导师姓名： 张晨 专业代码： 100205
性别： 男 专业名称： 精神病与精神卫生学
培养单位： 附属精神卫生中心 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师： 兼
联系方式： 上海市宛平南路600号2号楼三楼生化研究室
邮编： 200030 邮箱地址： zhangchen645@gmail.com

研究方向 (点击浏览详细信息)
精神药理学

社会任职
中华医学会心身医学分会睡眠障碍学组委员
中国研究型医院学会神经再生与修复分会情感障碍与神经再生学组委员
Journal of Behavior Therapy and Mental Health, Editor
上海市医师协会精神科医师分会委员
上海市医学会精神医学专科分会青年委员
《Shanghai Archives of Psychiatry》编委
中国神经科学学会精神病学基础与临床分会青年委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 基于iTRAQ/LC-MS平台探究抗精神病药物认知疗效的生物学标记物 上海市医学引导类（西医）科技项目 2019-04~2022-03 20万元 课题负责人
2018YFC** 精神分裂症神经生化标志物体系研究 国家重点研发计划 2018-10~2020-12 190万元 课题负责人
** 补体因子H在精神分裂症快感缺失中的作用及机制研究 国家自然科学基金 2018-01~2021-12 54万元 课题负责人
** 高峰高原计划—临床专职科研队伍 上海市教育委员会 2016-01~2018-12 100万元 课题负责人
5-HR2cR/PTEN交叉对话在奥氮平诱导代谢认知副反应中的作用机制 上海市卫计委科研课题重点项目 2016-01~2018-12 15万元 课题负责人
** ANK3基因对精神分裂症工作记忆缺陷的调控作用及其突触可塑性机制 国家自然科学基金 2015-01~2018-12 80万元 课题负责人
** 寻找精神分裂症工作记忆缺陷生物学标记物—ANK3基因 上海市医学引导类（西医）科技项目 2014-08~2017-09 10万元 课题负责人
2013M530410 PTEN在奥氮平副反应中的作用机制 中国博士后基金 2013-02~2013-11 8万元 课题负责人
树鼩抑郁症模型的构建及系统评估研究 上海市“科技创新行动计划”实验动物研究项目 2012-11~2014-10 15万元 课题负责人
10ZR** 从基因×环境交互作用研究DNMT3B基因对早发性精神分裂症发病的影响机制 上海市自然科学基金 2011-01~2012-12 10万元 课题负责人
** “打击”模型研究精神分裂症环境危险因素对大鼠行为的影响及神经发育机制 国家自然科学基金 2011-01~2013-12 20万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Fang X, Wang Y, Chen Y, Ren J, Zhang C. （通讯作者） Association between IL-6 and metabolic syndrome in schizophrenia patients treated with second-generation antipsychotics. Neuropsychiatr Dis Treat. 2019 15:2161-2170.
Fang X, Chen Y, Wang Y, Ren J, Zhang C. （通讯作者） Depressive symptoms in schizophrenia patients: A possible relationship between SIRT1 and BDNF. Prog Neuropsychopharmacol Biol Psychiatry. 2019 95:109673.
Xu F, Fan W, Wang W, Tang W, Yang F, Zhang Y, Cai J, Song L, Zhang C. （通讯作者） Effects of omega-3 fatty acids on metabolic syndrome in patients with schizophrenia: a 12-week randomized placebo-controlled trial. Psychopharmacology (Berl). 2019 271:195-199.
Fang X, Chen L, Wang D, Yu L, Wang Y, Chen Y, Ren J, Tang W, Zhang C. （通讯作者） Metabolic profiling identifies TC and LDL as potential serum biomarkers for depressive symptoms in schizophrenia. Psychiatry Res. 2019 281:112522.
Yang F, Fang X, Tang W, Hui L, Chen Y, Zhang C （通讯作者）, Tian X. Effects and potential mechanisms of transcranial direct current stimulation (tDCS) on auditory hallucinations: A meta-analysis. Psychiatry Res. 2019 273:343-349.
Fang X, Tang W, Yang F, Lu W, Cai J, Ni J, Zhang J, Tang W, Li T, Zhang DF, Zhang C. （通讯作者） A Comprehensive Analysis of the CaMK2A Gene and Susceptibility to Alzheimer's Disease in the Han Chinese Population. Front Aging Neurosci. 2019 11:84.
Fang X, Chen Y, Wang Y, Zhang C. （通讯作者） Identification of risk factors for suicidal ideation in patients with schizophrenia. Psychiatry Res. 2019 271:195-199.
Ni H, Xu M, Zhan GL, Fan Y, Zhou H, Jiang HY, Lu WH, Tan L, Zhang DF, Yao YG, Zhang C. （通讯作者） The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer's Disease. J Alzheimers Dis. 2018 64(4):1149-1161.
Chen Y, Fang X, Wang Y, Zhang C. （通讯作者） Meta-analysis of FOXP2 rs** polymorphism with schizophrenia. Asian J Psychiatr. 2018 35:50-51.
Fang X, Zhang C （通讯作者）, Wu Z, Peng D, Xia W, Xu J, Wang C, Cui L, Huang J, Fang Y. The association between somatic symptoms and suicidal ideation in Chinese first-episode major depressive disorder. J Affect Disord. 2018 245:17-21.
Fang X, Zhang C （通讯作者）, Wu Z, Peng D, Xia W, Xu J, Wang C, Cui L, Huang J, Fang Y. Prevalence, risk factors and clinical characteristics of suicidal ideation in Chinese patients with depression. J Affect Disord. 2018 235:135-141.
Fang X, Chen Y, Wang Y, Zhang C. （通讯作者） Identification of risk factors for suicidal ideation in patients with schizophrenia. Psychiatry Res. 2018 271:195-199.
Zhang Y, Fang X, Fan W, Tang W, Cai J, Song L, Zhang C. （通讯作者） Brain-derived neurotrophic factor as a biomarker for cognitive recovery in acute schizophrenia: 12-week results from a prospective longitudinal study. Psychopharmacology (Berl). 2018 235(4):1191-1198.
Tang W, Chen Y, Fang X, Wang Y, Fan W, Zhang C. （通讯作者） SIRT1 rs** and Major Depressive Disorder: New Data and Meta-Analysis. Neurosci Bull. 2018 34(5):863-866.
Fang X, Zhang Y, Fan W, Tang W, Zhang C. （通讯作者） Interleukin-17 Alteration in First-Episode Psychosis: A Meta-Analysis. Mol Neuropsychiatry. 2018 3(3):135-140.
Mao R, Zhang C （通讯作者）, Chen J, Zhao G, Zhou R, Wang F, Xu J, Yang T, Su Y, Huang J, Wu Z, Cao L, Wang Y, Hu Y, Yuan C, Yi Z, Hong W, Wang Z, Peng D, Fang Y. Different levels of pro- and anti-inflammatory cytokines in patients with unipolar and bipolar depression. J Affect Disord. 2018 237:65-72.
Zhao L, Chang H, Zhou DS, Cai J, Fan W, Tang W, Tang W, Li X, Liu W, Liu F, He Y, Bai Y, Sun Y, Dai J, Li L, Xiao X, Zhang C （通讯作者）, Li M. Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population. Transl Psychiatry. 2018 8(1):270.
Li X, Luo Z, Gu C, Hall LS, McIntosh AM, Zeng Y, Porteous DJ, Hayward C, Li M, Yao YG, Zhang C （通讯作者）, Luo XJ; 23andMe Research Team7. Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder Neuropsychopharmacology. 2018 43:2146–2153.
Xiao X, Zhang C （通讯作者）, Grigoroiu-Serbanescu M, Wang L, Li L, Zhou D, Yuan TF, Wang C, Chang H, Wu Y, Li Y, Wu DD, Yao YG, Li M. The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders. Mol Psychiatry. 2018 23(9):1-11.
Yang F, Chen L, Fang X, Zheng K, Zhu C, Xu C, Zhang C （通讯作者）, Tang W. Influence of olanzapine on serum prolactin levels and BMI in female patients with schizophrenia. Neuropsychiatr Dis Treat. 2018 14:3373-3379.
Ren J, Zhao G, Sun X, Liu H, Jiang P, Chen J, Wu Z, Peng D, Fang Y, Zhang C. （通讯作者） Identification of plasma biomarkers for distinguishing bipolar depression from major depressive disorder by iTRAQ-coupled LC-MS/MS and bioinformatics analysis. Psychoneuroendocrinology. 2017 86:17-24.
Zhao G, Zhang C （通讯作者）, Chen J, Su Y, Zhou R, Wang F, Xia W, Huang J, Wang Z, Hu Y, Cao L, Guo X, Yuan C, Wang Y, Yi Z, Lu W, Wu Y, Wu Z, Hong W, Peng D, Fang Y. Ratio of mBDNF to proBDNF for Differential Diagnosis of Major Depressive Disorder and Bipolar Depression. Mol Neurobiol. 2017 54(7):5573-5582.
Zhang C （通讯作者）, Lv Q, Fan W, Tang W, Yi Z. Influence of CFH gene on symptom severity of schizophrenia. Neuropsychiatr Dis Treat. 2017 13:697-706.
Zhang Y, Fang X, Fan W, Tang W, Cai J, Song L, Zhang C. （通讯作者） Interaction between BDNF and TNF-α genes in schizophrenia. Psychoneuroendocrinology. 2017 89:1-6.
Zhang C （通讯作者）, Zhang Y, Cai J, Chen M, Song L. Complement 3 and metabolic syndrome induced by clozapine: a cross-sectional study and retrospective cohort analysis. Pharmacogenomics J. 2017 17(1):92-97.
Lu W, Zhang Y, Fang X, Fan W, Tang W, Cai J, Song L, Zhang C. （通讯作者） Genetic association analysis of microRNA137 and its target complex 1 with schizophrenia in Han Chinese. Sci Rep. 2017 7(1):15084.
Zhang C （通讯作者）, Fang X, Yao P, Mao Y, Cai J, Zhang Y, Chen M, Fan W, Tang W, Song L. Metabolic adverse effects of olanzapine on cognitive dysfunction: A possible relationship between BDNF and TNF-alpha. Psychoneuroendocrinology. 2017 81:138-143.
Tang W, Yang F, Lu W, Ni J, Zhang J, Tang W, Tang W, Zhang C. （通讯作者） Association study of CREB1 and CBP genes with Alzheimer's disease in Han Chinese. Asia Pac Psychiatry. 2017 9(3)
Zhang C, Chen MJ, Wu GJ, Wang ZW, Rao SZ, Zhang Y, Yi ZH, Yang WM, Gao KM, Song LS. Effectiveness of antipsychotic drugs for 24-month maintenance treatment in first-episode schizophrenia: Evidence from a community-based real-world study J Clin Psychiatry 2016 77(11):e1460-e1466.
Chang H, Zhang C （通讯作者）, Xiao X, Pu X, Liu Z, Wu L, Li M. Further evidence of VRK2 rs** associated with schizophrenia. World J Biol Psychiatry. 2016 17(6):457-66.
Wang P, Cai J, Ni J, Zhang J, Tang W, Zhang C. （通讯作者） The NCAN gene: schizophrenia susceptibility and cognitive dysfunction. Neuropsychiatr Dis Treat. 2016 12:2875-2883.
Zhang C （通讯作者）, Lu W, Wang Z, Ni J, Zhang J, Tang W, Fang Y. A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese. Transl Psychiatry. 2016 6:e701.
Zhang C （通讯作者）, Wu Z, Hong W, Peng D, Fang Y. Evaluating the association between the SHANK3 gene and bipolar disorder. Psychiatry Res. 2016 244:284-288.
Huo YX, Huang L, Zhang DF, Yao YG, Fang YR, Zhang C （通讯作者）, Luo XJ. Identification of SLC25A37 as a major depressive disorder risk gene. J Psychiatr Res. 2016 83:168-175.
Zhang Z, Ni J, Zhang J, Tang W, Li X, Wu Z, Zhang C. （通讯作者） A haplotype in the 5'-upstream region of the NDUFV2 gene is associated with major depressive disorder in Han Chinese. J Affect Disord. 2016 190:329-332.
Hong W, Zhang C （通讯作者）, Xing MJ, Peng DH, Wu ZG, Wang ZW, Chen J, Yuan CM, Su YS, Hu YY, Cao L, Wang Y, Huang J, Lu WH, Yi ZH, Yu X, Zhao JP, Zhang Q, Fang YR. Contribution of long duration of undiagnosed bipolar disorder to high frequency of relapse: A naturalistic study in China. Compr Psychiatry. 2016 70:77-81.
Luo XJ, Zhang C. （共同第一作者） Down-Regulation of SIRT1 Gene Expression in Major Depressive Disorder. Am J Psychiatry. 2016 173(10):1046.
Zhang C （通讯作者）, Wang Z, Hong W, Wu Z, Peng D, Fang Y. ZNF804A Genetic Variation Confers Risk to Bipolar Disorder. Mol Neurobiol. 2016 53(5):2936-43.
Zhang C, Zhang DF, Wu ZG, Peng DH, Chen J, Ni J, Tang W, Xu L, Yao YG, Fang YR. Complement factor H and susceptibility to major depressive disorder in Han Chinese. Br J Psychiatry. 2016 208(5):446-52.
Zhang C （通讯作者）, Wu Z, Zhao G, Wang F, Fang Y. Identification of IL6 as a susceptibility gene for major depressive disorder. Sci Rep. 2016 6:31264.
Zhang C. （通讯作者） The involvement of family members in the treatment of patients with schizophrenia. Curr Treat Options Psych. 2016 3:111-118
Zhu Y, Wang Z, Ni J, Zhang Y, Chen M, Cai J, Li X, Zhang W, Zhang C. （通讯作者） Genetic variant in NDUFS1 gene is associated with schizophrenia and negative symptoms in Han Chinese. J Hum Genet. 2015 60(1):11-6.
Wang S, Lu H, Ni J, Zhang J, Tang W, Lu W, Cai J, Zhang C. （通讯作者） An evaluation of association between common variants in C4BPB/C4BPA genes and schizophrenia. Neurosci Lett. 2015 590:189-92.
Chen J, Kang Q, Jiang W, Fan J, Zhang M, Yu S, Zhang C （通讯作者） The 5-HTTLPR confers susceptibility to anorexia nervosa in Han Chinese: evidence from a case-control and family-based study. PLoS One. 2015 10(3):e**.
Ni J, Hu S, Zhang J, Tang W, Lu W, Zhang C. （通讯作者） A Preliminary Genetic Analysis of Complement 3 Gene and Schizophrenia. PLoS One. 2015 10(8):e**.
Cai J, Zhu Y, Zhang W, Wang Y, Zhang C. （通讯作者） Comprehensive family therapy: an effective approach for cognitive rehabilitation in schizophrenia. Neuropsychiatr Dis Treat. 2015 11:1247-53.
Li Z, Zhang C （共同第一作者）, Fan J, Yuan C, Huang J, Chen J, Yi Z, Wang Z, Hong W, Wang Y, Lu W, Guan Y, Wu Z, Su Y, Cao L, Hu Y, Hao Y, Liu M, Yu S, Cui D, Xu L, Song Y, Fang Y. Brain-derived neurotrophic factor levels and bipolar disorder in patients in their first depressive episode: 3-year prospective longitudinal study. Br J Psychiatry. 2014 205(1):29-35.
Zhang Y, Chen M, Chen J, Wu Z, Yu S, Fang Y, Zhang C. （通讯作者） Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype. Psychopharmacology (Berl). 2014 231(10):2211-8.
Dang J, Zhang J, Guo Z, Lu W, Cai J, Shi Z, Zhang C. （通讯作者） A pilot study of iPad-assisted cognitive training for schizophrenia. Arch Psychiatr Nurs. 2014 28(3):197-9.
Zhang C, Cai J, Zhang J, Li Z, Guo Z, Zhang X, Lu W, Zhang Y, Yuan A, Yu S, Fang Y. Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2014 50:110-5.
Zhang C, Li Z, Wu Z, Chen J, Wang Z, Peng D, Hong W, Yuan C, Wang Z, Yu S, Xu Y, Xu L, Xiao Z, Fang Y. A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression. Psychopharmacology (Berl). 2014 231(4):685-93.
Zhang C, Zhang J, Fan J, Cheng W, Du Y, Yu S, Fang Y. Identification of ANKK1 rs** variant in schizophrenia: new data and meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2014 165B(7):564-71.
Wang Z, Zhang C （通讯作者）, Huang J, Yuan C, Hong W, Chen J, Yu S, Xu L, Gao K, Fang Y. MiRNA-206 and BDNF genes interacted in bipolar I disorder. J Affect Disord. 2014 162:116-9.
Tang W, Cai J, Yi Z, Zhang Y, Lu W, Zhang C. （通讯作者） Association study of common variants within the G protein-coupled receptor kinase 6 gene and schizophrenia susceptibility in Han Chinese. Hum Psychopharmacol. 2014 29(1):100-3.
Zhang C, Wu Z, Hong W, Wang Z, Peng D, Chen J, Yuan C, Yu S, Xu L, Fang Y. Influence of BCL2 gene in major depression susceptibility and antidepressant treatment outcome. J Affect Disord. 2014 155:288-94.
Zhang C, Li Z, Fang Y. BDNF and proBDNF as biomarkers for bipolar disorder: Authors' reply Br J Psychiatry. 2014 205(5):410-1.
Zhang C, Fang Y, Xu L. Glutamate receptor 1 phosphorylation at serine 845 contributes to the therapeutic effect of olanzapine on schizophrenia-like cognitive impairments. Schizophr Res. 2014 159(2-3):376-84.
Zhang J, Cai J, Zhang X, Ni J, Guo Z, Zhang Y, Lu W, Zhang C. （通讯作者） Does the bipolar disorder-associated CACNA1C gene confer susceptibility to schizophrenia in Han Chinese? J Mol Neurosci. 2013 51(2):474-7.
Zhang C, Chen J, Jia X, Yu S, Jiang W, Zhang R, Yuan A, Qian Y, Fan J, Zhang M, Fang Y, Xiao Z. Estrogen receptor 1 gene rs** polymorphism and anorexia nervosa: new data and meta-analysis. Asia Pac Psychiatry. 2013 5(4):331-5.
Zhang Y, Chen M, Wu Z, Chen J, Yu S, Fang Y, Zhang C. （通讯作者） Association study of Val66Met polymorphism in brain-derived neurotrophic factor gene with clozapine-induced metabolic syndrome: preliminary results. PLoS One. 2013 8(8):e72652.
Cai J, Zhang W, Yi Z, Lu W, Wu Z, Chen J, Yu S, Fang Y, Zhang C. （通讯作者） Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive-compulsive symptoms. Psychopharmacology (Berl). 2013 230(1):49-55.
Cai J, Yi Z, Lu W, Fang Y, Zhang C. （通讯作者） Crosstalk between 5-HT2cR and PTEN signaling pathway in atypical antipsychotic-induced metabolic syndrome and cognitive dysfunction. Med Hypotheses. 2013 80(4):486-9.
Lu W, Wu H, Cai J, Wang Z, Yi Z, Yu S, Fang Y, Zhang C. （通讯作者） Lack of association of SLC1A1 variants with schizophrenia in Chinese Han population. Psychiatry Res. 2013 210(2):669-71.
Zhang C, Li M. Contextual and behavioral control of antipsychotic sensitization induced by haloperidol and olanzapine. Behav Pharmacol. 2012 23(1):66-79.
Yi Z, Zhang C （通讯作者）, Lu W, Song L, Liu D, Xu Y, Fang Y. Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia. J Mol Neurosci. 2012 47(3):465-9.
Lu W, Zhang C （通讯作者）, Yi Z, Li Z, Wu Z, Fang Y. Association between BDNF Val66Met polymorphism and cognitive performance in antipsychotic-na?ve patients with schizophrenia. J Mol Neurosci. 2012 47(3):505-10.
Chen XS, Zhang C （通讯作者）, Xu YF, Zhang MD, Lou FY, Chen C, Tang J. Neonatal ventral hippocampal lesion as a valid model of schizophrenia: evidence from sensory gating study. Chin Med J (Engl). 2012 125(15):2752-4.
Yi Z, Zhang C （通讯作者）, Wu Z, Hong W, Li Z, Fang Y, Yu S. Lack of effect of brain derived neurotrophic factor (BDNF) Val66Met polymorphism on early onset schizophrenia in Chinese Han population. Brain Res. 2011 1417:146-50.
Zhang C, Fang Y, Li M. Olanzapine and risperidone disrupt conditioned avoidance responding by selectively weakening motivational salience of conditioned stimulus: further evidence. Pharmacol Biochem Behav. 2011 98(1):155-60.
Zhang C, Li Z, Shao Y, Xie B, Du Y, Fang Y, Yu S. Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population. J Mol Neurosci. 2011 43(3):406-11.
Zhang C, Xie B, Fang Y, Cheng W, Du Y, Wang D, Yu S. Influence of maternal MTHFR A1298C polymorphism on the risk in offspring of schizophrenia. Brain Res. 2010 1320:130-4.
Zhang C, Fang Y, Xie B, Cheng W, Du Y, Wang D, Yu S. No genetic association between dopamine D1 receptor gene and [early onset] schizophrenia. Psychiatry Res. 2010 177(3):350-3.
Zhang C, Xie B, Du Y, Cheng W, Fang Y, Yu S. Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is a risk factor for schizophrenia. J Neural Transm. 2010 117(9):1115-7.
Zhang C, Fang Y, Xie B, Cheng W, Du Y, Wang D, Yu S. DNA methyltransferase 3B gene increases risk of early onset schizophrenia. Neurosci Lett. 2009 462(3):308-11.