郭圣荣 长聘教授

电话：(86)-
传真：(86)-
邮箱：srguo@sjtu.edu.cn
主页：http://srguo.sjtu.edu.cn


个人简历 研究方向 发表论文 科研成果
1996年浙江大学高分子化学与物理专业博士研究生毕业后进入复旦大学药学院（原上医大）工作，任讲师、副教授和硕士生导师。2000年上海交通大学药学院成立，即进入该学院工作至今。担任第一届本科生班主任和招收第一届研究生，2003年1月晋升为药剂学教授，创建医药用高分子与药物控释技术课题组。于2004年应邀到美国佐治亚理工大学开展合作研究；2013-2015 受欧盟玛丽居里国际引进人才基金资助，应聘到英国利兹大学工作2年。曾担任药学院首届团委书记、学生工作负责人，担任学院党支部/总支部/党委副书记十余年。
在国内外学术期刊发表论文100余篇，获中国专利授权10余项，主编出版专著和教材多部。受聘为全国高等学校药学专业研究生规划教材学术审定稿委员会委员（为包括7名院士在内的24 名委员之一）和首次全国高等学校药学类研究生规划教材《药用材料》主编。
已指导毕业硕士60名（其中全日制学生45名），博士11名，在读硕士研究生6名，博士研究生7名。据不完全统计：所指导的研究生获上海市及学校颁布的三好学生、优秀学生党员、优秀毕业生等荣誉称号25余人次；获国家奖学金14余人次，其它奖学金20余人次；多人次获全国性比赛（诺基亚创意大赛全国比赛）三等奖，中国药学会大会优秀论文三等奖及上海市药剂学年会暨青年论文报告会一等奖等。2018年有3位研究生获得国家奖学金。
获奖情况:
?上海交通大学首届优秀博士论文指导老师（13位优秀博导之一） (2017年)
?玛丽居里国际引进人才（Marie Curie International Incoming Fellowship） (欧盟，2015年)
?中国国际高新技术成果交易会优秀产品奖，2012年
?中国国际工业博览会高校展区二等奖，2012年
?国家科技进步二等奖 (国务院，2011)
?中国药学科技三等奖 (中国药学会, 2011)
?上海自然科学三等奖 (上海市政府, 2011)
?上海药学科技三等奖 (上海药学会2008)
?明治乳业生命科学（杰出奖）（上海每年生命科学领域2个获奖名额，2007年）
?上海交通大学“春兰”优秀教师奖二等奖，2002年
课题组成员：
沈园园，高级工程师


主要研究领域
1.新型药物输送系统，包括纳米药物输送系统和定位定向靶向药物输送系统。
2.新型药物/医疗器械组合体


Abid Hussain, Shengrong Guo*. NIR-triggered release of DOX from sophorolipid-coated mesoporous carbon nanoparticles with the phase-change material 1-tetradecanol to treat MCF-7/ADR cells[J]. Journal of Materials Chemistry B, 2019, 7, 974-985. （IF=4.776）
Huijie Han, Jingwen Hou, Ning Yang, Yihui Zhang, Huanfei Chen, Zhipeng Zhang, Yuanyuan Shen*, Shengtang Huang*, Shengrong Guo*. Insight on the changes of cassava and potato starch granules during gelatinization[J]. International journal of biological macromolecules, 2019, 126: 37-43. （IF=3.909）
Yun Wang, Feihu Wang, Yuanyuan Shen, Qianjun He*, Shengrong Guo*. Tumor-specific disintegratable nanohybrids containing ultrasmall inorganic nanoparticles: from design and improved properties to cancer applications[J]. Materials Horizons, 2018, 5(2): 184-205. （IF=13.183）
Zhu Jin, Keqin Wu, Jingwen Hou, Kunhong Yu, Yuanyuan Shen, Shengrong Guo*. A PTX/nitinol stent combination with temperature-responsive phase-change 1-hexadecanol for magnetocaloric drug delivery: Magnetocaloric drug release and esophagus tissue penetration[J]. Biomaterials, 2018, 153: 49-58. （IF=8.806）
Feihu Wang, Qian Huang, Yun Wang, Leilei Shi, Yuanyuan Shen, Shengrong Guo*. NIR-light and GSH activated cytosolic p65-shRNA delivery for precise treatment of metastatic cancer[J]. Journal of Controlled Release, 2018, 288: 126-135. （IF=7.877）
Yun Wang, Feihu Wang, Ying Liu, Shaohui Xu, Yuanyuan Shen, Nianping Feng*, Shengrong Guo*. Glutathione detonated and pH responsive nano-clusters of Au nanorods with a high dose of DOX for treatment of multidrug resistant cancer[J]. Acta biomaterialia, 2018, 75: 334-345. （IF=6.383）
Feihu Wang, Qian Huang, Yun Wang, Wenjun Zhang, Ran Lin, Yanna Yu, Yuanyuan Shen, Honggang Cui*, Shengrong Guo*. Rational design of multimodal therapeutic nanosystems for effective inhibition of tumor growth and metastasis[J]. Acta biomaterialia, 2018, 77: 240-254. （IF=6.383）
Zhipeng Zhang, Shaohui Xu, Yun Wang, Yanna Yu, Fangzhou Li, Hao Zhu, Yuanyuan Shen, Shengtang Huang*, Shengrong Guo*. Near-infrared triggered co-delivery of doxorubicin and quercetin by using gold nanocages with tetradecanol to maximize anti-tumor effects on MCF-7/ADR cells[J]. Journal of colloid and interface science, 2018, 509: 47-57. （IF=5.091）
Lijun Hu, Yun Wang, Yihui Zhang, NingYang, Huijie Han, Yuanyuan Shen, Derong Cui*, Shengrong Guo*. Angiopep-2 modified PEGylated 2-methoxyestradiol micelles to treat the PC12 cells with oxygen-glucose deprivation/reoxygenation[J]. Colloids and Surfaces B: Biointerfaces, 2018, 171: 638-646. （IF=3.997）
Ning Yang, Huanfei Chen, Huijie Han, Yuanyuan Shen, Song Gu*, Yong He, Shengrong Guo*. 3D printing and coating to fabricate a hollow bullet-shaped implant with porous surface for controlled cytoxan release[J]. International journal of pharmaceutics, 2018, 552(1-2): 91-98. （IF=3.862）
Lijun Hu, Min Li, Zhipeng Zhang, Yuanyuan Shen*, ShengrongGuo. Self-assembly of biotinylated poly (ethylene glycol)-poly (curcumin) for paclitaxel delivery[J]. International journal of pharmaceutics, 2018, 553(1-2): 510-521. （IF=3.862）
Keqin Wu, Jieying Liu, Lei Lei, Yuanyuan Shen*, ShengrongGuo. A stent film of paclitaxel presenting extreme accumulation of paclitaxel in tumor tissue and excellent antitumor efficacy after implantation beneath the subcutaneous tumor xenograft in mice[J]. International journal of pharmaceutics, 2018, 553(1-2): 29-36. （IF=3.862）
Kunhong Yu, Jingwen Hou, Zhu Jin, Keqin Wu, Shaohui Xu, Ning Yang, Yuanyuan Shen, Tingting Tang*, Shengrong Guo*. A cochlear implant loaded with dexamethasone and coated with hyaluronic acid to inhibit fibroblast adhesion and proliferation[J]. Journal of Drug Delivery Science and Technology, 2018, 46: 173-181. （IF=2.297）
Fangzhou Li, Yun Wang, Zhipeng Zhang, Yuanyuan Shen, Shengrong Guo*. A chemo/photo-co-therapeutic system for enhanced multidrug resistant cancer treatment using multifunctional mesoporous carbon nanoparticles coated with poly (curcumin-dithiodipropionic acid)[J]. Carbon, 2017, 122: 524-537. （IF=6.337）
Yanna Yu, Zhipeng Zhang, Yun Wang, Hao Zhu, Fangzhou Li, Yuanyuan Shen*, Shengrong Guo*. A new NIR-triggered doxorubicin and photosensitizer indocyanine green co-delivery system for enhanced multidrug resistant cancer treatment through simultaneous chemo/photothermal/photodynamic therapy[J]. Acta biomaterialia, 2017, 59: 170-180. （IF=6.319）
Yun Wang, Zhipeng Zhang, Shaohui Xu, Feihu Wang, Yuanyuan Shen*, Shengtang Huang*, ShengrongGuo*. pH, redox and photothermal tri-responsive DNA/polyethylenimine conjugated gold nanorods as nanocarriers for specific intracellular co-release of doxorubicin and chemosensitizer pyronaridine to combat multidrug resistant cancer[J]. Nanomedicine: Nanotechnology, Biology and Medicine, 2017, 13(5): 1785-1795. （IF=5.72）
Hao Zhu, Yun Wang, Abid Hussain, Zhipeng Zhang, Yuanyuan Shen* and Shengrong Guo*. Nanodiamond mediated co-delivery of doxorubicin and malaridine to maximize synergistic anti-tumor effects on multi-drug resistant MCF-7/ADR cells[J]. Journal of Materials Chemistry B, 2017, 5(19): 3531-3540. （IF=4.543）
Zhipeng Zhang, Yun Wang, Shaohui Xu, Yanna Yu, Abid Hussain, Yuanyuan Shen* and Shengrong Guo*. Photothermal gold nanocages filled with temperature sensitive tetradecanol and encapsulated with glutathione responsive polycurcumin for controlled DOX delivery to maximize anti-MDR tumor effects[J]. Journal of Materials Chemistry B, 2017, 5(27): 5464-5472. （IF=4.543）
Aijie Guo, Yun Wang, Shaohui Xu, Xiao Zhang, Min Li, Qing Liu, Yuanyuan Shen*, Derong Cui*, Shengrong Guo*. Preparation and evaluation of pH-responsive charge-convertible ternary complex FA-PEI-CCA/PEI/DNA with low cytotoxicity and efficient gene delivery[J]. Colloids and Surfaces B: Biointerfaces, 2017, 152: 58-67. （IF=3.887）
Wenjun Zhang, Feihu Wang, Yun Wang, Jining Wang, Yuanyuan Shen, Shengrong Guo*, Rongjun Chen*, Dejian Zhou*. pH and near-infrared light dual-stimuli responsive drug delivery using DNA-conjugated gold nanorods for effective treatment of multidrug resistant cancer cells [J]. Journal of Controlled Release, 2016, 232: 9-19. （IF=7.441）
Shengrong Guo*, Li Lv, Yuanyuan Shen, Zhongliang Hu, Qianjun He*, Xiaoyuan Chen*. A nanoparticulate pre-chemosensitizer for efficacious chemotherapy of multidrug resistant breast cancer[J]. Scientific reports, 2016, 6: 21459. （IF=5.228）
Jining Wang, Feihu Wang, Fangzhou Li, Wenjun Zhang, Yuanyuan Shen*, Dejian Zhou* and Shengrong Guo*. A multifunctional poly (curcumin) nanomedicine for dual-modal targeted delivery, intracellular responsive release, dual-drug treatment and imaging of multidrug resistant cancer cells[J]. Journal of Materials Chemistry B, 2016, 4(17): 2954-2962. （IF=4.872）
Qianjun He*, Shengrong Guo, Zhiyong Qian*, Xiaoyuan Chen*. Development of individualized anti-metastasis strategies by engineering nanomedicines[J]. Chemical Society Reviews, 2015, 44(17): 6258-6286. （IF=33.383）
Jieying Liu, Zhongmin Wang, Keqin Wu, Jing Li, Weiluan Chen, Yuanyuan Shen*, Shengrong Guo*. Paclitaxel or 5-fluorouracil/esophageal stent combinations as a novel approach for the treatment of esophageal cancer[J]. Biomaterials, 2015, 53: 592-599. （IF=8.557）
Lei Song, Yuan Guo, Deborah Roebuck, Chun Chen, Min Yang, Zhongqiang Yang, Sreejesh Sreedharan, Caroline Glover, Jim A. Thomas, Dongsheng Liu, Shengrong Guo*, Rongjun Chen*, Dejian Zhou*. Terminal pegylated DNA–Gold nanoparticle conjugates offering high resistance to nuclease degradation and efficient intracellular delivery of DNA binding agents[J]. ACS applied materials & interfaces, 2015, 7(33): 18707-18716. （IF=6.723）
Feihu Wang, Wenjun Zhang, Yuanyuan Shen, Qian Huang, Dejian Zhou*, Shengrong Guo*. Efficient RNA delivery by integrin-targeted glutathione responsive polyethyleneimine capped gold nanorods[J]. Acta biomaterialia, 2015, 23: 136-146. （IF=6.025）
Li Lv, Yuan Guo, Yuanyuan Shen, Jieying Liu, Wenjun Zhang, Dejian Zhou*, Shengrong Guo*. Intracellularly Degradable, Self‐Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy[J]. Advanced healthcare materials, 2015, 4(10): 1496-1501.（IF=5.797）
Zhongmin Wang, Jieying Liu, Keqin Wu, Yuanyuan Shen, Aiwu Mao, Jian Li, Zhijin Chen, Shengrong Guo*. Nitinol stents loaded with a high dose of antitumor 5-fluorouracil or paclitaxel: esophageal tissue responses in a porcine model[J]. Gastrointestinal endoscopy, 2015, 82(1): 153-160. e1.（IF=5.369）
Wei Tian, Jieying Liu, Yuan Guo, Yuanyuan Shen, Dejian Zhou*, Shengrong Guo*. Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells[J]. Journal of Materials Chemistry B, 2015, 3(7): 1204-1207. （IF=4.726）
Feihu Wang, Yuanyuan Shen, Wenju nZhang, Min Li, Yun Wang, Dejian Zhou*, Shengrong Guo*. Efficient, dual-stimuli responsive cytosolic gene delivery using a RGD modified disulfide-linked polyethylenimine functionalized gold nanorod[J]. Journal of Controlled Release, 2014, 196: 37-51. （IF=7.261）
Feihu Wang, Yun Wang, Xiao Zhang, Wenjun Zhang, Shengrong Guo*, Fang Jin*. Recent progress of cell-penetrating peptides as new carriers for intracellular cargo delivery[J]. Journal of Controlled Release, 2014, 174: 126-136. （IF=7.261）


*主要著作
1. 刘黎, 郭圣荣主编 《Polymers for Pharmaceutical Application-药用高分子材料（中文导读版）》, 化学工业出版社, 2015年1月。
2. 郭圣荣，主编《药用高分子材料》人民卫生出版社, 2009年9月出版
3. 郭圣荣, 主编《医药用生物降解性高分子材料》, 化学工业出版社， 2004年1月出版
4. 郭圣荣，参编教材《生物药剂学与药物动力学》, 人民卫生出版社，2011.
5. 郭圣荣,参编《肿瘤分子靶向治疗》第十四章“抗癌药物纳米粒的肿瘤治疗”，人民卫生出版社，2009年5月出版
6. 郭圣荣,参编《工业药剂学》第七章“液体制剂”，中国医药科技出版社,2009年10月出版
*授权专利
1. 郭圣荣(Shengrong Guo)，侯静文，雷磊。药用生物可降解聚（ε－己内酯）的合成及其应用方法。中国发明专利公开号：CN A。专利号：ZL7.5
2. 郭圣荣(Shengrong Guo)，雷磊，唐慕菲，刘茜。具有双侧药物释放性能的体内管腔内支架及其制备方法。中国发明专利公开号：CNA。专利号：ZL0.6
3. 郭圣荣(Shengrong Guo)，汪灵，汤亭亭，彭兆祥。壳聚糖季磷盐衍生物及其制备方法。中国发明专利公开号：CNA。专利号：ZL5.4
4. 郭圣荣(Shengrong Guo)，雷磊，洪薇。带翼聚合物支架。中国发明专利公开号：CNB。专利号：ZL2.1
5. 郭圣荣(Shengrong Guo)，雷磊，王立英，伍卫平,洪薇。具有内部支撑翼的药物释放型管状支架。中国发明专利公开号：CNB。专利号：ZL3.6
6. 郭圣荣(Shengrong Guo)，程亮，刘黎，唐奚敏。壳聚糖原位凝胶药剂的制备方法。中国发明专利公开号：CNB。专利号：ZL2.9
7. 郭圣荣(Shengrong Guo)，郭庆海，刘炯，王忠敏。抗癌药物粒子消化道支架。中国发明专利公开号：CNC。专利号：ZL0.1
8. 郭圣荣(Shengrong Guo)，郭庆海。载药缓释微/纳米球消化道支架的制备方法。中国发明专利公开号：CNC。专利号：ZL4.0