董常明


欢迎加入“生物高分子、生物医用材料与纳米医学”课题组！ 现招收 “生物高分子合成、免疫治疗、医用水凝胶方向”博士生！ 1、基本信息
姓名：董常明
职称：教授
电话：　
邮箱：cmdong@sjtu.edu.cn
主页：scce.sjtu.edu.cn
通讯地址：上海市东川路800号化学化工学院B楼418室
2、教育经历
1995-1998 武汉大学 化学系 硕士
1998-2001 北京大学 化学与分子工程学院 博士
2002-2003 美国Emory Univ 医学院 博士后

3、工作经历
2004-2008 上海交通大学 化学化工学院 讲师、副教授、硕士生导师、课题组长
2009-至今 上海交通大学 化学化工学院 教授、长聘教授（2020/08）、博士生导师、课题组长
4、研究方向

（1）生物高分子与生物医用材料（聚氨基酸或聚肽、糖聚合物、天然多糖）
（2）多功能性纳米医学与癌症治疗（免疫治疗、光热治疗、联合治疗）


（3）医用水凝胶及其止血愈合与软组织工程
（4）生物降解高分子与生物医用材料（聚乳酸、聚己内酯、脂肪族聚酯）
5、科研项目
主持和完成国家自然科学基金面上（青年）项目（8项）、上海市重大基础研究项目子课题、上海市教委科研创新计划重大项目子课题、交大医工交叉重点项目、教育部新世纪人才基金、教育部留学回国人员基金、交大晨星****基金等多项课题研究。
6、荣誉奖励
（1）2008年教育部新世纪优秀人才支持计划
（2）2008年上海交通大学晨星青年****奖励计划
（3）2012年、2013年获上海市优秀硕士论文导师（学生：华崇硕士和陈怡硕士）
（4）2012年上海交通大学晨星青年****A类计划
7、教学工作
（1）本科生课程：功能高分子（05年～）、生物医药大分子（06年）、高分子科学进展（13年）、大学化学（19年秋～）
（2）硕士生课程：有机功能材料（05年～，全日制硕士与工程硕士）
（3）博士生课程：材料科学前沿专题（04年～）
8、代表性论文及专著
71. YingyingSong, Yanzheng Chen, Pan Li, and Chang-Ming Dong*, Polypeptide-Glycosylated Dendron Amphiphiles: UV-Triggered Polymersomes, OVA Release, and In Vitro Enhanced Uptake and Immune Response,Biomacromolecules 2020, 21, 5345?5357.
70. Yue Ding, Chang Du, Jiwen Qian, and Chang-Ming Dong*,NIR-Responsive Polypeptide Nanocomposite Generates NO Gas, Mild Photothermia, and Chemotherapy to Reverse MultidrugResistant Cancer,Nano Letters 2019,19,4362-4370.
69.Chang Du, Yue Ding, Jiwen Qian, Rong Zhang*, Chang-Ming Dong*,Dual drug-paired polyprodrug nanotheranosticsreverse multidrug resistant cancers via mildphotothermal-cocktail chemotherapy,J. Mater. Chem. B, 2019, 7, 5306-5319.
68.Yue Ding, Chang Du, Jiwen Qian, and Chang-Ming Dong*,Zwitterionic polypeptide nanomedicine with dual NIR/reduction-responsivity for synergistic cancer photothermal-chemotherapy,Polym. Chem., 2019, 10,4825-4836.
67.Chang Du, Yue Ding, Jiwen Qian, Rong Zhang, Chang-Ming Dong*,Achieving traceless ablation of solid tumors without recurrence by mild photothermalchemotherapy of triple stimuli-responsive polymer–drug conjugate nanoparticles,J. Mater. Chem. B, 2019, 7, 415-432.
66.Pan Li, Yingying Song and Chang-Ming Dong*, Hyperbranched polypeptides synthesized from phototriggered ROP of a photocaged Nε-[1-(2-nitrophenyl)ethoxycarbonyl]-L-lysine-N-carboxyanhydride: microstructures and effects of irradiation intensity and nitrogen flow rate,Polym. Chem., 2018, 9, 3974-3986(Cover Paper).

65.Yue Ding,Chang Du,Jiwen Qian,Linzhu Zhou,Yue Su,Rong Zhang*,Chang-Ming Dong*,Tumor pH and intracellular reduction responsive polypeptide nanomedicine with a sheddable PEG
corona and a disulfide-cross-linked core,Polym. Chem., 2018, 9, 3488-3498 .

64.Yuanfeng Gao, Chang-Ming Dong*,Triple Redox/Temperature Responsive Diselenide-Containing Homopolypeptide Micelles and Supramolecular Hydrogels Thereof,J Polym Sci Polym Chem 2018, 56, 1067-1077 .

63.Pan Li and Chang-Ming Dong*，Phototriggered Ring-Opening Polymerization of a Photocaged L?Lysine N?Carboxyanhydride to Synthesize Hyperbranched and Linear Polypeptides，ACS Macro Lett. 2017, 6, 292-297.
62.Chang Du,Jiwen Qian, Linzhu Zhou,Yue Su, Rong Zhang,* and Chang-Ming Dong*,Biopolymer-Drug Conjugate Nanotheranostics for MultimodalImaging-Guided Synergistic Cancer Photothermal-Chemotherapy,ACS Appl. Mater. Interfaces 2017, 9, 31576-31588.
61.Pan Li, Jiacheng Zhang and Chang-Ming Dong *,Photosensitive poly(o-nitrobenzyloxycarbonylL-lysine)-b-PEO polypeptide copolymers: synthesis, multiple self-assembly behaviors, and the photo/pH-thermo-sensitive hydrogels,Polym. Chem., 2017, 8, 7033–7043.
60.Yuanfeng Gao and Chang-Ming Dong*，Reduction- and thermo-sensitive core-crosslinked polypeptide hybrid micelles for triggered and intracellular drug release,Polym. Chem. 2017,8, 1223-1232.
59. Wu Xingjie, Zhou Linzhu, Su Yue, Dong Chang-Ming*, Plasmonic, Targeted,and Dual Drugs-Loaded Polypeptide Composite Nanoparticles for Synergistic Cocktail Chemotherapy with Photothermal Therapy, Biomacromolecules, 2016, 17,2489-2501.
58. Wu Xingjie, Zhou Linzhu, Su Yue, Dong Chang-Ming*, A polypeptide micelle template method to prepare polydopamine composite nanoparticles for synergistic photothermal–chemotherapy, Polym. Chem., 2016, 7, 5552–5562.
57.Wu Xingjie, Zhou Linzhu, Su Yue, Dong Chang-Ming*, An autoreduction method to prepare plasmonic gold-embedded polypeptide micelles for synergistic chemo-photothermal therapy, J. Mater. Chem. B, 2016, 4, 2142–2152.
56.Liu Gang, Liu Na, Zhou Linzhu, Su Yue, Dong Chang-Ming*, NIR-responsive polypeptide copolymer upconversion composite nanoparticles for triggered drug release and enhanced cytotoxicity, Polym. Chem., 2015, 6, 4030–4039.
55.Wu Xingjie, Zhou Linzhu, Su Yue, Dong Chang-Ming*, Comb-like
poly(L-cysteine) derivatives with different side groups: synthesis via photochemistry and click chemistry, multi-responsive nanostructures, triggered drug release and cytotoxicity, Polym. Chem., 2015, 6, 6857–6869.
54.Gao Yanqin, Wu Xingjie, Zhou Linzhu, Su Yue, Dong Chang-Ming*, A Sweet Polydopamine Nanoplatform for Synergistic Combination of Targeted Chemo-Photothermal Therapy, Macromolecular Rapid Communications, 2015, 36,916–922.
53.Wu Xingjie, Gao Yanqin, Dong Chang-Ming*, Polymer/gold hybrid nanoparticles: from synthesis to cancer theranostic applications, RSC Advances, 2015,5, 13787–13796.
52. Gang Liu, Linzhu Zhou, Yue Su and Chang-Ming Dong*,An NIR-responsive and sugar-targeted polypeptide composite nanomedicine for intracellular cancer therapy, Chem Comm 2014,50,12538-12541.

51. Gang Liu , Linzhu Zhou , Yanfei Guan , Yue Su , Chang-Ming Dong *,Multi-Responsive Polypeptidosome: Characterization, Morphology Transformation,and Triggered Drug Delivery, Macromol. Rapid Commun. 2014, 35,1673-1678.
50. Xiao Chang, Lisha Liu, Yanfei Guan, Chang-Ming Dong*, Disulfide-Centered Star-Shaped Polypeptide-PEO Block Copolymers for Reduction-Triggered Drug Release, J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 2000-2010.
49. Lin Sun, Bangshang Zhu, Yue Su and Chang-Ming Dong*,
Light-responsive linear-dendritic amphiphiles and their nanomedicines for NIR-triggered drug release, Polym. Chem., 2014, 5, 1605-1613.
48. Xiao Chang, Chang-Ming Dong*,"Synthesis of Hyperbranched Polypeptide and PEO Block Copolymer by Consecutive Thiol-Yne Chemistry", Biomacromolecules 2013, 14, 3329?3337.
47. Gang Liu, Wei Liu, Chang-Ming Dong*, “UV- and NIR-Responsive Polymeric Nanomedicines for On-Demand Drug Delivery”, Polym. Chem., 2013, 4,3431-3443(Invited review).
46. Dong-Lin Liu, Xiao Chang, Chang-Ming Dong*, “Reduction- and thermo-sensitive star polypeptide micelles and hydrogels for on-demand drug delivery”, Chem Comm 2013, 49, 1229-1231.
45. Chang-Ming Dong*, Gang Liu, “Linear-Dendritic Biodegradable Block Copolymers: From Synthesis To Application In Bionanotechnology”, Polym. Chem., 2013, 4, 46-52 (Invited Minireview, 6# of Top 10 Most Read article in Septemper, 2012).
44. Lin Sun,Xiaofei Ma, Chang-Ming Dong*, Bangshang Zhu*, Xinyuan Zhu, 'NIR-Responsive and Lectin-Binding Doxorubicin-Loaded Nanomedicine from Janus-Type Dendritic PAMAM Amphiphiles', Biomacromolecules, 2012, 13, 3581-3591. (Most Read Articles: 6# of Top 20 in October 2012)
43. Gang Liu, Chang-Ming Dong*, "Photoresponsive Poly(S-(o-nitrobenzyl)-L-cysteine)-b-PEO from a LCysteine N-Carboxyanhydride Monomer: Synthesis, Self-Assembly, and Phototriggered Drug Release", Biomacromolecules, 2012, 13, 1573-1583. (Most Read Articles: Top 20 in April-May 2012)
42. Ye Liao, Chang-Ming Dong*, "Synthesis, Conformation Transition, Liquid Crystal Phase, and Self-Assembled Morphology of Thermosensitive Homopolypeptide",J Polym Sci Part A: Polym Chem 2012,50,1834–1843.
41.Yu-Jing Wang, Chang-Ming Dong*, "Bioreducible and Core-Crosslinked Hybrid Micelles from Trimethoxysilyl-Ended Poly(e-caprolactone)-S-S-Poly(ethylene oxide) Block Copolymers: Thiol-Ene Click Synthesis and Properties", J Polym Sci Part A: Polym Chem 2012,50,1645–1656.
40. You-Cui Xu, Chang-Ming Dong*, "Dendron-Like Poly(e-benzyloxycarbonyl-L-lysine)/Linear PEO Block Copolymers: Synthesis, Physical Characterization, Self-Assembly, and Drug-Release Behavior", J Polym Sci Part A: Polym Chem 2012, 50,1216–1225.
39. Lin Sun, Wei Liu, Chang-Ming Dong*, "Bioreducible Micelles and Hydrogels with Tunable Properties from Multi-Armed Biodegradable Copolymer", Chem Comm 2011, 47,11282-11284.
38. Lin Sun, Yang Yang, Chang-Ming Dong*, Yen Wei, "Two-Photon-Sensitive and Sugar-Targeted Nanocarriers from Degradable and Dendritic Amphiphiles", Small 2011, 7, 401-406.
37. Wei Liu, Chang-Ming Dong*, "Versatile Synthesis of Asymmetrical Dendron-Like/Dendron-Like Poly(Caprolactone)-b-Poly(Benzyl-L-Glutamate) Block Copolymers", J. Polym. Sci. Polym. Chem. 2011, 49, 3491-3498.
36. Wei Liu, Chang-Ming Dong*, “Versatile Strategy for the Synthesis of Hyperbranched Poly(e-caprolactone)s and Polypseudorotaxanes Thereof", Macromolecules 2010, 43, 8447-8455.
35. Lin Sun, Lin-Jing Shen, Ming-Qiang Zhu, Chang-Ming Dong*, Yen Wei, “Synthesis, Self-Assembly, Drug-Release Behavior, and Cytotoxicity of Triblock and Pentablock Copolymers Composed of Poly(e-caprolactone),Poly(L-lactide), and Poly(ethylene glycol)”, J Polym Sci Polym Chem 2010, 48, 4583-4593.
34. Yi Chen, Xiao-Hui Pang, Chang-Ming Dong*, “Dual Stimuli-Responsive Supramolecular Polypeptide-Based Hydrogel and Reverse Micellar Hydrogel Mediated by Host-Guest Chemistry”, Adv Funct Mater 2010, 20, 579-586.
33. Yi Chen, Chang-Ming Dong*, "pH-Sensitive Supramolecular Polypeptide-Based Micelles and Reverse Micelles Mediated by Hydrogen-Bonding Interactions or Host-Guest Chemistry: Characterization and In Vitro Controlled Drug Release", J. Phys. Chem. B 2010, 114, 7461–7468.
32. Yuan You, Yi Chen, Chong Hua, Chang-Ming Dong*, “Synthesis and Thermoreversible Gelation of Dendron-like Polypeptide/Linear Poly(e-caprolactone)/Dendron-like Polypeptide Triblock Copolymers”, J Polym Sci Polym Chem 2010, 48, 709-718.
31. Yang Yang, Chong Hua, Chang-Ming Dong*, “Synthesis, Self-Assembly, and In Vitro Doxorubicin Release Behavior of Dendron-like/Linear/Dendron-like Poly(ε-caprolactone)-b-Poly(ethylene glycol)-b-Poly(ε-caprolactone) Triblock Copolymers”, Biomacromolecules 2009, 10, 2310-2318.
30. Chong Hua, Chang-Ming Dong*, Yen Wei, " Versatile Strategy for the Synthesis of Dendron-like Polypeptide/Linear Pol(caprolactone) Block Copolymers via Click Chemistry", Biomacromolecules 2009, 10,1140-1148.
29. Qing Liu, Chen Cai, Chang-Ming Dong*, "Poly(L-lactide)-b-poly(ethylene oxide) copolymers with different arms: Hydrophilicity, biodegradable nanoparticles, in vitro degradation, and drug-release behavior", J Biomed Mater Res 2009, 88A, 990–999.
28. Xiao-Hui Dai, Hua-Dong Zhang, Chang-Ming Dong*, “Fabrication, biomolecular binding, in vitro drug release behavior of sugar-installed nanoparticles from star poly(ε-caprolactone)/glycopolymer biohybrid with a dendrimer core”, Polymer 2009, 50, 4626-4634.
27. Shuo Qiu, Hui Huang, Xiao-Hui Dai, Wei Zhou, Chang-Ming Dong*, "Star-Shaped Polypeptide/Glycopolymer Biohybrids: Synthesis, Self-Assembly, Biomolecular Recognition, and Controlled Drug Release Behavior", J Polym Sci Polym Chem 2009, 47, 2009-2023.
26. Song-Ming Peng, Yi Chen, Chong Hua, Chang-Ming Dong*, "Dendron-like Polypeptide/Linear Poly(ethylene oxide) Biohybrids with Both Asymmetrical and Symmetrical Topologies Synthesized via the Combination of Click Chemistry and Ring-Opening Polymerization", Macromolecules 2009, 42,104-113.
25. Chong Hua, Song-Ming Peng, Chang-Ming Dong*, "Synthesis and Characterization of Linear-Dendron-like Poly(ε-caprolactone)-b-poly(ethylene oxide) Copolymers via the Combination of Ring-Opening Polymerization and Click Chemistry", Macromolecules 2008, 41,6686-6695.
24. Xiao-Hui Dai, Chang-Ming Dong*, D. Yan, "Supramolecular and Biomimetic Polypseudorotaxane/Glycopolymer Biohybrids: Synthesis, Glucose-Surfaced Nanoparticles, and Recognition with Lectin", J Phys Chem B 2008, 112, 3644-3652.
23.Wei Zhou, Xiao-Hui Dai, Chang-Ming Dong*, "Biodegradable and Biomimetic Polycaprolactone/Poly(lactobionamidoethylmethacrylate) Biohybrids: Synthesis, Lactose-Installed Nanoparticles and Recognition Properties", Macromol. Biosci. 2008, 8, 268-278.
22. Xiao-Hui Dai, Chang-Ming Dong*, "Synthesis, Self-Assembly and Recognition Properties of Biomimetic Star-Shaped Pol(caprolactone)-b-Glycopolymer Block Copolymers", J Polym Sci Polym Chem 2008, 46, 817-829.
21. Hao Feng, Chang-Ming Dong*, "Synthesis and characterization of phthaloyl-chitosan-g-poly(L-lactide) using an organic catalyst", Carbohydrate Polymers 2007, 70, 258–264.
20. Chong Hua, Chang-Ming Dong*, "Synthesis, characterization, effect of architecture on crystallization of biodegradable poly(e-caprolactone)-b-poly(ethylene oxide) copolymers with different arms and nanoparticles thereof", J Biomed Mater Res 2007, 82A, 689–700.
19. Xiao Hui Dai, Chang-Ming Dong*, et al. "Supramolecular Polypseudorotaxanes Composed of Star-Shaped Porphyrin-Cored Poly(E-caprolactone) and Cyclodextrin", Biomacromolecules 2006, 7, 3527-33.
18. Hao Feng, Chang-Ming Dong*, "Preparation, Characterization, and Self-Assembled Properties of Biodegradable Chitosan-Poly(L-lactide) Hybrid Amphiphiles", Biomacromolecules 2006, 7, 3069-75. (Most-Accessed Articles: October-December, 2006).
17. Hao Feng, Chang-Ming Dong*, "Preparation and Characterization of Chitosan-g-Poly(ε-caprolactone) Using an Organic Catalyst", J Polym Sci Polym Chem 2006, 44, 5353-61.
16. Jing Liang Wang, Chang-Ming Dong*, “physical properties, crystallization kinetics, and spherulitic growth of well-defined poly(caprolactone)s with different arms", Polymer 2006, 47, 3218-3228.
15.Jing Liang Wang, Chang-Ming Dong*, “Synthesis, Sequential Crystallization, and Morphological Evolution of Star-Shaped Poly(caprolactone)-b-Poly(L-lactide) Block Copolymer”, Macromol Chem Phys 2006, 207,554-62.
14.Chen Cai, Lu, Wang, Chang-Ming Dong*, " Synthesis, Characterization, Effect of Architecture on Crystallization, and Spherulitic Growth of Poly(L-lactide)- b-Poly(ethylene oxide) Copolymers with Different Branch Arms”, J Polym Sci Polym Chem 2006, 44, 2034-44.
13.Lu Wang, Chang-Ming Dong*, “Synthesis, Crystallization Kinetics, and Spherulitic Growth of Linear and Star-Shaped Poly(L-lactide)s with Different Numbers of Arms”, J Polym Sci Polym Chem 2006, 44, 2226-36.
12. Jing-Liang Wang, Lu Wang, Chang-Ming Dong*, "Synthesis, Crystallization and Morphology of Star-Shaped Poly(caprolactone)", J. Polym. Sci. Polym Chem. 2005, 43, 5449-5457.
11.Lu, Wang, Jing-Liang Wang, Chang-Ming Dong*, "Supramolecular inclusion complexes of star-shaped poly(-caprolactone) with -cyclodextrin", J. Polym. Sci. Polym Chem. 2005, 43, 4721-4730.
10.Chang-Ming Dong*, Y. Z. Guo, K.Y Qiu*, Z.W. Gu, X.-D. Feng; "In vitro degradation and controlled release behavior of d,l-PLGA50 and PCL-b-d,l-PLGA50 copolymer microspheres", J. Control. Rel. 2005, 107 (1), 53-64.
9.Chang-Ming Dong, X.Y. Wu, J. Caves, S.S. Rele, B.S. Thomas, E. L. Chaikof, "Photomediated crosslinking of C6-cinnamate derivatized type I collagen", Biomaterials 2005, 26, 4041-4049.
8. Chang-Ming Dong*, E.L. Chaikof,Self-assembled nanostructures of a biomimetic glycopolymer–polypeptide triblock copolymer,Colloid Polym Sci 2005,283,1366-1370.

7.Chang-Ming Dong*, K M. Faucher,E.L. Chaikof, "Synthesis and Properties of Biomimetic Poly(L-glutamate)-b-Poly(2-acryloyloxyethyllactoside)-b-Poly(L-glutamate)Triblock Copolymers", J Polym Sci Polym Chem 2004, 42, 5754–5765.
6.Chang-Ming Dong, X.L.Sun, K. M. Faucher, R. Apkarian, E. L Chaikof, “Synthesis and Characterization of Glycopolymer-Polypeptide Triblock Copolymers”, Biomacromolecules, 2004, 5, 224-231.
5. Chang-Ming Dong, Kun-Yuan Qiu, Zhong-Wei Gu, Xin-De Feng; “Synthesis of Star-Shaped Poly(D,L-lactic acid-alt-glycolic acid)-b-Poly(L-Lactic Acid) with Multifunctional Initiator and SnOct2 Catalyst”, J Polym Sci Polym Chem, 2002, 40, 409-415.
4. Chang-Ming Dong, Kun-Yuan Qiu, Zhong-Wei Gu, Xin-De Feng; “Synthesis of Star-Shaped Poly(e-caprolactone)-b-(D,L-lactic acid-alt-glycolic acid) with Multifunctional Initiator and SnOct2 Catalyst”, Macromolecules, 2001, 34, 4691-4696.
3. Chang-Ming Dong, Kun-Yuan Qiu, Zhong-Wei Gu, Xin-De Feng; “Living Polymerization of D,L-3-Methylglycolide Initiated with Bimetallic (Al/Zn) m-oxo Alkoxide and Copolymers Thereof”, J Polym Sci Polym Chem, 2001, 39(3), 357-367.
2. Chang-Ming Dong, Kun-Yuan Qiu, Zhong-Wei Gu, Xin-De Feng; “Synthesis of Star-Shaped Poly(D,L-lactic acid-alt-glycolic acid) with Multifunctional Initiator and SnOct2 Catalyst”, Polymer, 2001, 42, 6891-6896.
1. Chang-Ming Dong, Kun-Yuan Qiu, Zhong-Wei Gu, Xin-De Feng; “Synthesis of Poly(D,L-lactic acid-alt-glycolic acid) from D,L-3-Methylglycolide”, J Polym Sci Polym Chem, 2000, 38 (23), 4179-4184.
专著（章节）
1. Xing-Jie Wu and Chang-Ming Dong, Chapter 4: Near-infrared-responsive gold nanoparticle-based photothermal agents: from synthesis to anticancer applications; Book "Photonanotechnology for Therapeutics and Imaging",2020, Page 83-104, Editor (Seok Ki, Choi), https://doi.org/10.1016/B978-0-12-817840-9.00004-7, Elsevier.
2. 董常明，生物降解高分子材料的新进展，2006年，P665-670，《高分子科学前沿与进展》董建华主编，科学出版社
9、其它
欢迎对“生物高分子、生物材料、纳米医学”感兴趣的博士后、研究生、本科生加入！
招收入学申请制博士生、直博生、硕博生（C9高校、985高校、中科院、211研究生院高校等）。