经莉莉 长聘教轨副教授

电话：
邮箱：lilijing@sjtu.edu.cn



个人简历 研究方向 发表论文 科研成果
简历
南京大学生命科学与技术系生物制药专业学士，美国宾夕法尼亚大学医学院生物医学博士，哈佛大学附属波士顿儿童医院血液和干细胞研究所博士后。曾在药明康德新药开发研究部负责血液肿瘤抗体药物研发工作。
于2016年10月加入上海交大药学院。目前主要研究方向为血液干细胞产生和向免疫细胞的定向分化，力求阐明血液系统等相关疾病发病机理，以及发现新型治疗靶点和新药研发。
获奖及荣誉
2016年上海市浦江人才计划
2009年美国宾夕法尼亚大学优秀博士论文奖


主要研究领域
通过分子生物学，遗传学，信息组学，微生物学，药理学以及活体成像等方法手段研究：
1)造血干细胞生产中的化学生物信号
2)免疫细胞分化和病变，新药筛选及化合物的作用机制
3)血液系统和微生物（感染和肠道菌群）作用机制和功能应用
4)基于斑马鱼模式生物的肿瘤个性化治疗以及药物药效和毒理作用研究


1. L. Jing, O. Tamplin, M. Chen, Q Deng, S. Patterson, P. Kim, E. Durand, A. McNeil, J. Green, S. Matsuno, J. Ablain, M. Brandt, A. Huttenlocher, T. Schleiger, G. Daley, K. Ravid and L. Zon. Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. Journal of Experimental Medicine, 212(5): 649-63, 2015.
2. J. Thornton, P. Du, L. Jing, L. Sjekloca, S. Lin, E. Grossi, P. Sliz, L. Zon and R. Gregory. Sequence-specific mono-uridylation of mature miRNAs by Zcchc6 and Zcchc11. Nucleic Acids Research, 42(18):11777-91, 2014.
3. X. Zhang, J. Ling, G. Barcia, L. Jing, R. Hill, B. Barry, J. Partlow, G. Mochida, T. Yu, J. Rodriguez, L. Zon, D. S?ll, C. Walsh, R. Nabbout. Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-Cerebellar Atrophy and Intractable Seizures. Am J Hum Genet, 94(4):547-58, 2014.
4. S. Boatman, F. Barrett, S. Satishchandran, L. Jing, I. Shestopalov and L. I. Zon. Assaying hematopoiesis using zebrafish. Blood Cells, Molecules, and Diseases, 51(4)271-76, 2013.
5. L.Jing, E. M. Durand, C. Ezzio, S. P. Pagliuca and L. I. Zon. In situ hybridization assay-based small molecule screening in zebrafish. Current Protocols in Chemical Biology, 4(2): **, 2012.
6. O.Tamplin, R. White, L. Jing, S. Lacadie, P. Li, A. Taylor, and L.I.Zon. Chemical screens in zebrafish embryos. Wiley Interdisciplinary Reviews Developmental Biology, 1(3):459-68, 2012.
7. L.Jing and L.I. Zon. Zebrafish as a model for normal and malignant hematopoiesis. Disease Models and Mechanisms, 4(4): 433-8, 2011.
8. L. Jing, L. Gordon, E. Shtibin and M. Granato. Temporal and spatial requirements of unplugged/MuSK function during zebrafish neuromuscular development. PLOS One, 5(1): e8843, 2010.
9. L. Jing, J. Lefebvre, L. Gordon and M. Granato. Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged /MuSK receptor. Neuron, 61(5): 721-733, 2009.
10. J. Lefebvre, L. Jing, S. Becaficco, C. Frenzini-Armstrong and M. Granato. Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation. Proc. Natl. Acad. Sci. USA 104: 2483-2488, 2007.


主要科研成果
1. L. Jing, O. Tamplin, M. Chen, Q Deng, S. Patterson, P. Kim, E. Durand, A. McNeil, J. Green, S. Matsuno, J. Ablain, M. Brandt, A. Huttenlocher, T. Schleiger, G. Daley, K. Ravid and L. Zon. Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. Journal of Experimental Medicine, 212(5): 649-63, 2015.
2. J. Thornton, P. Du, L. Jing, L. Sjekloca, S. Lin, E. Grossi, P. Sliz, L. Zon and R. Gregory. Sequence-specific mono-uridylation of mature miRNAs by Zcchc6 and Zcchc11. Nucleic Acids Research, 42(18):11777-91, 2014.
3. X. Zhang, J. Ling, G. Barcia, L. Jing, R. Hill, B. Barry, J. Partlow, G. Mochida, T. Yu, J. Rodriguez, L. Zon, D. S?ll, C. Walsh, R. Nabbout. Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-Cerebellar Atrophy and Intractable Seizures. Am J Hum Genet, 94(4):547-58, 2014.
4. S. Boatman, F. Barrett, S. Satishchandran, L. Jing, I. Shestopalov and L. I. Zon. Assaying hematopoiesis using zebrafish. Blood Cells, Molecules, and Diseases, 51(4)271-76, 2013.
5. L.Jing, E. M. Durand, C. Ezzio, S. P. Pagliuca and L. I. Zon. In situ hybridization assay-based small molecule screening in zebrafish. Current Protocols in Chemical Biology, 4(2): **, 2012.
6. O.Tamplin, R. White, L. Jing, S. Lacadie, P. Li, A. Taylor, and L.I.Zon. Chemical screens in zebrafish embryos. Wiley Interdisciplinary Reviews Developmental Biology, 1(3):459-68, 2012.
7. L.Jing and L.I. Zon. Zebrafish as a model for normal and malignant hematopoiesis. Disease Models and Mechanisms, 4(4): 433-8, 2011.
8. L. Jing, L. Gordon, E. Shtibin and M. Granato. Temporal and spatial requirements of unplugged/MuSK function during zebrafish neuromuscular development. PLOS One, 5(1): e8843, 2010.
9. L. Jing, J. Lefebvre, L. Gordon and M. Granato. Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged /MuSK receptor. Neuron, 61(5): 721-733, 2009.
10. J. Lefebvre, L. Jing, S. Becaficco, C. Frenzini-Armstrong and M. Granato. Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation. Proc. Natl. Acad. Sci. USA 104: 2483-2488, 2007.

本课题组热忱欢迎准备攻读硕士、博士学位的各位同学！热忱欢迎有兴趣从事博士后研究和专职科研的博士毕业生！
联系地址：
联系方式：
实验室：上海交通大学药学院6号楼309-311
办公室：上海交通大学药学院6号楼310