导师姓名： 吕晖 专业代码： 071000
性别： 男 专业名称： 生物学
培养单位： 附属儿童医院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： hui_genomehealth@qq.com
邮编： 邮箱地址： huilu.bioinfo@gmail.com

研究方向 (点击浏览详细信息)
生物信息，医学信息，生物统计，

社会任职
中国妇幼协会精准医学专委会委员
上海市生物信息学会理事

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
SQ2018YFC090124 精准医学大数据的有效挖掘与关键信息技术研发 国家重点研发计划 2018-07~2020-12 1475万元 课题负责人
** 信号传导中蛋白与细胞膜结合的生物信息研究 国家自然科学基金 2014-01~2014-12 15万元 课题负责人
** 基于蛋白DNA 相互作用的基因调控预测 国家自然科学基金 2011-01~2013-12 30万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Wenyi Qin, Xujun Wang, Hongyu Zhao and Hui Lu A Novel Joint Gene Set Analysis Framework Improves Identification of Enriched Pathways in Cross Disease Transcriptomic Analysis Frontiers in Genetics 2019 Volume 10, Article 293
Jianping Jiang, Jianlei Gu, Tingting Zhao, Hui Lu （通讯作者） VCF‐Server: A web‐based visualization tool for high‐throughput variant data mining and management Mol Genet Genomic Med 2019 (2019) 7:e641.
Cui Peng, Zhong Tingyan, Wang Zhuo, Wang Tao, Zhao Hongyu, Liu Chenglin, Lu Hui. （通讯作者） Identification of human circadian genes based on time course gene expression profiles by using a deep learning method BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2018 卷: 1864 期: 6 页: 2274-2283 子辑: B 特刊: SI
Gong, Xiaofeng ; Jiang, Jianping ; Duan, Zhongqu ; Lu （通讯作者）, Hui A new method to measure the semantic similarity from query phenotypic abnormalities to diseases based on the human phenotype ontology BMC BIOINFORMATICS 2018 卷: 19 增刊: 4 文献号: 162
Gong Zhijuan, Ma Qingwen, Wang Xujun, Cai Qin, Cong Xiuli, Genchev Georgi, Lu Hui （通讯作者）, Zeng Fanyi. A Herpes Simplex Virus Thymidine Kinase-Induced Mouse Model of Hepatocellular Carcinoma Associated with Up-Regulated Immune-Inflammatory-Related Signals GENES 2018 卷: 9 期: 8 文献号: 380
Liu Cong, Wang Xujun, Genchev Georgi Z., Lu Hui （通讯作者） Multi-omics facilitated variable selection in Cox-regression model for cancer prognosis prediction. Methods 2017 卷: 124? 页: 100-107
Gu Jian-lei, Chukhman Morris, Lu Yao, Liu Cong, Liu Shi-yi, Lu Hui （通讯作者） RNA-seq Based Transcription Characterization of Fusion Breakpoints as a Potential Estimator for Its Oncogenic Potential BIOMED RESEARCH INTERNATIONAL 2017 文献号: **
Carson Matthew B, Liu Cong, Lu Yao, Jia Caiyan, Lu Hui （通讯作者） A disease similarity matrix based on the uniqueness of shared gene BMC MEDICAL GENOMICS 2017 卷: 10?? 增刊: 1???? 文献号: 26
Zheng Bing, Liu Jun, Gu Jianlei, Du Jing, Wang Lin, Gu Shengli, Cheng Juan, Yang Jun, Lu Hui （通讯作者） Classification of Benign and Malignant Thyroid Nodules Using a Combined Clinical Information and Gene Expression Signatures PLoS One 2016 卷: 11 期: 10 文献号: e**
Jian-Lei Gu, Yi-Zhong Wang, Shi-Yi Liu, Guang-Jun Yu, Ting Zhang,Hui Lu （通讯作者） Gut microbiota community adaption during young children fecal microbiota transplantation by 16s rDNA sequencing Neurocomputing 2016 206, 66–72
Lu Y#, Lu Y#, Deng J, Peng H, Lu H* （通讯作者）, Lu LJ* A novel essential domain perspective for exploring gene essentiality Bioinformatics 2015 31(18):2921-9
Bing Zheng#, Jun Liu#, Jianlei Gu#, Yao Lu, Wei Zhang, Min Li and Hui Lu* A Three-Gene Panel That Distinguishes Benign from Malignant Thyroid Nodules Int J Cancer 2015 136(7):1646-1654
Carson MB, Gu Jian-lei, Yu Guang-jun*, Lu Hui* （通讯作者） Identification of cancer-related genes and motifs in the human gene regulatory network IET Syst Biol 2015 9(4):128-34
Lu Y, Deng J, Rhodes JC, Lu H* （通讯作者）, Lu LJ*. Predicting essential genes for identifying potential drug targets in Aspergillus fumigatus. Comput Biol Chem 2014 50:29-40
Jian-lei Gu#,Yao Lu#,Cong Liu#, Hui Lu* （通讯作者） Multiclass classification of sarcomas using pathway based feature selection method J THEOR BIOL 2014 362:3-8
Chen Y#, Sheng R#, K?llberg M#, Silkov A#, Tun MP, Bhardwaj N, Kurilova S, Hall RA, Honig B, Lu H* （通讯作者）, Cho W*. Genome-wide functional annotation of dual-specificity protein- and lipid-binding modules that regulate protein interactions Mol Cell 2012 46(2):226-37
He C#, Genchev GZ, Lu H* （通讯作者）, Li H* Mechanically untying a protein slipknot: multiple pathways revealed by force spectroscopy and steered molecular dynamics simulations J Am Chem Soc 2012 134(25):10428-35
Bhardwaj N#, Lu H* （通讯作者） Correlation between gene expression profiles and protein-protein interactions within and across genomes Bioinformatics 2005 21(11):2730-8