导师姓名： 刘晓华 专业代码： 100205
性别： 女 专业名称： 精神病与精神卫生学
培养单位： 附属精神卫生中心 三级学科/
专业领域：
导师类型： 硕士生导师 专业学位导师：
联系方式： 通讯地址：上海市宛平南路600号邮箱：drliuxiaohua@gmail.com
邮编： 200030 邮箱地址： drliuxiaohua@gmail.com

研究方向 (点击浏览详细信息)
精神疾病的生化研究
精神疾病遗传学

社会任职
上海市医学会精神医学专科分会青年委员
中国研究型医院学会心理与精神病学专业委员会委员

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
2018B 抑郁症诊治方法研究 广东省重点领域研发计划项目 2019-01~2022-12 3920万元 课题参与人
YG2017MS43 类外骨骼式智能约束保护装置的设计研究 上海交通大学医工交叉面上项目 2018-01~2020-12 21万元 课题参与人
2017YFC** 精神分裂症和双相障碍多模态精准诊疗方案优化研究 国家卫生计生委医药卫生科技发展研究中心 2017-07~2019-12 1800万元 课题参与人
** 实时人际交互的社会认知脑功能机制及其对精神病发病的影响 国家自然科学基金面上项目 2017-01~2020-12 57万元 课题参与人
CASIMM 建立抗抑郁药的药效评价体系和难治性抑郁症动物模型的关键技术 中国科学院药物创新研究院自主部署科研项目 2016-08~2018-07 25万元 课题参与人
15ZR** miR-374b-5p与miR-10a-5p在抑郁症病因与治疗机制中的作用研究 上海市自然科学基金项目 2015-01~2017-12 10万元 课题负责人
XYQ** 抑郁症与线粒体相关基因多态性的关联研究 上海市卫生系统优秀青年人才计划，上海市卫生局科研课题 2011-11~2014-10 60万元 课题负责人
** 抑郁症外周血中BDNF、CREB水平及其相关miRNAs的研究 国家自然科学基金青年科学基金项目 2011-01~2013-12 20万元 课题负责人
** 心境障碍外周血中神经营养相关标记物的探讨 上海市卫生局科研课题 2010-01~2011-12 4万元 课题负责人
09ZR** CREB的Ser142磷酸化对慢性轻度应激抑郁模型鼠海马神经发生的调控作用研究 上海市自然科学基金项目 2009-06~2011-06 10万元 课题参与人
** APC及其Wnt信号通路在精神分裂症发病中的作用机制研究 国家自然科学基金面上项目 2007-01~2009-12 29万元 课题参与人
06JC14061 抑郁症神经发生相关脑影像学和分子生物学研究 上海市科学技术委员会登山行动计划项目基础性研究重点项目 2006-08~2008-08 20万元 课题参与人
** 抑郁症遗传易感基因与环境因素交互作用的研究 国家自然科学基金面上项目 2003-01~2003-12 7万元 课题参与人

学术论文 作者论文标题期刊名出版年卷期页码
Zhang T, Zhu J, Xu L, Tang X, Cui H, Wei Y, Wang Y, Hu Q, Qian Z, Liu X, Tang Y, Li C, Wang J Add-on rTMS for the acute treatment of depressive symptoms is probably more effective in adolescents than in adults: Evidence from real-world clinical practice. Brain Stimul Brain Stimulation 2019 12(1):103-109
Zheng Y, He S, Zhang T, Lin Z, Shi S, Fang Y, Jiang K, Liu X （通讯作者） Detection Study of Bipolar Depression Through the Application of a Model-Based Algorithm in Terms of Clinical Feature and Peripheral Biomarkers Frontiers in Psychiatry 2019 10: 266
宋振华,郑雁群,符浩,陈海莹,胡瑶,史渊,方华,刘晓华 （通讯作者） 精神科进修医生自我导向学习倾向现状及影响因素的初步研究 心理学通讯 2019 2(1): 32-37
Zhang T, Xu L, Cui H, Tang Y, Wei Y, Tang X, Liu X, Cao X, Li C, Wang J Changes in correlation characteristics of time consumption and mind-reading performance in pre-onset and post-onset psychosis Psychiatry research 2018 262:168-174
Liu X, Wu Y Switch from previous major depression comorbid with CLIPPERS to mania-like episode following glucocorticosteroid therapy: a case report General psychiatry 2018 31(1):e000007
Zhang T, Cui H, Wei Y, Tang Y, Xu L, Tang X, Zhu Y, Jiang L, Zhang B, Qian Z, Chow A, Liu X, Li C, Xiao Z, Wang J Progressive decline of cognition during the conversion from prodrome to psychosis with a characteristic pattern of the theory of mind compensated by neurocognition Schizophrenia research 2018 195:554-559
Zhang T, Xu L, Tang Y, Li H, Tang X, Cui H, Wei Y, Wang Y, Hu Q, Liu X, Li C, Lu Z, McCarley RW, Seidman LJ, Wang J SHARP (ShangHai At Risk for Psychosis) Study Group. Prediction of psychosis in prodrome: development and validation of a simple, personalized risk calculator Psychological medicine 2018 14:1-9
Zhu S, Zhang T, Yang C, Wei Y, Xu L, Wang J, Chow A, Liu X, Jiang K, Xiao Z, Zhou H, Wang J A compromise solution between overlapping and overlooking DSM personality disorders in Chinese psychiatric practice Social Psychiatry and Psychiatric Epidemiology 2018 53(1):99-106
郑雁群,王燕,刘婉莹,张福旭,朱墨,宋振华,胡瑶,张天宏,刘晓华 （通讯作者） 烟酸皮肤潮红反应用于抑郁症诊断的研究 中国神经精神疾病杂志 2018 44(12): 710-715
Zhang T, Cui H, Wei Y, Tang Y, Xu L, Tang X, Zhu Y, Jiang L, Zhang B, Qian Z, Chow A, Liu X, Li C, Xiao Z, Wang J Progressive decline of cognition during the conversion from prodrome to psychosis with a characteristic pattern of the theory of mind compensated by neurocognition Schizophrenia research 2018 195:554-559
Zhang T, Xu L, Tang Y, Cui H, Wei Y, Tang X, Hu Q, Wang Y, Zhu Y, Jiang L, Hui L, Liu X （通讯作者）, Li C, Wang J Isolated hallucination is less predictive than thought disorder in psychosis: Insight from a longitudinal study in a clinical population at high risk for psychosis Scientific Reports 2018 18;8(1):13962
Zhang T, Xu L, Cui H, Tang Y, Wei Y, Tang X, Liu X, Cao X, Li C, Wang J Changes in correlation characteristics of time consumption and mind-reading performance in pre-onset and post-onset psychosis Psychiatry research 2018 262:168-174
Zhu S, Zhang T, Yang C, Wei Y, Xu L, Wang J, Chow A, Liu X, Jiang K, Xiao Z, Zhou H, Wang J A compromise solution between overlapping and overlooking DSM personality disorders in Chinese psychiatric practice Soc Psychiatry Psychiatr Epidemiol 2018 53(1):99-106
Liu X, Wu Y Switch from previous major depression comorbid with CLIPPERS to mania-like episode following glucocorticosteroid therapy: a case report Gen Psychiatr 2018 31(1):e000007
Zhang T, Guo X, Tang Y, Cui H, Wei Y, Xu L, Tang X, Liu X, Li C, Jiang K, Xiao Z, Wang J. Time consumption in mind-reading: A potentially important factor for social cognition assessment in early psychosis. Schizophr Res. 2017 Jun 15. pii: S0920-9964(17)30354-7.
Liu X, Bipolar Genome Study (BiGS), Kelsoe JR, Greenwood TA. A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region. J Affect Disord. 2016 Jan 1; 189: 141-149.
Zhang T, Tang Y, Cui H, Lu X, Xu L, Liu X, Li H, Chow A, Du Y, Li C, Jiang K, Xiao Z, Wang J. Theory of Mind Impairments in Youth at Clinical High Risk of Psychosis. Psychiatry. 2016 Spring; 79(1): 40-55.
Zhang T, Cui H, Tang Y, Xu L, Li H, Wei Y, Liu X, Chow A, Li C, Jiang K, Xiao Z, Wang J. Correlation of social cognition and neurocognition on psychotic outcome: a naturalistic follow-up study of subjects with attenuated psychosis syndrome. Sci Rep. 2016 Oct 10; 6: 35017.
He S, Liu X （通讯作者）, Jiang K, Peng D, Hong W, Fang Y, Qian Y, Yu S, Li H. Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder. J Psychiatr Res. 2016 Apr 1; 78: 65-71.
Zhang TH, Li HJ, Woodberry KA, Xu LH, Tang YY, Guo Q, Cui HR, Liu XH, Chow A, Li CB, Jiang KD, Xiao ZP, Seidman LJ, Wang JJ. Two-year follow-up of a Chinese sample at clinical high risk for psychosis: timeline of symptoms, help-seeking and conversion. Epidemiol Psychiatr Sci. 2016 Apr 8:1-12.
Wei Y, Zhang T, Chow A, Tang Y, Xu L, Dai Y, Liu X, Su T, Pan X, Cui Y, Li Z, Jiang K, Xiao Z, Tang Y, Wang J. Co-morbidity of personality disorder in schizophrenia among psychiatric outpatients in China: data from epidemiologic survey in a clinical population. BMC Psychiatry. 2016 Jul 8; 16: 224.
Liu X, Jiang K Why is Diagnosing MDD Challenging? Shanghai Arch Psychiatry 2016 28(6):343-345
Joseph J, Kremen WS, Glatt SJ, Franz CE, Chandler SD, Liu X, Johnson BK, Tsuang MT, Twamley EW. Assessment of Lifespan Functioning Attainment (ALFA) scale: A quantitative interview for self-reported current and functional decline in schizophrenia. Journal of Psychiatric Research 2015 65: 102-107.
Tylee DS, Chandler SD, Nievergelt CM, Liu X, Pazol J, Woelk CH, Lohr JB, Kremen WS, Baker DG, Glatt SJ, Tsuang MT; Marine Resiliency Study Investigators. Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: A pilot study. Psychoneuroendocrinology. 2015 51: 472-494.
张晨, 吴志国, 洪武, 汪作为, 胡莺燕, 曹岚, 陈俊, 王勇, 彭代辉, 刘晓华, 易正辉, 卢卫红, 苑成梅, 李则挚, 禹顺英, 吴彦, 方贻儒. Bcl-2基因启动子多态性与重度抑郁症及其临床表型的关联分析. 上海交通大学学报（医学版）. 2014 34(4): 422-425, 430.
He S, Zhang T, Hong B, Peng D, Su H, Lin Z, Fang Y, Jiang K, Liu X （通讯作者）, Li H. Decreased serum fibroblast growth factor-2 levels in pre- and post-treatment patients with major depressive disorder. Neuroscience Letters. 2014 579: 168-172.
Liu X （通讯作者）, Zhang T, He S, Hong B, Chen Z, Peng D, Wu Y, Wen H, Lin Z, Fang Y, Jiang K. Elevated serum levels of FGF-2, NGF and IGF-1 in patients with manic episode of bipolar disorder. Psychiatry Research. 2014 218(1-2): 54-60.
Hong W, Fan J, Yuan C, Zhang C, Hu Y, Peng D, Wang Y, Huang J, Li Z, Yu S, Liu X, Wu Z, Chen J, Yi Z, Xu L, Fang Y. Significantly decreased mRNA levels of BDNF and MEK1 genes in treatment-resistant depression. Neuroreport. 2014 25(10): 753-755.
Liu X （通讯作者）, Zhang T, He S, Hong B, Peng D, Su H, Li F, Tang Y, Lin Z, Fang Y, Jiang K. Nerve growth factor variations in patients with mood disorders: no changes in eight weeks of clinical treatment. Neuropsychiatric Disease and Treatment. 2014 10: 835-840.
Peng D, Shi F, Shen T, Peng Z, Zhang C, Liu X, Qiu M, Liu J, Jiang K, Fang Y, Shen D. Altered brain network modules induce helplessness in major depressive disorder. Journal of Affective Disorders. 2014 168: 21-29.
洪武,胡莺燕,李则挚,苑成梅,易正辉,陈俊,吴志国,黄佳,曹岚,禹顺英,刘晓华,彭代辉,江开达,方贻儒. 难治性抑郁症治疗前后外周血白细胞Bcl-2 mRNA表达研究. 中国神经精神疾病杂志. 2012 38(11): 656-661.
刘晓华,傅燚,彭代辉,江开达,蒋雨平,方贻儒. 甲基丙二酸血症伴同型半胱氨酸血症伴双相障碍1例并文献复习. 中国临床神经科学. 2012 20(1):78-84.
Guo X, Fu Y, Xu Y, Weng S, Liu D, Cui D, Yu S, Liu X, Jiang K, Dong Y. Chronic mild restraint stress rats decreased CMKLR1 expression in distinct brain region. Neuroscience Letters. 2012 524: 25-29.
刘晓华,徐一峰,崔东红,江三多,钱伊萍,禹顺英,江开达. 抑郁症患者外周血白细胞中CREB1基因表达研究. 中国神经精神疾病杂志. 2010 36(4): 237-240.
刘晓华,徐一峰,崔东红,江三多,钱伊萍,禹顺英,江开达. 抑郁症与cAMP反应元件结合蛋白基因的关联研究. 中华医学遗传学杂志. 2010 27(3): 263-266.
Liu X, Xu Y, Jiang S, Cui D, Qian Y, Jiang K. Family-based association study between brain-derived neurotrophic factor gene and major depressive disorder of Chinese descent. Psychiatry Research. 2009 169(2): 169-172.
李飞,徐一峰,刘晓华,彭代辉,禹顺英,钱伊萍,汪栋祥,江开达. 抑郁症与Nogo基因3’端未编码区CAA插入/缺失突变的关联研究. 中国神经精神疾病杂志. 2009 35(3): 145-147.
江开达,苏晖,徐一峰,李飞,刘晓华,刘义兰,潘桂花. 文拉法辛缓释剂和氟西汀治疗首发抑郁症的对照研究. 上海精神医学. 2007 19(1): 15-18.
彭代辉,江开达,徐一峰,沈婷,刘晓华. IAPS图片诱导首发抑郁症患者的情绪偏向性. 中国心理卫生杂志. 2007 21(11): 753-755.
刘晓华,徐一峰,江开达,赵兰英,江三多. 首发抑郁症遗传效应及方式的初步研究. 中华精神科杂志. 2005 38(1): 7-10.