Oncology reports 2019 42: 479-494.
Zhang JX, Qi MJ, Shi MZ, Chen JJ, Zhang XQ, Yang J, Zhang KZ, Han YL, and Guo C （通讯作者） Effects of Danhong injection, a traditional Chinese medicine, on nine cytochrome P450 isoforms in vitro Biomed Chromatogr 2019 e4454
Huang JL, Fu Y, Guo C （通讯作者） Questions and perspectives on involvement of S1PR1 in cancer-induced bone pain and neuroinflammation Pain 2018 159(5):999-1000
Yang QJ, Zhao JR, Hao J, Li B, Huo Y, Han YL, Wan LL, Li J, Huang J, Lu J, Yang GJ, Guo C （通讯作者） Serum and urine metabolomics study reveals a distinct diagnostic model for cancer cachexia Journal of cachexia, sarcopenia and muscle 2018 9(1):71-85
Wan L, Lu J, Fu J, Huang J, Yang Q, Xin B, Chen L, Huo Y, Zhong Y, Guo C （通讯作者） Acetylcholinesterase Inhibitor Donepezil Effects on Plasma β-Hydroxybutyrate Levels in the Treatment of Alzheimer’s Disease Current Alzheimer Research 2018 15:1-11
Jin Lu, JF, Yuan Zhong,Quanjun Yang , Jinlu Huang , Jie Li ,Yan Huo , Yuwu Zhao, Lili Wan, Cheng Guo （通讯作者） Accocication between ABCA1 gene polymorphism and the response to donepezil therapy in Han Chinese patients with Alzheimer’s disease Brain Research Bulletin 2018 140:1-4
Yang Quan-Jun, Huo Yan, Han Yong-Long, Wan Li-Li, Li Jie, Huang Jin-Lu, Lu Jin, Chen Peng-Guo, Gan Run, Guo Cheng （通讯作者） Selumetinib attenuate skeletal muscle wasting in murine cachexia model through ERK inhibition and AKT activation Molecular cancer therapeutics 2017 16(2), 334-343.
QuanJun Y, GenJin Y, LiLi W, YongLong H1, Yan H, Jie L, JinLu H, Jin L, Run G, Cheng G. （通讯作者） Protective Effects of Dexrazoxane against Doxorubicin-Induced Cardiotoxicity: A Metabolomic Study Plos One 2017 12(1):e**
Quan-Jun Y, Jian-Ping Z, Jian-Hua Z, Yong-Long H, Bo X, Jing-Xian Z, Bona D, Yuan Z, Cheng G （通讯作者） Distinct Metabolic Profile of Inhaled Budesonide and Salbutamol in Asthmatic Children during Acute Exacerbation Basic Clin Pharmacol Toxicol 2017 120(3):303-311
Sun XP, Wan LL, Yang QJ, Huo Y, Han YL, Guo C （通讯作者） Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart Archives of pharmacal research 2017 40(7):875-883
Pengguo Chen, Jie Li, Yan Huo, Jin Lu, Lili Wan, Quanjun Yang, Jinlu Huang, Run Gan,Cheng Guo （通讯作者） Adenovirus-mediated expression of orphan nuclear receptor NR4A2 targeting hepatic stellate cell attenuates liver fibrosis in rats Sci Rep. 2016 6:33593.
Jin Lu, Jianliang Fu, Yuan Zhong, Pengguo Chen, Quanjun Yang, Yuwu Zhao, Lili Wan, Cheng Guo （通讯作者） The roles of apolipoprotein E3 and CYP2D6 (rs**) gene polymorphisms in the predictability of responses to individualized therapy with donepezil in Han Chinese patients with Alzheimer's disease Neuroscience Letters 2016 614（43–48）
Zhi-yong Zhou, Li-li Wan, Quan-jun Yang, Yong-long Han, Dan Li, Jin Lu, Cheng Guo （通讯作者） Nilotinib reverses ABCB1/P-glycoprotein-mediated multidrug resistance but increases cardiotoxicity of doxorubicin in a MDR xenograft model Toxicology Letters 2016 DOI: 10.1016/j.toxlet.2016.07.710
Jin-lu Huang, Yan Huo, Li-li Wan, Quan-jun Yang, Jie Li, Cheng Guo （通讯作者） CerK might contribute to inflammatory pain. Comments on Yu WL, Sun Y (2015). CerK inhibition might be a good potential therapeutic target for diseases. Br J Pharmacol 172: 2165. British Journal of Pharmacology 2016 173:1248-1249
Jin Lu, Lili Wan, Yuan Zhong, Qi Yu, Yonglong Han, Pengguo Chen, Beiyun Wang, Wei Li, Ya Miao, Cheng Guo （通讯作者） Stereoselective metabolism of donepezil and steady-state plasma concentrations of S-donepezil based on CYP2D6 polymorphisms in the therapeutic responses of Han Chinese patients with Alzheimer's disease Journal of Pharmacological Sciences 2015 129(3): 188–195
Yang Quan-Jun, Bian Jun,Wan Li-Li,Han Yong-Long,Li Bin,Yu Qi, Li Yan, Guo Cheng （通讯作者） NMR-based metabolomics reveals distinct pathways mediated by curcumin in cachexia mice bearing CT26 tumor RSC Adv. 2015 5, 11766-11775
Liu LY,Han YL,Zhu JH,Yu Q,Yang QJ,Lu J,Guo C （通讯作者） A sensitive and high-throughput LC-MS/MS method for inhibition assay of seven major cytochrome P450s in human liver microsomes using an in vitro cocktail of probe substrates. Biomed Chromatogr. 2015 29(3):437-44
Pengguo Chen, Jie Li, Yan Huo, Jin Lu, Lili Wan, Bin Li, Run Gan, Cheng Guo （通讯作者） Orphan nuclear receptor NR4A2 inhibits hepatic stellate cell proliferation through MAPK pathway in liver fibrosis PeerJ 2015 29(3):437-44
Yang QuanJun,Yang GenJin,Wan LiLi,Huo Yan,Han YongLong, Lu Jin, Li Jie, Huang JinLu,Guo Cheng （通讯作者） Integrated Analysis of Serum and Intact Muscle Metabonomics Identify Metabolic Profiles of Cancer Cachexia in a Dynamic Mouse Model RSC ADVANCES 2015 5：92438 - 92448
Bin Li,Run Gan, Quanjun Yang, Jinlu Huang, Pengguo Chen, Lili Wan, Cheng Guo （通讯作者） Chinese Herbal Medicines as an Adjunctive Therapy for Unresectable Pancreatic Cancer: A Systematic Review and Meta-Analysis EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2015 2015：1-15
Li J,Li X,Xu W,Wang S,Hu Z,Zhang Q,Deng X,Wang J,Zhang J,Guo C. Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways Liver Int 2015 35(4):1222-33
Huo Y, Yi B, Chen M, Wang N, Chen P, Guo C* （通讯作者）, Sun J*. Induction of Nur77 by Hyperoside Inhibits Vascular Smooth Muscle Cell Biochem Pharmacol. 2014 2014(92):590-598
Li B, Wan L, Li Y, Yu Q, Chen P, Gan R, Yang Q, Han Y, Guo C*. （通讯作者） Baicalin, a component of Scutellaria baicalensis, alleviates anorexia and inhibits Tumour Biol. 2014 2014(3512):1241-525
Han YL, Li D, Yang QJ, Zhou ZY, Liu LY, Li B, Lu J, Guo C*. （通讯作者） In Vitro?Inhibitory Effects of Scutellarin on Six Human/Rat Cytochrome P450 Enzymes and P-glycoprotein Molecules 2014 2014(195):5748-5760
Yang Quanjun, Yang Genjin, Wan Lili, Li Bin, Lu Jin, Yu Qi, Li Yan, Han Yonglong, Guo Cheng* （通讯作者）, Zhang Junping* Serum metabolic profiles reveal the effect of formoterol on cachexia in tumor-bearing mice Molecular BioSystems 2013 2013(912):3015-3025
Zhiyong Zhou, Lili Wan, Yonglong Han, Xiangle Meng, Quanjun Yang, Yan Li, Qi Yu, Zan Shen, Cheng Guo* （通讯作者） ABCB1-overexpressing MG63/DOX cell xenograft model: Maintain the MDR phenotype in vivo Pharmaceutical Biology 2013 2013(518):968-973
Wan Lili, Sun Yehong, Yu Qi, Huo Yan, Zhu Jinhui, Li Yan, Guo Cheng * （通讯作者） In vitro permeability analysis, pharmacokinetic and brain distribution study in mice of imperatorin, isoimperatorin and cnidilin in Radix Angelicae Dahuricae Fitoerapia 2013 2013(85):144-153
Yang Quanjun, Wan Lili, Zhou Zhiyong, Li Yan, Yu Qi, Liu Liya, Li bin, Guo Cheng* （通讯作者） Parthenolide from Parthenium integrifolium reduces tumor burden and alleviate cachexia symptoms in the murine CT-26 model of colorectal carcinoma Phytomedicine 2013 2013(2011):992-998
Zhi-yong Zhou, Li-li Wan, Quan-jun Yang, Yong-long Han, Yan Li, Qi Yu , Cheng Guo* （通讯作者）, Xiao Li* Evaluation of the Pharmacokinetics and Cardiotoxicity of Doxorubicin in Rat Receiving Nilotinib Toxicology and Applied Pharmacology 2013 2013(272):238-244
Wan Lili, Guo Cheng* （通讯作者）, Zhou Zhiyong, Yu Qi, Li Yan, Li Dan, Zheng Xueli, Zhong Yuan Steady-State Plasma Concentration of Donepezil Enantiomers and Its Stereoselective Metabolism and Transport In Vitro chirality 2013 2013(25):498-505
黄金路,郭澄 （通讯作者） Contributions of spinal D-amino acid oxidase to bone cancer pain Amino Acids 2012 43:1905-1918
韩永龙,郭澄 （通讯作者） Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription,on rat hepatic cytochrome P450 enzymes by cocktail probe drugs Journal of Ethnopharmacology 2012 2012,139:104-109
霍炎,郭澄 （通讯作者） Chemical Constituents of root of Inula helenium chemistry of natural compounds 2012 48(3):522-524
韩永龙,郭澄 （通讯作者） In Vitro Inhibition of Huanglian [Rhizoma coptidis (L.)] and its Six Active Alkaloids on Six Cytochrome P450 Isoforms in Human Liver Microsomes Phytother Res 2011 2011,25（8）:1660-1665
韩永龙,郭澄 （通讯作者） Inhibitory effects of limonin on six human cytochrome P450 enzymes and P-glycoprotein in vitro Toxicology in Vitro 2011 2011,25（8）:1828-1833
余奇,郭澄 （通讯作者） HPLC–MS–MS for the Simultaneous Determination of Atorvastatin and Amlodipine in Plasma of Hypertensive Patients Chromatographia 2011 2011,73:257-262
万丽丽、辛艳飞、郭澄 Alleviation of the acute doxorubicin-induced cardiotoxicity by Lycium barbarum polysaccharides through the suppression of oxidative stress. Food Chem Toxicol. 2011 2011,49:259-264
万丽丽,郭澄 （通讯作者） A stereospecific high-performance liquid chromatographic method and its application in determination of pharmacoketics profice of two enantiomers of naringenin in rats Journal of chromatographic science 2011 2011,49:316-320
Yan Li, Tao Wu, Jinghui Zhu, Lili Wan, Qi Yu, Xingxia Li, Zhihong Cheng*, Cheng Guo* （通讯作者） Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers. Journal of pharmaceutical and biomedical analysis 2010 2010(52):597-602
李丹,郭澄 （通讯作者） Effect of regular organic solvents on CYP450 mediated metabolic activities in rat liver microsomes Drug Metabolism & Disposition 2010 2010,38（11）：1192-1195
胡振林,郭澄 （通讯作者） Effects of esculentoside A on autoimmune syndrome induced by Campylobacter jejuni in mice and its modulation on T-lymphocyte proliferation and apoptosis International Immunopharmacology 2010 2010,10（1）:65-71
Zhenlin Hu, Xueqing Guo, Qi Yu, Lei Qiu, Jianzhong Li, Kang Ying, Cheng Guo* （通讯作者）, Junping Zhang* Zhenlin Hu#, Xueqing Guo#, Qi Yu, Lei Qiu, Jianzhong Li, Kang Ying, Cheng Guo*, Junping Zhang* Febs Letters 2009 2009(583):383-388
Wan L,Guo C* （通讯作者）,Yu Q,Li Y,Wang X,Wang X,Chen C. Quantitative determination of apigenin and its metabolism in rat plasma after intravenous bolus administration by HPLC coupled with tandem mass spectrometry Journal of chromatography B 2007 2007(8552):286-289